Polyoxy And Halogen Containing Patents (Class 568/641)
  • Patent number: 9975832
    Abstract: Disclosed is a process for the synthesis of the active ingredients ospemifene and fispemifene which comprises reacting phenol 4 with an alkylating agent X—CH2CH2—Y of formula 7, wherein X is a leaving group and Y is the —(OCH2CH2)nOH group wherein n is zero or 1; or X and Y, taken together, represent an oxygen atom; to give ospemifene or fispemifene of formula 8.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: May 22, 2018
    Assignee: OLON S.P.A.
    Inventors: Tania Cristiano, Marco Alpegiani
  • Patent number: 9365510
    Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, R1, R2, R3, R4, M1, M2, X, L1, L2, J1, J2, a1, a2, b1 and b2 are as defined herein, and wherein at least one of M2 or L2 is a moiety comprising an aziridine, acrylamide or sulfonate functional group, are provided. Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.
    Type: Grant
    Filed: April 16, 2013
    Date of Patent: June 14, 2016
    Assignees: British Columbia Cancer Agency Branch, The University of British Columbia
    Inventors: Raymond John Andersen, Marianne Dorothy Sadar
  • Publication number: 20150125389
    Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R4, R5, X1, X2, X3 and X4 are as defined herein, and wherein the compound comprises at least one F, Cl, Br, I or 123I moiety, are provided. Uses of such compounds for imaging diagnostics in cancer and therapeutics methods for treatment of subjects in need thereof, including prostate cancer as well as methods and intermediates for preparing such compounds are also provided.
    Type: Application
    Filed: September 9, 2014
    Publication date: May 7, 2015
    Applicants: THE UNIVERSITY OF BRITISH COLUMBIA, BRITISH COLUMBIA CANCER AGENCY BRANCH
    Inventors: Raymond John Andersen, Carmen Adriana Banuelos, Javier GARCIA FERNANDEZ, Yusuke IMAMURA, Jian KUNZHONG, Nasrin R. MAWJI, Marianne Dorothy Sadar, Jun Wang, Amy (Hsing Chen) Tien
  • Publication number: 20140336259
    Abstract: The present document describes a phytochemical isolated from maple syrup and composition comprising the same. More specifically, the document describes an antioxidant phytochemical compound, derivates thereof, and composition comprising the same. The document also describes a process of synthesizing the antioxidant phytochemical compound.
    Type: Application
    Filed: June 11, 2012
    Publication date: November 13, 2014
    Inventors: Navindra Seeram, Julie Barbeau, Genevieve BeLand, Keykavous Parang
  • Publication number: 20140107336
    Abstract: The present invention relates to a novel class of tri-aryl compounds, compositions comprising the same and processes for the preparation thereof.
    Type: Application
    Filed: November 1, 2013
    Publication date: April 17, 2014
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Esther PRIEL, Aviv GAZIT, Shimon SLAVIN, Sara YITZCHAK
  • Patent number: 8686050
    Abstract: This invention provides compound having a structure of Formula I or Formula II Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: April 1, 2014
    Assignees: The University of British Columbia, British Columbia Cancer Agency Branch
    Inventors: Marianne D. Sadar, Nasrin R. Mawji, Jun Wang, Raymond J. Andersen, David E. Williams, Mike Leblanc
  • Publication number: 20140039194
    Abstract: The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.
    Type: Application
    Filed: August 1, 2013
    Publication date: February 6, 2014
    Applicant: Gilead Sciences, Inc.
