Containing Alicyclic Ring Having At Least Seven Members Patents (Class 568/375)
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Patent number: 9321713Abstract: The present invention provides a novel 11-step enantioselective approach to the natural product hyperforin, which enables access to a wide variety of hyperforin analogs. The present invention also provides pharmaceutical compositions comprising inventive hyperforin analogs. Hyperforin analogs synthesized using the present synthetic method are envisioned useful in the treatment of various conditions, including, but not limited to, depression and conditions characterized by depression, inflammatory skin conditions, diabetes, asthma, chronic obstructive pulmonary disease (COPD), kidney disorders, and ischemic brain damage.Type: GrantFiled: June 1, 2012Date of Patent: April 26, 2016Assignee: President and Fellows of Harvard CollegeInventors: Matthew D. Shair, Brian A. Sparling, David Moebius
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Publication number: 20150133693Abstract: The invention describes methods and systems for making particular organic compounds from unsaturated fatty acids derived from biological materials. Particular embodiments describe synthesizing civetone and olefins from a mixture of palmitoleic and oleic unsaturated fatty acid esters. The inventive methods use reaction steps such as metathesis, cyclization, hydrolysis, and/or decarboxylation.Type: ApplicationFiled: January 20, 2014Publication date: May 14, 2015Applicant: Heliae Development, LLCInventor: Sandip Shinde
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Patent number: 9000212Abstract: Provided by the present invention is a method for efficient oxidation of alcohols by using, as a catalyst for dehydrogenation oxidation, a ruthenium complex which can be easily produced and easily handled and is obtainable at a relatively low cost. The invention relates to a method of producing a compound having a carbonyl group by dehydrogenation oxidation of alcohols by using as a catalyst the ruthenium carbonyl complex represented by the following general formula (1) RuXY(CO)(L) (1) (in the general formula (1), X and Y may be the same or different from each other and represent an anionic ligand, and L represents a tridentate aminodiphosphine ligand).Type: GrantFiled: April 18, 2012Date of Patent: April 7, 2015Assignee: Takasago International CorporationInventors: Taichiro Touge, Kunimori Aoki, Hideki Nara, Wataru Kuriyama
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Publication number: 20150057207Abstract: The present invention relates to novel compounds and their use as fragrance materials.Type: ApplicationFiled: August 22, 2014Publication date: February 26, 2015Inventors: Benjamin Amorelli, Edward Mark Arruda, Robert P. Belko, Tingwei Cai, Adam P. Closson, Nicole L. Giffin, Gary J. Mertz, Michael G. Monteleone
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Patent number: 8940940Abstract: The present invention relates to a process for preparing cyclic compounds having at least eight carbon atoms and at least one keto group, to the cyclic compounds obtained by this process and to the use thereof, in particular as fragrance or for providing a fragrance.Type: GrantFiled: June 12, 2013Date of Patent: January 27, 2015Assignee: BASF SEInventors: Richard Dehn, Joaquim Henrique Teles, Michael Limbach, Stephan Deuerlein, Manuel Danz, Ralf Pelzer, Daniel Schneider
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Publication number: 20140323768Abstract: The present invention is directed to a novel fragrance compound, 3-methyl-cyclohexadec-6-enone.Type: ApplicationFiled: April 24, 2013Publication date: October 30, 2014Inventors: Anubhav P.S. Narula, Edward Mark Arruda, Benjamin Amorelli, Franc T. Schiet
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Patent number: 8859820Abstract: The present invention is directed to a novel fragrance compound, 3-methyl-cyclohexadec-6-enone.Type: GrantFiled: April 24, 2013Date of Patent: October 14, 2014Assignee: International Flavors & Fragrances Inc.Inventors: Anubhav P. S. Narula, Edward Mark Arruda, Benjamin Amorelli, Franc T. Schiet
