Abstract: A lateral flow assay cassette comprising a swab holder is provided herein. Also provided are kits comprising the lateral flow assay cassette and methods of detecting an analyte.

Abstract: The system comprises of a fluid container, a replaceable applicator head and a compatible, viscous antiseptic solution. The primary advantage is substantially drip free application. The system is non-vented and non-collapsible. The fluid container is non-compressible and comprises a prepping solution, a threaded spout and a container seal. The applicator head consists of a body to which a foam pad is attached and a channel through which the solution flows into the foam when the applicator head is connected to the fluid container. The applicator head when fixed onto the fluid container breaks the seal and creates a continuous channel that is non-vented for the solution to flow into the foam pad.

Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.

Abstract: Compositions comprising electrospun fibers and colorimetric detection encapsulated thereto are provided. Further, methods of use of said composition, including, but not limited to in-situ detection of molecules of interest, such as explosive compounds, are provided.

Abstract: The saliva collection kit includes a housing, a plunger, and a gum-like hydrogel that can be removably disposed in the housing. The housing is defined by a cylindrical barrel, which receives the plunger at one end and is connected to a hub at an opposing end. The hub includes an open free end and a cotton filter disposed within the hub. The gum-like hydrogel can be chewed to collect saliva in the mouth and disposed in the barrel after chewing. The hydrogel can then be compressed with the plunger to release purified saliva from the hydrogel into the hub. As the purified saliva flows through the hub, the cotton filter can further purify the saliva to provide a filtered saliva.

Abstract: In some embodiments, a system includes an applicator pad, an application device (e.g., a grip), and a reservoir. The grip can be releasably couplable to the applicator pad and configured to dispose the applicator pad against a wound of a subject such that pressure can be transferred to the wound via the applicator pad to enhance hemostasis. The reservoir can be configured to contain medication to be released to the wound via the applicator pad.

Abstract: A device for discharging a flowable substance, in particular for applying a medical substance, a pharmaceutical substance, a food supplement or a cosmetics, includes_an activation mechanism and a body which has a discharge opening at a first end and forms a containing space in which a frangible capsule is disposed. The capsule has two ends each having a first and a second tip and at least one of the two tips can be snapped off by actuating the activation mechanism so that the flowable substance is discharged.

Abstract: An improved biological sample preparation device and method of using the device, the device including a squeezable tube and a tip assembled to the squeezable tube. The tip includes a filter and a wick configured to enable controlled delivery to a diagnostic device by capillary action. The device provides precise and repeatable sample volume dispensing control, reduces potential contamination in the working environment, increases ease of use, and improves safety for healthcare workers.

Abstract: An apparatus configured for accommodating and dispensing a compound into a container is provided. The apparatus includes a body including an upper end portion, a lower end portion, and an opening defining a volume configured for accommodating the compound. The apparatus includes a lid removably coupled and moveable relative to the upper end portion of the body. The lid includes an upper end portion including an exterior surface and an interior surface. Further, the lid includes a protrusion extending downwardly from the interior surface of the lid by a second length greater than a first length of the body. The protrusion includes a gasket interposing between an inner surface of the body and an outer surface of the protrusion.

Abstract: A product applicator assembly includes a handle, an applicator, and a product dispensing assembly. The product dispensing assembly is disposed at least in part within the handle and stores a liquid product within a product container. A puncturing device within the product dispensing assembly has a base and a puncture element extending from the base toward the product container. The puncturing device further includes a mating member extending from the base and secured to the product container. The puncture element facilitates rupturing the product container to release a portion of the liquid product into the applicator.

Abstract: An applicator has a stem, one or more tips, and one or more chambers which may hold therapeutic or medicinal fluids. The applicator may be separated into two sections so the tips can be used independently. The fluids held in the chambers may be separated with one or more frangible walls which can be broken to release or mix the fluids. The tips are used as applicators for the therapeutic or medicinal effects produced by the fluids or the medicines contained in the cavity.

