Unsaturation In The Ring Patents (Class 568/377)
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Publication number: 20080200558Abstract: A method for inhibiting or blocking molecular generating and/or inducing functions of molecules using an inhibitory or blocking agent of the formula: wherein R1-6 are as defined herein.Type: ApplicationFiled: August 9, 2007Publication date: August 21, 2008Inventors: Shozo Koyama, Yoshihiro Yamaguchi
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Patent number: 7411003Abstract: The present invention relates to a compound of Antrodia camphorata used to inhibit HBV, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone which is isolated from Antrodia camphorata, and its use in inhibiting HBV effectively. The cyclohexenone compound according to the present invention showed cytotoxicity on HBV-secreting human hepatoma cell line HepG2 2.2.15, decreased synthesis of HBV particles, further inhibited synthesis of HbsAg and HbeAg effectively to achieve the goal of HBV inhibition.Type: GrantFiled: August 21, 2007Date of Patent: August 12, 2008Assignee: Golden Biotechnology CorporationInventors: Sheng-Yun Liu, Mao-Tien Kuo, Wu-Che Wen
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Patent number: 7402707Abstract: The synthesis of a precursor oligocene, particularly pentacene, is a two-step process. In the first step the Diels-Alder adduct of the a,b-dihydro-a,b-etheno-oligocene with a 1,1-dialkoxy-cyclopentadiene is formed. In the second step this Diels-Alder adduct is converted into the precursor oligocene, in that first the corresponding keto-compound is formed, which may be eliminated thereafter. The resulting precursor oligocene can be converted to the oligocene with a heat treatment, particularly after providing a solution hereof on a substrate. It is suitable for use as semiconductor material in a thin-film transistor. Formula (I).Type: GrantFiled: March 17, 2004Date of Patent: July 22, 2008Assignee: Koninklijke Philips Electronics N.V.Inventors: Wolter Ten Hoeve, Bart-Hendrik Huisman
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Patent number: 7399888Abstract: The invention relates to novel isoxylitones and their use as anticonvulsant and in the treatment of a variety of disorders.Type: GrantFiled: July 1, 2006Date of Patent: July 15, 2008Assignee: HEJ Research Institute Karachi UniversityInventors: Attaur Rahman, Mohammad Iqbal Choudhary, Farzana Shaheen, Arun Ganesan, Shabana Usman Simjee, A. Mohsin Raza
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Patent number: 7385088Abstract: The present invention relates to a novel compound and use thereof, in particular to Antroquinonol B and Antroquinonol C isolated from Antrodia camphorata extracts which can effectively inhibit the growth of cancer cells. The compounds from Antrodia camphorata are first reported, which can be applied not only in inhibiting growth of breast cancer, lung cancer, hepatic cancer and prostate cancer, but also in anti-cancer medicinal compositions for the abovementioned cancer cells.Type: GrantFiled: January 29, 2008Date of Patent: June 10, 2008Assignee: Golden Biotechnology CorporationInventors: Sheng-Yun Liu, Mao-Tien Kuo, Wu-Che Wen
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Patent number: 7342137Abstract: The present invention relates to a novel compound and its uses, which is an extract isolated and purified from Antrodia camphorate, in particular to 4-hydroxy-2,3 -dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, and its use in tumor growth inhibition. The compound of the invention, which has never been discovered in Antrodia camphorate, can be applied in inhibiting the growth of cancer cells, such as breast cancer, hepatic cancer and prostate cancer; and be used as a pharmaceutical composition to inhibit the tumor growth; or further be applied in prevention of heart and blood vessel disease or dietary supplements for health needs through its antioxidant activity.Type: GrantFiled: May 11, 2007Date of Patent: March 11, 2008Assignee: Golden Biotechnology CorporationInventors: Sheng-Yun Liu, Wu-Che Wen, Wan-Ling Tsou, Mao-Tien Kuo, Chun-Hung Huang, Ka-Hang Fok, Ya-Ying Li, Chun-Chou Chang