    Inventors: Dominika PCION, Carrie TOMASI, Mark Charles WHITCOMB, Eric D. DOWDY, Wenyi FU, Patricia MACLEOD
  • Publication number: 20130296613
    Abstract: A process for producing a hydroxystilbene derivative represented by formula (1) (wherein X1-X4 independently represent a hydrogen atom, a hydroxy group, a saturated or unsaturated linear or branched alkoxy group having 1-10 carbon atoms, or a saturated or unsaturated linear or branched alkyl group having 1-10 carbon atoms; Z1 and Z2 independently represent a hydrogen atom, or a group represented by the formula (2) (wherein X5 and X6 independently represent a hydrogen atom, a hydroxy group, a saturated or unsaturated linear or branched alkoxy group having 1-10 carbon atoms, or a saturated or unsaturated linear or branched alkyl group having 1-10 carbon atoms); and Z1 and Z2 may be the same as or different from each other; wherein X1-X6 may be the same as or different from one another), which is characterized by heating a 4-hydroxycinnamic acid compound and a hydroxystilbene compound in the presence of a metal salt.
    Type: Application
    Filed: November 25, 2011
    Publication date: November 7, 2013
    Applicant: UHA MIKAKUTO CO., LTD.
    Inventors: Akinobu Kishi, Satoshi Doi, Taiji Matsukawa, Takeki Matsui, Yasumasa Yamada, Ichiro Yamada
  • Publication number: 20130267694
    Abstract: Provided are methods of making compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides synthetic intermediates useful for preparing such compounds.
    Type: Application
    Filed: May 8, 2013
    Publication date: October 10, 2013
    Applicant: Theracos, Inc.
    Inventors: Baihua Xu, Binhua Lv, Ge Xu, Brian Seed, Jacques Y. Roberge
  • Publication number: 20130245129
    Abstract: This invention provides compound having a structure of Formula I or Formula II Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.
    Type: Application
    Filed: April 19, 2013
    Publication date: September 19, 2013
    Applicants: The University of British Columbia, British Columbia Cancer Agency Branch
    Inventors: Marianne D. Sadar, Nasrin R. Mawji, Jun Wang, Raymond J. Andersen, David E. Williams, Mike Leblanc
  • Publication number: 20130131167
    Abstract: This invention provides bisphenol derivatives having a structure of formula 1. Said compounds are modulators of the androgen receptor activity and are useful in the treatment of various diseases, including prostate cancer, breast cancer, ovarian cancer, endometrial cancer, acne, ovarian cysts, polycystic ovarian disease, age-related macular degeneration, precocious puberty, hirsutism and hair loss.
    Type: Application
    Filed: January 6, 2011
    Publication date: May 23, 2013
    Applicants: THE UNIVERSITY OF BRITISH COLUMBIA, BRITISH COLUMBIA CANCER AGENCY BRANCH
    Inventors: Marianne D. Sadar, Nasrin R. Mawji, Carmen Adriana Banuelos, Raymond J. Andersen, Javier Garcia Fernandez
  • Publication number: 20130131182
    Abstract: The present invention relates to chemical total synthesis methods of six novel protein tyrosine phosphatase-1B (PTP1B) inhibitors and application of the inhibitors in the preparation of medicaments for treating type 2 diabetes mellitus (T2DM). The PTP1B inhibitors use one or more of the six compounds represented by the structural formulae 1, 2, 3, 4, 5 and 6, as active components. The compounds can enhance the sensitivity of an insulin receptor by inhibiting the activity of PTP1B, thereby having a favorable therapeutic effect on insulin-resistant T2DM.
    Type: Application
    Filed: July 7, 2011
    Publication date: May 23, 2013
    Applicant: INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: Dayong Shi, Shuju Guo, Xiao Fan, Weishen Lu, Yongchao Cui
  • Publication number: 20130045204
    Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt or stereoisomer thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are as defined herein, and wherein at least one of R1, R2, R3, R4 or R5 is F, are provided. Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.
