Abstract: In one exemplary embodiment, an automated medication preparation is provided and typically involves the preparation and dispensing of drug products, whether they are in a bag, a syringe or via some other type of administration vehicle. The system includes: an automated device for delivering a prescribed unit dose of medication to a drug product container from a drug container. A label containing medication information (medication identifying indicia) is disposed about an outer surface, e.g., a circumference, of the drug container.

Abstract: In one exemplary embodiment, an automated syringe preparation mechanism for an automated medication preparation system is provided and the mechanism includes (1) a first automated gripping mechanism having a pair of adjustable gripper arms for removing a tip cap from a barrel of one syringe and placing the removed tip cap at a first location and (2) a second automated gripping mechanism having a pair of adjustable gripper arms for replacing the removed tip cap on the syringe barrel after the medication is injected therein.

Abstract: In one exemplary embodiment, an automated medication preparation system including automated syringe preparation that involves reconstitution of the medication is provided.

Abstract: A contrast dispensing system (10) including a mating pair of luer connectors (112, 202) to couple a reusable set (100) and a disposable set (200), a mating pair of luer connectors (204, 218) to couple the disposable set (200) to a manifold (16), a pair of luer connectors (230, 232) to couple a control syringe (18) to the manifold (16), and/or a pair of luer connectors (234, 236) to couple the manifold (16) to a patient catheter (238), wherein one or both of the connectors of a pair of coupled connectors (112, 202; 204, 218; 230, 232; 234, 236) is comprised of low surface energy plastic material, such as high density polyethelene, to reduce or eliminate sticking together from expelled (312) contrast media (14).

Abstract: A single-use system for separating blood and producing platelet concentrates includes an elongated container for receiving blood from a patient. The container has a movable plunger mounted within the blood container for expressing blood fractions separated during centrifugation of the container through a first port mounted at one end of said container, a second port mounted on the plunger, and a third port mounted on a plunger rod attached to the plunger.

Abstract: A needleless access system adapted to be mounted on a vial comprising a generally elongated tubular housing having an interior dividing wall, flexible hooks projecting upwardly from the dividing wall which are diametrically opposed, a pair of confronting splines projecting upwardly from the interior dividing wall, a hub insert having a piercing tip normally supported in an armed position by hook elements, a series of outwardly projecting teeth which engage and are guided in the splines during axial displacement of the hub insert relative to the splined housing, and said hub insert having means for mounting a syringe assembly whereby the hub insert maybe activated axially guided by the splines so that the piercing tip engages the stopper in a vial aligned therewith.

Abstract: A method for making a sex determination in avian hatchlings involves the following activities. A process line is equipped to process an endless plurality of hatchlings. The process line has an ultrasound inspection station for the hatchlings. The ultrasound inspection results are analyzed to find the presence of given sex-determinative structure for each hatchling. If the given sex-determinative structure is found then a first category assignment is made. The hatchling is sorted according to its category assignment. The category assignments might number two or three or so including positively-identified one sex, positively-identified other sex, and default to waste for any of various reasons.

Abstract: In a method for detecting the three-dimensional position of a medical examination instrument introduced into a body region, particularly a catheter introduced into a vessel, and an apparatus for registering radiation images having at least one C-arm system with a C-arm with a radiation source and a radiation detector, a number of two-dimensional angiography projection images of the examination region into which the instrument is to be introduced are registered for later three-dimensional volume reconstruction of the examination region. After introduction of the instrument, at least one two-dimensional projection image pair of the examination region with image planes residing at an angle relative to one another is registered. The spatial coordinates of a selected point of the instrument shown in the projection images in a common coordinate system forming the basis of the exposure of the angiography projection images and the projection images is identified.

Abstract: Disclosed is an infusion pump and a fluid container for expelling a fluid from the fluid container to a patient. The pump comprises a housing having a chamber therein for receiving the fluid reservoir. A first wall is provided on the housing for contacting the fluid reservoir, and a second wall is movable from a first position distanced from the first wall to form the chamber therebetween, and a second position relatively closer to the first wall. Advancing the movable wall from the first position to the second position expels fluid from the collapsible reservoir. Preferably, the first and second walls are provided with non-planar complementary surface configurations for contacting the collapsible reservoir. Retraction mechanisms for retracting the movable wall from the second position to the first position, and user readable indicium of the status of the dispensation cycle are also disclosed.

