Blood Transferred Between Different Bodies Along Continuous Flow Path (e.g., Transfusion, Etc.) Patents (Class 604/7)
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Patent number: 12098193Abstract: The present disclosure provides methods of inducing desmoplastic stroma to express a normal phenotype by detecting increased levels of NetG1 or NGL1 in tumor or in desmoplastic stroma isolated from a human subject, and/or detecting NetG1 in circulating extracellular vesicles, and/or detecting increased pFAK in the stroma, and treating the human subject with a therapeutic regimen; and by detecting NetG1 in a microvesicle isolated from a human subject, and/or treating the human subject with a therapeutic regimen.Type: GrantFiled: October 9, 2018Date of Patent: September 24, 2024Assignee: Institute For Cancer ResearchInventors: Edna Cukierman, Ralph Francescone, Janusz Franco-Barraza, Kristopher Raghavan
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Patent number: 11759556Abstract: The present teachings generally include parabiotic dialysis systems and techniques. For example, the present disclosure includes parabiotic liver dialysis, e.g., for use in settings with limited resources. To this end, a parabiotic liver dialysis system may include a device having a semipermeable membrane with an average pore size that allows for the passage of albumin therethrough. In such a system, a first extracorporeal circuit may connect the device to the vascular system of a first animal (e.g., a liver patient), and a second extracorporeal circuit may connect the device to the vascular system of a second animal (e.g., a human with normal liver function), where the exchange of albumin therebetween is facilitated through the device. The present disclosure also includes various safety measures for parabiotic dialysis systems and techniques, such as biometric verification systems and techniques.Type: GrantFiled: June 21, 2021Date of Patent: September 19, 2023Assignees: Fresenius Medical Care Holdings, Inc., Fresenius Medical Care Deutschland GmbH, Fresenius Medical Care AG & Co. KGaAInventors: Stefan Weiss, Peter Kotanko, Roland Sander
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Patent number: 11419966Abstract: A system includes a device having a blood side, a solution side, and a semipermeable membrane structurally configured for diffusion of one or more solutes therethrough. The system also includes a first extracorporeal circuit having one or more first fluid connectors for connecting the blood side of the device to the vascular system of a first animal, a second extracorporeal circuit including one or more second fluid connectors for connecting the solution side of the device to the vascular system of a second animal, a first pump in fluid communication with at least one of the first and second extracorporeal circuits, and a driver mechanically coupled to the first pump, the driver configured to drive the first pump using energy from an energy source.Type: GrantFiled: October 1, 2019Date of Patent: August 23, 2022Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Peter Kotanko, Stephan Thijssen
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Patent number: 11273243Abstract: A system includes a dialyzer having a blood side and a dialysate side, a first extracorporeal circuit including one or more first fluid connectors structurally configured to connect the blood side of the dialyzer to the vascular system of a kidney patient, and a second extracorporeal circuit including one or more second fluid connectors structurally configured to connect the dialysate side of the dialyzer to the vascular system of a healthy animal. The present teachings may thus include a system where hemodialysis is performed using a healthy animal (e.g., a person with normal kidney function) to help remove harmful solutes from, and provide helpful solutes to, a kidney patient. In this manner, the healthy animal is “virtually donating” its kidney function to the kidney patient.Type: GrantFiled: July 15, 2019Date of Patent: March 15, 2022Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Peter Kotanko, Stephan Thijssen
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Power system for and method of operation of magnetically-activated arteriovenous access valve system
Patent number: 10219806Abstract: A power system for and method of operation of an arteriovenous access valve system including two valves positioned near arteriovenous grafts, an actuator assembly in fluid communication with the valves and including a driver assembly, at least one pressure sensor, a separate activator device for driving the driver assembly, and a sensor communications device communicatively coupled to the at least one pressure sensor for wirelessly transmitting pressure measurements. The power system and method also include using an initiator device located in the activator device to power remotely the sensor communications device, for example via near field communication such as via a radio frequency field.Type: GrantFiled: February 19, 2018Date of Patent: March 5, 2019Assignee: SEALEVEL SYSTEMS, INC.Inventor: Thomas B. O'Hanlan -
