Blood Vessel Or Graft Preparation Patents (Class 600/36)
  • Patent number: 10434218
    Abstract: A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification is disclosed. The method includes preconditioning, pre-stressing, or pre-damaging fixed bioprosthetic tissue in a manner that mimics the damage associated with post-implant use, while, and/or subsequently applying a calcification mitigant such as a capping agent or a linking agent to the damaged tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the damage process (service stress) and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. The linking agent will act as an elastic reinforcement or shock-absorbing spring element in the tissue structure at the site of damage from the pre-stressing.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: October 8, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: James A. Davidson, Jeffrey S. Dove, Darin P. Dobler
  • Patent number: 10413409
    Abstract: The present invention relates to apparatus and methods for endovascularly delivering and releasing a prosthesis, e.g., an aortic prosthesis, within and/or across a patient's native heart valve, referred to hereinafter as replacing the patient's heart valve. In some embodiments the delivery system comprises a plurality of first actuatable element adapted to engage a plurality of second elements in a first configuration to capture the implant within the delivery system, and wherein the plurality of first actuatable element are adapted to engage the plurality of second elements in a second configuration and to release the implant from the delivery system.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: September 17, 2019
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Amr Salahieh, Hans F. Valencia, Brian D. Brandt, Claudio Argento, Ulrich R. Haug, Jean-Pierre Dueri, Daniel K. Hildebrand, Dwight P. Morejohn, Tom Saul
  • Patent number: 10413412
    Abstract: The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; and applying an external non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to change the shape of the anchor, such as by applying proximally and/or distally directed force on the anchor using a releasable deployment tool to expand and contract the anchor or parts of the anchor. Another aspect of the invention provides an apparatus including a replacement valve; an anchor; and a deployment tool comprising a plurality of anchor actuation elements adapted to apply a non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to reshape the anchor.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: September 17, 2019
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Amr Salahieh, Jean-Pierre Dueri, Hans F. Valencia, Brian D. Brandt, Dwight P. Morejohn, Claudio Argento, Tom Saul, Ulrich R. Haug
  • Patent number: 10405960
    Abstract: The invention relates to a prosthesis (1) comprising a textile (2) of elongate shape defining a longitudinal axis A, and a resilient frame (3) connected to said textile along substantially the peripheral edge of the textile, said frame forming, in the area of each short side of the textile, at least one U-shaped bend (4) extending in the direction of the longitudinal axis, said frame being able to adopt an unstressed configuration, in which said textile is deployed, and a stressed configuration, in which said frame is subjected to a radial force directed towards said longitudinal axis and said textile forms at least one longitudinal fold.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: September 10, 2019
    Assignee: Sofradim Production
    Inventor: Pierre Bailly
  • Patent number: 10369338
    Abstract: An expandable tissue dilator for dilating tissue around a spinal column includes a housing and a shaft at least partially positioned distally of the housing and adapted to pierce a tissue around the spinal column. An expandable member attached to the housing expands around a portion of the shaft to dilate the pierced tissue in a single-pass dilation resulting in a reduction of any traumatic impingement of nerves or muscle tissue and reduction in procedure time.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: August 6, 2019
    Assignee: GLOBUS MEDICAL, INC.
    Inventors: Andrew Berkowitz, Brian Flint
  • Patent number: 10335024
    Abstract: The various embodiments disclosed herein relate to procedural space maintenance devices, medical device positioning devices, and devices that provide both procedural space maintenance and device positioning. Further embodiments relate to medical device insertion and/or retraction devices.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: July 2, 2019
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Mark Rentschler, Shane Farritor
  • Patent number: 10335264
    Abstract: Provided is an artificial blood vessel including a cylindrical inner tube having a hollow part formed therein; an outer tube provided at an outer circumferential surface of the inner tube and surrounding the inner tube so as to form a double tube structure with the inner tube; and a connecting line formed in circumferential directions of the inner tube and the outer tube to connect the inner tube and the outer tube.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: July 2, 2019
    Inventor: Byung Choo Moon
  • Patent number: 10219925
    Abstract: Controlled deployable medical devices that are retained inside a body passage and in one particular application to vascular devices used in repairing arterial dilations, e.g., aneurysms. Such devices can be adjusted during deployment, thereby allowing at least one of a longitudinal or radial re-positioning, resulting in precise alignment of the device to an implant target site.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: March 5, 2019
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Edward H. Cully, Keith M. Flury, Michelle L. Gendron, Stanislaw L. Zukowski
  • Patent number: 10195307
    Abstract: The invention concerns a method for preparing an acellular organic tissue for revitalisation by means of the reimplantation of living cells, said method involving the following stages: preparing the acellular tissue on an essentially flat surface, creating a plurality of holes on the surface of the tissue, distributed all over said surface and positioned so that they penetrate at least through a portion of the thickness of said tissue. The holes are suitable for containing the living cells when they are reimplanted.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: February 5, 2019
    Assignee: Telea Biotech S.R.L.