    Type: Application
    Filed: August 17, 2012
    Publication date: February 21, 2013
    Applicants: The University of British Columbia, British Columbia Cancer Agency Branch
    Inventors: Raymond John Andersen, Javier Garcia Fernandez, Marianne Dorothy Sadar, Carmen Adriana Banuelos, Nasrin Mawji, Jun Wang
  • Patent number: 8378148
    Abstract: Bisphenol derivatives having both alcoholic hydroxyl and allyl groups are novel and useful as reagents for modifying organic resins and silicone resins.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: February 19, 2013
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Takato Sakurai, Michihiro Sugo, Takanobu Takeda, Hideto Kato
  • Publication number: 20130035514
    Abstract: There is provided a process for the preparation of a compound of formula I, wherein X, R1, R2a, R2b, R2c, R2d, R2e, R3a, R3b, R3c, R3d and R3e are as described in the description. Such compounds may, for example, be useful medicament (or intermediates for medicaments).
    Type: Application
    Filed: January 19, 2011
    Publication date: February 7, 2013
    Applicant: CAMBREX KARLSKOGA AB
    Inventors: Lars Eklund, Jonas Nilsson
  • Patent number: 8293948
    Abstract: A reagent for organic synthesis with which a chemical reaction can be conducted in a liquid phase and unnecessary compound(s) can be easily separated at low cost from the liquid phase after completion of the reaction. The reagent for organic synthesis reversibly changes from a liquid-phase state to a solid-phase state with changes in solution composition and/or solution temperature, and is for use in organic synthesis reactions. This reagent for organic syntheses facilitates process development. With the reagent, research on and development of, e.g., medicines through, e.g., compound library synthesis, etc. can be accelerated. It can hence contribute to technical innovations in the biochemical industry and chemical industry.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: October 23, 2012
    Assignee: Jitsubo Co., Ltd.
    Inventors: Kazuhiro Chiba, Shokaku Kim, Yusuke Kono
  • Patent number: 8293947
    Abstract: The present invention concerns a method for the preparation of therapeutically valuable triphenylbutene derivatives, especially ospemifene or fispemifene.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: October 23, 2012
    Assignee: Hormos Medical Ltd.
    Inventors: Marja Sodervall, Maire Eloranta, Arja Kalapudas
  • Publication number: 20120156879
    Abstract: To provide a resist pattern improving material, containing: a compound represented by the following general formula (1), or a compound represented by the following general formula (2), or both thereof; and water: where R1 and R2 are each independently a hydrogen atom, or a C1-C3 alkyl group; m is an integer of 1 to 3; and n is an integer of 3 to 30, where p is an integer of 8 to 20; q is an integer of 3 to 30; and r is an integer of 1 to 8.
    Type: Application
    Filed: September 23, 2011
    Publication date: June 21, 2012
    Applicant: FUJITSU LIMITED
    Inventors: Miwa KOZAWA, Koji Nozaki
  • Patent number: 8153801
    Abstract: The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.
    Type: Grant
    Filed: September 11, 2008
    Date of Patent: April 10, 2012
    Assignee: Gilead Sciences, Inc.
    Inventors: Eric Dowdy, Steven Pfeiffer
  • Publication number: 20110301366
    Abstract: A process comprising contacting a polyhydric phenol or a polyaliphatic alcohol with an epihalohydrin in the presence of a catalyst comprising a Schiff base metal complex is disclosed.
    Type: Application
    Filed: February 25, 2010
    Publication date: December 8, 2011
    Applicant: Dow Technologies LLC
    Inventors: Philip J. Carlberg, Thomas C. Young, Tina L. Arrowood, Ernesto Occhiello, Paul R. Elowe, Jason C. MacDonald
  • Publication number: 20110160458
    Abstract: The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.
    Type: Application
    Filed: September 28, 2010
    Publication date: June 30, 2011
    Applicant: Gilead Sciences, Inc.
    Inventors: Eric Dowdy, Xi Chen, Steven Pfeiffer
  • Patent number: 7951877
    Abstract: A process, advantageous in producibility, for the production of a vinyl compound containing very small amounts of ionic impurities and hydrolysable halogens, which is capable of curing by means of heat and/or light and giving a cured product having excellent dielectric characteristics and heat resistance, which process can efficiently remove a generated salt and comprises reacting a non-protonic polar solvent solution of a specific bifunctional phenylene ether oligomer with a vinylbenzyl halide in the presence of an alkoxide of an alkali metal, wherein the thus-obtained reaction solution is acidified with a specific amount of an acidic substance, then a salt generated is removed, an alkali substance containing a specific amount of an alkali metal is added to the thus-obtained solution, then a salt generated is removed, and the thus-obtained solution is mixed with water or a water-alcohol mixed solution, to precipitate a solid.