Abstract: A device is provided for removing a portion of a patient's skin and leaving an ink mark on the patient's skin to demark the area of the patient's skin where the portion of the patient's skin was removed. The device may include a flexible razor or blade which may be attached to a grip or handle to facilitate cutting accurately. An ink-filled membrane is attached to the blade and/or another part of the device, such as a bottom surface of the blade, such that, when a cut is made, the membrane ruptures, retracts or is otherwise impacted so that the ink is extruded and stains the skin at the location where the cut is made so that the location may be easily located during a subsequent examination.

Abstract: An apparatus for sanitizing is provided. The apparatus includes a housing having a reservoir for retaining sanitizing fluid. The apparatus also includes a holder disposed beneath the housing. The apparatus further includes an applicator pad received by the holder and adapted to be in selective fluid communication with the reservoir. The applicator pad includes a dome-shaped portion having a substantially hemi-spherical shape configured to extend into an interior region of a bell of a stethoscope head when the bell is placed over the dome-shaped portion.

Abstract: The invention relates to applicators for applying a solution or other composition (e.g., an antiseptic composition) to skin of a patient. The applicator may include a container body having a proximal end, a distal end, and a frangible member disposed at the distal end of the body. The applicator includes a first position where the container body and frangible member are a unitary piece (e.g., blow molded as a single piece), and a second position when the frangible member is rotated relative to the body to irreversibly break a weak point therebetween, releasing the composition in the hollow body through an opening. A porous applicator head may be positioned adjacent the distal end of the body and frangible member, so that the composition flows out the body, through the opening, and onto the head. The applicator may be formed in a blow-fill-seal process for improved sterility and ease of manufacture.

Abstract: Embodiments herein may relate to a unit dose system that may include a first applicator and a second applicator. The first applicator may include a crushable ampoule that includes approximately 1 milliliter (mL) of a silver salt solution disposed therein. The first applicator may further include a first syringe tip coupled with the crushable ampoule. The second applicator may include a flexible filled tube that includes approximately 4 mL of a varnish disposed therein and a second syringe tip coupled with the flexible filled tube. Other embodiments may be described and/or claimed.

Abstract: An apparatus for sanitizing a stethoscope head. The apparatus includes a housing, a reservoir disposed within the housing for containing the sanitizing fluid, one or more applicator pads mounted on the housing, and a dispensing valve for dispensing the sanitizing fluid from the reservoir onto the applicator pad.

Abstract: A unitary hand-held, single-use liquid dispenser and applicator is disclosed. A squeezable handle also serves as a reservoir for liquid. A non-forming thermoplastic film seals liquid within the reservoir. Novel weaknesses in the film can be broken on demand to create an opening for liquid to freely flow onto an absorbent pad. A user can thus dispense and apply the liquid without ever touching the liquid or the surface with his hands.

Abstract: Some embodiments of the present invention include a device for cleaning earwax from an ear canal, the device having a tube with a distal end and a proximal end, an absorbent tip attached to the distal end of the tube, a bulb attached to the proximal end of the tube, and a volume of hydrogen peroxide positioned within the bulb. The tube may be sealed with a diaphragm preventing the hydrogen peroxide from flowing down the tube into the absorbent tip. The diaphragm may be capable of rupturing upon an external force being applied to the bulb causing the cleaning solution to flow from the bulb through the tube and into the absorbent tip. A length of the tube may be shorter than an average adult's external ear canal.

Abstract: Most cotton swabs, that currently exist, are not designed for cleaning the external ear canal. The risk of eardrum perforation and/or earwax impaction is too great. This invention is unique in the sense that it is specially designed to clean the external ear canal. It is precisely designed to fit the external ear canal by measuring 2.54 centimeters in length, which is the size of the average adult ear canal. It is also distinctively designed in the sense that is utilizes the antiseptic effects of hydrogen peroxide to dissolve earwax (cerumen), and cleanse the ear of harmful bacteria.