Abstract: Valve for an aerosol container for dispensing a suspension of a substance in a liquid propellant contained therein. The valve comprises a valve body (1) having at least one orifice (16) to allow a quantity of the suspension to pass from the container into the valve. The valve further comprises a ring (18) disposed around the valve body (1), the ring being positioned below the at least one orifice to reduce the volume of suspension that can be accommodated within the container below the at least one orifice when the container is orientated with the valve at the bottom, the ring having at least one portion of reduced axial thickness to provide a trough (19) around the valve body below the at least one orifice.

Abstract: A manually operated dispensing device for delivering ophthalmic solution to the surface of an eye in a desired spray pattern with an impact pressure on the eye that is comfortably tolerated by an individual. The device comprises a pressure container having a closed bottom and an open top defining a neck, for accommodating a pressurized gas and a pouch; a sealed pouch, for said ophthalmic solution, made of a barrier material and exhibiting a valve which is integrated with a mounting cup adapted to fit the neck of the container; and an actuator adapted to fit the mounting cup of the sealed pouch, comprising a nozzle member including a cylindrical tube member, adapted to interact with the valve, and an actuator button for activating the interaction between the nozzle member and the valve, in order to accomplish said desired spray pattern.

Abstract: A device (100) such as a drip chamber that can be filled to a predetermined level is disclosed. The device comprises a housing (14) and a porous medium (10), wherein the porous medium allows gas to pass therethrough.

Abstract: Improvements in a mini-osmotic pump and coating compositions are described. The dispensing pump includes an inner fluid-filled bag encased by an osmotic layer and outer, semi-permeable membrane. The inner bag is formed with an arcuate edge at the open end of the bag to inhibit formation of fissures in the outer membrane in this edge region. The coating compositions include cellulose acetate butyrate, cellulose acetate propionate, and polymethylmethacrylate polymers, optionally mixed with ethyl cellulose in acetone based solvent systems.

Abstract: A reperfusion device for reperfusion of a blood vessel. Blood is withdrawn from a patient and is metered into a first compressible bag. The first bag is connected with a second compressible bag. Compression of the first bag transfers blood from the first bag to the second bag. The second bag is connected with a supply container for metered supply of reperfusion liquid which is mixed with the blood that enters the second bag. The mixture of blood and reperfusion liquid is transferred in a metered amount from the second bag through a reperfusion catheter into a blood vessel by compressing the second bag. The bags are compressed either manually or by a respective pressure cuffs. Hose clamps are provided on the tubing between the bags and on the reperfusion catheter. Meters measure and indicate the flow into and out of each of the bags and through the reperfusion catheter.

Abstract: A bottle having a sterility seal and a method for producing same are disclosed. The bottle, which can be configured to retain a medicament in powder or tablet form, features a protective cap configured to engage a transfer assembly associated with the bottle. The cap includes one or more raised ridges on an interior surface engageable with a portion of the transfer assembly. A band or layer configuration of a sealing material such as silicone is applied to the transfer assembly prior to insertion of the cap thereover. As the cap comes into surface contact with the sealing material, the ridges cause the material to “roll up” into a toroidal O-ring configuration, thereby forming a seal between the cap and the bottle adapted to the dimensional variations of those components.

Abstract: Disclosed is an infusion pump and a fluid container for expelling a fluid from the fluid container to a patient. The pump comprises a housing having a chamber therein for receiving the fluid reservoir. A first wall is provided on the housing for contacting the fluid reservoir, and a second wall is movable from a first position distanced from the first wall to form the chamber therebetween, and a second position relatively closer to the first wall. Advancing the movable wall from the first position to the second position expels fluid from the collapsible reservoir. Preferably, the first and second walls are provided with non-planar complementary surface configurations for contacting the collapsible reservoir. Retraction mechanisms for retracting the movable wall from the second position to the first position, and user readable indicium of the status of the dispensation cycle are also disclosed.

Abstract: An automated peritoneal dialysis machine is provided which is capable of selecting and changing the composition of dialysate delivered to a patient in the course of treatment to meet specific physiological needs. The apparatus includes means for metering solutions of osmotic agent, electrolytes and other desired dialysate components from separate solution containers into mixing chamber means for combination in desired proportions. The means for delivery of fresh dialysis fluid to a patient and for removing spent dialysis fluid from the patient includes means for monitoring intraperitoneal pressure and other conditions of the fluid in the peritoneum and electronic control means responsible to the signal of monitoring means for controlling rates of dialysate infusion and removal.