    Type: Grant
    Filed: June 17, 2008
    Date of Patent: May 31, 2011
    Assignee: Mitaubishi Gas Chemical Company, Inc.
    Inventors: Jun Nakano, Takeru Horino, Makoto Miyamoto, Atsushi Hirashima, Yasumasa Norisue
  • Publication number: 20110082321
    Abstract: Bisphenol derivatives having both alcoholic hydroxyl and allyl groups are novel and useful as reagents for modifying organic resins and silicone resins.
    Type: Application
    Filed: October 5, 2010
    Publication date: April 7, 2011
    Inventors: Takato SAKURAI, Michihiro Sugo, Takanobu Takeda, Hideto Kato
  • Publication number: 20110015448
    Abstract: The present invention concerns a method for the preparation of therapeutically valuable triphenylbutene derivatives, especially ospemifene or fispemifene.
    Type: Application
    Filed: September 16, 2010
    Publication date: January 20, 2011
    Inventors: Marja Sodervall, Maire Eloranta, Arja Kalapudas
  • Publication number: 20100292480
    Abstract: The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.
    Type: Application
    Filed: September 11, 2008
    Publication date: November 18, 2010
    Applicant: Gilead Sciences, Inc
    Inventors: Eric Dowdy, Steven Pfeiffer
  • Patent number: 7812197
    Abstract: The present invention concerns a method for the preparation of therapeutically valuable triphenylbutene derivatives, especially ospemifene or fispemifene.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: October 12, 2010
    Assignee: Hormos Medical Ltd.
    Inventors: Marja Sodervall, Maire Eloranta, Arja Kalapudas
  • Publication number: 20100256382
    Abstract: The present invention relates to a novel class of tri-aryl compounds, compositions comprising the same and processes for the preparation thereof.
    Type: Application
    Filed: June 3, 2008
    Publication date: October 7, 2010
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITKY
    Inventors: Esther Priel, Aviv Gazit, Shimon Slavin, Sara Yitzchak
  • Publication number: 20090099366
    Abstract: The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.
    Type: Application
    Filed: September 11, 2008
    Publication date: April 16, 2009
    Applicant: Gilead Sciences, Inc.
    Inventors: Eric Dowdy, Steven Pfeiffer
  • Publication number: 20090023926
    Abstract: The present invention provides a compound of the formula: (IIa); having a reactive functional group M, capable of reacting with a biopolymer, BP, having at least one group capable of reacting with M to form a covalent linkage, to provide a biopolymer derivative of the formula: (IIIa). The biopolymer derivatives of the invention have enhanced ionisability with respect to free 10 biopolymer (Bp) enabling improved analysis of the biopolymer using mass spectrometry. The invention further provides specific examples of compounds formula (IIa), e.g. compounds of formula: (IIa-2a) and (IIa-58a).
    Type: Application
    Filed: September 22, 2005
    Publication date: January 22, 2009
    Inventors: Edwin Mellor Southern, Vladimir Korshun, Mikhail Sergeevich Shchepinov
  • Publication number: 20080220407
    Abstract: The presently described subject matter is directed to water-soluble conjugated polyene compounds that exhibit aggregation induced emission, as well as to water dispersible, fluorescent, polymeric microparticles and/or nanoparticles comprising the water-soluble conjugated polyene compounds. Also provided are methods of making and using the compounds and particles. The described conjugated polyene compounds are useful as bioprobes for the detection biomacromolecules, as well as in the manufacture of sensors.