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Publication number: 20140303374Abstract: Provided by the present invention is a method for efficient oxidation of alcohols by using, as a catalyst for dehydrogenation oxidation, a ruthenium complex which can be easily produced and easily handled and is obtainable at a relatively low cost. The invention relates to a method of producing a compound having a carbonyl group by dehydrogenation oxidation of alcohols by using as a catalyst the ruthenium carbonyl complex represented by the following general formula (1) RuXY(CO)(L) (1) (in the general formula (1), X and Y may be the same or different from each other and represent an anionic ligand, and L represents a tridentate aminodiphosphine ligand).Type: ApplicationFiled: April 18, 2012Publication date: October 9, 2014Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventors: Taichiro Touge, Kunimori Aoki, Hideki Nara, Wataru Kuriyama
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Patent number: 8835693Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis, wherein R1-R6, Ra-Rc, Q, Y1, Y2 and n are as defined herein.Type: GrantFiled: November 30, 2012Date of Patent: September 16, 2014Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Samuel J. Danishefsky, Christoph Gaul, Jon T. Njardarson
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Publication number: 20140200226Abstract: Novel compositions and methods for the treatment and prevention of malaria are disclosed herein.Type: ApplicationFiled: December 12, 2013Publication date: July 17, 2014Applicants: Florida Atlantic University, University of Central Florida Research Foundation, Inc.Inventors: Debopam Chakrabarti, Amy Wright
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Publication number: 20140135402Abstract: The present invention relates to compounds of Formula (I), wherein one R group is a hydrogen atom and the other is a hydrogen atom or a C1-3 alkyl group; and each carbon-carbon double bond of said compound, independently from each other, can be in a configuration Z or E or a mixture thereof; which are useful perfuming ingredients.Type: ApplicationFiled: June 18, 2012Publication date: May 15, 2014Applicant: FIRMENICH SAInventor: Peter Fankhauser
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Publication number: 20130338402Abstract: The present invention relates to a process for preparing cyclic compounds having at least eight carbon atoms and at least one keto group, to the cyclic compounds obtained by this process and to the use thereof, in particular as fragrance or for providing a fragrance.Type: ApplicationFiled: June 12, 2013Publication date: December 19, 2013Inventors: Richard Dehn, Joaquim Henrique Teles, Michael Limbach, Stephan Deuerlein, Manuel Danz, Ralf Pelzer, Daniel Schneider
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Publication number: 20130303432Abstract: The use of certain compounds for masking or decreasing the or one or a plurality of unpleasant olfactory impressions of one or a plurality of substances with an unpleasant odor and/or for enhancing the or one or a plurality of pleasant olfactory impressions of one or a plurality of substances with a pleasant odor and new fragrance mixtures and perfumed products containing such compounds.Type: ApplicationFiled: May 2, 2013Publication date: November 14, 2013Applicant: Symrise AGInventor: Symrise AG
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Patent number: 8563781Abstract: Ketones of the formula II where A is optionally alkyl-substituted C2-C12-alkanediyl, R1 and R2 are each, independently of one another, C1-C6-alkyl, or R1 and R2 together form optionally alkyl-substituted C3-C10-alkanediyl, and R3 is hydrogen or C1-C6-alkyl, are prepared by reacting a cyclic olefin of the formula I with dinitrogen monoxide to form the ketone of the formula II. The ketone of the formula II can be further hydrogenated to form the saturated ketone of the formula III. Macrocyclic ketones of the formula III, e.g. muscone, are sought after as fragrances.Type: GrantFiled: October 7, 2011Date of Patent: October 22, 2013Assignee: BASF SEInventors: Michael Schelper, Christoph Stock, Klaus Ebel, Joaquim Henrique Teles, Ralf Pelzer