Abstract: A patient controllable drug delivery system including a metering device (30) having an intermittent dose reservoir (34) and a plunger, a main reservoir (26), a fill line (32connecting the main reservoir (26) and the intermittent reservoir (34) via a metering device fill point (26) and a flow regulating means (10) between the metering device (30) and the patient line (36), the flow regulating means (10) comprising a means for receiving and dispensing a dose of drug (12) and a pressure set one way valve (16), the intermittent dose reservoir (34) and the patient line (36) being in restricted fluid communication, dispensation of the drug being effected by pressure applied by the receiving and dispensing means (12). Systems for the supply of a continuous dose in addition to the patient controllable delivered dose, and a secondary delivery system are also disclosed.

Abstract: A hand held device for loading a hypodermic syringe from a medicine vial is configured for easy placement of the syringe into a closely conforming channel in the proximal end of the device, with the needle end pointing towards the other end. The other end of the device is configured for easy placement of a standard vial into a closely conforming chamber with its penetrable cap facing the needle tip. Closing the device causes or permits the further action required for piercing the vial with the syringe needle. A sliding pull tab engages the syringe plunger so that gripping and pulling on the tab withdraws the plunger from the syringe, thus drawing fluid from the vial. An amplified or enhanced readout capability visually indicates the dosage of fluid withdrawn from the vial. An auxiliary needle mounted so as to be slightly offset from the syringe, provides for a supplemental piercing of the vial so that make-up air is available when large dosages are drawn from the vial with a single pull of the plunger.

Abstract: A system and method for automated filling of one or more medical syringes with desired volume(s) and concentration(s) of an injectate solution, such as a contrast solution usable for medical imaging procedures (e.g., x-ray, MRI, ultrasound). The system may incorporate an automated syringe magazine which interfaces with the programmable system controller to deliver the desired number of syringes after the syringes have been filled. Also, the system may utilize a low-pressure pumping arrangement wherein a pumping device engages each receiving syringe and withdraws the plunger of the receiving syringe to pull the desired injectate solution into the receiving syringe by negative pressure.

Abstract: A new Method and Apparatus for Self Injecting Medicine for offering a device designed to assist individuals who must give self injections. The inventive device includes a support base, a track, a sub-base, syringe plunger retainer, syringe nose retainer and a medicine vial support.

Abstract: A multiprotocol blood-processing machine and disposable units for use therewith. The disposable units generally comprise a centrifuge bowl for separating whole blood into blood constituents, an inlet tube for conveying blood into the bowl, an outlet tube for conveying the blood constituents away from the bowl, and a manifold for placing the inlet tube and the outlet tube in fluid communication with a tube from a donor. The manifold has a machine-readable bar-code label for identifying to the blood processing machine which type of disposable unit is being coupled to it. The machine itself comprises a central processing unit that controls overall operation, a first computer memory containing safety-monitoring instructions that cause the central processing unit to monitor various state parameters in order to ensure donor safety, and a second computer memory containing instructions that define at least one apheresis or blood-processing protocol.

Abstract: A venous reservoir bag subassembly is provided which is adapted to cooperate with a mounting assembly having a bracket frame and a front plate reproducibly relatively movable to enable constant accurate blood volume readout, cooperating means between the subassembly and the mounting assembly to provide against unduly low blood volume, and angled conduit means cooperating with the bag and recesses in the subassembly and assembly to provide further failsafe against passage of the undesirable gas.

Abstract: This apparatus operates with disposable strips which are inserted therein by a user. It comprises a circulation passage (29) for the strips (34) wherein a cursor (35) is able to slide, each strip being able to be coupled to the cursor. A mechansim is provided so that the cursor (35) is able to move in the passage (29) only if it is coupled to a strip. Moreover, the cursor (35) remains blocked in the vicinity of the opening (28) of the circulation passage when no strips (34) are present. This invention can be applied in particular to objects dispensing devices such as medical tablets or to blood sugar level measuring devices.

Abstract: A venous reservoir bag subassembly which is adapted to cooperate with a mounting assembly having a bracket frame and a front plate reproducibly relatively movable to enable constant accurate blood volume readout, a cooperating mechanism between the subassembly and the mounting assembly to provide against unduly low blood volume, and an angled conduit cooperating with the bag and recesses in the subassembly and assembly to provide further failsafe against passage of the undesirable gas.

