Abstract: Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device, removing a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device, and rotating a locking clip on the first aseptic coupling device to compress a first seal member of the first aseptic coupling device with a second seal member of the second aseptic coupling device to form a sterile fluid passageway.

Abstract: Fluid transfer devices for filling a drug pump cartridge with liquid drug contents for administration purposes. Fluid transfer device includes a dual open ended barrel partitioned by a transverse partition into a drug vial port for telescopic mounting on a drug vial and an open ended piston cylinder for slidingly receiving a piston head including a drug pump cartridge port for telescopic mounting on a leading cartridge end of a drug pump cartridge. Sliding insertion of the piston head into the piston cylinder to butt against the transverse partition urges air trapped in the compression chamber into the drug vial which in turn urges its liquid drug contents into the vented drug pump cartridge.

Abstract: A liquid-transfer adapter operatively interposable between an injector and a vial is provided. The liquid-transfer has an injector engaging portion configured for fluidly coupling to an injector and a vial coupling. The vial coupling includes a spike that has a spike axis and a tip portion configured for piercing a septum of a vial. The tip portion includes a plurality of facets that meet each other at one or more edges and at least one of the one or more edges is sloped with respect to the spike axis. The spike defines a channel extending therethrough in fluid communication with the injector engaging portion. A channel opening is defined in at least one of the facets and disposed without interrupting the edges.

Abstract: A tracheostomy tube (1) has an adjustable flange (2) that can be slid along the tube and locked in the desired position. The flange has a one-piece resilient nut (40) that is threaded on a tubular projection (30) on the flange. The nut has an integral inner sleeve (44) divided into separate fingers (48) the outside of which are engaged by the inside of the tubular projection. The flange is locked in position by screwing the nut onto the projection so that the fingers that are forced inwardly to engage the outside of the tube.

Abstract: The present disclosure relates to an injection device for delivery of a liquid medicament including a housing, a cartridge having a tubular shaped barrel filled with a liquid medicament and sealed in a proximal direction by a piston displaceably arranged in the barrel, and a drive mechanism having a piston rod to advance in a distal direction against a proximally facing surface of the piston of the cartridge. The drive mechanism is configured to advance the piston rod in the distal direction by a distance z1 to dispense a reference volume V1 of the medicament when operably engaged with a reference cartridge having a reference diameter D1, and, the cartridge has a diameter D2 smaller than the reference diameter D1 to dispense a volume V2 of the medicament smaller than the reference volume V1 when the piston rod advances in distal direction by the distance z1.

Abstract: A closure (1) for a container comprising a connecting element (2) for connection of the closure to a container, a sealing device (3) for sealing the access to a container content and an interface (4) to an adapter having a coupling receptacle (5). The closure (1) has a delivery position and a use position. In the use position, the sealing device (3) is open. In the delivery position, the sealing device (3) is sealed in a gas and liquid fight manner.

Abstract: A transfer member (128) comprising a housing (24) having a top, a side wall (26), an open bottom, the open bottom permitting insertion of a vial (12) within the housing, a piercing member (34) mounted within the housing (24), the piercing member (34) having a piercing tip (36) located at a bottom end thereof, the piercing member having an interior passageway formed therein, a connector (30) located on an exterior side of the top, a moveable member (40) mounted within the housing (24), the moveable member (40) being moveable from a first position wherein the moveable member (40) prevents access to the piercing tip (36) to a second position permitting access to the piercing tip when the vial is inserted in the housing, a transfer member (128), the transfer member (128) having first and second transfer member ends (131, 133) wherein the moveable member (40) and the housing (24) cause the moveable member (40) to rotate when the moveable member (40) moves upwardly upon insertion of the vial (12), the moveable memb

Abstract: Disclosed are methods, systems and devices for evacuation of fluid, for example, air or gas, from a container or enclosed area.