    Inventor: Maurizio Marzaro
  • Patent number: 10179043
    Abstract: Embodiments of a prosthetic heart valve are disclosed. An implantable prosthetic valve may be radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. The prosthetic valve may comprise an annular frame, a leaflet structure positioned within the frame and a plurality of outer skirts positioned around an outer surface of the frame, each outer skirt comprising an inflow edge secured to the frame and an outflow edge secured at intervals to the frame. The plurality of outer skirts may include a first outer skirt and a second outer skirt, wherein in the expanded configuration the first and second outer skirts include openings unsecured to the frame between the intervals. The inflow edge of the first annular outer skirt may be secured to the frame with sutures including radiopaque material. The first annular outer skirt may include radiopaque dye.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: January 15, 2019
    Assignee: Edwards Lifesciences Corporation
    Inventors: Hanoch Cohen-Tzemach, Tamir S. Levi, Noam Nir, Bella Felsen
  • Patent number: 10052415
    Abstract: The invention provides methods, compositions, and devices for promoting adhesion or migration of endothelial cell.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: August 21, 2018
    Assignee: University of Utah Research Foundation
    Inventors: Dean Y. Li, Brent D. Wilson, Lise Sorensen Brunhart
  • Patent number: 10052218
    Abstract: In an aspect of some embodiments there is provided apparatuses and methods including a sleeve expander capable of covering with an implantable sleeve an exterior of a bodily vessel, along a chosen length thereof, the sleeve expander configured to maintain at least a portion of the implantable sleeve in an expanded size greater than a cross sectional dimension thereof when in apposition to the exterior. In some embodiments of the present invention, the apparatus further includes a cutting mechanism configured to cut down the implantable sleeve and/or external fixating means configured to fixate a covering section of the implantable sleeve to a corresponding covered section of the bodily vessel.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: August 21, 2018
    Assignee: Vascular Graft Solutions Ltd.
    Inventors: Ronny Winshtein, Eyal Orion
  • Patent number: 10039454
    Abstract: A method for quantifying, during pacemapping, a comparison of a BSPM of interest to a pace site BSPM. The method may include receiving at a computing device a plurality of ECG signals from an acquisition system. The pace site BSPM may be calculated using the plurality of ECG signals. The BSPM of interest may be compared to the pace site BSPM, by: retrieving the BSPM of interest from memory accessible by the computing device; and, calculating one or more comparison metrics for the BSPM of interest as compared to the pace site BSPM. An indication of similarity between the BSPM of interest and the pace site BSPM based on the comparison metric calculated may be displayed on a user interface in communication with the computing device.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: August 7, 2018
    Assignee: Dalhousie University
    Inventors: John Lewis Sapp, Jr., Bohumil Milan Horacek, Ahmed Mohamed Fahmey El-Damaty
  • Patent number: 9907683
    Abstract: Controlled deployable medical devices that are retained inside a body passage and in one particular application to vascular devices used in repairing arterial dilations, e.g., aneurysms. Such devices can be adjusted during deployment, thereby allowing at least one of a longitudinal or radial re-positioning, resulting in precise alignment of the device to an implant target site.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: March 6, 2018
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Stanislaw L. Zukowski, Edward H. Cully, Keith M. Flury, Michelle L. Gendron, Patrick S. Young
  • Patent number: 9849220
    Abstract: An implantable medical device, which comprises a device substrate, a coating on the substrate which includes a drug which is highly soluble in water, and a protective layer which overlies the coating. The protective layer comprises a polymer selected from the group consisting of polylactic acid, polyglycolic acid and a lactic acid/glycolic acid copolymer having a weight average molecular weight of not more than 40,000.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: December 26, 2017
    Assignee: DePuy International Limited
    Inventors: Yufu Li, Deborah Schachter, Raymond S. Shissias, Sandra Wechsler
  • Patent number: 9814563
