Preparing By Hydrolysis Or Saponification Of Alkyl Polyhalide Or Halohydrin Patents (Class 568/859)
  • Patent number: 7335799
    Abstract: The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: February 26, 2008
    Assignee: Esperion Therapeutics, Inc.
    Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
  • Patent number: 6720434
    Abstract: The present invention relates to chiral salen catalysts and a process for preparing chiral compounds from racemic epoxides by using them. More particularly, the present invention is to provide chiral salen catalysts and its use for producing chiral compounds such as chiral epoxides and chiral 1,2-diols economically in high yield and high optical purity by performing stereoselective hydrolysis of racemic epoxides, wherein the chiral salen catalyst comprises a cationic cobalt as a center metal of chiral salen ligand and counterions having weak nucleophilic property to resolve disadvantages associated with conventional chiral salen catalysts, and can be used continuously without any activating process of used catalysts because it does not loose a catalytic activity during the reaction process.
    Type: Grant
    Filed: July 11, 2002
    Date of Patent: April 13, 2004
    Assignee: RSTECH Co., Ltd.
    Inventors: Geon-Joong Kim, Dae-Woon Park, Ho Seong Lee, Jin Won Yun, Seong Jin Kim
  • Patent number: 6100412
    Abstract: A process for the production of an epoxide and/or its corresponding vicinal diol by a reaction of an olefinic compound with hydrogen peroxide, wherein the reaction is performed in the presence of a carbon dioxide phase at a temperature and a pressure above the critical point of carbon dioxide.
    Type: Grant
    Filed: September 10, 1999
    Date of Patent: August 8, 2000
    Assignee: Degussa-Huls AG
    Inventors: Georg Thiele, Shane A. Nolan, James S. Brown, Jie Lu, Brandon C. Eason, Charles A. Eckert, Charles L. Liotta
  • Patent number: 5998679
    Abstract: The present invention is directed to methods for converting lower alkanes and alkenes to the corresponding lower alkanols and diols. In the methods of the present invention, a gaseous halogen, preferably bromine, is produced by decomposing a metal halide in a liquid having a melting point below and a boiling point above the decomposition temperature of the metal halide. The preferred liquid is molten, hydrated ferric chloride maintained at a temperature between about C. The lower alkane or alkene is halogenated in a gas phase reaction with the produced halogen. The alkyl halide or alkyl dihalide is contacted with a metal hydroxide, preferably an aqueous solution of ferric hydroxide, to regenerate the metal halide and produce the corresponding lower alkanol or diol. The present invention is particularly efficient for converting methane to methanol using ferric bromide to provide the halogen.
    Type: Grant
    Filed: July 26, 1998
    Date of Patent: December 7, 1999
    Assignee: JLM Technology, Ltd.
    Inventor: Jorge Miller
  • Patent number: 5334777
    Abstract: Lower monobasic or dibasic alcohols are produced by the following steps:a) reacting a starting material with a metallic halide (wherein the metal is in the higher of two possible valence states) to obtain a reaction product, a corresponding metallous halide (wherein the metal is in the lower of the two possible valence states) and hydrohalic acid, andb) reacting the reaction product of step (a) and hydrohalic acid with magnesium oxide to form the corresponding lower monobasic or dibasic alkanol;wherein the starting material for forming a lower monobasic alcohol is a lower alkane, from which the corresponding lower alkanol is obtained; and the starting material for forming a lower dibasic alcohol is either a lower alkanol or a lower alkene, from which the corresponding lower glycol is obtained. Two continuous fluidized-bed systems are provided for conducting the necessary reactions.
    Type: Grant
    Filed: August 4, 1993
    Date of Patent: August 2, 1994
    Assignee: Energia Andina Ltd.
    Inventors: Jorge Miller, Miguel Kling
  • Patent number: 4822925
    Abstract: Novel vicinal dioxyalkylene organometalates comprising a cation having a hydrocarbyl-containing substituent are disclosed. The vicinal dioxyalkylene organometalates can be reacted with water to yield alkylene glycols.
    Type: Grant
    Filed: February 6, 1987
    Date of Patent: April 18, 1989
    Assignee: Union Carbide Corporation
    Inventors: John R. Briggs, John H. Robson
  • Patent number: 4683347
    Abstract: The level of impurities such as glycerol-based acetals and/or ketals in glycerine, particularly glycerol-dimethylketal, is reduced by extraction of the glycerine with supercritical or near critical carbon dioxide.
    Type: Grant
    Filed: June 23, 1986
    Date of Patent: July 28, 1987
    Assignee: Shell Oil Company
    Inventors: Zaida Diaz, James H. Miller
  • Patent number: 4460797
    Abstract: A reagent comprising the product of the reaction of an alkali metal hydroxide with a polyglycol or a polyglycol monoalkyl ether and oxygen, effects complete decomposition of halogenated organic compounds, such as polychlorinated biphenyls (PCBs), when mixed therewith in the presence of oxygen.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: July 17, 1984
    Assignee: The Franklin Institute
    Inventors: Louis L. Pytlewski, Kenneth Krevitz, Arthur B. Smith
  • Patent number: 4338290
    Abstract: Glycols are readily and conveniently prepared by hydrolysis of halohydrins and/or dihaloalkanes in the presence of a catalytically effective amount of a strong acid.
    Type: Grant
    Filed: June 16, 1980
    Date of Patent: July 6, 1982
    Assignee: National Distillers & Chemical Corp.
    Inventors: Jawad H. Murib, John M. Inskeep
  • Patent number: 4258208
    Abstract: A process for the preparation of 2-bromoalkyl esters and vicinal glycol esters which comprises thermally decomposing at temperatures of from C. to C. an organic bromoalkyl tellurium compound selected from 2-bromoalkyltellurium tribromide or bis(2-bromoalkyl)tellurium dibromide, wherein the alkyl group is ethyl, propyl or butyl, in a carboxylic acid having from 1 to 4 carbon atoms which is employed as solvent as well as to supply the ester moiety to the esters produced. The esters may be converted to the respective glycol with water or an aqueous base.
    Type: Grant
    Filed: July 23, 1979
    Date of Patent: March 24, 1981
    Assignee: Atlantic Richfield Company
    Inventors: Jar-lin Kao, Ming N. Sheng
  • Patent number: 4107221
    Abstract: Minor amounts of olefin oxide such as butylene oxide are removed from a chlorinated solvent by contacting the solvent with the hydrogen form of a strong acid cation exchange resin in the presence of water.
    Type: Grant
    Filed: July 28, 1977
    Date of Patent: August 15, 1978
    Assignee: The Dow Chemical Company
    Inventors: William D. Tasto, Thomas E. Morris