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Patent number: 8461392Abstract: The present invention relates to a process for preparing at least one monocyclic ketone having from 4 to 20 carbon atoms by reacting a mixture G1 comprising at least one monocyclic olefin having from 4 to 20 carbon atoms with a mixture G2 comprising at least dinitrogen monoxide, wherein said reaction is performed adiabatically.Type: GrantFiled: August 26, 2009Date of Patent: June 11, 2013Assignee: BASF SEInventors: Joaquim Henrique Teles, Wilhelm Ruppel, Ulrike Wegerle, Anton Meier, Thomas Genger, Michael Schelper, Peter Resch
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Publication number: 20130052151Abstract: The present invention is directed to a novel compound, 3-methyl-cyclohexadec-6-enone, and a method of improving, enhancing or modifying a fragrance formulation through the addition of an olfactory acceptable amount of 3-methyl-cyclohexadec-6-enone.Type: ApplicationFiled: August 22, 2011Publication date: February 28, 2013Inventors: Anubhav P.S. Narula, Edward Mark Arruda, Benjamin Amorelli, Franc T. Schiet
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Patent number: 8324284Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis, wherein R1-R6, Ra-Rc, Q, Y1, Y2 and n are as defined herein.Type: GrantFiled: May 12, 2011Date of Patent: December 4, 2012Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Samuel J. Danishefsky, Christoph Gaul, Jon T. Njardarson
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Process and apparatus for separating and recovering waste alkali from cyclohexane oxidation solution
Patent number: 8221634Abstract: A process and an apparatus for separating and recovering waste alkali from a cyclohexane oxidation solution are provided. A gradient combination of the gravity separation technique, the vortex separation technique and the coalescence separation technique is used to carry out fine separation of the waste alkali liquor from the cyclohexane oxidation solution. The purified cyclohexane oxidation solution is fed into a down-stream apparatus. Most of the waste alkali liquor thus separated is recycled, while the remaining is expelled. The expelled waste alkali liquor is incinerated in an incinerator, followed by recovering the molten species using a pneumatic pulverization process.Type: GrantFiled: January 22, 2009Date of Patent: July 17, 2012Assignee: East China University of Science and TechnologyInventors: Zhishan Bai, Zhuoqun Qian, Ji Ma, Ping Zhou, Yanhong Zhang, Hualin Wang -
Patent number: 8202911Abstract: In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R1-R6, Ra-Rc, Q, Y1, Y2 and n are as defined herein, whereby the composition is formulated for administration to a subject at a dosage between about 0.1 mg/kg to about 50 mg/kg of body weight. In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.Type: GrantFiled: March 21, 2011Date of Patent: June 19, 2012Assignees: Cornell Research Foundation, Inc., Sloan-Kettering Institute for Cancer ResearchInventors: Xin-Yun Huang, Samuel J. Danishefsky, Christoph Gaul, Jón T. Njardarson
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Patent number: 8188141Abstract: The present invention provides compounds having formula (I): (I) wherein n, R1-R5, Ra-Rb, Q, Y1 and Y2 are as defined herein; and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis.Type: GrantFiled: September 23, 2005Date of Patent: May 29, 2012Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Samuel J. Danishefsky, Mihirbaran Mandal, David C. Dorn, Malcolm A. S. Moore
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Publication number: 20110313201Abstract: (Problem) The object of the invention relates to a development of a new musk-feeling fragrance material which is a highly scenting musk-feeling fragrance, and is to provide a fragrance composition which, when added to fragrances or cosmetics, can improve the fixative property and express a high performance and excellent musky aromatic quality. (Means for resolution) A fragrance composition is prepared using, as the active ingredient, a mixture of (R)-form of optically active muscone with (S)-form of optically active muscone with the mixing ratio thereof within the range of from 90:10 to 95:5 (weight ratio) in terms of weight ratio, or a mixture of (R)-form of optically active muscone with (S)-form of optically active muscone with the mixing ratio thereof within the range of from 75:25 to 80:20 (weight ratio) in terms of weight ratio.Type: ApplicationFiled: August 26, 2011Publication date: December 22, 2011Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventors: Kenichi Yamamoto, Misao Yagi, Hiroyuki Matsuda, Kenji Maruyama