Patent number: 8932246Abstract: The present invention relates to a device for circulating a body fluid in a body of a living organism, especially to support the heart and/or circulation of the living organism, comprising a catheter device which has at least one inlet portion to take up the body fluid at at least one first location within the body of the living organism, at least one outlet portion some distance from the at least one inlet portion to discharge the body fluid at at least one second location some distance from the at least one first location within the body of the living organism and a pump device for directed transport of the body fluid between the at least one inlet portion and the at least one outlet portion of the catheter device; and a valve arrangement coupled to the catheter device for controlled uptake of the body fluid as a function of operation of the pump device at the at least one inlet portion of the catheter device and controlled discharge of the body fluid at the at least one outlet portion of the catheter devicType: GrantFiled: March 15, 2013Date of Patent: January 13, 2015Assignee: NovaPump GmbHInventor: Markus Ferrari
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Patent number: 8888733Abstract: Devices, systems, and methods for autoretroperfusion.Type: GrantFiled: April 22, 2011Date of Patent: November 18, 2014Assignee: CVDevices, LLCInventor: Ghassan S. Kassab
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Patent number: 8858489Abstract: Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue wall. Some embodiments of the present invention further provide a system for implanting a conduit device in a tissue wall. More specifically, some embodiments provide a system including a coring device for defining an aperture in a tissue by removing and retaining a tissue core and securely implanting a conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the conduit device.Type: GrantFiled: March 18, 2013Date of Patent: October 14, 2014Assignees: Emory University, Georgia Tech Research CorporationInventors: Thomas A. Vassiliades, Ajit Yoganathan, Jorge Hernan Jimenez
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Patent number: 8808977Abstract: The present invention relates to a method for illuminating the viruses in a circulatory blood, comprising the following steps of: 1) Adding an anticoagulant into a whole blood source and establishing a circulation system for the whole blood source; 2) Withdrawing the whole blood with the anticoagulant into a plasma-separating device for a separation, when finished, directly pumping the red-blood cells back into the whole blood source and transporting the plasma into a mixing transport pump after the separation; 3) Meanwhile, pumping a photosensitizer methylene blue into the mixing transport pump so that the methylene blue is mixed with the plasma and pumped together into a plasma container; 4) Using an illumination device to illuminate the plasma in the plasma container for virus illumination, and pumping the virus-illuminated plasma into a removing device for removing off the photosensitizer; 5) The methylene blue being absorbed by the removing device and the plasma illuminated being transfused back into theType: GrantFiled: May 21, 2004Date of Patent: August 19, 2014Assignee: Beijing Jingjing Medical Equipment Co., LtdInventors: Weixing Wu, Yuen Kam
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Patent number: 8802362Abstract: Methods and devices for preparing a solid-fibrin web are provided. One method may include drawing blood from a patient, separating plasma from the blood, contacting the plasma with a calcium-coagulation activator and concurrently coagulating and axially centrifuging the plasma to form the solid-fibrin web. The solid-fibrin web may be suitable for regenerating body tissue in a living organism. Devices used in the methods may also be provided.Type: GrantFiled: May 18, 2010Date of Patent: August 12, 2014Assignee: Cascade Medical Enterprises, LLCInventors: Nicholas A. Grippi, Roberto C. Beretta
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Patent number: 8764698Abstract: An arteriovenous graft system is described. The arteriovenous graft system includes an arteriovenous graft that is well suited for use during hemodialysis. In order to minimize or prevent arterial steal, at least one valve device is positioned at the arterial end of the arteriovenous graft. In one embodiment, a subcutaneous arteriovenous graft system is described. The system includes an arteriovenous graft having an arterial end and an opposite venous end with a first valve device positioned at the arterial end of the arteriovenous graft and a second valve device positioned at the venous end of the arteriovenous graft. The system also includes an actuator having an accumulator. The actuator is in communication with both the first valve device and the second valve device and is configured to cause each valve device to open or close simultaneously. The accumulator assists in maintaining a generally constant pressure when the actuator causes each valve device to close.Type: GrantFiled: December 21, 2012Date of Patent: July 1, 2014Assignee: CreatiVasc Medical, LLCInventor: David L. Cull
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Patent number: 8747344Abstract: An apparatus for positioning a graft and catheter operable for subcutaneous access to the vascular system of a patient. A surgically created, hybrid arteriovenous shunt is provided which comprises a flexible graft and a venous outflow catheter connected to the graft via surgical anastomosis over a cuff. The graft is connected to an arterial source and then to a single lumen venous outflow catheter which deposits dialyzed blood directly into the heart at the right atrium. Methods of surgical placement and performing hemodialysis using embodiments of the apparatus are provided.Type: GrantFiled: October 5, 2012Date of Patent: June 10, 2014Inventor: Nazir A. Khan