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Publication number: 20080004353Abstract: The invention relates to novel isoxylitones and their use as anticonvulsant and in the treatment of a variety of disordersType: ApplicationFiled: July 1, 2006Publication date: January 3, 2008Applicant: HEJ RESEARCH INSTITUTE OF CHEMISTRYInventors: Attaur Rahman, Mohammad Iqbal Choudhary, Farzana Shaheen, A Ganesan, Shabana Usman Simjee, A Mohsin Raza
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Patent number: 7223803Abstract: An activated, substantially water soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reactive groups. The free reactive groups are capable of reacting with active moieties in a biologically active agent such as a protein or peptide thus forming conjugates between the activated poly(ethylene glycol) and the biologically active agent.Type: GrantFiled: December 21, 2005Date of Patent: May 29, 2007Assignee: Nektar Therapeutics AL, CorporationInventors: J. Milton Harris, Antoni Kozlowski
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Patent number: 7211604Abstract: Compounds used to block non-essential androgen receptors are described. In particular, cyclohexenone compounds containing an alkyl group may be used in the treatment of conditions mediated by the blocking of non-essential androgen receptors such as acne, male patterned baldness, keloids, skin-wrinkling, and osteoarthritis. The cyclohexenone compound may be administered orally, topically, or internally.Type: GrantFiled: July 12, 2004Date of Patent: May 1, 2007Assignee: Trident Sciences LLCInventor: John P. Mamana
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Patent number: 7208145Abstract: Polymeric reagents comprising a polymer attached, either directly or through one or more atoms to a ketone or a related functional group such as ketone hydrate, thione, monothiohydrate, dithiohydrate, hemiketal, monothiohemiketal, dithiohemiketal, ketal, or dithioketal are provided. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.Type: GrantFiled: December 31, 2003Date of Patent: April 24, 2007Assignee: Nektar Therapeutics AL, CorporationInventors: Samuel P. McManus, Antoni Kozlowski, Xiaoming Shen, Daniel C. Cook
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Patent number: 7199161Abstract: The invention relates to the use of substituted bicyclo[3.3.1]nonan-2,4,9-triones, especially clusianon and clusianon derivatives, as pharmaceutical active ingredients or medicamentous active ingredients, especially for producing medicaments for the prophylactic and/or therapeutic (curative) treatment of tumour or cancer diseases, and of viral diseases. The above-mentioned compounds can be used in cytostatic agents and antiviral agents (virostatic agents). They are especially used as inhibitors of topoisomerases and telomerases and as regulators during the MAP kinase signal transduction and can thus intervene on a cellular scale in the mechanism for multiplication of tumour or cancer cells and viruses.Type: GrantFiled: November 20, 2002Date of Patent: April 3, 2007Assignee: Diagenics International CorporationInventors: Siegfried Seeber, Ralf Axel Hilger, David Diaz-Carballo
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Patent number: 7199271Abstract: A method for reducing the concentration of cyclohexenone in a cyclohexenone containing organic mixture is disclosed. The method includes contacting an organic mixture comprising cyclohexenone with an effective amount of at least one of sulfurous acid, a salt of sulfurous acid, an alkali hydroxide, or a mixture of two or more of these compounds.Type: GrantFiled: March 17, 2005Date of Patent: April 3, 2007Assignee: Invista North America S.A.R.L.Inventor: Ludovic Fodor
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Patent number: 7160852Abstract: The compound according to the formula set forth below and the use of the compound in creating fragrances, and scents in items such as perfumes, colognes and personal care products is disclosed.Type: GrantFiled: August 7, 2003Date of Patent: January 9, 2007Assignee: International Flavors & Fragrances IncInventors: Anthony T. Levorse, Jr., Anubhav P. S. Narula, Edward Mark Arruda, Charles E. J. Beck