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Patent number: 8071529Abstract: The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.1-bicyclo-octene and -octane compounds of the present invention are represented by formula: wherein R is selected from the group consisting of hydrogen, acetate, carbonate monomethyl ester, and allyloxy; and wherein the broken line represents a single or double bond.Type: GrantFiled: October 8, 2010Date of Patent: December 6, 2011Assignee: International Flavors & Fragrances Inc.Inventors: Adam P. Closson, Benjamin Amorelli, Nicole O'Keefe
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Patent number: 7943800Abstract: The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis, wherein R1—R6, Ra—Rc, Q, Y1, Y2 and n are as defined herein.Type: GrantFiled: March 26, 2004Date of Patent: May 17, 2011Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Samuel J. Danishefsky, Christoph Gaul, Jon T. Njardarson
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Patent number: 7868201Abstract: A process for the oxidation of hydrocarbons comprises contacting the hydrocarbon with an oxygen-containing gas in the presence of a catalyst comprising a microporous solid support, preferably a zeolite, having from 8- to 12-ring open windows and comprising non-framework metal cations selected from manganese, iron, cobalt, vanadium, chromium, copper, nickel, and ruthenium, and mixtures thereof, providing that the oxygen-containing gas does not contain significant amounts of added hydrogen. The catalyst is novel and forms part of the invention. The process may be used for oxidation of alkanes, cycloalkanes, benzene and alkylbenzenes, and is suitable for use in regioselective terminal oxidation of straight chain alkanes and for selective oxidation/separation of p-dialkylbenzenes from an alkylbenzene mixture, for example, p-xylene from an isomeric mixture of xylenes.Type: GrantFiled: July 1, 2005Date of Patent: January 11, 2011Assignee: ExxonMobil Research and Engineering CompanyInventors: Bi-Zeng Zhan, Bjorn Moden, Jihad Dakka, Jose Santiesteban, Sebastian C. Reyes, Enrique Iglesia
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Publication number: 20100196758Abstract: An electrode active material for a power storage device of the invention includes a ketone compound that includes a ring structure in a molecule, the ring structure being a five-membered or seven-membered ring composed of atoms at least three adjacent ones of which are each bonded to a ketone group. The electrode active material for a power storage device of the invention has a high weight-energy density and good reversibility of oxidation-reduction reaction. The use of the electrode active material for a power storage device of the invention can provide a power storage device having a high capacity, a high voltage, and good charge/discharge cycle characteristics.Type: ApplicationFiled: February 16, 2009Publication date: August 5, 2010Inventors: Nobuhiko Hojo, Yu Ohtsuka, Junichi Yoshida, Toshiki Nokami
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Publication number: 20100130758Abstract: Disclosed are a catalyst including a hydrotalcite and, immobilized on a surface thereof, particles of at least one metal selected from the group consisting of Cu, Ag, and Au; a method for producing a carbonyl compound through dehydrogenation of an alcohol in the presence of the catalyst; and a method for producing a carbonyl compound through dehydrogenation of an alcohol in the presence of a catalyst including a hydrotalcite and, immobilized on a surface thereof, particles of a metal, in which dehydrogenation is performed in the absence of oxygen.Type: ApplicationFiled: March 9, 2007Publication date: May 27, 2010Inventors: Kiyotomi Kaneda, Noritsugu Yamasaki
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Patent number: 7674765Abstract: The invention relates to a method for producing cyclohexadecanone by hydrogenating cyclohexadecenone, to mixtures of aromatic substances, and to products containing the inventive cyclohexadecanone.Type: GrantFiled: May 22, 2003Date of Patent: March 9, 2010Assignee: Symrise GmbH & Co., KGInventors: Ingo Wöhrle, Walter Kuhn, Hans-Ulrich Funk, Alfred Körber
