Abstract: A system and method for collecting whole blood from blood donors includes first and second whole blood collection devices disposed at different blood donation centers. A remote server computer is in communication with the blood collection devices. The whole blood collection devices transfer donation procedure information to the remote server. The remote server computer facilitates retrieval of the donation procedure information at a handheld computing device. The donation procedure information includes data based on product volume collected and data indicating performance of operators of the whole blood collection devices. The handheld computing device displays a number of whole blood units collected. Blood collection can be improved using the donation procedure information.

Abstract: Provided is a cell preserving vessel which is protected against damage during storage. The cell preserving vessel 1 includes: a vessel body 10 which is made of a flexible resin member and has a cell accommodating part 11; a cell introducing tube 20 which is connected to the vessel body 10 and through which cells are introduced into the cell accommodating part 11; and a pair of tube protecting parts 40 which are arranged to hold the cell introducing tube 20 therebetween and which protect a vicinity of a joined portion of the cell introducing tube 20, the joined portion being joined to the vessel body 10. The tube protecting parts 40 are preferably constituted by sheet members 50 and 60 that form the vessel body 10.

Abstract: A lid for closing an open ended blood chamber is provided. The lid is a one piece device forming an inlet to the blood chamber. The one piece device includes a filter media spaced apart from the inlet and wherein blood passing through the inlet passes through the filter media upon entry into the blood chamber. The filter media filters gross particulate from the blood passing therethrough. The one piece device further includes a vent port with an associated vent port cover to allow air separated to vent from the blood chamber.

Abstract: A collection liner for a medical or a surgical operation is disclosed which includes a closed bag portion and inlets opening into the bag portion. The collection liner can include a handle which includes at least one of the inlets inside the handle.

Abstract: An apparatus includes a cannula assembly, a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing includes an inlet port removably coupled to the cannula assembly and defines an inner volume. The fluid reservoir is fluidically coupled to the housing and configured to receive and isolate a volume of bodily fluid from a patient. The flow control mechanism is at least partially disposed in the inner volume. The actuator is operably coupled to the flow control mechanism and is configured to move the flow control mechanism between a first configuration, in which bodily fluid can flow, via a fluid flow path defined by the flow control mechanism, from the cannula assembly, through the inlet port and into the fluid reservoir, to a second configuration, in which the fluid reservoir is fluidically isolated from the cannula assembly.

Abstract: The connector for a fluid line of an extracorporeal circuit comprises a tubular body which internally defines a fluid passage, a first connection port predisposed for coupling to the fluid line, a second connection port predisposed for coupling to a male Luer connector borne by an external element, and a closure element of the second connection port. The closure element is formed of a breakable membrane made in a single piece with the tubular body. On coupling, the membrane is broken by the truncoconical projection of the male Luer connector. The connector connects a service line of an extracorporeal circuit to a pressure sensor of a dialysis machine.

Abstract: A multi-chamber container of two liquid mixing type, aiming for obtaining an increased reliability for preventing an administration from being practiced under a non separated condition of a weak seal. The medical bag 10 has an outer peripheral strong seal 14 and a weak seal 18 for separating the space inside the medical bag into two partitions 20 and 22. At the tip end of an outlet port 12, a flap 28 as a valve member is provided, which usually closes the outlet port 12 to the space inside the medical bag. The flap 28 is connected to the opposite surface of the medical bag, so that the flap 28 is displaced in cooperation with an expansion deformation of the medical bag as obtained when the weak seal 18 is opened, resulting in opening of the outlet port 12. The flap is formed with a small hole 44 for limiting a liquid flow amount to a small value.

Abstract: The present invention relates to a bag (1) for packaging a biological substance, such as animal semen, which is formed by two plastic walls (10, 11) assembled so as to define a pouch (P) for receiving said substance and that comprises a line (15) communicating with said pouch (P) a line for filling the same, this bag comprising in addition at least one pair of openings (3, 4) located on both sides of said line (15), in order to get hung, via these openings, to fingers that are complementary to a supporting device. This bag is characterized in that at least one of these openings (3, 4) has an oblong shape, extends perpendicularly to said line (15), and comprises an area forming a hard spot. The invention relates also to a strip formed by juxtaposing such bags (1), and an assembly comprised of a bag and a hanging support.