Abstract: An automated, syringe filling apparatus is disclosed for the on-site filling of syringes with a viscoelastic fluid material from a supply reservoir. A housing has a port for receiving the outlet end region of the viscoelastic supply reservoir and a retainer is provided for releasably retaining a conventional syringe to be filled from the viscoelastic supply reservoir. A flexible plastic tube, preferably formed as part of the viscoelastic supply reservoir, is used to interconnect the supply reservoir with a filling end of a syringe retained in the syringe retainer. A peristaltic pump mounted in the housing has a rotating head with a plurality of rollers which force the viscoelastic material through the tube from the supply reservoir into a retained syringe when the tube is locked between the pump head and a back-up member. Electric pump controls include a timer calibrated for causing the automatic filling of the syringe with predetermined amounts of viscoelastic material from the supply reservoir.

Abstract: An apparatus for withdrawing blood from a vein and simultaneously filling multiple collection tubes. The apparatus includes a movable sheath which protects the technician from inadvertently contacting the withdrawn needle after use and a laminar flow transition chamber between the blood withdrawal needle and the multiple collection tubes.

Abstract: A hypodermic dosage measuring device to be utilized with a hypodermic syringe and a conventional drug vial, the dosage measuring device including a vial holding portion adapted to hold a head of the drug vial non-slidably therein, a syringe holding portion adapted to hold the syringe in a non-slidable position with a needle of the syringe disposed within the drug vial, and a dose adjustment portion, the dose adjustment portion including an elongate plunger holder and gear element, the plunger holder and gear element each including a plurality of teeth thereon such that movement of the gear element results in an elongate track segment of the plunger holder sliding in a longitudinal direction parallel to a length of the syringe.

Abstract: A method of using a multi-compartment fluid assembly for calibrating an apparatus external to the assembly, while conveniently maintaining sterility. The method includes providing calibration fluid in a closed calibration container disposed within a bag that includes a connector for conveying fluids between the interior of the bag and a conventional intravascular tube. In use, fluids may be directed through the external apparatus and the intravascular tube and into the bag's interior. At an appropriate time, the calibration container is opened and the calibration fluid is withdrawn from the container to the intravascular tube, through the connector, without mixing the calibration fluid with any fluids in a remaining volume of the bag. Subsequently, the calibration fluid is transferred from the intravascular tube to the bag's interior, again through the connector.

Abstract: A solution administration apparatus for patient care, for use with an associated solution administration system, which apparatus includes a laser drilled orifice flow control device to provide a controlled, predetermined flow rate of solution to the patient. The apparatus includes a tubing set and a laser drilled orifice flow restrictor, formed in a body, and in fluid communication therewith, for use with an associated fluid supply container. The system provides a controlled, predetermined flow rate of solution to the patient which is independent of, and relatively constant over minor variations in solution supply pressure and viscosity.

Abstract: A new and improved visual magnification apparatus for a syringe includes a base portion, a lens support portion attached to the base portion, and a magnifying lens attached to the lens support portion, wherein a syringe can be placed on the base portion and magnified by the magnifying lens. The base portion may include an internally concave cross-sectional contour that has a bottommost valley portion, such that a generally cylindrically-shaped syringe tends to rest in the valley portion under the influence of gravity. The base portion includes an ampule-supporting portion. The base portion also includes a slot portion capable of supporting a top portion of a syringe placed on the base portion. The base portion, the lens support portion, and the slot portion are in the form of a unified, integrated structure. The lens support portion may include an extension portion capable of retaining an ampule on the ampule-supporting portion of the base portion.

Abstract: A venous reservoir bag subassembly is provided which is adapted to cooperate with a mounting assembly having a bracket frame and a front plate reproducibly relatively movable to enable constant accurate blood volume readout, cooperating means between the subassembly and the mounting assembly to provide against unduly low blood volume, and angled conduit means cooperating with the bag and recesses in the subassembly and assembly to provide further failsafe against passage of the undesirable gas.

Abstract: A pharmaceutical container comprises a housing with a wall structure and bottom defining an inner volume, a pierceable diaphragm sealingly positioned within an opening in the housing, and a protective cover received over the diaphragm. The diaphragm has at least one fluid check valve integrally formed therein and affording one way fluid communication from ambient toward the inner volume of the housing when the fluid pressure inside the container is less than ambient. The protective cover has one or more openings in fluid communication with the diaphragm check valves either via a set of grooves formed in the upper surface of the diaphragm or through a path provided by a spacer positioned between the cover and the diaphragm. A tear away seal covers the holes in the cover to prevent air flow toward the check valves prior to initial use.