    Type: Application
    Filed: December 10, 2007
    Publication date: September 11, 2008
    Applicant: The Hong Kong University of Science and Technology
    Inventors: Benzhong Tang, Yuning Hong, Matthias Haeussler, Hui Tong, Yonggiang Dong, Zhen Li, Changmin Xin
  • Publication number: 20080214860
    Abstract: The present invention concerns a method for preparation of fispemifene by use of ospemifene as a starting material.
    Type: Application
    Filed: February 13, 2008
    Publication date: September 4, 2008
    Inventors: Marja Sodervall, Maire Eloranta, Arja Kalapudas, Brian Kearton, Michael McKenzie
  • Publication number: 20080207956
    Abstract: The present invention concerns a method for the preparation of therapeutically valuable triphenylbutene derivatives, especially ospemifene or fispemifene.
    Type: Application
    Filed: February 13, 2008
    Publication date: August 28, 2008
    Inventors: Marja Sodervall, Maire Eloranta, Arja Kalapudas
  • Patent number: 7193019
    Abstract: A process for the production of a vinyl compound of the formula (1), which process comprises reacting a bifunctional phenylene ether oligomer of the formula (2) with a vinylbenzyl halide in an aprotic polar solvent in the presence of an alkali metal alkoxide and then adding the reaction solution to water or a water/alcohol mixed solution to precipitate a solid
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: March 20, 2007
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Yasumasa Norisue, Makoto Miyamoto, Daisuke Ohno, Kenji Ishii, Michio Nawata
  • Patent number: 7169955
    Abstract: Perfluoroisopropylbenzene derivatives of the general formula (I) or salts thereof, useful as intermediates or raw materials in the synthesis of various industrial materials including agricultural chemicals, drugs and surfactants: wherein X1 is H, halogen, formyl, optionally halogenated (C1–C6) alkyl, (C1–C6) alkylthio, or the like; X2 is H, halogen, formyl, hydroxyl, (C1–C6) alkyl, —C(?O)—R1 (wherein R1 is H, halogen, hydroxyl, (C1–C6) alkyl, or NR2R3, with R2 and R3 being each H, C1-6 alkyl, or the like), or the like; X3 is H, halogen, hydroxyl, cyano, isocyanate, hydrazino, diazo, —C(?O)—R1, —SO2—R4 (wherein R4 is halogen, hydroxyl, (C1–C6) alkyl, or NR5R6, with R5 and R6 being each H or (C1–C6) alkyl), or the like; and X4 is H, halogen, (C1–C6) alkyl, or (C1–C6) alkoxy, with publicly known compounds being excepted.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: January 30, 2007
    Assignee: Nihon Nohyaku Co., Ltd.
    Inventors: Masanobu Onishi, Kenichi Ikeda, Takashi Shimaoka, Masanori Yoshida
  • Patent number: 6891070
    Abstract: A new method for the preparation of a selective estrogen receptor modulator and its isomers. Also disclosed is the preparation of new intermediates and their use in the preparation of the selective estrogen receptor modulator.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: May 10, 2005
    Assignee: Hormos Medical Corporation
    Inventors: Arja Kalapudas, Marja Södervall
  • Patent number: 6875895
    Abstract: Provided is a bis(diphenylvinyl)arene compound having a reactive functional group on phenyl group, represented by below formula (1), wherein, Ar is an arylene group and has one or more substituents; R1-R22 each independently represent a hydrogen atom, a halogen atom, cyano group, nitro group, etc., and at least one of R1-R20 is a halogen atom, etc. The arene compound has sufficient solubility in an organic solvent and excellent reactivity.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: April 5, 2005
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Takahiro Ueoka, Hideyuki Ikehira, Yoshiaki Tsubata
  • Patent number: 6864397
    Abstract: The present invention provides a process for producing a difluoromethyl ether derivative simple and efficient process for producing the difluoromethyl ether derivative represented by Formula (1d?) or a difluoromethyl ether derivative represented by Formula (1c?): wherein all the variables are defined in the specification.