    Abstract: The imperfect hemodymamics and non-endothelialized surface of the BT shunt and RV-PA conduit can be improved by utilizing a shape that has more uniform flow and lower shear stress. Accordingly, the shunt will have an acute takeoff angle with a fluted inlet portion that eliminates fluid separation and maintains the shear stress within or near the physiologic range. The distal aspect of the shunt may be fluted in one or both directions along the pulmonary artery to improve the flow transition and reduce the shear forces on the posterior wall the pulmonary artery. An autologous umbilical vein may be used as the shunt with fluted proximal and distal portions with an autologous endothelialized surface to minimize platelet deposition and thrombus formation. The umbilical vein shunt may have an external support for diameter constraint and maintaining the hemodynamically optimized fluted design.
    Type: Grant
    Filed: April 25, 2015
    Date of Patent: November 14, 2017
    Inventor: David M. Hoganson
  • Patent number: 9801707
    Abstract: A whip stitched graft construct and method of formation. The whip stitched graft construct includes a plurality of tendon strand regions or soft tissue grafts placed together so that at least a portion of the plurality of the tendon strand regions are stitched together by employing multiple suture passes placed according to a whip stitching technique. Preferably, the multiple suture passes start at about the mid length of the plurality of tendon strand regions and are advanced toward one of the free ends of the tendon strands. The whip stitched graft construct is provided with at least two regions, one region formed of at least a plurality of tendon strand regions tied and whip stitched together, and the other region formed of untied segments of the plurality of tendon strands.
    Type: Grant
    Filed: September 25, 2012
    Date of Patent: October 31, 2017
    Assignee: ARTHREX, INC.
    Inventor: Mark A. Cassani
  • Patent number: 9802363
    Abstract: A method for producing an object includes forming and laying N unit layers into which an object is divided, sequentially from a first layer to an Nth layer, using a resin material as a material, or using a resin material for implementing a step, to form the object, the method including performing a discharge treatment at either or both of a timing while forming a unit layer among the N unit layers, and a timing after forming the unit layer, but before starting forming a next unit layer among the N unit layers.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: October 31, 2017
    Assignee: Seiko Epson Corporation
    Inventors: Atsushi Denda, Kenji Kitada, Maki Nariai
  • Patent number: 9770488
    Abstract: The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: September 26, 2017
    Assignee: Anthrogenesis Corporation
    Inventors: Mohit Bhatia, Chris Lugo, Qian Ye, James W. Edinger
  • Patent number: 9757233
    Abstract: A device, a kit and a method is presented for permanently augmenting the pump function of the left heart. The mitral valve plane is assisted in a movement along the left ventricular long axis during each heart cycle. The very close relationship between the coronary sinus and the mitral valve is used by various embodiments of a medical device providing this assisted movement. By means of catheter technique an implant is inserted into the coronary sinus, the device is augmenting the up and down movement of the mitral valve and thereby increasing the left ventricular diastolic filling when moving upwards and the piston effect of the closed mitral valve when moving downwards.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: September 12, 2017
    Assignee: Synergio AG
    Inventor: Jan Otto Solem
  • Patent number: 9713696
    Abstract: A device for regulating blood pressure between a patient's left atrium and right atrium, and apparatus for delivery the device, are provided. The delivery apparatus may include one or more latching legs, a release ring, a pull chord, and a catheter wherein the latching legs are configured to engage the device for delivery. The inventive devices may reduce left atrial pressure and left ventricular end diastolic pressure, and may increase cardiac output, increase ejection fraction, relieve pulmonary congestion, and lower pulmonary artery pressure, among other benefits. The inventive devices may be used, for example, to treat subjects having heart failure, pulmonary congestion, or myocardial infarction, among other pathologies.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: July 25, 2017
    Assignee: V-Wave Ltd.