Abstract: Apparatus, systems and methods are disclosed relating to certain aspects of blood processing, collecting or storing, including method and system for automated authentication, processing device with scanner, blood container with two dimensional barcode, blood collection containers, blood container label and related tracking method, integrated container system, and processing device with sterile connection device.

Abstract: The present invention includes a device cleaner, and method of use, for cleaning a device port, particularly a medical device port, that may be inserted into the device port cleaner for cleaning and/or disinfecting.

Abstract: The invention relates to an interfacing device for establishing a connection between a fluid-injection instrument and a flask, said device comprising: fluid flow means configured such as to open into the flask to be perforated when the interfacing device is attached to the flask to be perforated; and a distal opening allowing the flow of gases and a proximal opening allowing the flow of liquids.

Abstract: A device for mixing a first substance and a second substance, or for transferring at least one of the substances, which are present in a first or second receptacle, the device including a first adapter with a circumferential wall, along which extends a cannula body, and a hollow-cylindrical section that is connected to the cannula body; a second adapter with a circumferential wall, along which extends a cannula body; and a hollow-cylindrical section that is connected to the cannula body; when the first and the second adapter are assembled, the hollow-cylindrical sections inter-engage in a liquid-tight manner, and the first and the second adapter are connected to each other in a detachably screwed manner.

Abstract: A perforating needle intended to be inserted into a flask through a stopper or septum to inject and remove a fluid includes a pointed end for piercing the stopper and a cylindrical body. The central body includes a central channel through which the fluid may enter and leave the flask and a side wall having at least one lateral orifice. The orifice is in fluid communication with the central channel. A lower end of the orifice is, in use, essentially level with an inner face of the stopper. The orifice is extended toward the pointed end by at least one slot, a shape of which is essentially tangential to a flow of the fluid so as to channel the fluid along an axis of the needle. The side wall includes at least two diametrically opposite lateral orifices arranged on either side of a central island.

Abstract: A harvesting cannula, including a plurality of ports configured and positioned to improve performance as compared to existing harvesting devices, according to various embodiments, is described herein.

Abstract: An apparatus for processing a fluid module, including a collapsible vessel supported on a planar substrate, comprises a first actuator component configured to be movable in a first direction is generally parallel to the plane of the substrate, a second actuator component configured to be movable in a second direction having a component that is normal to the plane of the substrate, and a motion conversion mechanism coupling the first actuator component with the second actuator component and configured to convert movement of the first actuator component in the first direction into movement of the second actuator component in the second direction.

Abstract: A liquid drug transfer device that includes a vial adapter having at least two non-adjacent vial retention flex members and at least two non-adjacent vial guidance flex members. The vial guidance flex members are each provisioned with a purpose design hinged zone distanced from a vial adapter top wall for intentionally being hinged thereat on telescopic snap fitting on an injection vial. The vial retention flex members can double as vial guidance flex members with the condition that their hinged zones are distal to their inwardly protruding vial retention ribs relative to the vial adapter top wall.

Abstract: In certain embodiments, a vial adaptor for removing liquid contents from a vial comprises a piercing member and a bag. The bag can be contained within the piercing member such that the bag is introduced to the vial when the vial adaptor is coupled with the vial. In some embodiments, the bag expands within the vial as liquid is removed from the vial via the adaptor, thereby regulating pressure within the vial. In other embodiments, a vial comprises a bag for regulating pressure within the vial as liquid is removed therefrom. In some embodiments, a vial adaptor is coupled with the vial in order to remove the liquid. In some embodiments, as the liquid is removed from the vial via the adaptor, the bag expands within the vial, and in other embodiments, the bag contracts within the vial.

Abstract: A vial adaptor can include a connector interface and/or a piercing member. The vial adaptor can include a regulator assembly. The regulator assembly can include a regulator base, a regulator nest coupled with the regulator base, and/or a storage chamber formed at least partially by one or both of the regulator base and regulator nest. The regulator assembly can include a cover connected to one or both of the regulator base and regulator nest and fitted around a radially outward portion of one or both of the regulator base and regulator nest. In some cases, the regular assembly includes a flexible enclosure connected to the regulator nest and configured to transition between a contracted configuration and an expanded configuration. In some cases, the flexible enclosure is inhibited from transitioning to the expanded configuration prior to removal or modification of the cover from the regulator assembly.