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: March 8, 2005
    Assignees: Chisso Corporation, Chisso Petrochemical Corporation
    Inventors: Tomoyuki Kondo, Kouki Sagou, Shuichi Matsui, Hiroyuki Takeuchi, Yasuhiro Kubo, Etsuo Nakagawa
  • Patent number: 6767923
    Abstract: Benzhydryl derivatives of the formula I, where the index and the variables are as defined below: X is oxygen or sulfur; R1, R3 are halogen, cyano, nitro, hydroxyl, mercapto, amino, alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylcarbonyloxy, formyloxy, alkylthio, alkenylthio, alkynylthio, alkylamino, dialkylamino, alkylcarbonyl or formyl, where the carbon atoms in the radicals mentioned may be partially or fully halogenated; R2 is halogen, cyano, nitro, hydroxyl, mercapto, amino, alkyl, alkoxy, haloalkyl or haloalkoxy, where the groups R2 may be different if n=2; R4 is alkyl, alkenyl or alkynyl, where the carbon atoms in these radicals may be unsubstituted or partially or fully halogenated; R5, R6 are hydroxyl, alkyl, alkenyl, haloalkyl, haloalkenyl, alkoxy, alkenyloxy, haloalkoxy, haloalkenyloxy, cycloalkyl, cycloalkylalkyl, cycloalkoxy or cycloalkylalkoxy; n is 0, 1 or 2; processes for preparing the compounds I, compositions comprising them and their use for con
    Type: Grant
    Filed: October 29, 2002
    Date of Patent: July 27, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Ingo Rose, Jordi Tormo i Blasco, Markus Gewehr, Wassilios Grammenos, Bernd Müller, Joachim Rheinheimer, Peter Schäfer, Frank Schieweck, Thomas Grote, Andreas Gypser, Eberhard Ammermann, Gisela Lorenz, Reinhard Stierl, Siegfried Strathmann, Paul Carter, Jürgen Curtze
  • Patent number: 6395785
    Abstract: The present invention relates to E-2-[4-(chloro-1,2-diphenyl-butleny1)phenoxy]ethanol which is useful in lowering serum cholesterol and to pharmaceutical compositions thereof. The invention also describes methods of lowering serum cholesterol and methods for the prevention of or the treatment of atherosclerosis.
    Type: Grant
    Filed: September 7, 2000
    Date of Patent: May 28, 2002
    Assignee: Orion Corporation
    Inventors: Marja-Liisa Södervall, Arja Kalapudas, Antti Viitanen, Eero Mäntylä
  • Patent number: 6235870
    Abstract: Process for the preparation of compounds of the formula wherein Hal represents chlorine, bromine or iodine and preferably chlorine, wherein Ra represents hydrogen or a residue comprising one or more additional groups of the formula, from compounds wherein R2 represents hydrogen or a residue comprising one or more additional groups of the formula by reaction with gaseous hydrogen halide in the presence of a catalytic amount of an organic acid; process for the preparation of epoxy compounds starting from the reaction to produce a compound of formula (III) which is converted to a compound of formula (A) that is dehydrohalogenated to form the epoxy rings of a diepoxy compound.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: May 22, 2001
    Assignee: Shell Oil Company
    Inventors: Jozef Jacobus Titus Smits, Judith Johanna Berendina Walhof
  • Patent number: 6207835
    Abstract: Arylmetal compounds are prepared by deprotonation of aromatics which have a hydrogen atom in the ortho position relative to a halogen atom or a trifluoromethoxy group, using a suitable base or by halogen-metal exchange of haloaromatics using a suitable metalating reagent. The arylmetal compounds are prepared in a continuous-flow reactor. The arylmetal compound can be further reacted with an electrophilic reagent.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: March 27, 2001
    Assignee: Merck KGaA
    Inventors: Volker Reiffenrath, Hans Christian Stiasny
  • Patent number: 6005063
    Abstract: Process for the preparation of compound of the formula: ##STR1## wherein R.sub.c represents a residue comprising one or more additional groups of the formula: ##STR2## by heating a compound of the formula (A) ##STR3## at a temperature in the range of from 120 to 220.degree. C. in the presence of hydrogen halide addition salt of tertiary amine;process for the preparation of epoxy compounds starting from the reaction of a polyphenol compound and glycidol; andepoxy resins obtained by this process showing a significantly lower content of intermingled clorine and being substantially free of usual build-up products.