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Patent number: 7157417Abstract: The present invention relates to the perfumery industry. It concerns more particularly a ?-? unsaturated hindered ketone of formula wherein R represents, simultaneously or independently, a C1 to C4 linear or branched alkyl group, and in the form of any one of its isomers, i.e. optical isomers or diastereoisomers, or of a mixture thereof. The use of the compound as a perfuming ingredient, as well as the perfumed articles or perfuming compositions that contain as an active ingredient a compound of formula (I), are also embodiments of the invention.Type: GrantFiled: September 28, 2004Date of Patent: January 2, 2007Assignee: Firmenich SAInventor: Alexandre Huboux
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Patent number: 7135501Abstract: The invention relates to a clusianon isomer and to the use thereof, in particular as a pharmaceutical or medical active ingredient, in particular for producing medicaments for the prophylactic and/or therapeutic (curative) treatment of tumor or cancer diseases as well as viral diseases. The aforementioned compound can be used in cytostatics and antiviral agents (virostatics). Said compound acts, in particular, as a topoisomerase and telomerase inhibitor and as a regulator in the MAP kinase signal transduction. Said compound can thus intervene at the cellular level in the proliferation mechanism of tumor or cancer cells and viruses.Type: GrantFiled: November 20, 2002Date of Patent: November 14, 2006Inventors: Siegfried Seeber, Ralf Axel Hilger, David Diaz-Carballo
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Patent number: 7105705Abstract: The use of the reduction products of hyperforin and adhyperforin, pharmaceutically acceptable salts or esters thereof, in the pharmaceutical and/or nutritional field, in particular in the treatment of depression and Alzheimer's disease.Type: GrantFiled: April 18, 2003Date of Patent: September 12, 2006Assignee: Indena S.p.A.Inventors: Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, Nicola Fuzzati
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Patent number: 7074967Abstract: The present invention is directed to novel 3-cyclopropyl-1-propanone compounds of the general formula wherein R1, R2, R3, R4, R5 and R6 each independently is a hydrogen or a straight, branched or cyclic hydrocarbon moiety consisting of less then 10, preferably less then 5 carbon atoms and containing single and/or double bonds; wherein m and n each independently is an integer of 0–10; and wherein the dotted line represents a possible double bond.Type: GrantFiled: November 23, 2005Date of Patent: July 11, 2006Assignee: International Flavors & Fragrances Inc.Inventors: Anubhav P. S. Narula, Edward Mark Arruda, Franc T. Schiet
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Patent number: 7057078Abstract: Hyperforin and adhyperforin halogenated derivatives of general formula (I) in which X, R and R1 have the meanings as defined in the disclosure, the process for the preparation thereof and the use thereof in the pharmaceutical and/or nutritional field, in particular in the treatment of depression, and Alzheimer's disease.Type: GrantFiled: April 15, 2003Date of Patent: June 6, 2006Assignee: INDENA S.p.A.Inventors: Ezio Bombardelli, Paolo Morazzoni, Antonella Riva, Nicola Fuzzati
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Patent number: 7041854Abstract: The present invention relates to a process for the preparation of an xanthophyll, and in particular to a process for the preparation of an xanthophyll through the oxidation of a carotenoid in the presence of hydrogen peroxide and an iodine-containing compound. In particular, the process of the invention applies to the oxidation of beta-carotene to produce canthaxanthin, and to the oxidation of lutein or zeaxanthin to produce astaxanthin.Type: GrantFiled: April 18, 2002Date of Patent: May 9, 2006Assignee: Adisseo France S.A.S.Inventors: Yannick Quesnel, Richard Flacher
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Patent number: 7030278Abstract: An activated, substantially water soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reactive groups. The free reactive groups are capable of reacting with active moieties in a biologically active agent such as a protein or peptide thus forming conjugates between the activated poly(ethylene glycol) and the biologically active agent.Type: GrantFiled: September 23, 2003Date of Patent: April 18, 2006Inventors: J. Milton Harris, Antoni Kozlowski