Abstract: An exemplary vial adapter may include a moveable member, an elongated member with a first passage, a second passage coupled to an expandable first reservoir, and a third passage coupled to an expandable second reservoir. In a first orientation of an exemplary vial adapter, a fluid may be directed through the first passage into the first reservoir or the second reservoir. In a second orientation of an exemplary vial adapter, a fluid may be drawn through the first passage and a fluid drawn through an air passage into the second passage. In a second orientation of an exemplary vial adapter, a fluid may be directed through the first passage and through the third passage into the second reservoir. In a first orientation of an exemplary vial adapter, a moveable member may be activated to direct a fluid from the second reservoir through the third passage.

Abstract: A puncture needle sensor manufacturing method includes applying an insulation layer to a metal sheet and applying spaced apart stripe-shaped electrodes on the insulation layer after the insulation layer is applied on the metal sheet. The manufacturing method also includes cutting the metal sheet to produce a plate-shaped body that includes at least two of the electrodes. The plate-shaped body is press-worked to form the plate-shaped body into a tubular body, and a pointed, beveled end portion is formed at the distal end of the tubular body.

Abstract: The present disclosure provides aseptic vial piercing and sterilization systems, and methods of assembling, using and sterilizing same. The systems and methods utilize a pre-sterilized primary container including a first end, a first cavity, a second end with an opening in communication with the first cavity, a septum at least partially sealing the opening, and a product within the first cavity. The systems and methods include an injection assembly including a first end portion of a hollow flowpath forming member. The injection assembly and the primary container may be assembled in a non-sterile environment to form a second cavity extending about the first end portion of the flowpath forming member and to the primary container. The second cavity may then be selectively sterilized in a non-deleterious manner to the product to allow the first end portion to aseptically pierce the septum to extend into the first cavity.

Abstract: A coded collapsible drug reservoir and a drug delivery system including the coded collapsible drug reservoir. The drug reservoir includes a collapsible housing and a port in communication with the collapsible housing. The drug reservoir further includes a coding feature disposed on the drug reservoir, and the coding feature identifies the drug reservoir.

Abstract: In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure.

Abstract: A medicament transport system includes a syringe adapter assembly; and a vial adapter assembly including a base defining an opening having a seal member disposed therewithin, a stem extending from the base and defining a lumen therethrough and an opening through a wall thereof, a needle shuttle valve slidably disposed within the lumen of the stem and supporting a transfer needle and a vacuum needle; and a vacuum cup slidably supported on the stem, wherein a vacuum chamber is defined in the space between the base, the stem and the vacuum cup. The medicament transport system includes a condition where the transfer needle and the vacuum needles penetrate the seal member of the vial adapter assembly, and the vacuum cup is moved to draw a vacuum through the vacuum needle. An automation system is provided that utilizes a medicament transport system for forming a medicament solution from a liquid/non-liquid solution.

Abstract: The invention relates to a transfer device for tapping or delivering a fluid from a bottle sealed with a closure, the device having a hollow cylinder-shaped first part having a circumferential wall, which first part can be placed on the bottle and surrounds the closure, a hollow cylinder-shaped second part which can be adjusted with respect to the first part, the second part having a first wall running transverse to the longitudinal axis direction, and a puncturing needle originating from the first wall and extending in the direction of the first part permitting piercing of the closure, wherein the first part cannot be adjusted axially with respect to the second part if the closure is not surrounded and, if the first part surrounds the closure, the first part can be adjusted with respect to the second part for piercing the closure.

