Metal Halide Reactant Patents (Class 570/235)
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Publication number: 20140371494Abstract: Processes for the production of chlorinated propanes and propenes are provided. The present processes comprise catalyzing at least one chlorination step with one or more regios elective catalysts that provide a regioselectivity to one chloropropane of at least 5:1 relative to other chloropropanes.Type: ApplicationFiled: December 12, 2012Publication date: December 18, 2014Inventors: Max Markus Tirtowidjojo, Matthew Lee Grandbois, William J. Kruper, JR., Edward M. Calverley, David Stephen Laitar, Kurt Frederick Hirksekorn
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Publication number: 20140323744Abstract: The specification relates to compounds and process for the preparation of a compound of formula 7, where LG is a leaving group and hal is a halide and is Cl, Br or I. The compound of formula 7 can be useful in the preparation of natural products, such as halichondrin and its derivatives.Type: ApplicationFiled: November 29, 2012Publication date: October 30, 2014Inventors: Fabio E.S. Souza, Huzaifa Rangwala, Boris Gorin, Ming Pan
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Publication number: 20130209361Abstract: The present invention relates to a new synthetic process in which an alkyne and an azide react to form a radioisotopic bioconjugate construct. The reaction is particularly useful for producing compounds for use in imaging and radiotherapy applications. The present invention also provides bioconjugate labels and further relates to the use of these compounds in diagnostic and therapeutic methods. In addition, the invention provides a related process for introducing a radioisotopic halogen atom into a terminal alkyne.Type: ApplicationFiled: August 12, 2011Publication date: August 15, 2013Applicant: UCL BUSINESS PLCInventors: Erik Arstad, Ran Yan
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Patent number: 7268262Abstract: Describes a method for recovering trans-1,2-dichloroethene from a liquid feed composition comprising both the cis-and trans-isomers of 1,2-dichloroethene and contaminating amounts of other chlorinated hydrocarbons, e.g., lower alkyl chlorinated hydrocarbons, such as C1-C2 chlorinated hydrocarbons. In one of the described methods, the liquid feed composition is introduced into a first distillation column 10 wherein the stereoisomers and chlorinated hydrocarbons more volatile than the stereoisomers are removed as overhead 12 and charged to a second distillation column 20. In column 20, the stereoisomers are separated from the more volatile chlorinated hydrocarbons, and a bottoms fraction 24 comprising the stereoisomers is charged to a reactive distillation column 30 wherein the cis-isomer is isomerized to the trans-isomer in the liquid phase and in the presence of an organic free-radical initiator, e.g., an azonitrile initiator.Type: GrantFiled: April 29, 2004Date of Patent: September 11, 2007Assignee: PPG Industries Ohio, Inc.Inventors: Clark S. Graybill, Stephen R. Lester
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Patent number: 7109386Abstract: Process for the preparation of a halogenated olefin by reaction of an alkyne and/or of an allene compound with a hydrogen halide in a liquid medium comprising at least one hydrohalogenation catalyst comprising at least one palladium compound.Type: GrantFiled: March 20, 2002Date of Patent: September 19, 2006Assignee: Solvay (Societe Anonyme)Inventor: VĂ©ronique Mathieu
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Patent number: 6740253Abstract: The present invention relates to a non-hazardous brominating reagent from an aqueous alkaline bromine byproduct solution obtained from bromine recovery plant and containing 25 to 35% bromine dissolved in aqueous lime or sodium hydroxide containing alkali bromide and alkali bromate mixture having bromide to bromate stoichiometric ratio in the range of 5:1 to 5.1:1 or 2:1 to 2.1:1 and a pH ranging between 8-12 and also relates to a method for borminating aromatic compounds by using the above brominating agent.Type: GrantFiled: January 23, 2002Date of Patent: May 25, 2004Assignee: Council of Scientific and Industrial ResearchInventors: Rajinder Nath Vohra, Pushpito Kumar Ghosh, Maheshkumar Ramniklal Gandhi, Himanshu Labhshanker Joshi, Hasina Hajibhai Deraiya, Rohit Harshadray Dave, Koushik Halder, Kishorkumar Manmohandas Majeethia, Sohan Lal Daga, Vadakke Puthoor Mohandas, Rahul Jasvantrai Sanghavi