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Patent number: 6995291Abstract: The present invention relates to the field of organic synthesis and more precisely to a process for the synthesis of an unsaturated aldehyde or ketone by oxidation of the corresponding alcohol. The oxidation is performed by a hypochlorite salt and a catalytic amount of a N-(2,2,6,6-tetraalkyl-4-piperidinyl-N-oxyl)-2-amino-1,3,5-triazine compound, preferably a N-oxyl derivative of one of the polymers known under the trademark Chimassorb® 944 or 2020.Type: GrantFiled: September 22, 2003Date of Patent: February 7, 2006Assignee: Firmenich SAInventor: Eric Walther
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Patent number: 6951964Abstract: The present invention relates to a novel thermo-isomerization method for rapidly and simply producing macrocyclic ketones of the formula Ia or Ib. The macrocyclic ketones are prepared in the gas phase at temperatures above 500° C. rapidly and in a simple manner from alcohols of the formula IIa and IIb directly with a high yield. In the formulae Ia, Ib, IIa and IIb, R1-R5, and n have the meanings given in the description.Type: GrantFiled: February 15, 2002Date of Patent: October 4, 2005Assignee: Givaudan SAInventors: Georg Frater, Matthias Nagel
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Patent number: 6946579Abstract: A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.Type: GrantFiled: July 2, 2003Date of Patent: September 20, 2005Assignee: Eli Lilly and CompanyInventors: Alexander Glenn Godfrey, Daniel Timothy Kohlman, John Cunningham O'Toole, Yao-Chang Xu, Tony Yantao Zhang
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Patent number: 6943272Abstract: The invention concerns a novel compounds of formula (I), wherein the dotted line bond is present or not, and wherein R1 represents: when the dotted line bond is present —CHCH3OH or —CHCH3OCOR or —CHCH3XCH2CHOHR? or —CHCH3OCHR?CH2OH or formula (II) when the dotted line bond is absent —CHCH3OH or —CHCH3OCOR or —COCH3 or formula (II) or —CHCH3XCH2CHOHR? or —CH2CH2XCH2CHOHR? or —CHCH3OCHR?CH2OH or —CHCHCOR? or —CH2CH2CHR?OH or —CH2CH2CHR?OCOR or CHCHCHOHR? or —CHCHCHR?OCOR, wherein R represents H, Me, Et, Pr, isoPr, But, isoBut, CH3CH2)4, (CH3)2CHCH2, CH2CH, (CH3)2CCH, and R? represents H, Me or Et, and X represents O, N or S, and their preparation method. Because of their fragrance, said compounds are highly interesting for the perfume industry, for cosmetic and care products.Type: GrantFiled: October 23, 2002Date of Patent: September 13, 2005Assignee: V. Mane FilsInventors: Jean Mane, Jean-Jacques Chanot, Fabrice Le Borgne, Martin Schroeder
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Patent number: 6939845Abstract: The present invention provides a fragrance precursor of formula I: that is capable of forming a fragrant ketone of formula II: and a fragrant lactone of formula III:Type: GrantFiled: June 18, 2001Date of Patent: September 6, 2005Assignee: Givaudan SAInventors: Markus Gautschi, Caroline Plessis, Samuel Derrer
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Patent number: 6861564Abstract: The present invention relates to an improved process for preparing 4-substituted resorcinol derivatives, and intermediate compounds useful in the preparation of such resorcinol derivatives.Type: GrantFiled: October 28, 2002Date of Patent: March 1, 2005Assignee: Pfizer Inc.Inventors: Stuart Edward Bradley, John Kitchin, Graham Michael Wynne
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Publication number: 20040266884Abstract: Compounds used to block non-essential androgen receptors are described. In particular, cyclohexenone compounds containing an alkyl group may be used in the treatment of conditions mediated by the blocking of non-essential androgen receptors such as acne, male patterned baldness, keloids, skin-wrinkling, and osteoarthritis. The cyclohexenone compound may be administered orally, topically, or internally.Type: ApplicationFiled: July 12, 2004Publication date: December 30, 2004Inventor: John P. Mamana
