Abstract: The present application is generally directed to systems, methods, and devices for diagnostics for sensing and/or identifying pathogens, genomic materials, proteins, and/or other small molecules or biomarkers. In some implementations, a small footprint low cost device provides rapid and robust sensing and identification. Such a device may utilize microfluidics, biochemistry, and electronics to detect one or more targets at once in the field and closer to or at the point of care. In some implementations, the systems and methods herein implement a reader device, an assay cartridge, and a mobile or external device configured to receive abiological sample, test the biological sample, and provide test results to a patient or user associated with the patient. The test results may be packaged with additional information, including symptoms suffered by the patient, a diagnosis, and follow-up instructions.

Abstract: A medication and identification information transfer system is provided that includes a primary medication container, a secondary medication container, a secondary container label and a medication information transfer apparatus. The medication information transfer apparatus, when coupled to the primary medication container, can transfer information indicative of the contents of the primary medication container to a medication delivery device such as an intelligent injection site. The medication information transfer apparatus has a shape and size enabling it to be connected to an adapter for removal of medication from the primary medication container which enables transfer of the medication to a secondary container while simultaneously transferring information about the medication in the primary medication container to the injection site. In some implementations, the medication injection site can be placed on a fluid delivery line for infusion into a patient.

Abstract: Techniques for liquid cooling interfaces with rotatable connector assemblies are disclosed. In one embodiment, a collar contacts flanges on two components of a connector assembly, preventing them from separating. In another embodiment, a housing is positioned around a stem component. The stem component has a gap between a top part and a bottom part held apart by pillars, allowing water to flow to a tubing fitting connected to the housing. A retainer on top of the stem component holds the housing in place. In yet another embodiment, an internal retainer holds a housing component in place over a stem. Other embodiments are disclosed.

Abstract: A catheter drainage member (112) configured to be attached to a catheter tube (116), the drainage member comprising: body (115) having an inner surface (114); a well (120) defined by the inner surface of the body, the well configured to receive the catheter tube and an adhesive (122); and wherein the well is configured to selectively distribute the adhesive between the inner surface and the tube.

Abstract: Devices and methods for providing respiratory therapy are disclosed. One device includes a first lumen, a second lumen, and a bridge with at least one opening. The first lumen has a first inlet end to receive a first flow of breathing gas, a first outlet end to deliver the first flow, and a first bend between the first inlet end and the first outlet end. The second lumen has a second inlet end to receive a second flow of breathing gas, a second outlet end to deliver the second flow, and a second bend between the second inlet end and the second outlet end. The bridge separates the first lumen and the second lumen, attaches to the first lumen at the first bend and the second lumen at the second bend, and is configured to maintain the first flow of breathing gas separate from the second flow of breathing gas.

Abstract: A disinfecting connector of a dialysis system, including: a disinfecting chamber positioned within an internal lumen of the disinfecting connector, including: at least one barrier between the internal lumen and a tube connected to the disinfecting connector; a disinfecting material that is approved for usage inside the body; wherein penetration of a second connector through the at least one barrier causes or allows flow of said disinfecting material into the second connector in an amount and surface coverage sufficient disinfects a flow path between the second connector and the tube.

Abstract: Fluid connector assemblies that seal off fluid paths in the respective connectors are disclosed. When connectors of a fluid connector assembly are connected to each other, respective compressible members in the connectors are displaced, allowing downstream fluid passage through the fluid connector assembly. The connectors maintain a connection by a snap mechanism that provides a threshold retention force. When an external force greater than the threshold force is applied to the fluid connector assembly, the snap mechanism may no longer maintain the connectors together, causing the connectors to decouple from each other. However, each of the compressible members can return to their respective original positions and shapes to seal off respective fluid paths in the connectors, thus preventing further downstream and upstream flow through the fluid connector assembly and limiting or preventing fluid loss.