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Patent number: 8641657Abstract: In a blood transfer chamber, a filter (4) is arranged at an outlet located on a bottom of the chamber. The filter is truncoconical with a vertically-disposed axis. The filter has a plurality of openings (13, 14) for fluid passage, a size of which openings increases gradually in an upwards direction going from bottom to top of the chamber. The filter is used in a venous air-blood separation chamber of a dialysis set. The invention enables a reduction of a risk of hemolysis during treatment as well as a reduction of the risk of formation of air bubble retention in the filter during a priming stage.Type: GrantFiled: December 1, 2006Date of Patent: February 4, 2014Assignee: Gambro Lundia ABInventors: Francesco Ribolzi, Ranko Sakota, Luca Caleffi, Giuseppe Franzoni
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Patent number: 8568488Abstract: A satiation device is described which includes a sheath or liner extending from the proximal or middle stomach to the distal antrum. Food ingested by the patient passes through the sheath or liner, thereby minimizing contact between the ingested food and the stomach. It is believed that over time, reduced contact between food and the stomach will result in decreased Ghrelin production by the patient and a consequent decrease in appetite. In some embodiments, the satiation device may also include a proximal pouch and/or a distal bypass tube.Type: GrantFiled: October 1, 2009Date of Patent: October 29, 2013Assignee: Boston Scientific Scimed, Inc.Inventors: Richard S. Stack, Richard A. Glenn, William L. Athas, Michael S. William, Trevor J. Moody, Fred E. Silverstein, Nathan Every
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Publication number: 20130090589Abstract: A transfusion tube set includes: a transfusion tube; and a transfusion tube which does not have a filter and a transfusion tube which has the filter, wherein the transfusion tubes and are detachable from the transfusion tube. The transfusion tube includes a tube and a reservoir needle provided at a upstream end of the tube, and a drip tube, a roller clamp, an upstream connector and a downstream connector are provided downstream of the reservoir needle of the tube. A filter mesh is disposed at the upstream end of a main tube of the downstream connector.Type: ApplicationFiled: June 27, 2011Publication date: April 11, 2013Applicant: TERUMO KABUSHIKI KAISHAInventor: Masaomi Imai
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Patent number: 8409128Abstract: The present invention relates to a device for circulating a body fluid in a body of a living organism, especially to support the heart and/or circulation of the living organism, comprising a catheter device which has at least one inlet portion to take up the body fluid at at least one first location within the body of the living organism, at least one outlet portion some distance from the at least one inlet portion to discharge the body fluid at at least one second location some distance from the at least one first location within the body of the living organism and a pump device for directed transport of the body fluid between the at least one inlet portion and the at least one outlet portion of the catheter device; and a valve arrangement coupled to the catheter device for controlled uptake of the body fluid as a function of operation of the pump device at the at least one inlet portion of the catheter device and controlled discharge of the body fluid at the at least one outlet portion of the catheter devicType: GrantFiled: March 17, 2008Date of Patent: April 2, 2013Assignee: MWF Consult Ltd.Inventor: Markus Ferrari
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Patent number: 8382697Abstract: Devices, systems and methods are disclosed for the formation of an arteriovenous fistula in the limb of the patient. Embodiments include an apparatus for the creation, modification and maintenance of a fistula, including the modification of an existing dialysis fistula; and a method of supplying oxygenated blood to the venous circulation of a patient. A kit of anastomotic implants is described which supports a broad base of patient anatomies and fistula locations. The devices, systems and methods can be used to treat patients with one or more numerous ailments including chronic obstructive pulmonary disease, congestive heart failure, hypertension, hypotension, respiratory failure, pulmonary arterial hypertension, lung fibrosis and adult respiratory distress syndrome.Type: GrantFiled: January 22, 2008Date of Patent: February 26, 2013Assignee: Rox Medical, Inc.Inventors: Rodney Brenneman, Dean A. Schaefer, J. Christopher Flaherty
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Patent number: 8349174Abstract: A fuel-cell powered medical fluid processing machine or dialysis machine is disclosed. The machine is intended for remote or rural areas where standard household or utility power is not available or is subject to interruption. The fuel cell is powered by hydrogen or other source of protons, or may instead be powered by methanol or ethanol, such as a direct methanol fuel cell. The fuel cell may be operated directly, as in powering a portable, wearable dialysis device, or may be operated indirectly, to generate and store power in an electric power storage device of the medical fluid or dialysis device. The medical fluid processing machine or dialysis machine may include circuitry allowing for use by household or utility power while also including a fuel cell for use when other power is not available. A catalytic heater may be used to warm the dialysis fluid.Type: GrantFiled: July 23, 2008Date of Patent: January 8, 2013Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: John A. Bedingfield, Richard E. Kienman, Brian C. Lauman