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Patent number: 7632791Abstract: Described are spirocyclic ketols of formula (I) wherein n and A have the same meaning as given in the description. Also disclosed is a method for their production and flavour and fragrance compositions containing them.Type: GrantFiled: November 7, 2005Date of Patent: December 15, 2009Assignee: Givaudan SAInventor: Philip Kraft
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Publication number: 20090239953Abstract: The present invention relates to a compound represented by the formula (I), method of preparation, pharmaceutical preparation containing said compound, and the use of said compound in the manufacture of a pharmaceutical preparation for the prevention and treatment of cancer by way of inhibiting the proliferation of carcinoma cells of the cervix and ovaries.Type: ApplicationFiled: November 20, 2007Publication date: September 24, 2009Inventors: Ahmad Bustamam Abdul, Muhammad Nazrul Hakim Abdullah, Mohd Nordin Lajis, Nirmala Devi Tailan, Zetty Nadia Mohd Zain, Siddig Ibrahim Abdel Wahab, Adel Sharaf Al-Zubairi
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Patent number: 7547697Abstract: Compounds of formula (I): as well as pharmaceutically acceptable salts and esters thereof for use as pharmaceutical compositions.Type: GrantFiled: July 2, 2007Date of Patent: June 16, 2009Assignee: Hoffmann-La Roche Inc.Inventors: Kurt Amrein, Daniel Hunziker, Bernd Kuhn, Werner Neidhart, Alexander V. Mayweg
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Patent number: 7402712Abstract: Provided by the present invention are an adamantyl vinyl ether compound which is useful as a monomer for functional resins in the photolithography field or a raw material therefor and medical and agricultural intermediates and a production process for the same. The present invention relates to a production process for an adamantyl vinyl ether compound, characterized by subjecting an adamantyl vinyl ether compound having a specific structure and alcohol having an eliminating group in a ? position to chloroalkyl-etherification, then subjecting it to etherification to form an adamantyl group-containing ether and then subjecting it to vinyl-etherification.Type: GrantFiled: June 8, 2004Date of Patent: July 22, 2008Assignee: Idemitsu Petrochemical Co., Ltd.Inventors: Naoyoshi Hatakeyama, Shinji Tanaka, Hidetoshi Ono, Kouichi Kodoi
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Publication number: 20080171796Abstract: The present invention is directed to novel compounds of the structure and a method for enhancing a perfume composition by incorporating an olfactory acceptable amount of the compounds provided above.Type: ApplicationFiled: January 16, 2007Publication date: July 17, 2008Inventors: Anthony T. Levorse,, Brett D. Newirth
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Publication number: 20080139446Abstract: The invention relates to a compound of general formula (I) wherein: A) a) R4, R5, and R7 each represent a hydrogen atom and R3, R6 and R8 each represent a methyl radical, or b) R4, R6, and R7 each represent a hydrogen atom and R3, R5 and R8 each represent a methyl radical, or c) R3, R6 and R7 each represent a hydrogen atom and R4, R5 and R8 each represent a methyl radical, and the dotted lines are present and represent cis-double bonds or trans-double bonds, and R1 represents a hydrogen atom and R2 represents an OH, OCH3 or OC2H5 group, or the dotted lines are absent and R1 represents a hydrogen atom and R2 represents an OCH3 group or an OC2H5 group; or B) R1, R4, and R6 each represent a hydrogen atom and R2, R3 and R5 each represent a methyl radical, and the dotted lines are present and represent cis-double bonds or trans-double bonds, and R7 represents a hydrogen atom and R8 represents an OH, OCH3 or OC2H5 bond, or the dotted lines are absent and R7 represents a hydrogen atom and R8 represents an OCH3 groupType: ApplicationFiled: January 13, 2006Publication date: June 12, 2008Applicant: V. MANE FILSInventors: Jean Mane, Jean-Jacques Chanot, Martin Schroeder
