Preparing By Hydrolysis Or Saponification Of Alkyl Polyhalide Or Halohydrin Patents (Class 568/859)
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Patent number: 7335799Abstract: The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient.Type: GrantFiled: December 23, 2003Date of Patent: February 26, 2008Assignee: Esperion Therapeutics, Inc.Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
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Patent number: 6720434Abstract: The present invention relates to chiral salen catalysts and a process for preparing chiral compounds from racemic epoxides by using them. More particularly, the present invention is to provide chiral salen catalysts and its use for producing chiral compounds such as chiral epoxides and chiral 1,2-diols economically in high yield and high optical purity by performing stereoselective hydrolysis of racemic epoxides, wherein the chiral salen catalyst comprises a cationic cobalt as a center metal of chiral salen ligand and counterions having weak nucleophilic property to resolve disadvantages associated with conventional chiral salen catalysts, and can be used continuously without any activating process of used catalysts because it does not loose a catalytic activity during the reaction process.Type: GrantFiled: July 11, 2002Date of Patent: April 13, 2004Assignee: RSTECH Co., Ltd.Inventors: Geon-Joong Kim, Dae-Woon Park, Ho Seong Lee, Jin Won Yun, Seong Jin Kim
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Patent number: 6100412Abstract: A process for the production of an epoxide and/or its corresponding vicinal diol by a reaction of an olefinic compound with hydrogen peroxide, wherein the reaction is performed in the presence of a carbon dioxide phase at a temperature and a pressure above the critical point of carbon dioxide.Type: GrantFiled: September 10, 1999Date of Patent: August 8, 2000Assignee: Degussa-Huls AGInventors: Georg Thiele, Shane A. Nolan, James S. Brown, Jie Lu, Brandon C. Eason, Charles A. Eckert, Charles L. Liotta
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Patent number: 5998679Abstract: The present invention is directed to methods for converting lower alkanes and alkenes to the corresponding lower alkanols and diols. In the methods of the present invention, a gaseous halogen, preferably bromine, is produced by decomposing a metal halide in a liquid having a melting point below and a boiling point above the decomposition temperature of the metal halide. The preferred liquid is molten, hydrated ferric chloride maintained at a temperature between about 37-280.degree. C. The lower alkane or alkene is halogenated in a gas phase reaction with the produced halogen. The alkyl halide or alkyl dihalide is contacted with a metal hydroxide, preferably an aqueous solution of ferric hydroxide, to regenerate the metal halide and produce the corresponding lower alkanol or diol. The present invention is particularly efficient for converting methane to methanol using ferric bromide to provide the halogen.Type: GrantFiled: July 26, 1998Date of Patent: December 7, 1999Assignee: JLM Technology, Ltd.Inventor: Jorge Miller
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Patent number: 5334777Abstract: Lower monobasic or dibasic alcohols are produced by the following steps:a) reacting a starting material with a metallic halide (wherein the metal is in the higher of two possible valence states) to obtain a reaction product, a corresponding metallous halide (wherein the metal is in the lower of the two possible valence states) and hydrohalic acid, andb) reacting the reaction product of step (a) and hydrohalic acid with magnesium oxide to form the corresponding lower monobasic or dibasic alkanol;wherein the starting material for forming a lower monobasic alcohol is a lower alkane, from which the corresponding lower alkanol is obtained; and the starting material for forming a lower dibasic alcohol is either a lower alkanol or a lower alkene, from which the corresponding lower glycol is obtained. Two continuous fluidized-bed systems are provided for conducting the necessary reactions.Type: GrantFiled: August 4, 1993Date of Patent: August 2, 1994Assignee: Energia Andina Ltd.Inventors: Jorge Miller, Miguel Kling
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Patent number: 4822925Abstract: Novel vicinal dioxyalkylene organometalates comprising a cation having a hydrocarbyl-containing substituent are disclosed. The vicinal dioxyalkylene organometalates can be reacted with water to yield alkylene glycols.Type: GrantFiled: February 6, 1987Date of Patent: April 18, 1989Assignee: Union Carbide CorporationInventors: John R. Briggs, John H. Robson
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Patent number: 4683347Abstract: The level of impurities such as glycerol-based acetals and/or ketals in glycerine, particularly glycerol-dimethylketal, is reduced by extraction of the glycerine with supercritical or near critical carbon dioxide.Type: GrantFiled: June 23, 1986Date of Patent: July 28, 1987Assignee: Shell Oil CompanyInventors: Zaida Diaz, James H. Miller
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Patent number: 4460797Abstract: A reagent comprising the product of the reaction of an alkali metal hydroxide with a polyglycol or a polyglycol monoalkyl ether and oxygen, effects complete decomposition of halogenated organic compounds, such as polychlorinated biphenyls (PCBs), when mixed therewith in the presence of oxygen.Type: GrantFiled: June 13, 1983Date of Patent: July 17, 1984Assignee: The Franklin InstituteInventors: Louis L. Pytlewski, Kenneth Krevitz, Arthur B. Smith
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Patent number: 4338290Abstract: Glycols are readily and conveniently prepared by hydrolysis of halohydrins and/or dihaloalkanes in the presence of a catalytically effective amount of a strong acid.Type: GrantFiled: June 16, 1980Date of Patent: July 6, 1982Assignee: National Distillers & Chemical Corp.Inventors: Jawad H. Murib, John M. Inskeep
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Patent number: 4258208Abstract: A process for the preparation of 2-bromoalkyl esters and vicinal glycol esters which comprises thermally decomposing at temperatures of from 100.degree. C. to 200.degree. C. an organic bromoalkyl tellurium compound selected from 2-bromoalkyltellurium tribromide or bis(2-bromoalkyl)tellurium dibromide, wherein the alkyl group is ethyl, propyl or butyl, in a carboxylic acid having from 1 to 4 carbon atoms which is employed as solvent as well as to supply the ester moiety to the esters produced. The esters may be converted to the respective glycol with water or an aqueous base.Type: GrantFiled: July 23, 1979Date of Patent: March 24, 1981Assignee: Atlantic Richfield CompanyInventors: Jar-lin Kao, Ming N. Sheng
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Patent number: 4107221Abstract: Minor amounts of olefin oxide such as butylene oxide are removed from a chlorinated solvent by contacting the solvent with the hydrogen form of a strong acid cation exchange resin in the presence of water.Type: GrantFiled: July 28, 1977Date of Patent: August 15, 1978Assignee: The Dow Chemical CompanyInventors: William D. Tasto, Thomas E. Morris