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Patent number: 6787674Abstract: The present invention relates to anti-microbial activity of the essential oil of Cymbopogon flexuosus (Nees ex Steud) Wats and the process of isolation of novel sesquiterpene compound which is mainly responsible for the strong anti-microbial/anti-bacterial activity. The present invention particularly relates to anti-bacterial activity of the essential oil and a pure isolate identified as (+)-1-bisabolone of formula 1 against gram positive bacteria from a strain of a grass identified as Cymbopogon flexuosus.Type: GrantFiled: March 27, 2003Date of Patent: September 7, 2004Assignee: Council of Scientific and Industrial ResearchInventors: Subhash Chandra Taneja, Ashok Kumar Shahi, Vijeshwar Verma, Vijay Kumar Sethi, Samar Singh Andotra, Abid Zaffar Hashmi, Prabhu Dutt, Sanotosh Kumar Bakshi, Maharaj Krishan Koul, Satya Narayan Sharma, Suresh Chandra, Ghulam Nabi Qazi
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Patent number: 6770618Abstract: Trans-2,2,6-trimethylcyclohexyl methyl ketone, including (1S,6R)-2,2,6-trimethylcyclohexyl methyl ketone represented by the formula (1a): and (1R,6S)-2,2,6-trimethylcyclohexyl methyl ketone represented by the formula (1b): are useful components in a perfume composition. A process for producing the same is also described. A unique eucalyptus, mint-like and white floral perfume material is provided using the ketone compounds disclosed in the present invention. The process of the present invention produces the optically active ketone compounds having optical purity up to at least 98.0 % e.e.Type: GrantFiled: June 7, 2001Date of Patent: August 3, 2004Assignee: Takasago International Corp.Inventors: Hideo Ujihara, Shinya Watanabe, Takeshi Yamamoto, Toshimitsu Hagiwara
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Patent number: 6768026Abstract: Compounds used to block non-essential androgen receptors are described. In particular, cyclohexenone compounds containing an alkyl group may be used in the treatment of conditions mediated by the blocking of non-essential androgen receptors such as acne, male patterned baldness, keloids, skin-wrinkling, and osteoarthritis. The cyclohexenone compound may be administered orally, topically, or internally.Type: GrantFiled: January 9, 2003Date of Patent: July 27, 2004Inventor: John P. Mamana
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Patent number: 6759557Abstract: A melanin synthesis inhibitor composition containing at least one macrocyclic compound represented by Formula (1) wherein X is a group selected among the groups consisting of C═O; CH—OH and O═C—CHOH; R being a chain hydrocarbon having 13 to 24 carbon atoms, R forms a ring with X and may be saturated or contain 1 to 3 unsaturated bonds and may be substituted by a lower alkyl group of 1 to 3 carbon atoms.Type: GrantFiled: June 10, 2002Date of Patent: July 6, 2004Assignee: Takasago International CorporationInventors: Hiroyuki Matsuda, Hiroyasu Kumamoto, Eiko Tamai, Misao Yagi, Kenichi Yamamoto, Toshimitsu Hagiwara, Shinya Watanabe
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Patent number: 6753127Abstract: Disclosed is an norbornene-based copolymer for photoresist, a preparation method thereof, and a photoresist composition comprising the same. The copolymer of the present invention exhibits high transparency to light of 193 nm wavelength and an excellent etching resistance, excellent resolution due to the remarkable difference between light-exposed part and light-unexposed part in the dissolving rate and excellent adhesion to the substrate due to very hydrophilic diketone group of its own. As a result, the copolymer of the present invention is very useful as ArF exposure photoresist material in the fabrication of semiconductor devices.Type: GrantFiled: September 19, 2002Date of Patent: June 22, 2004Assignee: Samsung Electronics Co., Ltd.Inventors: Eun Sil Han, Bong Seok Moon, Jung Han Shin, Ouck Han
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Patent number: 6740785Abstract: Improved oxidation methods are provided wherein a reaction mixture comprising a substrate to be oxidized (e.g., phenols, alkenes) and an oxidation catalyst (typically dispersed in an organic solvent system) is supplemented with a compressed gas which expands the reaction mixture, thus accelerating the oxidation reaction. In preferred practice pressurized subcritical or supercritical carbon dioxide is used as the expanding gas, which is introduced into the reaction mixture together with an oxidizing agent. The inventive methods improve the substrate conversion and product selectivity by increasing the solubility of the oxidizing agent in the reaction mixture.Type: GrantFiled: July 26, 2002Date of Patent: May 25, 2004Assignee: The University of KansasInventors: Bala Subramaniam, Daryle H. Busch, Ghezai T. Musie, Ming Wei