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Patent number: 8343139Abstract: A portable systems release fluid pressure with a cavity within a patient. These systems include a drainage catheter, a pressure-responsive one-way valve, and a fluid reservoir all adapted to be mounted in proximity to the cavity being drained. One system in particular is used in relieving intracranial pressure. This intracranial pressure relief system may include a headband to which are mounted the one-way valve and reservoir. The drainage catheter may have mounted thereon a cranium seal formed of a soft material that contacts the inner wall of a cranium bore hole. The cranium seal may have threads to facilitate advancement into the bore hole.Type: GrantFiled: October 26, 2007Date of Patent: January 1, 2013Inventor: A. Mateen Ahmed
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Publication number: 20120330117Abstract: Tools and techniques for estimating a probability that a patient is bleeding or has sustained intravascular volume loss (e.g., due to hemodialysis or dehydration) and/or to estimate a patient's current hemodynamic reserve index, track the patient's hemodynamic reserve index over time, and/or predict a patient's hemodynamic reserve index in the future. Tools and techniques for estimating and/or predicting a patient's dehydration state. Tools and techniques for controlling a hemodialysis machine based on the patient's estimated and/or predicted hemodynamic reserve index.Type: ApplicationFiled: July 20, 2012Publication date: December 27, 2012Applicants: The Regents of the University of Colorado, a body corporate, Flashback Technologies, Inc.Inventors: Gregory Zlatko Grudic, Steven Lee Moulton, Isobel Jane Mulligan
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Patent number: 8337567Abstract: A device for inducing weight loss in a patient includes a tubular prosthesis self-expandable from a collapsed position in which the prosthesis has a first diameter to an expanded position in which the prosthesis has a second, larger, diameter. In a method for inducing weight loss, the prosthesis is placed in the collapsed position and inserted into a stomach of a patient. The prosthesis is allowed to self-expand from the collapsed position to the expanded position and into contact with the walls of the stomach, where it induces feelings of satiety and/or inhibits modulation of satiety-controlling factors such as Ghrelin.Type: GrantFiled: September 28, 2011Date of Patent: December 25, 2012Assignee: Barosense, Inc.Inventors: Richard S. Stack, Richard A. Glenn, Trevor J. Moody, Fred E. Silverstein, Nathan Every, William S. Eubanks, Jr.
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Patent number: 8333725Abstract: The invention relates to a device for separating a bodily fluid, in particular blood platelet concentrate, into fractions under centrifugal force. The device comprises a flexible container system which comprises at least a first container for the fluid to be separated and a second container for a separated fraction, wherein the containers are mutually connected using a connecting conduit for a fluid, wherein a widened portion is arranged in the connecting conduit between the first and second container, wherein during use a detectable separating layer is created in the widened portion. The invention also relates to a flexible container system intended for the device, a method for separating blood platelet concentrate into fractions under centrifugal force, and a blood platelet concentrate with low leukocyte content.Type: GrantFiled: June 27, 2007Date of Patent: December 18, 2012Assignee: Klip Consultancy B.V.Inventors: Evert Jan Klip, Carl Gustav Figdor
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Patent number: 8282591Abstract: An apparatus for positioning a graft and catheter operable for subcutaneous access to the vascular system of a patient. A surgically created, hybrid arteriovenous shunt is provided which comprises a flexible graft and a venous outflow catheter connected to the graft via surgical anastomosis over a cuff. The graft is connected to an arterial source and then to a single lumen venous outflow catheter which deposits dialyzed blood directly into the heart at the right atrium. Methods of surgical placement and performing hemodialysis using embodiments of the apparatus are provided.Type: GrantFiled: March 29, 2004Date of Patent: October 9, 2012Inventors: Iftikhar Khan, Nazir Khan
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Publication number: 20120191029Abstract: The present invention relates to a lockable connection system for components in medicine and medical technology that have fluids passing through them with a female, tube- or cone-shaped receptacle (11, 21, 41, 51) having an interior receptacle section and an external first fixing section, and a male, tube- or cone-shaped insertion element (12, 62, 72, 82, 92, 112, 132, 152) to be accommodated in the female receptacle section (11, 21, 41, 51) and an external second fixing section (14, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150) interacting with the first fixing section for fixing the connection system. The invention is characterized in that the first or second fixing section has at least two radially outward-protruding lobes (13, 13?, 23, 23?, 33, 33?, 43, 43?, 53, 53?), the radial external edge of which lies on a diameter greater than 7.83 mm and/or whose axial thickness at the base is greater than 1.3 mm.Type: ApplicationFiled: June 22, 2010Publication date: July 26, 2012Inventors: Hans Juergen Hopf, Norbert Kassai, Alexander Hopf, Michael Hopf