Abstract: The present invention relates to a process of fusion-bonding a plastic film (8a, 8b) to an object to be fusion-bonded such as a port member (16) in manufacturing a drug bag, and relates to a drug bag. The present fusion-bonding process comprises steps of disposing a heat generation element generating heat by absorbing infrared laser, on an opposite surface (8c) of the plastic film (8a, 8b) from the port member (16), or between the port member (16) and the plastic film (8a, 8b), pressing a press member (30a, 30b), which allows infrared laser to be transmitted therethrough, from a side of the plastic film (8a, 8b), and irradiating the infrared laser (L) to the heat generation element (24a, 24b) through the press member (30a, 30b).

Abstract: The invention includes a bag system for collecting a biological fluid, in particular blood. The system includes a device for collecting the fluid which is in fluid communication with at least one fluid collection bag, and a device for sampling the fluid to be collected which includes at least one sampling receptacle. The sampling device includes a device for transferring the fluid from the bag system into the sampling receptacle or receptacles, in which the transfer device is provided with a device for associating the receptacle or receptacles. The transfer device may be arranged to allow the support of the receptacle or receptacles in a standby position, the guidance of the receptacle or receptacles to a transfer position and, after transfer, the dissociation of the receptacle or receptacles from the bag system.

Abstract: An antiseptic applicator device having a reservoir for storing an antiseptic agent, the reservoir being coupled to an applicator pad, and a defeatable membrane being interposed between the reservoir and the applicator pad. Embodiments of the device further include opposing handles, wherein an interior lumen of each handle houses a breakable phial containing a desired solution, and wherein upon moving the handles to a closed position, the phials are broken to release the desired solutions which are then absorbed by the applicator pad.

Abstract: The present disclosure relates to clamps for controlling the flow of liquid through a fluid circuit. More particularly, the present disclosure relates to flow control clamps that can be substantially irreversibly secured in a closed position, thereby discouraging reopening of the flow path of the tube.

Abstract: A multiple chamber medical fluid bag includes: (i) a flexible enclosure; (ii) a first fluid chamber formed in the enclosure; (iii) a second fluid chamber formed in the enclosure; (iv) the first fluid chamber and the second fluid chamber separated by a frangible seal; and (v) an access port connected to the enclosure, the port imbedded into the enclosure so as to completely surround the access port, the enclosure further configured such that the frangible seal is broken to uncover the access port.

Abstract: In order to provide a medical liquid container which allows for no forgetful failure to open the partition wall and can realize simple and easy sterilization of the liquid medicament bag and thereby decrease the production cost, the present invention provides a medical liquid container having a plurality of communicatably partitioned medical liquid-housing chambers and a discharge reserve chamber having formed therein a discharge port for a liquid medicament, the medical liquid container comprising liquidtightly partitioning portion for liquidtightly separating said liquid medicament-housing chambers from each other, and non-liquidtightly partitioning portion for non-liquidtightly separating between at least one of said liquid medicament-housing chambers and said discharge reserve chamber.

Abstract: The disclosure relates to a connector for packaging containing medical fluids, in particular infusion or transfusion bags, including a tubular connection part for receiving a spike for the withdrawal of fluid, and having a lower opening on the packaging side and an upper opening on the connection side. A self-sealing membrane, which is pierced by the spike, is located in the connection part. The membrane has an upper, annular section leading into a lower, plate-shaped section, said annular section of the membrane surrounding the spike in a sealing manner, when the latter pierces the plate-shaped section. The membrane acts as a guide for the spike and also reseals the connector, once the spike has been removed.

Abstract: A welding boat for a pouch has a center part and two prolongations extending therefrom in opposite directions and tapering acutely. The welding boat has an opening for the filling of the pouch with a substance in manufacture and inlets and outlets for the actual use of the pouch. The center part is substantially filled by an opening with a lumen which is as large as possible and preferably circular, and the side edges of the side prolongations contact the opening tangentially.