    Inventors: Menashe Yacoby, Boaz Harari, Yaacov Nitzan
  • Patent number: 9630019
    Abstract: One embodiment of the invention provides a method and apparatus for performing deep brain stimulation with an electromagnetic field. The includes an electrode assembly having multiple electrodes and a phased array system for driving the electrodes to generate the electromagnetic field. By controlling delays within the phased array system, the generated electromagnetic field can be steered to a desired region of the brain.
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: April 25, 2017
    Assignee: UCL BUSINESS PLC
    Inventors: Virgilio Valente, Andreas Demosthenous, Richard Bayford
  • Patent number: 9610160
    Abstract: A method is provided for implanting a valve having at least one valve leaflet within the cardiovascular system of a subject. One step of the method includes preparing a substantially dehydrated bioprosthetic valve and then providing an expandable support member having oppositely disposed first and second ends and a main body portion extending between the ends. Next, the substantially dehydrated bioprosthetic valve is attached to the expandable support member so that the substantially dehydrated bioprosthetic valve is operably secured within the main body portion of the expandable support member. The expandable support member is then crimped into a compressed configuration and placed at a desired location within the cardiovascular system of the subject. Either before or after placement at the desired location, fluid or blood re-hydrates the substantially dehydrated bioprosthetic valve.
    Type: Grant
    Filed: April 23, 2013
    Date of Patent: April 4, 2017
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Jose Luis Navia, Ji-Feng Chen
  • Patent number: 9539122
    Abstract: An apparatus for treating vascular aneurysms includes an occlusive support device comprised of one or more support members. The occlusive device has, an end cap member and an anchoring member. The end cap member is comprised of at least one of one or more of the support members. The end cap member has openings and the end cap member comprises a reactive material that is configured to hydrate upon delivery of the device and to reduce the size of said openings. The device is configured so that the occlusive members can be positioned in the blood vessel proximate the neck of a vascular aneurysm, the reactive material hydrates and increases the resistance to blood flow into the aneurysm, and the anchoring member anchors the device in the blood vessel without occluding flow through the blood vessel.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: January 10, 2017
    Assignee: MicroVention, Inc.
    Inventors: Thomas H. Burke, Brian J. Cox, Matthew J. Fitz, David Ferrera
  • Patent number: 9506040
    Abstract: This application discloses methods and materials for preparing functional microvascular beds in the laboratory. These prevascularized constructs can be used to vascularize engineered tissue constructs or to revascularize damaged or diseased tissues or organs following implantation. The prevascularized constructs may also deliver genetically engineered gene products to the bloodstream.
    Type: Grant
    Filed: May 11, 2009
    Date of Patent: November 29, 2016
    Assignee: The Arizona Board of Regents on behalf of the University of Arizona
    Inventors: Stuart K. Williams, James B. Hoying, Benjamin R. Shepherd
  • Patent number: 9452070
    Abstract: A vascular device is provided that includes a mesh structure formed of a plurality of spaced members. The structure has (i) a first, collapsed configuration, (ii) a second, expanded configuration, and (iii) a density of the plurality of members. The vascular device further includes an elastic member disposed along a region of the structure, the region having a proximal end and a distal end. The Elastic member is configured to increase the density within the region by drawing at least one of the proximal and distal ends of the region toward the other of the proximal and distal ends when the structure is in the second configuration.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: September 27, 2016
    Assignee: Covidien LP
    Inventor: Rich Kusleika
  • Patent number: 9452046
    Abstract: A method for replacing a diseased aortic valve includes selecting a prosthetic heart valve based on a measurement of a patient's aortic annulus, the prosthetic heart valve stored in a storage container while in an expanded configuration. The preservative solution is drained from the storage container and the prosthetic heart valve is removed. The prosthetic heart valve is compressed to a contracted configuration and advanced through a patient's vasculature along a distal end portion of a catheter system. The prosthetic heart valve is positioned within the diseased aortic valve and re-expanded to an initial expanded configuration. A deployment mechanism is actuated via an operating handle to further expand the prosthetic heart valve into secure engagement with surrounding tissue until lockout features on the prosthetic heart valve secure the prosthetic heart valve in a final expanded configuration.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: September 27, 2016