Abstract: The apparatus (1) is designed to mix at least two ingredients coming from at least two distinct reservoirs (2, 3). It has at least two distinct orifices (6, 7) suitable for being connected to the reservoirs (2, 3), a motor-driven pump (15), a fluid-connection selector (9) including at least one network of through channels (12) suitable for putting at least one of the orifices into communication with the pump (15), the fluid-connection selector (9) being arranged to be movable between a plurality of positions in order to make it possible, selectively and by means of the pump (15), to transfer at least one ingredient from one orifice to the other orifice or towards the pump (15) and to blend the resulting mixture.

Abstract: Embodiments of the invention are directed to flush syringe assemblies comprising an integrated contamination-prevention device integrated with device connector flushing positioned so that the practitioner cannot forget to apply disinfectant. The flush syringe assemblies comprise a barrel with an elongate plunger rod disposed therein and a cap comprising a passageway. The plunger rod includes a stopper of which at least a portion can be embedded in the passageway of the cap to form a plug in the cap.

Abstract: A device for transferring fluids includes a piercing member having a distal end and a proximal end and defines a longitudinal fluid channel. An opening is positioned at the distal end of the piercing member with the opening in fluid communication with the longitudinal fluid channel. Further, a sleeve having a proximal end and a distal end includes an extended position where the sleeve surrounds the piercing member and a retracted position where the sleeve is retracted from the distal end of the piercing member. The sleeve defines an opening at the distal end of the sleeve with a gap defined between the retractable sleeve and the piercing member.

Abstract: In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure.

Abstract: A tubing set suitable for use in co-operation with a hemodialysis machine includes an out-tube for supplying the blood from the patient to a filter of the machine, an in-tube for supplying the blood from the filter back to the patient, a drip chamber placed along one of the tubes, adapted to let the blood drip through an air buffer, and a vial gate for the connection of vials containing drugs to be delivered into the blood. The vial gate includes a delivery lumen, suitable for delivering the drug from the vial to the drip chamber, and a vent lumen, suitable for providing air inside the vial in order to replace the delivered drug.

Abstract: A medical article, such as a catheter hub, is stabilized on a patient with a retainer having a base and clamp or moveable collet. A lever is configured to move the collet in a longitudinal direction relative to the based to secure the medical article to the retainer. When rotated, the lever pulls the collet in a direction away from the patient while collapsing the collet around at least a portion of the catheter hub.

Abstract: A catheter assembly includes a catheter hub and an introducer needle. The introducer needle extends through the catheter hub and through a catheter tube so as to assist placement of the catheter tube into a patient's blood vessel. Blood flashback into the catheter tube and/or catheter hub can indicate when the catheter tube is properly positioned within the blood vessel. After proper catheter tube placement is confirmed through blood flashback, the introducer needle is withdrawn. A septum blocks flashback blood from flowing proximally out of the catheter hub. One or more air vents enable air within the hub to vent when flashback blood enters the catheter hub. A porous hydrophobic material covers the one or more air vents. The hydrophobic material allows the air to flow therethrough and through the vents, but repels blood, blocking blood from flowing through the air vents.

Abstract: A medical device is presented, which includes a fluid pathway and a septum slidably housed within the fluid pathway. The septum can be opened by a septum actuator disposed in a fixed position within the fluid pathway. In some examples, both the septum actuator and the septum have at least one surface exposed to the fluid pathway. An anti-pathogenic material can be applied to these surfaces.

Abstract: A method and apparatus for a connection interface between a reservoir or syringe, infusion set tubing, and an infusion pump is provided. A base is provided which is adapted to receive a reservoir. The base has a base engagement member, such as a detent, projecting therefrom. A cap is provided which is adapted to receive the base. The cap includes a first cap engagement member, such as a detent opening, which is adapted to removably engage the base detent. The cap further includes a second cap detent opening which is adapted to removably engage the base detent. A piercing member, such as a needle, is disposed in the interior of the cap in such a manner that the needle is separated from the reservoir septum when the base detent is in the first cap detent opening, and the needle pierces the reservoir septum when the base detent is in the second cap detent opening.