Abstract: The invention relates to a medical bag which is intended for the infusion of a medicament by means of gravity. The inventive bag comprises: at least two compartments, namely a first compartment (1) containing a medicament in the form of a solution and a second compartment (2) containing a rinsing solution; and means for separating/communicating the compartments, which prevent the rinsing solution from automatically entering the medicament compartment except at the end of the infusion period. The rinsing solution ends the infusion, by rinsing the medicament bag and the infusion line, such as to prevent any risk of contamination or leakage of residual medicament from the bag or line.

Abstract: The present invention provides an improved kit for the collection of umbilical cord blood and placental blood, and collection of the placenta from which such blood is obtained. The kit improves upon existing kits in that it provides for improved user convenience, provides for the collection of the placenta itself, and better maintains the internal temperature of the container in which the collected blood and placenta are shipped to a blood bank or registry. The invention further provides a method of collecting umbilical cord and placental blood, and the placenta from which such blood is obtained, comprising using the kit described herein.

Abstract: The invention relates to a sealed, sterile system for filtering fluids, in particular whole blood. The system comprises a first collapsible container for receiving the fluid to be filtered and a second collapsible container for receiving the filtered fluid, both containers interconnected by a fluid line, in which a filter and a third container, for deaeration, are located. The first collapsible container contains a predetermined quantity of air, which is sufficient to ensure that no blood remains in the filter and the adjacent tube line sections when the whole blood is transferred from the first container into the second container. The air that is present in the second container, after the whole blood has been filtered, is transferred to the deaeration container.

Abstract: A port assembly includes a valve housing with an inlet opening, a valve disposed in the valve housing to control access through the inlet opening, and a base having an outlet opening that is initially occluded by a membrane. A pivot is disposed within the base and has a cutting surface disposed within the base, the cutting surface rupturing the membrane at least in part as the pivot is pivoted about an axis between first and second positions. The port assembly may be used in a fluid container that includes a receptacle for retaining a fluid, and at least one conduit in communication with the receptacle. The at least one conduit is defined, at least in part, by the port assembly.

Abstract: A flexible multi-chamber container for preparation of medical mixed solutions includes at least three chambers separated from each other by leaktight seams. The chambers are designated to be filled with different solutions and are separated from each other by leaktight seams. At least a part of the first leaktight seam is provided with a separation zone to be opened for fluid transfer from the first chamber into the second chamber. At least a part of the second leaktight seam is provided with a separation zone to be opened for fluid transfer from the second chamber into the third chamber. The leaktight seams are arranged and the separation zones are formed such that, in use of the container for preparation of the medical mixed solution, the first separation and second separation zones are opened in a sequential order. The first zone is opened before the second separation zone is opened. Thus, the components are mixed one after another in a predetermined sequential order.

Abstract: In a peritoneal dialysis embodiment of the present invention, spent dialysate from the patient's peritoneal cavity passes, along a patient loop, through a dialyzer having a membrane that separates waste components from the spent dialysate, wherein the patient loop returns fresh dialysate to the patient's peritoneal cavity. The waste components are carried away in a second regeneration loop to a regeneration unit or sorbent cartridge, which absorbs the waste components. The regeneration unit removes undesirable components in the dialysate that were removed from the patient loop by the dialyzer, for example, excess water (ultrafiltrate or UF), toxins and metabolic wastes. Desirable components can be added to the dialysate by the system, such as glucose and electrolytes. The additives assist in maintaining the proper osmotic gradients in the patient to perform dialysis and provide the necessary compounds to the patient.

Abstract: The disclosure relates to a connector for packaging containing medical fluids, in particular infusion or transfusion bags, including a tubular connection part for receiving a spike for the withdrawal of fluid, and having a lower opening on the packaging side and an upper opening on the connection side. A self-sealing membrane, which is pierced by the spike, is located in the connection part. The membrane has an upper, annular section leading into a lower, plate-shaped section, said annular section of the membrane surrounding the spike in a sealing manner, when the latter pierces the plate-shaped section. The membrane acts as a guide for the spike and also reseals the connector, once the spike has been removed.

