Alicyclic Terpenic Wherein The Number Of Carbons Is A Multiple Of Five Patents (Class 568/666)
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Patent number: 8932585Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.Type: GrantFiled: January 27, 2014Date of Patent: January 13, 2015Assignee: Soft Gel Technologies, Inc.Inventor: Michael Fantuzzi
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Patent number: 8932584Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.Type: GrantFiled: December 27, 2013Date of Patent: January 13, 2015Assignee: Soft Gel Technologies, Inc.Inventor: Michael Fantuzzi
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Patent number: 8658161Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.Type: GrantFiled: January 24, 2012Date of Patent: February 25, 2014Assignee: Soft Gel Technologies, Inc.Inventor: Michael Fantuzzi
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Patent number: 7923585Abstract: The invention relates to innovative menthol derivatives which are represented by the general formula (I) below and are excellent in a cooling effect and cool retaining effect, cooling agent compositions comprising the menthol derivatives, and sensory stimulation agent compositions containing the cooling agent compositions, as well as fragrance compositions, beverage or food products, cosmetic products, toiletry products, bathing agents, and pharmaceutical products containing the cooling agent compositions or sensory stimulation agent compositions. (general formula (I)) wherein R<1> represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an acyl group having 1 to 5 carbon atoms; R<2> and R<3> independently represent an alkylene group having 2 to 5 carbon atoms and optionally having a substituent; double dotted line represents a single bond or a double bond; and n is an integer of 1 to 3.Type: GrantFiled: May 31, 2004Date of Patent: April 12, 2011Assignee: Takasago International CorporationInventors: Kenya Ishida, Takashi Aida, Hiroyuki Matsuda, Fumihiro Yanaka
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Patent number: 7172994Abstract: The present invention is directed to compounds which possess unique organoleptic propertied of the general formula wherein R is a hydrogen or selected from the group consisting of C1–C7 moieties and the use of these materials as a fragrance chemical to enhance fragrance in perfumes, toilet waters, colognes, personal products and the like.Type: GrantFiled: December 9, 2005Date of Patent: February 6, 2007Assignee: International Flavors & Fragrances IncInventors: Anubhav P. S. Narula, Edward Mark Arruda, Franc T. Schiet
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Patent number: 6956139Abstract: A cooling sensate compound having the general formula (I): where n is an integer from 2 to 6. The compound is effective in imparting a refreshing and cooling sensation of long duration. A cooling sensate composition having the general formula (I) is used in a variety of formulations to impart the refreshing and cooling sensation. These cooling sensates are useful in a variety of consumer products including mouth formulations, food products and toiletries.Type: GrantFiled: June 10, 2002Date of Patent: October 18, 2005Assignees: Takasago International Corporation, Takasago International Corporation (U.S.A.)Inventors: Carter B. Green, Tetsuo Nakatsu, Takero Ishizaki, Andrew T. Lupo, Jr.
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Patent number: 6653344Abstract: The present invention relates to the use of a dibenzocyclooctane lignan derivative of the following general formula (I) for treatment of neurodegenerative disorders: wherein R1 is H or C1-4 lower alkyl; R2, R3, R4 and R5 are respectively H, OH, C1-4 lower alkyl, C1-4 lower alkoxy, or R2 and R3 or R4 and R5 are respectively combined to form the group of —OCH2O—. Pharmaceutical preparations containing the dibenzocyclooctane lignan derivative as the active ingredient also are disclosed.Type: GrantFiled: June 19, 2002Date of Patent: November 25, 2003Assignee: Elcom Bio Technology Co., Ltd.Inventors: Young-Joong Kim, Sang-Hyun Sung, Mi-Gyeong Lee, So-Ra Kim, Gyeong-A Gu, Won-Ju Jeong
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Patent number: 6515188Abstract: A method for safely and efficiently producing high purity 3-l-menthoxypropane-1,2-diol and intermediates to be used in the method. As shown in the following reaction formula, 3-l-menthoxypropane-1,2-diol represented by the chemical formula (IV) is produced by adding l-menthol to a 1,2-epoxy-3-halogenopropane represented by the general formula (I) (wherein X represents a halogen atom) in an organic solvent in the presence of a Lewis acid, thereby producing a 1-halogeno-3-l-menthoxypropan-2-ol represented by the general formula (II), allowing the first intermediate to react with an alkali metal salt of an aliphatic carboxylic acid having from 1 to 5 carbon atoms to produce a 1-acyloxy-2-substituted-3-l-menthoxypropane represented by the general formula (III) and then hydrolyzing the second intermediate.Type: GrantFiled: April 4, 2002Date of Patent: February 4, 2003Assignee: Takasago International CorporationInventors: Akira Amano, Teruyoshi Akiyama, Takashi Miura, Toshimitsu Hagiwara