    Type: Grant
    Filed: February 6, 1998
    Date of Patent: December 21, 1999
    Assignee: Shell Oil Company
    Inventors: Johannes Adrianus Van Doorn, Jozef Jacobus Titus Smits, Eric Johannes Vos
  • Patent number: 6001954
    Abstract: Process for the preparation of compounds of the formula ##STR1## wherein Hal represents chlorine, bromine or iodine and preferably chlorine, wherein R.sub.a represents hydrogen or a residue comprising one or more additional groups of the formula, ##STR2## from compounds ##STR3## wherein R.sub.2 represents hydrogen or a residue comprising one or more additional groups of the formula ##STR4## by reaction with gaseous hydrogen halide in the presence of a catalytic amount of an organic acid. Epoxy resins are prepared via the reaction of a compound of formula (A) in the presence of a basic compound.
    Type: Grant
    Filed: February 6, 1998
    Date of Patent: December 14, 1999
    Assignee: Shell Oil Company
    Inventors: Jozef Jacobus Titus Smits, Judith Johanna Berendina Walhof
  • Patent number: 5998674
    Abstract: Method of producing a bromine compound having an aliphatic unsaturated bond which includes reacting a compound having an aliphatic unsaturated bond represented by the following general formula (1) with bromine:R.sup.1 --O--Ar.sup.1 --Y--Ar.sup.2 --O--R.sup.2 (1)to produce a bromine compound represented by the following formula (2):R.sup.3 --O--Ar.sup.1 --Y--Ar.sup.2 --O--R.sup.4 (2)wherein Ar.sup.1, Ar.sup.2 and Y are the same as defined in the above general formula (1) , and R.sup.3 and R.sup.4 are groups obtained by saturating the unsaturated groups of R.sup.1 and R.sup.2 in the above general formula (1) with bromine, respectively.The reaction is carried out in the presence of a solvent which is inactive in the reaction, and a substantial amount of the heat of reaction is removed from a reaction system by the vaporization of the solvent or bromine. A high-purity bromine compound in high yield which is useful as flame retardant, can be obtained.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: December 7, 1999
    Assignee: Teijin Chemicals, Ltd.
    Inventors: Yutaka Taketani, Haruhisa Hoshimi, Masanori Monri, Seiichi Tanabe, Yasuhiro Shimidzu
  • Patent number: 5547593
    Abstract: Disclosed is a lubricant oil composition comprising: (A) a fluorine-containing aromatic compound, and(B) an alkyl- or alkyl derivative-substituted aromatic compound having a kinetic viscosity of from 0.1 to 500 cSt as measured at 40 .degree. C., wherein:the compound (A) is represented by the formula:R(XR.sub.f).sub.n (A)wherein X represents an oxygen or a sulfur atom; n is an integer of from 1 to 4; R represents an n-valent, unsubstituted or substituted aromatic group having from 6 to 60 carbon atoms; and R.sub.f represents an unsubstituted or partially substituted fluorocarbon group having from 1 to 25 carbon atoms; andthe compound (B) comprises at least one substituted aromatic nucleus, wherein a substituent is an unsubstituted or substituted alkyl group having from 1 to 30 carbon atoms, or a derivative thereof. The lubricant oil composition having a kinetic viscosity of from 2 to 500 cSt as measured at 40.degree. C.