Abstract: Methods and apparatus for collecting blood samples in vacuum sample tubes are disclosed. The samples, including the initial blood sample, are substantially free of excess air.

Abstract: An enteral feeding device, includes a system for delivering liquid nutrients to an enteral feeding tube. The device includes: (a) a container, having first, second and third openings; (b) a tip configured to be coupled to the container, the tip having an opening in fluid communication with the first opening of the container, the second opening of the container configured such that nutrient can be delivered to the second opening and the third opening configured to receive nutrient or to allow gas expelled from the patient (e.g., through burping) to flow there through.

Abstract: A blood chamber for an extracorporeal blood circuit comprises a blood inlet port (2), a blood containment chamber (3), a first conduit (8) which connects the blood inlet port (2) with the blood containment chamber (3) and which has an end tract (8a) that terminates in the blood containment chamber (3) with a horizontal inlet component. The first conduit (8) comprises a pre-terminal tract (8b) which precedes the end tract (8a) and which has at least a second horizontal component which is directed in an opposite direction to the horizontal inlet component. The blood chamber is used in an arterial line of a dialysis set for guaranteeing a regular and gentle blood flow.

Abstract: The present disclosure relates to clamps for controlling the flow of liquid through a fluid circuit. More particularly, the present disclosure relates to flow control clamps that can be substantially irreversibly secured in a closed position, thereby discouraging reopening of the flow path of the tube.

Abstract: A medical bag formed of a flexible material includes a front bag part and a rear bag part joined together to form a bag body. A closable liquid inlet port is provided in an upper part of the bag body. The medical bag further includes a deformable elongated member provided in the vicinity of the liquid inlet port on at least one of the front and rear bag parts. The elongated member is deformable so as to retain the liquid inlet port in an open configuration when the elongated member is in a deformed state.

Abstract: The invention relates to a medical bag which is intended for the infusion of a medicament by means of gravity. The inventive bag comprises: at least two compartments, namely a first compartment (1) containing a medicament in the form of a solution and a second compartment (2) containing a rinsing solution; and means for separating/communicating the compartments, which prevent the rinsing solution from automatically entering the medicament compartment except at the end of the infusion period. The rinsing solution ends the infusion, by rinsing the medicament bag and the infusion line, such as to prevent any risk of contamination or leakage of residual medicament from the bag or line.

Abstract: A holder for receiving a sampling tube of a blood sampling system is disclosed. The holder has an interior pocket which can be conformed from a closed position to an open position for receiving the sampling tube.

Abstract: A flow control clamp having first and second legs disposed in a generally facing relationship. The clamp includes apertures receiving a flexible tube therethrough. The first and second legs include surfaces disposed to irreversibly secure the legs together in the closed position.

Abstract: The invention includes a bag system for collecting a biological fluid, in particular blood. The system includes a device for collecting the fluid which is in fluid communication with at least one fluid collection bag, and a device for sampling the fluid to be collected which includes at least one sampling receptacle. The sampling device includes a device for transferring the fluid from the bag system into the sampling receptacle or receptacles, in which the transfer device is provided with a device for associating the receptacle or receptacles. The transfer device may be arranged to allow the support of the receptacle or receptacles in a standby position, the guidance of the receptacle or receptacles to a transfer position and, after transfer, the dissociation of the receptacle or receptacles from the bag system.

Abstract: A multiple chamber medical fluid bag including: (i) a flexible enclosure; (ii) a first fluid chamber formed in the enclosure; (iii) a second fluid chamber formed in the enclosure; (iv) the first fluid chamber and the second fluid chamber separated by a frangible seal; and (v) an access port connected to the enclosure, the enclosure folded so as to cover the access port and so that the frangible seal is broken to uncover the access port.