    Assignee: Edwards Lifesciences Corporation
    Inventors: Jibin Yang, Matthew L. Pease, Scott H. Heneveld, Brandon G. Walsh
  • Patent number: 9433517
    Abstract: Disclosed is a method of treating a bodily lumen with a stent, the method comprising: disposing a stent within a bodily lumen, the stent comprising a plurality of deformable struts configured to selectively deform in localized regions in the struts upon application of an outward radial force; and expanding the stent by applying the outward radial force, wherein the outward radial force causes selective deformation of the deformable struts in a localized region in the struts.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: September 6, 2016
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Bin Huang, David C. Gale
  • Patent number: 9416470
    Abstract: A method for substantially reducing the elasticity of at least one selected textile region of a garment. The method includes producing the garment including a conductive textile electrode and rigidifying the at least one selected textile region. The rigidifying process includes applying rigidifying matter onto or into the at least one selected textile region. The at least one selected textile region is selected from the group consisting of a conductive textile electrode and a region of the garment situated between two adjacent textile electrodes. The invention further provides a garment having a tubular form, knitted by a seamless knitting machine with base-yarns. The garment includes at least one conductive textile electrode, composed of multiple knitted line segments, each knitted with a conductive yarn and a spandex yarn, wherein the spandex yarn and at least one base-yarn are knitted continuously.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: August 16, 2016
    Assignee: HEALTHWATCH LTD.
    Inventors: Boaz Shoshani, Uri Amir
  • Patent number: 9408687
    Abstract: A tissue modification apparatus includes a first and a second guide, a first and a second set of mounts, and a first and a second actuator. The first guide defines a first axis, and the second guide defines a second axis intersecting the first axis. The mounts of the first set of mounts are movable relative to one another along the first axis, and the mounts of the second set of mounts are movable relative to one another along the second axis. The first actuator and the second actuator are each settable to a stress load, with the first actuator and the second actuator movable, respectively, along the first axis and the second axis to transmit each respective stress load to a piece of tissue mechanically coupled to the first and second set of mounts.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: August 9, 2016
    Assignee: Boston Scientific SciMed, Inc.
    Inventors: Jarad Waisblatt, Benjamin Sutton, Ali Salahieh, Peter W. Gregg, Crystal M. Anderson-Cunanan
  • Patent number: 9381102
    Abstract: A medical device with an outer surface prepared to reduce crystalline growth or surface fowling thereon is provided. The device includes an elongate member that extends between a distal end and a proximal end, and a lumen defined through at least a central portion of the member. The member is defined from a wire that is coiled to define the lumen therethrough, the coils of the wire are configured such that a plurality of the neighboring coils define a small space therebetween. The coiled wire includes a central metallic core that extends along the entire length of the wire defining the member and a polymeric jacket is wrapped around the core, wherein the polymeric jacket is configured to retain an electric charge disposed therethrough.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: July 5, 2016
    Assignee: Cook Medical Technologies LLC
    Inventor: Shay James Lavelle
  • Patent number: 9381282
    Abstract: The invention provides methods, compositions, and devices for promoting adhesion or migration of endothelial cell.
    Type: Grant
    Filed: July 30, 2014
    Date of Patent: July 5, 2016
    Assignee: University of Utah Research Foundation
    Inventors: Dean Y. Li, Brent D. Wilson, Lise Sorensen Brunhart
  • Patent number: 9321872
    Abstract: The present invention aims to provide a surface modification method for a rubber vulcanizate or a thermoplastic elastomer, which can impart various functions such as sliding properties and biocompatibility according to its use. The present invention relates to a surface modification method for modifying a rubber vulcanizate or a thermoplastic elastomer as an object to be modified, the method including: Step 1 of forming polymerization initiation points on a surface of the object to be modified; Step 2 of radical polymerizing monomers starting from the polymerization initiation points to grow polymer chains on the surface of the object to be modified; and Step 3 of functionalizing the polymer chains.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: April 26, 2016
    Assignee: SUMITOMO RUBBER INDUSTRIES, LTD.