Abstract: An applicator device for applying a fluid is provided. The applicator device may include a handle. The handle may comprise an elongate hollow body having a proximal end and a distal end and at least one longitudinal, interior rib disposed on an inner surface of an outer wall of the hollow body and configured to orient and guide a container for containing the fluid when the container is disposed within the hollow body. In addition, the applicator device may include a base at the distal end of the hollow body. Further, the applicator device may include an applicator pad coupled to the base.

Abstract: A device for coating a medical implant includes a container that contains a liquid having at least one pharmaceutically active substance. An elastic head for application of the liquid onto a surface to be coated is connected to an inside of the container through at least one channel.

Abstract: A device for applying at least one product at a desired surface, for instance a human's skin. The device comprises several layers 1-6, where an impermeable front layer (1) and an impermeable utility layer (6) together with a contact layer (2) will form the outer surfaces of the device (D), between which contact layer (2) and utility layer (6) are arranged a valve layer (3), a top layer (4) and a bottom layer (5). The top layer (4) and bottom layer (5) are connected to each other through a weld (11) in order to form a storage chamber (8) to accommodate a product. Furthermore, the valve layer (3) and top layer (4) are provided with a plurality of incisions or indentations (9a, 9b), where the incisions or indentations (9a) of the valve layer are welded to corresponding incisions or indentations (9b) of the top layer to form an opening mechanism in the device (D), where the device (D) is opened when the valve layer (3) is moved relatively to the top layer (4).

Abstract: A liquid dispensing applicator has a container body holding liquid, a longitudinal axis for rotation and an offset projection located to avoid traversing the longitudinal axis. The applicator also has a head component receiving an end of the container body and has a slot system for receiving the offset projection. The container body and the head component are rotatable with respect to each other to cause the offset projection and the slot system to engage and break the offset projection, allowing liquid release through the head for application. The applicator may have an axial locking system and a radial locking system for locking the container body and the head component together at various positions for improved stability, alignment or reliability.

Abstract: An applicator assembly includes a body defining a pocket, a closed ampoule received in the pocket, an integrated protective device attached to the body and enclosing the pocket, a lever projecting from the body, at least one tappet that bears against an external surface of the pocket and fractures the ampoule when the lever is pivoted, and an application member secured to the body, wherein an interior of the pocket is placed in fluid communication with the application member by way of through-holes provided in the integrated protective device. A method for manufacturing the applicator assembly includes rotating the protective device from an open position into a closed position to enclose the ampoule in the pocket before the application member is attached to the body so that the fluid to be dispensed will flow through the protective device and contact the application member when the ampoule is fractured.

Abstract: The present invention provides a device, a system, and a method for application of fluids.

Abstract: An applicator assembly includes a head portion having a proximal, a distal end, and an interior portion defining a fluid chamber, a container slidably coupled to the body, a breakable membrane sealing an end of the container, and a hollow puncture mechanism, wherein the hollow puncture mechanism is mounted in the interior portion of the head portion and an interior of the container is placed in fluid communication with the application member by way of a fluid conduit that is formed through the hollow puncture mechanism from the container to the fluid chamber when the container is axially translated toward the head portion and the puncture mechanism pierces the breakable membrane.

Abstract: An applicator assembly may include body having a proximal end portion and a distal end portion, a container having a closed proximal end, an interior, and an open distal end, wherein the container is coupled to the proximal end portion, a material bonded to the open distal end and sealing the interior of the container, and an application member attached to the distal end portion, wherein the interior of the container is placed in fluid communication with the application member by way of a compressive force applied along circumferential areas toward the distal end of the container. A method of manufacturing an applicator for applying a solution to a surface is provided.