Abstract: A fluid collection apparatus is provided that includes a housing configured for receipt of fluid and/or tissue for collecting fluid therefrom. A holder is configured with the housing to receive an evacuated tube. The holder can include a needle hub supporting a needle cannula in fluid communication with a port extending into a fluid well of the housing. A sloped bottom surface of the housing directs fluid to the fluid well. A sidewall extension or support component extends downward beyond the sloped bottom surface to allow the housing to be stood upright on a flat surface. In certain embodiments, the apparatus includes a tubular cavity to provide a recessed location of the needle cannula for preventing accidental needle injuries. An optional cap provides further shielding from needle cannula and safely maintains fluid in housing after use.

Abstract: A sampling apparatus is disclosed that includes a sample container including at least one wall defining a fluid-receiving interior chamber and including a fluid inlet for receiving fluid into the chamber and a sample device receiver carried by the container wall and in fluid communication with the chamber, the receiver being adapted to receive a sampling device for withdrawing a fluid sample from the chamber.

Abstract: A medicant reconstitution system is provided which has a generally flexible fluid bag with associated administration and reconstitution ports. The reconstitution port is adapted for receiving a medicant container and the administration port is for administering a medical fluid to a patient. According to one aspect of the present invention, the administration and reconstitution ports are integrated in a relatively rigid port structure. According to another aspect of the present invention, the reconstitution port receives a piercing member which is rotatable to a selected position to establish fluid flow. According to yet another aspect of the present invention, one of the reconstitution port and the piercing member includes a cutting edge, while the other includes a frangible member. Contact between the cutting edge and the frangible member opens the frangible member to establish fluid flow.

Abstract: A biological fluid collection system including a collecting device, a collecting container, a first channel connecting the two, a sampling bag, a second channel connecting the sampling bag and the first tube and at least one substantially irreversible closure device in an open position on at least the first or second channel. The biological fluid may be blood. A method of collecting biological fluid such as blood using the system so that fluid in the sampling bag is substantially irreversibly prevented from entering the collecting container.

Abstract: A biological fluid collection system including a collecting device, a collecting container, a first channel connecting the two, a sampling bag, a second channel connecting the sampling bag and the first tube and at least one substantially irreversible closure device in an open position on at least the first or second channel. The biological fluid may be blood. A method of collecting biological fluid such as blood using the system so that fluid in the sampling bag is substantially irreversibly prevented from entering the collecting container.

Abstract: A bag system for the collection and sampling of a biological fluid such as blood is described. The system may include a fluid collection bag and a first tube connected on one end to a collection means and on the other end to the collecting bag. It may also include a flexible sampling bag defining an internal volume having a bottom side and an introduction side which is opposite to the bottom and has an inlet orifice. The system also has a second tube, a first end part of which is connected to the first tube and a second end part of which is inserted in the inlet orifice of the sampling bag, so as to extend inside the sampling bag over a distance of between 25% and 60% of the distance between the bottom and the introduction side of the internal volume of the sampling bag.

Abstract: The present invention provides an improved kit for the collection of umbilical cord blood and placental blood, and collection of the placenta from which such blood is obtained. The kit improves upon existing kits in that it provides for improved user convenience, provides for the collection of the placenta itself, and better maintains the internal temperature of the container in which the collected blood and placenta are shipped to a blood bank or registry. The invention further provides a method of collecting umbilical cord and placental blood, and the placenta from which such blood is obtained, comprising using the kit described herein.

Abstract: A holder for receiving a sampling tube of a blood sampling system is disclosed. The holder has an interior pocket which can be conformed from a closed position to an open position for receiving the sampling tube.

Abstract: A disposable flexible vessel contains a septum, dividing a first chamber from a second chamber. By flowing a fluid through the septum, the fluid is treated as it moves from the first chamber to the second chamber. The particular configuration of the septum allows for treatments such as mixing, reacting, heating, and cooling, as well as filtering of the fluid.