Abstract: A medication dispenser (2, 120) is used to directly fill a syringe (8, 134) with measured amounts of one or more liquid medications, typically two different types of insulin, from containers, such as vials (4, 6) and cartridges (230, 232, 234) each having a septum at one end; each cartridge has a pierceable piston (256) at the other end. The septum of each container is pierced by hollow liquid spikes (54) while hollow gas spikes (56) pierce the septum of the vial and the piston of the cartridge. Liquid is pumped out of the container and air is replaced into the container through the liquid and gas spikes. Two of the cartridges can contain a diluent (231) and a lyophilized component (233) respectively; the diluent in the first cartridge can be pumped into the second cartridge through a one-way valve to create a mixed pharmaceutical which is then pumped into the syringe, with or without another pharmaceutical.

Abstract: A syringe filling and metering device (2, 90) for pharmaceutical containers (4) including a variable volume region housing the liquid pharmaceutical (78) and a needle access portion, such as a septum (74) or piston (104), which is pierced by the needle cannula (72) of the syringe (6), such as by mounting the syringe in a syringe carrier (8). An elongate piston stop (58) is held in place by a piston driver (42) to which the syringe carrier is threadably connected. The syringe carrier is screwed into the piston driver to drive the barrel of the cartridge over the piston, thus forcing the contents of the cartridge through the needle cannula and into the syringe. The invention can also be practiced with the needle cannula piercing the piston so that the movement of the piston into the barrel of the container forces the liquid pharmaceutical through the needle cannula and into the syringe.

Abstract: A dispenser cap for use with a fluid container having an aperture through a flexible portion of a stopper closing the mouth of the container comprises a main body portion and a fluid communicating spike extending through the body portion. The spike has an outer diameter of sufficient size to form a seal with and to permit flexing of the flexible portion of the container stopper upon insertion of the spike in the stopper and upon movement of the cap toward the flexible portion of the stopper. The main body portion of the dispenser cap comprises a disk portion with a skirt extending from the disk portion and circumferentially encircling the container stopper.

Abstract: A filling device for filling an injection syringe is provided which enables the user to count the intake dosage by means of a sound indicator which may be mechanical, electrical or an electronic sound device. The filling device includes a moveable syringe holder to which is attached a removable syringe that is connectable to a medicinal bottle. The filling device mounts a gear which is moveable one notch at a time to actuate a linear gear to which the syringe is mounted. The device is connected to a microprocessor controlled voice chip device to obtain a suitable voice readout indicating the amount of liquid medicinal uptake by the syringe.

Abstract: A feeding system for connecting a humidifier to a reservoir comprising, a first elongated conduit for feeding water from the reservoir to the humidifier, a second elongated conduit alongside the first conduit for passing air from the humidifier to the reservoir, with an upper end of the first and second conduits being connected in fluid communication to the reservoir. The conduits are connected to the humidifier with a lower end of the first and second conduits located inside the humidifier, and with the lower end of the first conduit being located adjacent the lower end of the second conduit.

Abstract: A device for dispensing enteral feeding solutions and other therapeutic fluids from penetrable, shape retentive containers comprising a unitary dispensing spike for penetrating a topside panel of such containers which are suspended in an orientation to define an uppermost end and a lowermost end. The dispensing spike of the present invention includes an ambient air vent integrally formed therein. The present invention further includes a fluid visualization chamber which permits a user to determine the volume of fluid within the container.

Abstract: A filling device for filling an injection syringe is provided which enables the user to count the intake dosage by means of a sound indicator which may be mechanical, electrical or an electronic sound device. The filling device includes a movable syringe holder to which is attached a removable syringe that is connectable to a medicinal bottle. The filling device mounts a gear which is movable one gear tooth at a time to actuate a linear gear to which the syringe is mounted. A spring loaded ball bearing is biased against the gear wheel and produces a distinctly audible clicking sound when the gear moves a single notch. These clicking sounds can be counted by a user when the attached syringe holder moves, and hence will accurately indicate the amount of liquid medicine drawn into the syringe. The same device may be connected to a microprocessor controlled voice device to obtain a suitable readout indicating the amount of liquid medicinal uptake by the syringe.

Abstract: A progammable intelligent reader unit receives drug data from hand held and fixed scanners which read bar codes in place on syringes, ampules, vials, vaporizer controls, flow meters, etc., from or through which drugs are administrered to a patient. A scale additionally provides a data stream to the reader to provide a reader display of syringe weight before and after injection to enable the system user to immediately verify drug and dosage administered. A printer interfaced with the reader provides a time indicating anesthesia record. A program provides warnings, instructions and prompts for reader display to assist the system user.