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Publication number: 20040097767Abstract: An oxidative halogenation process involving contacting a hydrocarbon, for example, ethylene, or a halogenated hydrocarbon with a source of halogen, such as hydrogen chloride, and a source of oxygen in the presence of a catalyst so as to form a halocarbon, preferably a chlorocarbon, having a greater number of halogen substituents than the starting hydrocarbon or halogenated hydrocarbon, for example, 1,2-dichloroethane. The catalyst is a novel composition comprising copper dispersed on a porous rare earth halide support, preferably, a porous rare earth chloride support. A catalyst precursor composition comprising copper dispersed on a porous rare earth oxyhalide support is disclosed. Use of the porous rare earth halide and oxyhalide as support materials for catalytic components is disclosed.Type: ApplicationFiled: November 12, 2003Publication date: May 20, 2004Inventors: Robert J. Gulotty, Mark E. Jones, Daniel A. Hickman
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Publication number: 20040097763Abstract: There is provided an industrially advantageous process for producing a 1-chloro-4-arylbutane represented by the general formula (2): 1Type: ApplicationFiled: August 18, 2003Publication date: May 20, 2004Inventors: Hiroaki Hibino, Susumu Ohtsuka, Yasunobu Miyamoto, Itsuo Okumoto
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Publication number: 20040092728Abstract: The present invention provides a process for producing aromatic bromide or aromatic iodide from an aromatic amine derivative using nitrite ion and holodimethylsulfonium halide generated in situ from hydrobromic acid/DMSO or hydriodic acid/DMSO. The process for producing compounds of the formula (1) is disclosed (1) wherein X is bromine or iodine: Y is carbon C or nitrogen; R1, R?2?, R3, R4 which may be the same or different and are selected independently from the group consisting of a hydrogen, a hologen, a C1-C8 alkyl, a C1-C10 alkoxy, a nitro, a formyl, an aryl, a benzyl, a C2-C10 alkylcarbonyl and an arylcarbonyl, provided that adjacent groups as selected from among R1, R2, R3, R4 and R1 may combine to form a ring.Type: ApplicationFiled: November 25, 2002Publication date: May 13, 2004Inventors: Woon Phil Baik, Jung Min Kim, Young Sam Kim, Cheol Hun Yoon, Shin Jong Kim, Seok Woo Lee
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Publication number: 20030136941Abstract: The present invention relates to a non-hazardous brominating reagent from an aqueous alkaline bromine byproduct solution obtained from bromine recovery plant and containing 25 to 35% bromine dissolved in aqueous lime or sodium hydroxide containing alkali bromide and alkali bromate mixture having bromide to bromate stoichiometric ratio in the range of 5:1 to 5.1:1 or 2:1 to 2.Type: ApplicationFiled: January 23, 2002Publication date: July 24, 2003Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Rajinder Nath Vohra, Pushpito Kumar Ghosh, Maheshkumar Ramniklal Gandhi, Himanshu Labhshanker Joshi, Hasina Hajibhai Deraiya, Rohit Harshadray Dave, Koushik Halder, Kishorkumar Manmohandas Majeethia, Sohan Lal Daga, Vadakke Puthoor Mohandas, Rahul Jasvantrai Sanghavi
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Publication number: 20030065231Abstract: Methods of converting methyl chloride to methyl bromide include the steps of providing a composition comprising a bromide salt and a liquid; contacting the composition with gaseous methyl chloride and/or methyl chloride dissolved in a water-immiscible solvent; and recovering methyl bromide.Type: ApplicationFiled: October 3, 2001Publication date: April 3, 2003Inventors: David T. Erdman, Jonathan D. Spicher, Mary F. Lamar
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Patent number: 6369275Abstract: The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.Type: GrantFiled: November 17, 2000Date of Patent: April 9, 2002Assignee: Merck & Co., Inc.Inventors: Ian W. Davies, Michel Journet, Linda Gerena, Robert D. Larsen, Philip J. Pye, Kai Rossen
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Patent number: 6080568Abstract: Novel .alpha.-amylase enzymes are disclosed in which one or more of residues corresponding to A210, H405 and T412 in Bacillus licheniformis are mutated. The disclosed .alpha.-amylase enzymes show altered or improved stability and/or activity profiles.Type: GrantFiled: August 19, 1997Date of Patent: June 27, 2000Assignee: Genencor International, Inc.Inventors: Anthony G. Day, Barbara A. Swanson
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Patent number: 5347060Abstract: This invention relates to phase transfer catalysis (PTC) using a composition of synthetic ultra-large pore crystalline material which contains a cation of an onium compound, e.g. cetyltrimethylammonium, within the pores of said material. The crystalline material has, after calcination, an X-ray diffraction pattern with at least one peak at a d-spacing greater than 18 Angstrom Units and a benzene adsorption capacity of greater than 15 grams benzene per 100 grams of said material at 6.7 kPa (50 torr) and 25.degree. C.Type: GrantFiled: June 11, 1993Date of Patent: September 13, 1994Assignee: Mobil Oil CorporationInventors: Stuart D. Hellring, Jeffrey S. Beck