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Patent number: 6717017Abstract: The present invention provides a method of synthesizing compounds of formula (I) or (II): wherein R1 is hydrogen, R′ is (C1-C4)alkyl and X is a hydroxyl protecting group.Type: GrantFiled: August 30, 2002Date of Patent: April 6, 2004Assignee: The Regents of the University of CaliforniaInventor: Trevor C. McMorris
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Patent number: 6710090Abstract: A method for inhibiting or blocking molecular generating and/or inducing functions of molecules using an inhibitory or blocking agent of the formula: wherein R1-6 and A are as defined herein.Type: GrantFiled: December 28, 2001Date of Patent: March 23, 2004Inventors: Shozo Koyama, Yoshihiro Yamaguchi
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Patent number: 6667410Abstract: The present invention provides a novel process for the conversion of &agr;,&bgr;-unsaturated ketones. This invention is an improvement over existing processes in that it operates at neutral reaction conditions that prevent the formation of side reactions and that it is a single step, which proceeds with complete selectivity and gives a yield that is approximately 30% higher than the currently used processes. An example of this process is the conversion of 16-dehydroprogesterone into 17 &agr;-hydroxyprogesterone.Type: GrantFiled: September 14, 2001Date of Patent: December 23, 2003Assignee: Board of Regents, The University of Texas SystemInventors: Philip D. Magnus, Andrew H. Payne
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Patent number: 6639113Abstract: A process is described for preparing dry powders of one or more oxygenated carotenoids by a) dispersing one or more oxygenated carotenoids in an aqueous molecular dispersion or colloidal dispersion of a protecting colloid and b) converting the dispersion formed into a dry powder by removing the water and any solvents additionally used and drying, in the presence or absence of a coating material, which comprises using as protecting colloid in process step a) at least one partially hydrolyzed soybean protein having a degree of hydrolysis greater than 5%.Type: GrantFiled: December 17, 2001Date of Patent: October 28, 2003Assignee: BASF AktiengesellschaftInventors: Frank Runge, Erik Lüddecke, Helmut Auweter, Angelika-Maria Pfeiffer, Willy Hinz
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Patent number: 6632788Abstract: The compound according to the formula set forth below where A is B is or A and B together form the ring structure and X, R′ and R are independently H and CH3 and m=0 or 1. and the use of the compound in creating fragrances, and scents in items such as perfumes, colognes and personal care products is disclosed.Type: GrantFiled: May 17, 2001Date of Patent: October 14, 2003Assignee: International Flavors & Fragrances Inc.Inventors: Anthony T. Levorse, Jr., Anubhav P.S. Narula, Edward Mark Arruda, Charles E.J. Beck
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Publication number: 20030153627Abstract: Compounds used to block non-essential androgen receptors are described. In particular, cyclohexenone compounds containing an alkyl group may be used in the treatment of conditions mediated by the blocking of non-essential androgen receptors such as acne, male patterned baldness, keloids, skin-wrinkling, and osteoarthritis. The cyclohexenone compound may be administered orally, topically, or internally.Type: ApplicationFiled: January 9, 2003Publication date: August 14, 2003Inventor: John P. Mamana
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Publication number: 20030118933Abstract: Disclosed is an norbornene-based copolymer for photoresist, a preparation method thereof, and a photoresist composition comprising the same. The copolymer of the present invention exhibits high transparency to light of 193 nm wavelength and an excellent etching resistance, excellent resolution due to the remarkable difference between light-exposed part and light-unexposed part in the dissolving rate and excellent adhesion to the substrate due to very hydrophilic diketone group of its own. As a result, the copolymer of the present invention is very useful as ArF exposure photoresist material in the fabrication of semiconductor devices.Type: ApplicationFiled: September 19, 2002Publication date: June 26, 2003Inventors: Eun Sil Han, Bong Seok Moon, Jung Han Shin, Ouck Han