Abstract: A wiper comprises a rod (20), a wiping body (30) provided at one end of the rod and an outer packing; the rod (20) is of elasticity, the outer packing is a tube-like container (10) having both ends closed permanently and an easy break-off mark (13) provided on the tube wall; the wiper is firm, airtight and capable of being opened easily, and can be used conveniently and rapidly; the rod and the tube-like container are made from thermoplastic materials by technologies such as extruding, injection-molding and the like, both ends of the tube-like container are closed through fusion, mechanical seal and other manners, and the wiper has a simple production technology and is suitable for mass production and wide application.

Abstract: An applicator that dispenses a predetermined dose of topical anesthetic to a zone of tissue. When tissue is contacted, the topical anesthetic applicator also releases a visible spectrum temporary marking agent that generates a target for the preoperative injection of a numbing dose of local anesthetic.

Abstract: A replacement cartridge for a safety razor includes a dispensing head and a reservoir for a flowable shaving aid material. A removable shield is between the reservoir and the dispensing head and the shield interrupts fluid communication between channels of the reservoir and the dispensing head when the shield is in place. Fluid communication is permitted when the shield is removed. Removal of the shield is a onetime event. The shield can be a thermoplastic film. A razor cartridge can be disposed adjacent the dispensing head and the housing of the razor cartridge can be integrally formed with the housing of the dispensing head.

Abstract: A hand-held dispensing applicator includes a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. In one embodiment, the dispensing applicator comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region there between. Optionally, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. Also optionally, the applicator tip includes a semi-permeable or non-permeable partial shield member disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose.

Abstract: A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region therebetween. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose.

Abstract: An applicator apparatus having a sealed container pod which may be opened through an actuating tab. In certain embodiments the terminal end of the open package covered by an applicator surface that may be adherently affixed to the container pod. In certain embodiments, actuating tab passes through a void defined by a suitably shaped applicator surface. Certain embodiments describe a rupturable seal permitting mixing of contents within the container pod before distribution to applicator surface. A method for applying material to a desired surface, and method of applying a therapeutic substance to a desired tissue is disclosed.

Abstract: An applicator device for storing and dispensing an adhesive or sealant material, which are compatible with irradiation sterilization techniques, the applicator comprising: an applicator body comprising a cutting portion to break the frangible seal of the container for the adhesive, and a grasping and squeezing portion for controlling the flow rate of the adhesive; a container for an adhesive material that is movable relative to the applicator body and is made of materials with high barrier property; and a porous applicator tip that is secured to or frictionally fits into the applicator body.

Abstract: A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region there between. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member.

Abstract: A method for remotely applying a force to a tether affixed to a sterilizing swab package to open the package for use of a swab disposed therein. The method may be applied to sterilizing a septum of a vial disposed within a bag.

Abstract: A medical skin applicator apparatus includes a fluid housing having a fluid chamber for storing a medical agent and an applicator coupled to the housing. The fluid housing has a penetrable wall to permit access to the fluid chamber and release of the medical agent therefrom. The applicator includes an applicator surface for applying the medical agent to a patient. The applicator has a penetrating member adapted to penetrate the penetrable wall of the fluid housing upon achieving a predetermined coupled relation of the fluid housing and the applicator, to thereby permit the medical agent to be dispensed from the fluid chamber and applied to the patient with the applicator surface.

Abstract: An antiseptic applicator device having a reservoir for storing an antiseptic agent, the reservoir being coupled to an applicator pad, and a defeatable membrane being interposed between the reservoir and the applicator pad. Embodiments of the device further include opposing handles, wherein an interior lumen of each handle houses a breakable phial containing a desired solution, and wherein upon moving the handles to a closed position, the phials are broken to release the desired solutions which are then absorbed by the applicator pad.

Abstract: This invention generally relates to a method of dispensing an adhesive material using an applicator comprising: a body having a cavity; at least one breaking member integral with the body and having a surrounding gap, the breaking member deflectable into the cavity and having a first engagement member; an annular housing movable with respect to the body and having a second engagement member complementary with the first engagement member, the first and the second engagement members being cooperatively engageable; a reservoir secured to body and having applicator means; a retaining member between the body and reservoir; and a frangible container of adhesive material disposed within the cavity; moving the annular housing relative to the body from a first position to a second position where the engagement members are cooperatively engaged; deflecting the breaking members and breaking the frangible container; and squeezing the reservoir and dispensing adhesive material.