    Type: Grant
    Filed: August 11, 1994
    Date of Patent: August 20, 1996
    Assignee: Asahi Kasei Kogyo Kabushiki Kaisha
    Inventors: Kenichi Sanechika, Hiroyuki Fukui, Masanori Ikeda
  • Patent number: 5510540
    Abstract: A polyfunctional vinyl ether compound represented by formula (I): ##STR1## wherein n, which is an average repeating number, represents a number of from 0 to 20; R.sub.1 and R.sub.2 each independently represents a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, an aryloxy group, or a cycloalkyl group; Q each independently represents --OH or a group represented by the formula --OROCH.dbd.CH.sub.2, wherein R represents an alkylene group having from 1 to 12 carbon atoms, the molar ratio of (--OH)/(--OROCH.dbd.CH.sub.2) being from 10/90 to 90/10; and A each independently represents a divalent hydrocarbon group having from 1 to 30 carbon atoms.
    Type: Grant
    Filed: February 16, 1994
    Date of Patent: April 23, 1996
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Shigeo Hozumi, Shinichiro Kitayama, Hiroya Nakagawa
  • Patent number: 5463133
    Abstract: The present invention is to provide phenethyl alcohol derivative represented by the general formula (I), which is a stabilizing agent for colored images, particularly improved in resistance to plasticizers for the use in recording materials. ##STR1## (wherein Y: formula (II) or formula (III) R.sup.1 : H, alkyl, aralkylR.sup.2, R.sup.3 and R.sup.4 : halogen, nitro, alkyl, alkoxy, alkenyl, alkenyloxy,R.sup.5, R.sup.6 and R.sup.7 : H, alkyl,Z: --SO.sub.2 --, --CO--, --C(CH.sub.3).sub.
    Type: Grant
    Filed: May 31, 1994
    Date of Patent: October 31, 1995
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Takehiro Sato, Kimiaki Kinosita, Minoru Kaeriyama, Tomoya Hidaka
  • Patent number: 5362822
    Abstract: An adduct is prepared by reacting (A) a compound containing at least one epoxy group per molecule, with (B) a compound containing at least one epoxide reactive group per molecule selected from the group consisting of phenolic, thiol, secondary amine and carboxyl; wherein (i) when compound (A) is a polyepoxide, compound (B) contains a single epoxide reactive group per molecule; (ii) when compound (A) is a monoepoxide it is a monoglycidyl ether and compound (B) contains at least two epoxide reactive groups per molecule; and (iii) at least one of components (A) and (B) contains a rodlike mesogenic moiety. These adducts are useful in the preparation of polyurethanes.
    Type: Grant
    Filed: January 3, 1994
    Date of Patent: November 8, 1994
    Assignee: The Dow Chemical Company
    Inventor: Robert E. Hefner, Jr.
  • Patent number: 5278215
    Abstract: A flame-retardant synthetic resin composition containing (A) a synthetic resin and (B) a compound having a 3-halogeno-2-hydroxypropyl group, which shows excellent thermal stability during molding and having good light resistance, is disclosed. A flame retardant comprising a compound having a 3-halogeno-2-hydroxypropyl group is also disclosed.
    Type: Grant
    Filed: March 27, 1992
    Date of Patent: January 11, 1994
    Assignee: Dainippon Ink and Chemicals, Inc.
    Inventors: Katsuji Takahashi, Yuji Satoh
  • Patent number: 5242996
    Abstract: A modified epoxy resin or compound of the formula: ##STR1## wherein A is the backbone reside of a glycidyl ether epoxy resin with removal of the glycidyloxy groups; R.sup.1 and R.sup.2 are independently a hydrogen atom or C.sub.1 -C.sub.12 alkyl; R.sup.3 is a glycidyl group; and n is an integer of greater than 1. A method for producing the modified epoxy resin is also disclosed.
    Type: Grant
    Filed: May 22, 1991
    Date of Patent: September 7, 1993
    Assignee: Nippon Paint Co., Ltd.
    Inventors: Mitsuo Yamada, Kei Aoki, Ryuzo Mizuguchi