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Patent number: 6583322Abstract: This invention describes heretofore unknown forms of dihydro (DHIA) and hexahydro (HHIA) isoalpha acids having a high ratio of trans to cis isomers and a process for their production. Also, non-precipitating clear 5, 10, 20% and higher aqueous solutions thereof, since they are soluble at room temperature in soft water. This is due to the high ratio of trans to cis isomers. Unlike prior art essentially all cis isomer products, they remain haze free both at a neutral pH in water and at 1% to 2% and higher concentrations. This invention has the advantage over the prior art in that DHIA and HHIA can be provided as stable, non-separating liquids, at practical concentrations in the range of 5% to about 40%, which do not require heating to about 50° to 90° C. and above with stirring to effect dissolution of precipitates. The high trans products described herein can be admixed with isoalpha- and tetrahydro-isoalpha acids.Type: GrantFiled: February 25, 2000Date of Patent: June 24, 2003Assignee: Kalamazoo Holdings, Inc.Inventors: Khalil Shahlai, Randall H. Mennett, Paul H. Todd, James A. Guzinski
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Publication number: 20030109747Abstract: A high-purity alicyclic ketone which is a raw material for an alkyl-substituted alicyclic ester such as an alkyl adamantyl ester compound which is useful as a resist raw material can be obtained by a simple operation such as extraction without a special purification step such as distillation or recrystallization. In this process, when an alicyclic hydrocarbon is oxidized with concentrated sulfuric acid or fuming sulfuric acid, the reaction solution after oxidation is poured into water and a solid is extracted with an organic solvent, the concentration of sulfuric acid in the water layer at the time of extraction is adjusted to 60 to 90 wt % to carry out extraction so as to obtain an alicyclic ketone.Type: ApplicationFiled: October 28, 2002Publication date: June 12, 2003Inventors: Masao Yamaguchi, Hiromasa Yamamoto, Hideki Kikuchi, Yoshihiro Hirota, Atsushi Kadokura, Takashi Matsumura
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Patent number: 6545186Abstract: Improved, safe process for the purification of ketones obtained by ozonolysis and subsequent reduction of the corresponding terpenes, in which, after the ozonolysis and reduction of acyclic mono-, bi- or tricyclic terpenes with ozonizable double bonds, converting the resulting corresponding crude ketone into a high-purity ketone by means of steam distillation at atmospheric pressure or at reduced pressure, extraction of the steam distillate and subsequent distillation.Type: GrantFiled: December 12, 2001Date of Patent: April 8, 2003Assignee: DSM Fine Chemicals Austria Nfg GmbH & Co., KGInventors: Karlheinz Giselbrecht, Josef Schaller, Rudolf Hermanseder, Klaus Reiter
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Patent number: 6521796Abstract: This invention describes heretofore unknown forms of dihydro (DHIA) and hexahydro (HHIA) isoalpha acids having a high ratio of trans to cis isomers and a process for their production. Also, non-precipitating clear 5, 10, 20% and higher aqueous solutions thereof, since they are soluble at room temperature in soft water. This is due to the high ratio of trans to cis isomers. Unlike prior art essentially all cis isomer products, they remain haze free both at a neutral pH in water and at 1% to 2% and higher concentrations. This invention has the advantage over the prior art in that DHIA and HHIA can be provided as stable, non-separating liquids, at practical concentrations in the range of 5% to about 40%, which do not require heating to about 50° to 90° C. and above with stirring to effect dissolution of precipitates. The high trans products described herein can be admixed with isoalpha- and tetrahydro-isoalpha acids.Type: GrantFiled: July 23, 2001Date of Patent: February 18, 2003Assignee: Kalamazoo Holdings, Inc.Inventors: Khalil Shahlai, Randall H. Mennett, Paul H. Todd, James A. Guzinski