Abstract: A device and process that creates active molecular iodine on a swab. The device has two chambers sealed from one-another. One of the chambers contains a swab. Each chamber contains a different reagent such that when the device is broken or crushed to activate it, the contents of both chambers mix on the swab. The reagents are such that, when mixed, they produce molecular iodine on the swab which acts as a topical antiseptic. The reagents can be an iodide in one chamber and an iodate in the second chamber with a buffer. Alternatively one of the chambers can contain dry molecular iodine in contact with the swab. Finally, one of the chambers can contain molecular iodine in a solution of ethanol, while the other can contain a aqueous solution of a buffer to maintain a proper pH.

Abstract: A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region therebetween. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose.

Abstract: A method for packaging an agent for delivery within a body cavity. A reservoir within a package contains a specified quantity of the agent and is either contiguous with, or coupled to, a dispensing node such as a swab. Depth of insertion of the dispensing node into the body cavity is restricted to a specified depth by a penetration-restricting feature that forms part of the package.

Abstract: A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region there between. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose.

Abstract: Skin antiseptic composition dispensers and methods of use are disclosed. The skin antiseptic composition dispenser may include a container with one or more walls that are substantially impermeable to ethylene oxide gas during normal ethylene oxide sterilization processes. In some embodiments, the container may include flexible walls free of metallic foil barrier layers. The containers may also include one or more vents in addition to one or more openings used to dispense the skin antiseptic composition within the container. The dispenser may include an applicator with a hydrophilic foam.

Abstract: An applicator device for dispensing a polymerizable adhesive material comprising a body portion comprising a closed proximal end and an open distal end providing a cavity sized to accept a frangible container having a polymerizable adhesive material; at least one breaking member at least partially deflectable into the cavity; an annular housing movable with respect to the body portion; and a reservoir secured to the open distal end of the body portion, the reservoir further comprising an applicator; wherein the annular housing is movable relative to the body portion from a first position to a second position to deflect at least a portion of the breaking member into the cavity.

Abstract: A device for applying a liquid, pasty or other flowable substance includes a pack with a receiving section comprising a wet portion for receiving the substance and a closure section defining a dry portion. The closure section is separated from the receiving section by a tear line. The wet portion is separated from the dry portion by means of a separation element comprising an orifice closed off by a closure element which is releasable from the separation element after tearing open the pack along the tear line.

Abstract: A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region there between. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose.

Abstract: A device including a base layer; a wipe layer attached to the base layer to define an interior space between the wipe and base layers; a plurality of blisters positioned within the interior space, each blister having a blister volume, wherein the sum of the blister volumes is a total blister volume; and an indication disposed on the wipe layer or the base layer corresponding to a single blister or a group of blisters indicating the ratio of the blister volume of that single blister or the sum of the blister volumes of that group of blisters to the total blister volume is disclosed.

Abstract: An applicator for dispensing uniform thickness layers of liquid to surfaces and especially surgical sealants to surgical sites to create, in situ, a surgical incise drape is disclosed. The applicator employs a supported thin layer of foam which achieves layer thickness which are substantially independent of the pressure applied to the applicator during use. Methods of using the applicator are also disclosed.

Abstract: A catheter system for positioning an instrument within a body that includes a hub defining a lumen therethrough for passage of the instrument toward the body. The catheter system also includes an elongate tubular member defining a lumen therethrough. The lumen of the elongate tubular member is in communication with the lumen of the hub for further passage of the instrument toward the body. The system also includes a slitter member that is coupled to the hub. The slitter member is disposed to slit the elongate tubular member as the elongate tubular member moves relative to the hub.