    Inventor: Yasuhisa Minagawa
  • Patent number: 9180003
    Abstract: An intravascular cuff acts as a lining between a native vessel and an intravascular prosthetic device. During deployment, the ends of the cuff curl back upon themselves and are capable of trapping native tissue, such as valve leaflet tissue, between the ends. The cuff creates a seal between the vessel and the prosthetic, thereby preventing leakage around the prosthetic. The cuff also traps any embolic material dislodged from the vessel during expansion of the prosthetic.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: November 10, 2015
    Assignee: HLT, Inc.
    Inventors: Robert Foster Wilson, John P. Gainor
  • Patent number: 9060890
    Abstract: Methods and devices are disclosed for supporting and holding open a tubular structure in the body of an animal or human. In one form, the device is a manually adjustable variable outside diameter stent that can be repositioned or removed. The stent includes an elastic tubular body and an adjustment mechanism for the moving two ends of the body toward or away from each other. The elastic tubular body comprises a braiding of two groups of spaced apart helically wound elastic strands. The adjustment mechanism includes a bracket, a tension adjustor, and a tensioning wire attached to the bracket and the tension adjuster. The bracket and the tension adjuster are attached to one or more of the elastic strands of the two groups. Using the adjustment mechanism, the distance between the bracket and the tension adjustor can be decreased causing the outside diameter of the body to increase, or vice versa.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: June 23, 2015
    Assignee: Mayo Foundation For Medical Education and Research
    Inventors: Juliane Bingener-Casey, Navtej S. Buttar, Louis-Michel Wong Kee Song
  • Patent number: 9063145
    Abstract: Embodiments of the present invention relate to devices and methods for detecting opsonophagocytotic antibodies using detection particles having product-specific detection reagents and having a characteristic spectral feature. Detection substrates, include microwells. Phagocytic cells are grown in the microwells, and a sample of serum or other bodily fluid from a patient is introduced into the wells, along with a set of detection particles, each set having an antigen recognized by opsonophagocytotic antibodies. The detection particles bind to the antibodies present in the sample and the phagocytic cells then take up the detection particles, labeling the phagocytic cells. The cells are then visualized via image analysis, thereby detecting the presence of, and the types of the opsonophagocytotic antibodies in the sample.
    Type: Grant
    Filed: January 3, 2012
    Date of Patent: June 23, 2015
    Assignee: Cellular Technology Limited
    Inventor: Paul Lehmann
  • Patent number: 9056007
    Abstract: A tissue modification apparatus includes a first and a second guide, a first and a second set of mounts, and a first and a second actuator. The first guide defines a first axis, and the second guide defines a second axis intersecting the first axis. The mounts of the first set of mounts are movable relative to one another along the first axis, and the mounts of the second set of mounts are movable relative to one another along the second axis. The first actuator and the second actuator are each settable to a stress load, with the first actuator and the second actuator movable, respectively, along the first axis and the second axis to transmit each respective stress load to a piece of tissue mechanically coupled to the first and second set of mounts.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: June 16, 2015
    Assignee: Boston Scientific SciMed, Inc.
    Inventors: Jarad Waisblatt, Benjamin Sutton, Ali Salahieh, Peter W. Gregg, Crystal M. Anderson-Cunanan
  • Patent number: 9044547
    Abstract: A device and a method for preparing adipose tissue for transplantation from lobular fat extracted, for instance by liposuction, the fat including a fluid component that have an oily component, a blood component and/or sterile solutions, and a solid component including cell fragments, cells and one or more cell macroagglomerates of heterogeneous size, wherein the device includes at least one washing and separating container having a washing chamber, the container has an inlet and an outlet for the liposuctioned material to enter the washing chamber through the inlet and for at least part of the material to exit the washing chamber through the outlet, the washing chamber including stirring means for forming an emulsion of fluid components.