Abstract: Intravenous infusion sets suitable for the parenteral administration of nitroglycerin solutions and methods of using such sets are provided. The intravenous infusion sets and methods herein utilize flexible drip tubes having their inner surfaces constructed of polyolefin plastic material. Polyolefin or polyolefin-lined drip tubes can be advantageously used to infuse nitroglycerin solutions with minimized loss of nitroglycerin solution potency.

Abstract: Citrate esters are formed utilizing organic titanates as a catalyst allowing excess alcohol to be removed. Four citrate esters have been found which provide advantageous plasticizing properties to PVC compositions which include superior toxicity test results and superior soapy water extraction test results. The four citrate esters are: acetyltri-n-hexyl citrate, n-butyryltri-n-hexyl citrate, acetyltri-n-(hexyl/octyl/decyl) citrate, and acetyltri-n-(octyl/decyl) citrate. Articles formed from the PVC plasticized mixtures are extremely useful in the medical or health care field as they demonstrate a low order of toxicity.

Abstract: Citrate esters are formed utilizing organic titanates as a catalyst allowing excess alcohol to be removed. Four citrate esters have been found which provide advantageous plasticizing properties to PVC compositions which include superior toxicity test results and superior soapy water extraction test results. The four citrate esters are: acetyltri-n-hexyl citrate, n-butyryltri-n-hexyl citrate, acetyltri-n-(hexyl/octyl/decyl) citrate, and acetyltri-n-(octyl/decyl) citrate. Articles formed from the PVC plasticized mixtures are extremely useful in the medical or health care field as they demonstrate a low order of toxicity.

Abstract: An interconnect connects a vial to a syringe for the transfer of material to the syringe or back to the vial. The interconnect includes a vial connecting mechanism and a tapered sleeve to receive the syringe. A metering port allows control of the material transfer rate and prevents partial transfers which could cause material spillage.

Abstract: A fixture for loading a syringe from a vial of liquid which is of particular value to those with poor (or no) vision, the fixture being characterized by a gauge for measuring the quantity of air to be injected into the vial prior to loading and the quantity of liquid to be loaded into the syringe.

Abstract: An elongated sleeve member having an upper open end and a lower open end, and with an annular flange extending radially outwardly from adjacent the open lower end is affixed to an elongated stem member in a substantially vertical orientation for immersion in a liquid substance held in a vial. A sleeve-like surface extending between the open ends of the elongated sleeve member, and a surface defining the lower end of the sleeve and an outwardly extending annular flange provide means to remove a consistent quantity of a liquid substance, such as a liquid allergenic agent, from a storage vessel or vial, and to transfer the liquid to a receiving scarifier structure, such as a cluster of multiple scarifier points. The outer periphery and upper surface of the flange provide a means for carrying excess liquid, and the flange provides for wiping the excess liquid from the sleeve member and flange prior to dispensing a desired quantity of liquid allergenic agent onto a cluster of scarifier points.

Abstract: A container of flexible material for receiving and apportionately discharging liquid through an outflow opening for the purpose of enteral feeding, has arranged therein a tube of hard material, the tube being connected at one of its ends to the outflow connection of the container and being provided at specified distances with notches serving as intended breaking points.

Abstract: Citrate esters are formed utilizing organic titanates as a catalyst allowing excess alcohol to be removed. Four citrate esters have been found which provide advantageous plasticizing properties to PVC compositions which include superior toxicity test results and superior soapy water extraction test results. The four citrate esters are: acetyltri-n-hexyl citrate, n-butyryltri-n-hexyl citrate, acetyltri-n-(hexyl/octyl/decyl) citrate, and acetyltri-n-(octyl/decyl) citrate. Articles formed from the PVC plasticized mixtures are extremely useful in the medical or health care field as they demonstrate a low order of toxicity.

Abstract: Citrate esters are formed utilizing organic titanates as a catalyst allowing excess alcohol to be removed. Four citrate esters have been found which provide advantageous plasticizing properties to PVC compositions which include superior toxicity test results and superior soapy water extraction test results. The four citrate esters are: acetyltri-n-hexyl citrate, n-butyryltri-n-hexyl citrate, acetyltri-n-(hexyl/octyl/decyl) citrate, and acetyltri-n-(octyl/decyl) citrate. Articles formed from the PVC plasticized mixtures are extremely useful in the medical or health care field as they demonstrate a low order of toxicity.