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Patent number: 8226592Abstract: A method for treatment of COPD, hypertension, and left ventricular hypertrophy, and chronic hypoxia including creation of an artificial arterio-venous fistula and installation of a flow mediating device proximate the fistula. The flow mediating device is operated to limit flow as medically indicated to provide the optimum amount of bypass flow.Type: GrantFiled: December 15, 2004Date of Patent: July 24, 2012Assignee: ROX Medical, Inc.Inventors: Rodney A. Brenneman, J. Christopher Flaherty
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Patent number: 8204694Abstract: In one embodiment the present invention relates to a method for automatically tracking blood product administration in a computerized healthcare environment. Information regarding a blood product unit received by the blood bank department is documented in a database. An indication that the blood product unit has been administered to the patient by a healthcare provider is received and the database is automatically updated to reflect that the blood product unit has been administered to the patient. The present invention also relates to a method for automatically notifying a blood bank database of administration of a blood product to a patient in a computerized healthcare environment is provided.Type: GrantFiled: January 8, 2009Date of Patent: June 19, 2012Assignee: Cerner Innovation, Inc.Inventors: Arthur J. Hauck, Lori N. Cross, Jeffrey D. Fry
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Patent number: 8114044Abstract: An arteriovenous graft system is described. The arteriovenous graft system includes an arteriovenous graft that is well suited for use during hemodialysis. In order to minimize or prevent arterial steal, at least one valve device is positioned at the arterial end of the arteriovenous graft. In one embodiment, for instance, the arteriovenous graft system includes a first valve device positioned at the arterial end and a second valve device positioned at the venous end. In one embodiment, the valve devices may include an inflatable balloon that, when inflated, constricts and closes off the arteriovenous graft. By minimizing or preventing arterial steal, other complications associated with arteriovenous grafts are also avoided. For instance, the present invention is also well suited to preventing arteriovenous graft thrombosis, eliminating dialysis needle hole bleeding, and eliminating or minimizing arteriovenous graft pseudoaneurism formation.Type: GrantFiled: February 27, 2006Date of Patent: February 14, 2012Assignee: CreatiVasc Medical, LLCInventor: David L. Cull
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Patent number: 8075511Abstract: Systems and methods for treating ocular disorders are disclosed. One system has an implant and a delivery device. The implant has inlet and outlet portions, a lumen extending therebetween and communicating with inlet and outlet ports. The implant is sized so that in use aqueous humor flows from an anterior chamber of an eye through the implant and into a uveal scleral outflow path of the eye. The delivery device is configured to advance the implant from within the anterior chamber, with the outlet portion leading the inlet portion, to a location where the outlet and inlet ports respectively communicate with the uveal scleral outflow path and the anterior chamber. One method involves advancing an implant from within the anterior chamber, and draining fluid from therein such that fluid flows into an implant inlet port and out through an implant outlet port and into the uveal scleral outflow path.Type: GrantFiled: April 28, 2008Date of Patent: December 13, 2011Assignee: Glaukos CorporationInventors: Hosheng Tu, Gregory T. Smedley, David Haffner, Barbara A. Niksch
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Patent number: 8070708Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in a body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments a control mechanism coupled to the adjustable flow regulation mechanism may be provided, to remotely activate the adjustable flow regulation mechanism.Type: GrantFiled: February 3, 2005Date of Patent: December 6, 2011Assignee: V-Wave LimitedInventors: Dan Rottenberg, Ori Braun, Avraham Aba Zakay, Ascher Shmulewitz, Yoram Rozy, Gad Keren
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Patent number: 8043246Abstract: A nitric oxide gas-releasing conduit configured for surgical implantation through a patient's tympanic membrane. The nitric oxide gas-releasing conduit comprises a gas-permeable cured resin material configured for releasably sequestering therein gas. The gas-permeable cured resin material is charged with nitric oxide gas. The nitric oxide gas-releasing conduit may be optionally coated with an antimicrobial gas-releasing composition. The gas-releasing coating composition may be configured to release nitric oxide.Type: GrantFiled: September 19, 2008Date of Patent: October 25, 2011Assignee: Enox Biopharma, Inc.Inventors: Yossef Av-Gay, David Greenberg