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Patent number: 7282612Abstract: The invention relates to a method for producing monocyclic ketones C4-C5. The inventive method is based on the reaction of a liquid-phase oxidation of monocyclic alkenes C4-C5 into corresponding cyclic ketones by nitrogen oxide or the mixture thereof with an inert gas. The process is carried out at a temperature ranging from 20 to 300° C. and a pressure of nitrogen oxide ranging from 0,01 to 100 atm. The inventive process ensures the high selectivity with respect to target products, the explosion safety at work and is promising for industrial use.Type: GrantFiled: November 6, 2002Date of Patent: October 16, 2007Assignee: Institut Kataliza Imeni G.K. Boreskova Sibirskogo Otdelenia Rossiliskoi Akademii NaukInventors: Gennady Ivanovich Panov, Konstantin Alexandrovich Dubkov, Evgeny Vladimirovich Starokon, Larisa Vladimirovna Pirutko
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Patent number: 7247753Abstract: The invention relates to a method for producing macrocyclic ketones of general formula (I) by direct cyclisation of compounds of general formula (II) in the gas phase on a heterogeneous catalyst. In general formula (I), X represents a monounsaturated or polyunsaturated or saturated C10–C17 alkyl radical which can be optionally substituted by a C1–C6 alkyl radical, and in general formula (II), R1, R2 can respectively be the same or different and represent hydrogen or C1–C6 alkyl, and has the above-mentioned designation.Type: GrantFiled: July 10, 2003Date of Patent: July 24, 2007Assignee: BASF AktiengesellschaftInventors: Alexander Wartini, Klaus Ebel, Gisela Hieber, Hagen Weigl
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Patent number: 7199161Abstract: The invention relates to the use of substituted bicyclo[3.3.1]nonan-2,4,9-triones, especially clusianon and clusianon derivatives, as pharmaceutical active ingredients or medicamentous active ingredients, especially for producing medicaments for the prophylactic and/or therapeutic (curative) treatment of tumour or cancer diseases, and of viral diseases. The above-mentioned compounds can be used in cytostatic agents and antiviral agents (virostatic agents). They are especially used as inhibitors of topoisomerases and telomerases and as regulators during the MAP kinase signal transduction and can thus intervene on a cellular scale in the mechanism for multiplication of tumour or cancer cells and viruses.Type: GrantFiled: November 20, 2002Date of Patent: April 3, 2007Assignee: Diagenics International CorporationInventors: Siegfried Seeber, Ralf Axel Hilger, David Diaz-Carballo
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Patent number: 7135501Abstract: The invention relates to a clusianon isomer and to the use thereof, in particular as a pharmaceutical or medical active ingredient, in particular for producing medicaments for the prophylactic and/or therapeutic (curative) treatment of tumor or cancer diseases as well as viral diseases. The aforementioned compound can be used in cytostatics and antiviral agents (virostatics). Said compound acts, in particular, as a topoisomerase and telomerase inhibitor and as a regulator in the MAP kinase signal transduction. Said compound can thus intervene at the cellular level in the proliferation mechanism of tumor or cancer cells and viruses.Type: GrantFiled: November 20, 2002Date of Patent: November 14, 2006Inventors: Siegfried Seeber, Ralf Axel Hilger, David Diaz-Carballo
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Patent number: 7129380Abstract: The compound (Z)-7-cyclohexadecen-1-one is described as a musk odorant. Also described are odorant or aroma mixtures comprising (Z)-7-cyclohexadecen-1-one and one or more other odorants or aromas.Type: GrantFiled: December 21, 2004Date of Patent: October 31, 2006Assignee: Symrise GmbH & Co. KGInventors: Aurelia Reckziegel, Ingo Wöhrle, Steffen Sonnenberg