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Patent number: 5208357Abstract: There are provided enantiomerically enhanced chiral substituted cyclopentadienyl ligands and compounds thereof, and a process for their making comprising contacting a substituted fulvene or derivative thereof with an enantiomerically enhanced or pure nucleophile having at least one chiral center. There are further provided enantiomerically enhanced chiral organometallic complexes having one or more chiral substituted cyclopentadienyl groups.Type: GrantFiled: December 31, 1990Date of Patent: May 4, 1993Assignee: Exxon Chemical Patents, Inc.Inventor: Eric A. Mintz
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Patent number: 5136066Abstract: The present invention provides a process for preparing an optically active cyclopentenone derivative represented by the formula ##STR1## by oxidizing an optically active cyclopentanone derivative represented by the formula ##STR2## with an oxidizing agent, and subsequently subjecting the oxidized compound to an elimination reaction. (In the above formulae, R.sup.1 is a protective group for hydroxyl, R.sup.5 is straight-chain or branched alkyl, alkenyl, alkynyl or alkylaryl having 5 to 22 carbon atoms and containing or not containing oxygen, sulfur or silicon, R.sup.6 is alkyl, aryl or heterocyclic group having or not having a substituent, Z is selenium or sulfur, and the symbol * represents an asymmetic carbon atom.Type: GrantFiled: July 9, 1991Date of Patent: August 4, 1992Assignee: Daiso Co., Ltd.Inventors: Takashi Takahashi, Yoshikazu Takehira
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Patent number: 5087612Abstract: A compound of formula ##STR1## wherein R.sup.1 represents a hydrogen atom or a saturated, linear or branched, alkyl radical, having from 1 to 4 carbon atoms, and R.sup.2 designates a lower alkyl radical, saturated or unsaturated, linear or branched;or any mixture containing a predominant amount of said compound (I), together with its isomer of formula ##STR2## wherein R.sup.1 and R.sup.2 are defined as above. Compounds (I) and their mixtures mentioned above develop odor notes of the woody-amber type and are therefore used as perfuming ingredients for the preparation of perfuming compositions and perfumed articles.A process for the preparation of compounds (I) and their mixtures is disclosed.Type: GrantFiled: September 4, 1990Date of Patent: February 11, 1992Assignee: Firmenich SAInventor: Christian Chapuis
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Patent number: 5051534Abstract: The present invention relates to a group of compounds which are novel squalene derivatives containing the cyclopropyloxy functionality and which act to inhibit the synthesis of cholesterol in mammals and in fungi.Type: GrantFiled: March 22, 1990Date of Patent: September 24, 1991Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Michael R. Angelastro, Norton P. Peet, Philippe Bey
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Patent number: 4459425Abstract: 3-l-Menthoxypropane-1,2-diol having the formula: ##STR1##Type: GrantFiled: August 25, 1982Date of Patent: July 10, 1984Assignee: Takasago Perfumery Co., Ltd.Inventors: Akira Amano, Michio Moroe, Toshio Yoshida
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Patent number: 4338469Abstract: In the acid-catalyzed etherification of olefins with alcohols, substantially complete recovery of alcohol and catalyst is obtained when small amounts of water (1-10%) are added to the reaction. The addition of water provides a two-phase reaction medium in which olefin and ether are in the upper phase and alcohol and catalyst are in the lower phase. These phase are maintained during the course of the reaction, which continues as a two-phase system.Certain novel ethers produced by this process are likewise disclosed herein.Type: GrantFiled: December 22, 1977Date of Patent: July 6, 1982Assignee: Suntech, Inc.Inventors: James E. Lyons, Peter Hosler
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Patent number: 4311861Abstract: Described are the compounds having the structures: ##STR1## wherein R represents C.sub.3 -C.sub.6 alkyl; aralkyl; hydroxy alkyl; and alkoxy alkyl, and uses thereof in augmenting or enhancing the aroma of perfume compositions, colognes, and perfumed articles (including fabric softener compositions, fabric softener articles, hair conditioners, floor waxes, solid or liquid anionic, cationic nonionic or zwitterionic detergents, and deodorant compositions and deodorant articles), as well as processes for preparing such compounds.Type: GrantFiled: October 23, 1980Date of Patent: January 19, 1982Assignee: International Flavors & Fragrances Inc.Inventor: Mark A. Sprecker
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Patent number: 4292219Abstract: In the acid-catalyzed etherification of olefins with alcohols, substantially complete recovery of alcohol and catalyst is obtained when small amounts of water (1-10%) are added to the reaction. The addition of water provides a two-phase reaction medium in which olefin and ether are in the upper phase and alcohol and catalyst are in the lower phase. These phases are maintained during the course of the reaction, which continues as a two-phase system. Certain novel ethers produced by this process are likewise disclosed herein.Type: GrantFiled: December 10, 1979Date of Patent: September 29, 1981Assignee: Suntech, Inc.Inventors: James E. Lyons, Peter Hosler