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Publication number: 20110245751Abstract: Methods and devices for performing percutaneous and surgical interventions. The devices comprising a tubular portion and retractable mechanism at the distal end of the tubular portion. The retractable mechanism prevents the device from pulling out of an anatomical structure during complex interventions, for example, when switching from an antegrade to a retrograde approach within a blood vessel, enables the use of a single sheath when declotting AV hemodialysis fistulas and can provide occlusion of blood flow during interventions and means of removal of debris or clot from the blood vessel.Type: ApplicationFiled: March 3, 2011Publication date: October 6, 2011Applicant: THE JOHN HOPKINS UNIVERSITYInventor: Lawrence Hofmann
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Patent number: 8032306Abstract: A computerized system and method for processing patient vital signs during blood product administration in a computerized healthcare environment is provided. A blood product to be administered to a patient is identified. The patient is identified. Vital signs for the patient are received during blood product administration by a healthcare provider and automatically, without user intervention, the vital signs for the patient are documented in a database.Type: GrantFiled: December 29, 2004Date of Patent: October 4, 2011Assignee: Cerner Innovation, Inc.Inventors: Arthur J. Hauck, Lori N. Cross, Jeffrey D. Fry
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Patent number: 8012116Abstract: We have developed a novel method of brain surface dialysis that reduces intracranial pressure and modifies movement of extracellular fluid in a rat model of brain injury. A chamber with a semipermeable membrane at the site of brain contact is perfused with a hyperosmolar solution (e.g. 15% dextran, inulin, hydroxyethyl starch). It is also capable of providing local brain cooling. In principle, osmotic forces draw water and small molecules from the injured brain into the dialysis chamber thereby reducing brain swelling. The dialysate does not move into the brain.Type: GrantFiled: August 18, 2008Date of Patent: September 6, 2011Inventors: Marc Ronald Del Bigio, Alexander Viktor Shulyakov
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Publication number: 20110208097Abstract: A device and method for carrying out a dialysis of a patient and a stimulation of said patient at the same time either during dialysis sessions, or between dialysis sessions or both.Type: ApplicationFiled: August 22, 2008Publication date: August 25, 2011Inventors: Stefan Farese, Dominik Uehlinger, Klaus Schonenberger, Felix Buhlmann
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Patent number: 8005622Abstract: The present invention relates to a system and method for safely transfusing blood to a patient in a computerized healthcare environment is provided. A blood product to be administered to a patient is identified and the patient is identified. A database containing a plurality of blood compatibility test results is accessed and it is determined whether the database contains a blood compatibility test result for the identified blood product and identified patient. If so, it is determined whether the test result indicates that the identified blood product is compatible for the identified patient.Type: GrantFiled: December 21, 2004Date of Patent: August 23, 2011Assignee: Cerner Innovation, Inc.Inventors: Arthur J. Hauck, Lori N. Cross, Jeffrey D. Fry
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Mitigating Thrombus Formation On Medical Devices By Influencing pH Microenvironment Near The Surface
Publication number: 20110093057Abstract: The present disclosure provides treatments of medical devices which inhibit thrombus formation. At least a portion of a substrate of a medical device includes a surface possessing a functionality and/or surface charge adapted to modulate the pH of the surface of the medical device, as well as the pH microenvironment near the surface of a medical device.Type: ApplicationFiled: March 16, 2010Publication date: April 21, 2011Inventors: Rachit Ohri, Phillip Blaskovich, Steven L. Bennett, Valentino Tramontano -
Patent number: 7871825Abstract: A test for diagnostic tests, particularly for testing blood prior to a transfusion is disclosed. The test element includes at least two test units for carrying out at least two tests. The test element is provided with a fixing means for fixing the test element.Type: GrantFiled: February 2, 2005Date of Patent: January 18, 2011Assignee: Medión Diagnostics AGInventor: Peter Schwind
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Patent number: 7833280Abstract: A device for inducing weight loss in a patient includes a tubular prosthesis self-expandable from a collapsed position in which the prosthesis has a first diameter to an expanded position in which the prosthesis has a second, larger, diameter. In a method for inducing weight loss, the prosthesis is placed in the collapsed position and inserted into a stomach of a patient. The prosthesis is allowed to self-expand from the collapsed position to the expanded position and into contact with the walls of the stomach, where it induces feelings of satiety and/or inhibits modulation of satiety-controlling factors such as Ghrelin.Type: GrantFiled: April 8, 2008Date of Patent: November 16, 2010Assignee: Barosense, Inc.Inventors: Richard S. Stack, Richard A. Glenn, Trevor J. Moody, Fred E. Silverstein, Nathan Every, William S. Eubanks, Jr.