    Type: Grant
    Filed: May 20, 2011
    Date of Patent: June 2, 2015
    Assignee: LIPOGEMS INTERNATIONAL S.P.A.
    Inventor: Carlo Tremolada
  • Patent number: 9038514
    Abstract: A fabric cutting system and/or method can include a mandrel having a body and first and second legs, a centered chuck, and an offset chuck, each chuck configured to receive either one of the legs or body to rotatingly support the mandrel between the chucks. When one of the legs is inserted into the centered chuck and the mandrel body is inserted into the offset chuck, the mandrel can be rotated and the fabric mounted on the mandrel can be cut about the leg at a location beyond the end of the other leg. One of the legs can include a leg extension removable from a leg base that when removed allows the other leg to be cut beyond the end of the leg base. The fabric can be cut with a cutting laser, which may be a multi-axis laser, and/or have low power.
    Type: Grant
    Filed: July 24, 2013
    Date of Patent: May 26, 2015
    Assignee: ATEX TECHNOLOGIES, INC.
    Inventors: Danny Severino, Paul Van Hulle, Timothy Warner
  • Publication number: 20150112126
    Abstract: A system for visualizing an anatomical target includes a scope (102) for internal imaging having a field of view less than a region to be imaged. A planning module (104) is configured to receive video from the scope such that field of view images of the scope are stitched together to generate a composite image of the region to be imaged. An image guidance module (016) is configured to move the scope along the anatomical target during a procedure such that an image generated in the field of view of the scope is displayed as live video overlaid on a field of the composite image.
    Type: Application
    Filed: June 20, 2013
    Publication date: April 23, 2015
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Aleksandra Popovic, Haytham Elhawary
  • Publication number: 20150100118
    Abstract: A contoured biological tissue for a bioprostheses, such as a cardiac/vascular patch or a bioprosthetic heart valve, and methods of contouring the tissue, are described. A predetermined pattern is provided on the tissue, comprising a plurality of ridges or depressions that are configured to facilitate cellular migration in a first direction and discourage cellular migration in a second direction. The biological tissue can be used in connection with a bioprosthetic heart valve comprising a biological tissue leaflet structure coupled to a supporting frame.
    Type: Application
    Filed: September 24, 2014
    Publication date: April 9, 2015
    Inventor: Julie A. Benton
  • Patent number: 8992444
    Abstract: Devices, systems, and methods for determining isometric and isotonic activity of luminal organs. In an exemplary method for detecting a luminal organ response to mechanical stimulation of the present disclosure, the method comprises the steps of maintaining a luminal organ at a first internal pressure, increasing the first internal pressure of the luminal organ, and measuring a first organ parameter change in response to the increase in internal pressure.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: March 31, 2015
    Assignee: DTherapeutics, LLC
    Inventors: Ghassan S. Kassab, Xiao Lu
  • Publication number: 20150073207
    Abstract: An endoscopic harvesting device removes a vessel from a body. The vessel has an anterior side closest to the skin. A sheath extends in a longitudinal direction with a dissector tip for advancing along the vessel substantially along the anterior side to create a flanking tunnel spaced away from the vessel. A ring-shaped blade is mounted to the sheath and is disposed in a plane substantially perpendicular to the longitudinal direction and proximal of the dissector tip. The blade forms a lateral loop to encircle the vessel from the flanking tunnel and to make a vasiform cut including a pedicle around the vessel as the sheath advances.
    Type: Application
    Filed: September 9, 2013
    Publication date: March 12, 2015
    Inventor: Robert R. Langford
  • Publication number: 20150032199
    Abstract: Disclosed is the use of serous tissue, such as pericardium, as a component of intracorporeal implants. Particularly, disclosed is a jacketed stent assembly comprising an expandable stent provided with a jacket of processed serous tissue which, in some embodiments, is impregnated with a therapeutic or diagnostic agent. In a preferred embodiment, the jacket of the expandable stent is formed of pericardial tissue, preferably bovine or porcine pericardial tissue.