Abstract: A hydraulic bicycle hose structure includes a hydraulic hose and a first seal. The hydraulic hose has a first end with a first opening. The hydraulic hose is configured to be coupled to a hydraulic component. The hydraulic hose is filled with hydraulic fluid. The first seal is arranged to seal the first opening of the first end of the hydraulic hose. The first seal is configured to be physically ruptured.

Abstract: A drug mixing system including at least one receptacle port adaptor adapted to be inserted into a port of a fluid receptacle, at least one syringe adaptor adapted to be attached to a syringe and to the at least one receptacle port adaptor and at least one vial adaptor adapted for connection to a vial containing a drug and adapted for connection to the at least one syringe adaptor, the system being characterized in that at least one of the receptacle port adaptor, the at least one syringe adaptor and the at least one vial adaptor being vented to the atmosphere in a manner which prevents release to the atmosphere of possibly harmful contents of the vial in a liquid, solid or gaseous form.

Abstract: A vial adapter modular assembly (10) including a bag spike port (12) connectable to an output port (16) of a bag (18), a vial port (20) connectable to a vial, and an exit port (24), characterized by a lumen (32) having a vial port flow opening (36) in fluid communication with the vial port (20), and a plunger element (34) that slides in the lumen (32) between a non-blocking position and a blocking position, wherein in the non-blocking position, the plunger element (34) does not block the vial port flow opening (36) and permits fluid flow between the bag spike port (12) and the vial port (20), and wherein in the blocking position, the plunger element (34) blocks the vial port flow opening (36) and blocks fluid flow between the bag spike port (12) and the vial port (20).

Abstract: The present invention relates to a medical device (1, 100) comprising a first container (10, 110) holding a first medium and defining a general axis, a second container (20, 120) holding a second medium, and fluid connection means (50, 150) for establishing fluid connection between the first container (10, 110) and the second container (20, 120), the fluid connection means (50, 150) being arranged at least partially between the first container (10, 110) and the second container (20, 120). The device further comprises a cover receiving portion (42, 42) and a cover (4, 104) removably mounted thereon to shield at least an operable portion of the first container (10, 110).

Abstract: The integrated puncture needle adapter is equipped with: a puncture needle; a needle hub; a tubular fixing part for fixing the needle hub; a tubular puncture needle accommodating part provided on a distal side of the tubular fixing part and having therein an accommodating space for accommodating the puncture needle; a second connecting part provided on a distal side of the puncture needle accommodating part; and a separable part which is formed between the tubular fixing part and the puncture needle accommodating part. A part on the distal side of the separable part is separable from a part on the proximal side of the separable part. The puncture needle is exposed when separated.

Abstract: A closed fluid transfer system for fluidly interconnecting a syringe to any one of a patient I.V. set, a vial and an I.V. bag, is provided and includes a housing defining an open distal end and an open proximal end, a base supported in the open proximal end of the housing and including a syringe adapter luer connector, a collar slidably and rotatably supported in the housing, the collar defining a longitudinal opening therethrough, a shuttle slidably extending through longitudinal opening of the collar, the shuttle defining a shuttle lumen extending longitudinally therethrough, a barrel supported on and extending over a distal end of the shuttle, a biasing member interposed between the collar and the shuttle for urging the collar away from the shuttle, and a seal interposed between the shuttle and the barrel, wherein the seal extends across the shuttle lumen and the central opening of the barrel.

Abstract: A connector for coupling to a base of medical device equipped with a circular hub having a circumferential recess. The connector includes a cap having a top surface, a bottom surface, a central region, and a circumferential region. The cap defines at least two slots extending from the circumferential region towards the central region, the slots defining the cap into at least one lobe. The at least one lobe has an outward projecting lift tab and an inward projecting catch. Positioning the connector on the circular hub and depressing the connector engage the catch with the circumferential recess of the circular hub so the connector can rotate completely about the circular hub. Lifting the one lift tab to reversibly displace the lobe and its respective catch radially to disengage from the circumferential recess decouples the connector.