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Patent number: 7824358Abstract: A heart assist device connection system comprises an inflow connector in fluid-tight communication with an inflow section of a heart assist device. The connector is configured to be releasably connected to an inlet extension inserted into a patient's ventricle. The connector has one or more recesses configured to match a protrusion on the inlet extension. The system also comprises an outflow connector in fluid communication with an outflow section of the heart assist device. The outflow connector is configured to be releasably connected to a conduit attached-to the patient's vasculature.Type: GrantFiled: July 22, 2004Date of Patent: November 2, 2010Assignee: Thoratec CorporationInventors: Christopher J. Cotter, Olivier C. Bataille
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Publication number: 20100256547Abstract: In a blood transfer chamber, a filter (4) is arranged at an outlet located on a bottom of the chamber. The filter is truncoconical with a vertically-disposed axis. The filter has a plurality of openings (13, 14) for fluid passage, a size of which openings increases gradually in an upwards direction going from bottom to top of the chamber. The filter is used in a venous air-blood separation chamber of a dialysis set. The invention enables a reduction of a risk of hemolysis during treatment as well as a reduction of the risk of formation of air bubble retention in the filter during a priming stage.Type: ApplicationFiled: December 1, 2006Publication date: October 7, 2010Applicant: GAMBRO LUNDIA ABInventors: Francesco Ribolzi, Luca Caleffi, Ranko Sakota, Giuseppe Franzoni
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Patent number: 7794420Abstract: A process for treating the hemorrhage fluids of a patient at the time of a surgical procedure with the aim of carrying out an autotransfusion, includes a stage for recovering the hemorrhage fluids with simultaneous introduction of agents such as anticoagulant and/or diluting agents, at least one stage for the mechanical separation/concentration of this hemodiluted hemorrhage fluid in order to concentrate its content in red blood cells and partially purify it, this phase being collected in a sterile manner so as to be fit for injecting back to the patient. Also described is the related device.Type: GrantFiled: August 4, 2005Date of Patent: September 14, 2010Assignee: Direction et Priorites SAInventors: Philippe Perovitch, Francis Gadrat, Bertrand Chastenet
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Patent number: 7788038Abstract: The invention comprises a patient information server device which automatically accumulates together with time information: biological information detected by a bedside monitoring device of a patient or a biological-measuring device; biological information and device information detected by a blood purification device which treats a blood sample taken from the patient; and blood information detected by a circulating blood volume measuring device that detects blood information about a circulating blood sample taken from the patient. A client device simultaneously and chronologically displays or records the patient information stored in the patient information server device. Through this arrangement, it is possible to obtain on a real time basis the biological information of a human body such as a patient's body, and the device information, for example, of a blood treating device.Type: GrantFiled: December 27, 2001Date of Patent: August 31, 2010Assignee: Koninklijke Philips Electronics N.V.Inventors: Shuzo Oshita, Yasuhiro Kuroda, Toshiya Okahisa, Yoshiaki Ohnishi, Noriko Okumura
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Publication number: 20100196426Abstract: The presently disclosed subject matter is directed to methods of aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a subject by detecting a biomarker in microvesicles isolated from a biological sample from the subject.Type: ApplicationFiled: January 28, 2010Publication date: August 5, 2010Applicant: THE GENERAL HOSPITAL CORPORATIONInventors: Johan Karl Olov Skog, Xandra O. Breakefield, Dennis Brown, Kevin C. Miranda, Leileata M. Russo
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Patent number: 7762976Abstract: An apparatus for extracorporeal oxygenation of a patient's blood during cardiopulmonary bypass surgery. The apparatus comprises a bubble sensor, arranged at or connected to a venous line, for detecting bubbles in the venous blood received from the patient. When air bubbles are detected, a second pump is activated to draw air from an air chamber provided in an air filter connected to the venous line and arranged downstream of the bubble sensor. A first pump draws the blood from the air filter and supplies the blood to an oxygenator and to the patient via an arterial line.Type: GrantFiled: January 20, 2005Date of Patent: July 27, 2010Assignee: Sorin Group Deutschland GmbHInventors: Johann Schreyer, Erwin Knott, Andreas Hahn