    Type: Application
    Filed: October 14, 2014
    Publication date: January 29, 2015
    Inventor: Carlos Vonderwalde
  • Publication number: 20140371522
    Abstract: A tissue illumination system and a method for harvesting a section of a blood vessel from a patient's body for further use. The tissue illumination system includes a light catheter inserted into a lumen of the blood vessel section to illuminate the vessel section and vessel side branches with an intensity which is visible to the physician from an exterior of the vessel section and also includes a viewing element insertable into the lumen and capable of viewing the illuminated vessel section. The tissue illumination system also includes at least one tool insertable into the lumen and used to harvest the vessel section.
    Type: Application
    Filed: June 6, 2014
    Publication date: December 18, 2014
    Applicant: EMBRO CORPORATION
    Inventors: David R. Knighton, Vance D. Fiegel
  • Patent number: 8906048
    Abstract: A vessel harvesting system that is suitable for harvesting target vessels such as the saphenous vein or radial artery for cardiac artery bypass graft surgery. The system includes a vessel harvesting tool with an elongated cannula and a plurality of surgical instruments therein for separating the target vessels from the surrounding tissue and side branches. The harvesting tool includes a modular handle unit with a base attached to the elongated cannula and a sled that can adapt the base to various types of vessel severing/securing tools, such as tissue welders, bipolar scissors, and bipolar bisectors. The handle unit may be relatively rigid and integrated with the various tool movement controls to facilitate one-handed operation by a user. A severing/securing tool rotation mechanism may be incorporated within the handle and operated by a thumbwheel or other such mechanism. The vessel harvesting system may also provide distal CO2 insufflation for enhanced maintenance of the operating cavity.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: December 9, 2014
    Assignee: MAQUET Cardiovascular LLC
    Inventors: Arthur M. Lin, Joseph N. Lamberti, Kenny Dang, Michael C. Stewart, Charles J. Adam, Justin N. Williams
  • Patent number: 8876692
    Abstract: Blood vessel preservation technology is disclosed wherein harvested blood vessels are attached to stationary attachment fixtures at one end, and to a non-stationary (freely extending) fixture at the other end. The vessel and fixtures are placed within a container. Thereafter, a stream of pulsatile blood is directed through the fixtures and the lumen of the vessel causing the vessel to assume full natural length and aligning the vessel with the container. The pulsatile blood then completely bathes the outside surface of the vessel before being re-circulated. The methods disclosed include those wherein the patient's own circulatory system is part of the circulatory path flowing through the vessel and methods in which the circulatory path is outside and apart from the patient. A pulsatile pump, blood heater and pressure regulator may all be utilized in preferred embodiments of the disclosed methods and devices.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: November 4, 2014
    Inventor: Mark Genovesi
  • Publication number: 20140323800
    Abstract: Apparatus, systems, and methods for endoscopic dissection of blood vessels and control over cavity pressure within an endoscopic procedure are described herein. Apparatus, systems, and methods for harvesting of blood vessels are also described herein.
    Type: Application
    Filed: December 23, 2011
    Publication date: October 30, 2014
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventor: Kenneth R. Dye
  • Publication number: 20140296622
    Abstract: Apparatus for marking a blood vessel for use as a bypass graft in a patient includes a preparation plate for supporting an isolated blood vessel that is in a state for anastomosing to the patient. A stencil plate is configured for overlying the blood vessel and preparation plate, wherein the stencil plate has an opening adapted to expose a portion of the blood vessel to a dye applied through the opening. The stencil plate around the opening is adapted to shield the blood vessel from the dye. A dye applicator is configured to direct a metered amount of the dye through the opening and onto the exposed portion of the blood vessel, preferably as a mist. Preferably, the opening is a lineal slot for creating a guide line extending longitudinally along an outer wall of the blood vessel.
    Type: Application
    Filed: March 27, 2013
    Publication date: October 2, 2014
    Applicant: Terumo Cardiovascular Systems Corporation
    Inventor: Randal J. Kadykowski
  • Patent number: 8846390
    Abstract: Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: September 30, 2014
    Assignee: Edwards Lifesciences Corporation
    Inventors: Jeffrey S. Dove, Bin Tian, Ralph Schneider, Jeffrey S. Cohen, Ivan Jankovic, John F. Migliazza, Gregory A. Wright, James M. Young, Louis A. Campbell