Abstract: A connector for coupling to a base of medical device equipped with a circular hub having a circumferential recess. The connector includes a cap having a top surface, a bottom surface, a central region, and a circumferential region. The cap defines at least two pairs of slots extending from the circumferential region towards the central region dividing the cap into at least two fixed lobes and at least two resilient lobes. Each resilient lobe has an outward projecting lift tab, an inward projecting catch, and at least a resilient region. Positioning the connector on the circular hub and pressing the connector engage the catches with the circumferential recess of the circular hub so the connector can rotate completely about the circular hub. Lifting at least one lift tab to reversibly displace the resilient lobe and its respective catch radially to disengage from the circumferential recess decouples the connector.

Abstract: Disclosed herein are apparatuses and methods for installing a sterilized peripheral in a bio-processing vessel. One aspect is an aseptic peripheral connection assembly for installing a sterilized peripheral in a bio-processing vessel via an aseptic connector affixed to the vessel. The aseptic peripheral connection assembly may include a carrier, an applicator, a plunger, and a removable hermetic sealing tab.

Abstract: A device for providing sterilized or cleaned fluid to a receptacle and thereby facilitating conveyance of a substance out of the receptacle, comprising a connector and a container which form an integrated unit. The connector is provided with a first means for connection to a receptacle. Sterilized or cleaned fluid is transferred from the container to the receptacle.

Abstract: A fluid delivery connection includes a cuff to engage a port. A finger extends away from the cuff, and the finger is configured to interact with the port. A locking sleeve is movably disposed at least partially about the cuff and the finger. The locking sleeve is selectively movable between an unlocked configuration wherein the finger is movable and a locked configuration wherein the finger is secured to the port. A method of connection to a gas port includes moving a locking sleeve of a connector into an unlocked configuration. A finger of the connector is translated along the gas port and the locking sleeve is moved into a locked configuration.

Abstract: According to the invention, the tubular prosthesis for connecting an anatomical duct includes at least two individual tubular elements and a sealed mechanical element for connecting said separate elements to each other.

Abstract: Fluid transfer devices for use in manual cartridge filling procedures for filling cartridges with liquid drug dosages from medicament containing vials. The fluid transfer devices include a double ended main body having a longitudinal axis, a vial port for telescopic receiving a drug vial and a cartridge port for slidingly receiving a leading cartridge end. The cartridge port includes a cartridge securing arrangement for releasably securing a leading cartridge end therein and a cartridge ejection arrangement for at least partially ejecting a cartridge therefrom for assisting manual sliding ejection of a filled cartridge. The cartridge port can include either a combined cartridge securing and ejection arrangement or a discrete cartridge securing arrangement and a discrete cartridge ejection arrangement.

Abstract: A multi-container transfer and delivery device configured to allow multiple containers to transfer and mix their respective materials and for receiving of the mixed materials to a delivery device. The transfer device comprises a plurality of flow conduits for fluid flow between the multiple containers and the delivery device. Methods of mixing using the device and methods of sterilizing the device are described. A drug mixing kit comprising a multi-container housing with a plurality of flow conduits and a plurality of compartments for receiving containers and a transfer device is also described.

Abstract: A portable auto-injector configured to store various wet and dry medicament components separately. Wherein prior to injection the various medicaments within the portable auto-injector are mixed through a multi-stage process in one or more chambers within the portable auto-injector. The various chambers being connected by corresponding fluidic channels.

Abstract: A medical device, particularly for mixing medical fluids, includes two tubular bodies made of materials of different elasticity having respective open ends to be joined together. The end of the second body is inserted axially by friction within the end of the first body and is then blocked via radial projections, which are obtained by plastic deformation of the wall of the end of the first body and are engaged against the end of the second body.