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Patent number: 7748275Abstract: A pressure sensor for an extracorporeal circulating circuit includes a liquid chamber, a pressure measuring means, and a liquid flow path. The liquid chamber includes a reference surface not deformed by a pressure in the extracorporeal circulating circuit, a deforming surface disposed separated from the reference surface and deformed at least partially by a pressure in the extracorporeal circulating circuit, a first connection surface that joins the deforming surface with the reference surface to form a closed liquid-tight space inside them and is not deformed by a pressure in the extracorporeal circulating circuit, a liquid inflowing port provided in the side surface of the first connection surface, and a liquid outflowing port disposed away by ½ to less than one round from the inflowing port in the flowing direction of liquid introduced along the inner periphery of the side surface of the first connection surface.Type: GrantFiled: April 18, 2007Date of Patent: July 6, 2010Assignee: Asahi Kasei Kuraray Medical Co., Ltd.Inventors: Masaaki Kouda, Kengo Kobayashi
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Patent number: 7745106Abstract: Methods and devices for preparing a solid-fibrin web are provided. One method may include drawing blood from a patient, separating plasma from the blood, contacting the plasma with a calcium-coagulation activator and concurrently coagulating and axially centrifuging the plasma to form the solid-fibrin web. The solid-fibrin web may be suitable for regenerating body tissue in a living organism. Devices used in the methods may also be provided.Type: GrantFiled: June 26, 2003Date of Patent: June 29, 2010Assignee: Cascade Medical Enterprises, LLCInventors: Roberto C. Beretta, Nicholas A. Grippi
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Publication number: 20100130905Abstract: This invention relates to a method for checking the correct coupling of an adding device to a therapeutic appliance, which includes an extracorporeal circuit with which the adding device is connected such that a drug can be introduced into the extracorporeal circuit by means of the adding device during operation of the therapeutic appliance, wherein the adding device is coupled to the extracorporeal circuit on the suction side of a pump disposed in the extracorporeal circuit, wherein a portion in the region of negative pressure of the extracorporeal circuit in connection with a portion of the adding device is closed with respect to the other parts of the extracorporeal circuit, and wherein the pressure in this closed portion is varied and measured.Type: ApplicationFiled: May 13, 2008Publication date: May 27, 2010Inventors: Thomas Nürnberger, Marco Blasek, Peter Klöffel
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Publication number: 20100087773Abstract: The present invention relates to a device for circulating a body fluid in a body of a living organism, especially to support the heart and/or circulation of the living organism, comprising a catheter device which has at least one inlet portion to take up the body fluid at at least one first location within the body of the living organism, at least one outlet portion some distance from the at least one inlet portion to discharge the body fluid at at least one second location some distance from the at least one first location within the body of the living organism and a pump device for directed transport of the body fluid between the at least one inlet portion and the at least one outlet portion of the catheter device; and a valve arrangement coupled to the catheter device for controlled uptake of the body fluid as a function of operation of the pump device at the at least one inlet portion of the catheter device and controlled discharge of the body fluid at the at least one outlet portion of the catheter devicType: ApplicationFiled: March 17, 2008Publication date: April 8, 2010Inventor: Markus Ferrari
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Patent number: 7384416Abstract: A biological fluid collection system including a collecting device, a collecting container, a first channel connecting the two, a sampling bag, a second channel connecting the sampling bag and the first tube and at least one substantially irreversible closure device in an open position on at least the first or second channel. The biological fluid may be blood. A method of collecting biological fluid such as blood using the system so that fluid in the sampling bag is substantially irreversibly prevented from entering the collecting container.Type: GrantFiled: August 12, 2002Date of Patent: June 10, 2008Assignee: MacopharmaInventors: Francis Goudaliez, Thierry Verpoort
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Patent number: 7354454Abstract: A device for inducing weight loss in a patient includes a tubular prosthesis self-expandable from a collapsed position in which the prosthesis has a first diameter to an expanded position in which the prosthesis has a second, larger, diameter. In a method for inducing weight loss, the prosthesis is placed in the collapsed position and inserted into a stomach of a patient. The prosthesis is allowed to self-expand from the collapsed position to the expanded position and into contact with the walls of the stomach, where it induces feelings of satiety and/or inhibits modulation of satiety-controlling factors such as Ghrelin.Type: GrantFiled: July 16, 2004Date of Patent: April 8, 2008Assignee: Synecor, LLCInventors: Richard S. Stack, Richard A. Glenn, Trevor J. Moody, Fred E. Silverstein, Nathan Every, William S. Eubanks, Jr.