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Patent number: 7105704Abstract: The invention relates to a method for producing monocyclic ketones C7–C20. The method of patent protection sought is based on the oxidation reaction of monocyclic alkenes C7–C20 into corresponding monocyclic ketones with nitrous oxide or a mixture thereof with inert gas. The process proceeds at a temperature ranging from 20 to 350° C. and a pressure of the nitrous oxide ranging from 0.01 to 100 atm. The process provides a high selectivity involving the target product, blast-resistant work operations and is promising for industrial use.Type: GrantFiled: November 6, 2002Date of Patent: September 12, 2006Assignee: Institut Kataliza Imeni G.K. Boreskova Sibirskogo Otdeleniya Rossiiskoi Akademii NaukInventors: Gennady Ivanovich Panov, Constantin Alexandrovich Dubkov, Eygeny Vladimirovich Starokon, Dmitry Petrovich Ivanov
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Patent number: 7105705Abstract: The use of the reduction products of hyperforin and adhyperforin, pharmaceutically acceptable salts or esters thereof, in the pharmaceutical and/or nutritional field, in particular in the treatment of depression and Alzheimer's disease.Type: GrantFiled: April 18, 2003Date of Patent: September 12, 2006Assignee: Indena S.p.A.Inventors: Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, Nicola Fuzzati
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Patent number: 7087793Abstract: The present invention provides a process for producing cycloalkanol and/or cycloalkanone by oxidizing cycloalkane with molecular oxygen in the presence of a heteropolyacid compound comprising a cobalt atom as a central element and a cobalt atom as a frame element.Type: GrantFiled: August 26, 2005Date of Patent: August 8, 2006Assignee: Sumitomo Chemical Company, LimitedInventors: Avelino Corma, Jose Manuel Lopez Nieto
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Patent number: 7057078Abstract: Hyperforin and adhyperforin halogenated derivatives of general formula (I) in which X, R and R1 have the meanings as defined in the disclosure, the process for the preparation thereof and the use thereof in the pharmaceutical and/or nutritional field, in particular in the treatment of depression, and Alzheimer's disease.Type: GrantFiled: April 15, 2003Date of Patent: June 6, 2006Assignee: INDENA S.p.A.Inventors: Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, Nicola Fuzzati
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Patent number: 7034188Abstract: A method for producing a ketone, particularly a macrocyclic ketone, from a 2-hydroxycycloalkanone having from 12 to 18 carbon atoms by efficiently dehydrating and reducing the acyloin in a single reaction vessel. A method for producing a ketone compound, which comprises dehydrating and reducing an acyloin in the coexistence of an acid catalyst and a reduction catalyst and in the presence of hydrogen, particularly using a 2-hydroxycycloalkanone having from 12 to 18 carbon atoms as the acyloin.Type: GrantFiled: January 21, 2004Date of Patent: April 25, 2006Assignee: Japan Energy CorporationInventors: Tadafumi Yokota, Hiroshi Yano
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Patent number: 7019175Abstract: The invention provides a process for the catalytic oxidation of an alkane, which comprises contacting the alkane with a source of oxygen in the presence of a catalyst comprising a compound of the formula (2) where R1 and R2 independently represent a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group, a hydroxyl group, an alkoxy group, a carboxyl group, an alkoxycarbonyl group, or an acyl group, or R1 and R2 may together form a double bond or an aromatic or non-aromatic ring; Y represents an oxygen atom or a sulfur atom; X represents an oxygen atom or a hydroxyl group; m denotes an integer of 0 to 4; and n denotes an integer of 1 to 3. Compounds in accordance with formula (2) possess good catalytic properties, such that when they are employed in a process in accordance with the present invention, they are capable of activating a source of oxygen and promoting the oxidation of an alkane at mild reaction temperatures.Type: GrantFiled: May 30, 2002Date of Patent: March 28, 2006Assignee: Imperial Chemical Industries PLCInventors: Xavier Baucherel, Roger Arthur Sheldon