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Publication number: 20030004090Abstract: The compound according to the formula set forth below 1Type: ApplicationFiled: May 17, 2001Publication date: January 2, 2003Inventors: Anthony T. Levorse, Anubahv P.S. Narula, Edward Mark Arruda, Charles E.J. Beck
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Patent number: 6492563Abstract: The present invention is a fragrance precursor of formula I: for a fragrant ketone of formula II: and a fragrant ester of formula III: wherein, R1 to R5 represent independently H, —NO2, linear or branched C1-C6-alkyl, C1-C6-alkenyl, C1-C6-alkinyl or C1-C4-alkoxy, R1 and R2,R2 and R3, R3 and R4, and R4 and R5 may form together one or two aliphatic or aromatic rings, R6 and R7 are independently H, linear or branched C1-C6-alkyl-, C1-C6-alkenyl, C1-C6-alkinyl, and R8 and R9 are the residues of an acid R8-COOH and an alcohol R9OH respectively forming the fragrant ester of formula III. A method for providing an odor by admixing with a product a fragrance precursor as detailed above.Type: GrantFiled: April 10, 2001Date of Patent: December 10, 2002Assignee: Givaudan SAInventors: Markus Gautschi, Caroline Plessis, Samuel Derrer
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Patent number: 6479554Abstract: Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor &agr;, nuclear factor &kgr;B, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is 3,3-bis-(3,4-dimethoxyphenyl)acrylonitrile.Type: GrantFiled: July 16, 2001Date of Patent: November 12, 2002Assignee: Celgene CorporationInventors: George W. Muller, Mary Shire
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Patent number: 6448454Abstract: Improved oxidation methods are provided wherein a reaction mixture comprising a substrate to be oxidized (e.g., phenols, alkenes) and an oxidation catalyst (typically dispersed in an organic solvent system) is supplemented with a compressed gas which expands the reaction mixture, thus accelerating the oxidation reaction. In preferred practice pressurized subcritical or supercritical carbon dioxide is used as the expanding gas, which is introduced into the reaction mixture together with an oxidizing agent. The inventive methods improve the substrate conversion and product selectivity by increasing the solubility of the oxidizing agent in the reaction mixture.Type: GrantFiled: April 7, 2000Date of Patent: September 10, 2002Assignee: The University of KansasInventors: Bala Subramaniam, Daryle H. Busch, Ghezai T. Musie, Ming Wei
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Patent number: 6448220Abstract: The novel ketones having the structure in which R is H or an alkyl group and X is a hydrocarbon group having between 4 and 12 carbon atoms, the ring being saturated or unsaturated, excluding 4-(1-ethylpropylidene)-1-cyclohexanone, 4-cyclohexylidene-1-cyclohexanone, 4-butylidene-1-cyclohex-2-enone, 4-(1-ethylpropylidene)-1-cyclohex-2-enone, 4-(2-methylpropylidene)-1-cyclohexanone, 4-cyclohexyliden-2-cyclohexen-1-one, 4-(1,5-dimethyl-4-hexenylidene)-1-cyclohexanone, 4-[4-(cyclohexyliden)cyclohexyliden]-1-cyclohexanone, 4-[4-(tert-butyl)cyclohexyliden]-1-cyclohexanone, 4-[-(cyclohexyl)cyclohexyliden]-1-cyclohexanone, 4-(2-isopropyl-5-methylcyclohexyliden)-2-cyclohexen-1-one and 4-(3-phenylpropylidene)-1-cyclohex-2-enone exhibit interesting odor characteristics, generally aldehydic in nature, and so find use in perfumes and in perfumed products.Type: GrantFiled: March 30, 1999Date of Patent: September 10, 2002Assignee: Quest International B.V.Inventor: Karl Andrew Dean Swift
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Patent number: 6410798Abstract: A process for the preparation of 2,3,5-trimethyl-p-benzoquinone by oxidation of 2,3,5- or 2,3,6-trimethylphenol using oxygen or a gas mixture containing oxygen in the presence of a two-phase liquid reaction medium composed of water and a neocarboxylic acid having to 11 carbon atoms with a copper (II) halide-containing catalyst system at elevated temperature.Type: GrantFiled: March 8, 2001Date of Patent: June 25, 2002Assignee: Degussa-Huls AktiengesellschaftInventors: Ralf Maassen, Steffen Krill, Klaus Huthmacher