Abstract: The invention is a novel cell freezing and storage bag assembly and method for using the assembly in the seed train expansion of mammalian cells. The bag is constructed principally of polytetrafluoroethylene fabric. The bag is designed to hold enough cells that a bioreactor can be inoculated directly. The bag is designed to be filled to a fraction of its maximum capacity so that the cell suspension has a very thin cross-section (less than about 10 millimeters). The bag design includes a transfer set that can be sterilely welded to the source of the mammalian cells. This sterile-weldable transfer set allows the bags to be filled quickly with minimal risk of contamination. In the method, once each bag is filled, it is sealed below the connection with the transfer set and the bag is cut “above” the new seal (on the same side of the seal as the transfer set). When a bioreactor is to be inoculated, the contents of the bag are drained via a sterile-weldable inoculation line.

Abstract: Methods and apparatus are disclosed for reducing the degradation of heat sensitive components contained in a medical substance during heat sterilization of a heat sterilizable container including a first chamber including a first amount of a first medical substance and a second chamber including a second amount of a second medical substance, the first amount being greater than the second amount. The method includes heating the heat sterilizable container to a first predetermined temperature for sterilizing the first and second medical substances, thermally insulating the second chamber during at least a portion of the heating of the heat sterilizable container to the first predetermined temperature, holding the heat sterilizable container at the first predetermined temperature for a first predetermined time period, and cooling the heat sterilizable container thereafter.

Abstract: A fluid collection apparatus is provided that includes a housing configured for receipt of fluid and having a first surface which defines a needleless first mating portion. A holder has a first end and a second end configured to receive an evacuated tube. The first end defines a second mating portion on an outer surface thereof which is in fluid communication with the evacuated tube. The first mating portion sealingly engages the second mating portion to establish fluid communication therebetween. The first mating portion may have a locking surface that engages the second mating portion. The first end of the holder can include a needle hub supporting a needle cannula in fluid communication with the second mating portion and extending away from the first mating portion. In an alternate embodiment, an umbilical cord fluid collection apparatus includes a housing defining a cavity for receipt of at least a portion of an umbilical cord. The housing has a funnel surface which defines a male luer connector.

Abstract: Methods and apparatus are disclosed whereby the initial flow of blood during blood collection is diverted to a sample pouch to trap the skin plug and to allow samples to be taken during subsequent blood collection to a normal blood bag. This is effected by connecting the needle line (106), the sample line (118) to the sample pouch (116) and the bag line (114) to the blood bag to a multi-port valve (110) that includes an actuator (120). During the procedure, the valve (110) may be attached to the arm (100) of the donor by means of a wrist-strap (112).

Abstract: The invention relates to a method and an apparatus for collecting and transporting liquids, for example blood, into one or more closed packages, for instance so called transfer bags (11, 12), or alternatively, directly transfering the blood into another liquid system, for instance a heart-lung machine, without any admixture of air or any other gas or gas mixture. The blood is collected without contact by human hand and without contamination of the blood and under sterile conditions. The apparatus comprises a suction nozzle (4) for sucking up the liquid or a liquid/air/gas mixture, a suction hose (5) for directing the liquid to a defoaming separator (7) for separating air from the liquid, and a recipient (8) in which the deacrated liquid is filtered and collected. When a certain volume has been collected, the liquid is directed without introducing air into said closed packages (11, 12) or communicated to another liquid system.

Abstract: The disposable set includes an infusion device having an outflow conduit and a needle. The packager is defined by a single bag made of transparent, flexible, plastic material and having a first compartment enclosing the medicinal fluid, and a second compartment enclosing the infusion device. The two compartments are formed from two sheets of the aforementioned material, heat sealed along the outer edges of the sheets, so as to be sealed with respect to the outside environment, and the compartments are also separated in airtight manner from each other by another seal. The conduit communicates with the first compartment via a chamber formed by a further seal and acting as a drip for visually controlling the infusion treatment.

Abstract: Systems and methods manually process blood and blood components in sterile, closed environments, which further condition the blood components for subsequent pathogen inactivation processes. The systems and methods mate the manual collection of random donor platelet units with the creation of larger therapeutic doses of platelets targeted to undergo pathogen inactivation prior to long term storage and/or transfusion.

Abstract: A fluid delivery system including a fluid container and cannula assembly that in turn includes a separable tube portion formed of a material having a lower specific gravity than the fluid in the container that in turn becomes a float within the container to improve the visibility of the fluid level therein.