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Patent number: 5262575Abstract: This invention, in one respect, is a process for producing allylic chlorides which comprises contacting a feedstream containing an olefin in the gas phase with a chlorination composition under conditions effective to produce an allylic chlorine and wherein the mole ratio of oxygen to olefin is from 0 to about 1:20 in the feedstream. The chlorination composition contains supported palladium chloride, platinum chloride, or palladium chloride and a chloride of a Group 1 alkali metal selected from the group consisting of lithium, sodium, and potassium; a Group 2 alkaline earth metal; a Group 9 metal; nickel; and a Group 12 metal. The chlorination composition can be regenerated by contacting the chlorination composition with chlorine in a cyclic reaction scheme.Type: GrantFiled: August 4, 1992Date of Patent: November 16, 1993Assignee: The Dow Chemical CompanyInventor: William P. Dianis
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Patent number: 5208400Abstract: An improved process for producing allyl bromides by halogen exchange by reaction of an allyl chloride, with a metal bromide, wherein the reaction is conducted in an aprotic polar solvent. The allyl bromides obtained by the process of the invention are useful as intermediates for producing medicines, agricultural chemicals, dyes, and the like.Type: GrantFiled: January 2, 1992Date of Patent: May 4, 1993Assignee: Mitsui Toatsu Chemicals, Inc.Inventors: Ryuichi Mita, Yuji Fukunaga, Hironobu Horie, Mitsumasa Umemoto, Yasuhiro Matsuki
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Patent number: 4895993Abstract: An isomerization of a haloalkene is conducted in the presence of a mixture of a copper compound and a trithiocarbonic acid derivative or dithiocarbonic acid derivative.Type: GrantFiled: September 15, 1988Date of Patent: January 23, 1990Assignee: Phillips Petroleum CompanyInventors: H. Wayne Mark, Richard C. Doss, Clarence R. Bresson
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Patent number: 4849534Abstract: A process for functionalizing methane comprising:(a) reacting methane with a hydridoalkyl metal complex of the formula:CpIr[P(R.sub.1).sub.3 ]H(R.sub.2)wherein Cp represents a cyclopentadienyl or alkylcyclopentadienyl radical having from 1 to 5 carbon atoms;Ir represents an iridium atom;P represents a phosphorus atom;R.sub.1 represents an alkyl group;R.sub.2 represents an alkyl group having at least two carbon atoms; andH represents a hydrogen atom, in the presence of a liquid alkane R.sub.3 H having at least three carbon atoms to form a hydridomethyl complex of the formula:CpIr[P(R.sub.1).sub.3 ]HMewhere Me represents a methyl radical.(b) reacting said hydridomethyl complex with an organic halogenating agent such as a tetrahalomethane or a haloform of the formulas:CX'X"X'"X"" or CHX'X"X'";wherein X', X", X"', and X"" represent halogens selected from bromine, iodine and chlorine, to halomethyl complex of step (a) having the formula:CpIr[P(R.sub.1).sub.Type: GrantFiled: February 21, 1985Date of Patent: July 18, 1989Inventors: Robert G. Bergman, J. Michael Buchanan, Jeffrey M. Stryker, Michael J. Wax
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Patent number: 4465867Abstract: A process for preparing o-methallyloxyphenol by reacting catechol with methallyl chloride in the presence of at least one of KI and NaI serving as a catalyst with use of a base, and an organic solvent or a mixture of an organic solvent and water, the process being characterized in that methallyl chloride is reacted with the catalyst after the reaction to recover the catalyst as converted to methallyl iodide and reuse the catalyst.Type: GrantFiled: June 11, 1982Date of Patent: August 14, 1984Assignee: Otsuka Kagaku Yakuhin Kabushiki KaishaInventors: Tsukasa Maekawa, Takeshi Gondo, Shigeo Takahashi, Hidetoshi Kume
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Patent number: 4306100Abstract: Alkenediols are produced by hydrolysis of a dibromoalkenes in the presence of alkali metal formate. In a preferred embodiment, alkenediols, and particularly 2-butene-1,4-diol, are produced in a series of steps comprising bromination of conjugated diene with cupric bromide, hydrolysis of the resulting dibromobutenes to alkenediols in the presence of alkali metal formate, and regeneration of cupric bromide and alkali metal formate such that only conjugated diene, oxygen and water are consumed.Type: GrantFiled: June 16, 1980Date of Patent: December 15, 1981Assignee: Standard Oil Company (Indiana)Inventor: George R. Wood