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Patent number: 6951964Abstract: The present invention relates to a novel thermo-isomerization method for rapidly and simply producing macrocyclic ketones of the formula Ia or Ib. The macrocyclic ketones are prepared in the gas phase at temperatures above 500° C. rapidly and in a simple manner from alcohols of the formula IIa and IIb directly with a high yield. In the formulae Ia, Ib, IIa and IIb, R1-R5, and n have the meanings given in the description.Type: GrantFiled: February 15, 2002Date of Patent: October 4, 2005Assignee: Givaudan SAInventors: Georg Frater, Matthias Nagel
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Patent number: 6930209Abstract: A method for liquid phase oxidation of a cycloalkane compound is provided by which the cycloalkane compound intended to be oxidized mixes with water to form an azeotropic mixture, and then an oxygen enriched gas is introduced to perform an oxidation reaction. This method is particularly suitable for liquid phase oxidation of cyclohexane by using an oxygen enriched gas or pure oxygen, which not only enhances conversion rate and selectivity of the cyclohexane oxidation process but also improves process safety in the use of an oxygen enriched gas or pure oxygen for cyclohexane oxidation.Type: GrantFiled: May 20, 2003Date of Patent: August 16, 2005Assignee: Chinese Petrochemical Development Co., Ltd.Inventors: Jenq-Renn Chen, Hsiao-Hui Yang, Chung-Ho Wu
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Patent number: 6924398Abstract: The present invention relates to novel tropolone compounds of the present invention and to oral care compositions suitable for preventing or treating diseases or conditions of the oral cavity in warm-blooded animals including humans, comprising an oral care effective amount of at least one novel tropolone compounds, and a pharmaceutically acceptable oral carrier. This invention further relates to a method for preventing or treating diseases or conditions of the oral cavity in warm-blooded animals including humans, by applying an oral care effective amount of the oral care composition to the oral cavity.Type: GrantFiled: April 19, 2004Date of Patent: August 2, 2005Assignee: Warner-Lambert Company LLCInventors: Pauline Pan, Marybeth Finnegan, Andre Soshinsky, Georgia Arvanitis, Michael Berardini
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Patent number: 6861563Abstract: In the process for producing a cyclododecanone by isomerizing an epoxycyclododecane-containing starting material in the presence of an isomerization reaction catalyst containing lithium bromide and/or lithium iodide, in order to perform the reaction with high efficiency (high reaction rate) and high selectivity and stably produce a high-purity cyclododecanone in industry while maintaining a high-level reaction rate, the epoxycyclododecane-containing starting material is produced by contacting an epoxycyclododecadiene with hydrogen in the presence of a hydrogen-reduction catalyst and has a content of the hydroxyl group-containing cyclododecane compounds contained in the epoxycyclododecane-containing starting material controlled to 5 mol % or less.Type: GrantFiled: August 9, 2002Date of Patent: March 1, 2005Assignees: Ube Industries, Ltd., EMS-Chemie AGInventors: Ryoji Sugise, Shuji Tanaka, Takashi Doi, Masayuki Nishio, Sadao Niida, Tsunao Matsuura
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Patent number: 6855831Abstract: The present invention relates to a process for the preparation of compounds of formula I: wherein the substituents are as defined in claim 1, by conversion of a compound of formula II: reaction of that compound with a compound of formula IV: X—C(O)—Q??(IV), wherein X is a leaving group, to form a compound of formula V: and treatment of that compound in the presence of a base with catalytic amounts of cyanide ions.Type: GrantFiled: April 8, 2003Date of Patent: February 15, 2005Assignee: Syngenta Crop Protection, Inc.Inventors: Hermann Schneider, Christoph Lüthy, Andrew Edmunds
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Patent number: RE43280Abstract: The use of the reduction products of hyperforin and adhyperforin, pharmaceutically acceptable salts or esters thereof, in the pharmaceutical and/or nutritional field, in particular in the treatment of depression and Alzheimer's disease.Type: GrantFiled: April 18, 2003Date of Patent: March 27, 2012Assignee: Indena S.p.A.Inventors: Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, Nicola Fuzzati