Abstract: Disclosed is a convenient joining of tubing in a secure, leak-free connection, suitable for aseptic fluid transfer, wherein two holders each have a channel designed to house tubing and each holder has a mating surface at one end of the channel. The ends of the respective tubing closest to the mating surfaces are fitted with male and female hollow connectors. Tape is attached to the region of the connectors near the tubing and/or to the tubing itself. After the holders are joined, the ends of the tape are pulled to advance the male and female connectors to mate and form a secure connection.

Abstract: This invention provides a system and method for sterilizing an ISO 594 female Luer fitting and an attached catheter using UV light. An optical plug can be inserted into a female Luer fitting, and UV-C light or a combination of UV-C and UV-A light can be radiated through the optical plug and into the female Luer fitting and attached catheter, thereby sterilizing the fitting and catheter. A sterilizer device can be used to hold the female Luer fitting and catheter, with an optical plug inserted into the female Luer fitting. The sterilizer device can include a UV light source that radiates UV light through the optical plug and into the female Luer fitting and attached catheter. A protective cover can be placed over the optical plug before inserting the optical plug into the female Luer fitting. The protective cover can be disposable.

Abstract: Fluid connector systems including first and second connector portions couplable together to form a fluid pathway therethrough and can resist separation or permit separation as desired. A connector portion can include a connector housing and a cover portion. The connector housing includes a connector body and an engagement portion. The connector body defines a tubing opening and a mating opening. The connector body defines a flow path between the tubing opening and the mating opening. The engagement portion at least partially surrounds the connector body. The engagement portion defines an engagement lip extending radially toward the connector body and is configured to releasably engage the connector housing. The flow path includes at least one portion that is normal to the engagement portion. Fluid flow through the flow path exerts a normal force on the connector housing and prevent release of the connector housing with the mating connector portion.

Abstract: A sterile connector includes a first section of tubing with a first end portion to be connected to a second end portion of a second section of tubing and/or another counterpart to establish fluid communication. An axial protrusion extends away from the first end portion of the first section of tubing in an axial direction, and a separation layer closes off an inside of the section of tubing. The separation layer has a predetermined breaking site, and the axial protrusion is connected pivotally to the first end portion of the first section of tubing to pivot from a first position to a second position when engaged with a second axial protrusion and/or with the other counterpart and is coupled to the separation layer to exert a breaking force on the separation layer in the second position.

Abstract: The present invention relates to an apparatus for providing a dialysis solution and preferably a peritoneal dialysis solution comprising a reception container that can accommodate a solution volume that is intended for at least two treatments, wherein the apparatus has a plurality of extraction ports for extracting the dialysis solution from the reception container.

Abstract: A medical fluid suspension generating apparatus includes a Venturi-agitating tip assembly, a source of pressurized chemical solution, a source of a medical solution, and a dual lumen catheter connecting the Venturi-agitating tip assembly to the source of pressurized chemical solution and the source of the medical solution.

Abstract: A flow controller having an internal tubing is provided. The flow controller may include an upper housing having a plurality of graduations, a lower housing engaged with and slidably coupled to the lower housing, and a cavity defined between the upper and lower housings for accommodating at least a portion of internal tubing. The flow controller may further include a flexible clamp having an upper section mounted in the upper housing and a lower section slidably disposed in the lower housing. The upper and lower housings may be slidably coupled relative to each other to transition the internal tubing from (i) an open position where a lumen of the internal tubing is uncompressed by the flexible clamp to (ii) a closed position where the lumen of the tubing is at least partially constricted by the flexible clamp.

Abstract: A connector includes an outer housing defining a lumen, a first male coupler mateable with a needle-free valve and positioned at a first end of the outer housing, a second male coupler positioned at a second end of the outer housing, a valve system to control fluid flow through the lumen, and an actuator movable within the outer housing between a first position and a second position. A pinch clamp of the connector operates to selectively deflect locking fingers of the actuator from a locked position to a movement position to selectively enable or prevent movement of the actuator from the first position to the second position. The actuator, based on its positioning in the first or second position, causes the valve system to be in a closed state or an open state and blocks or allows the first coupler to couple with the needle-free valve.

Abstract: A medical connector includes: a housing comprising a male connector attachment/detachment part, the housing defining a liquid flow path; and a valve that is vertically movable with respect to the housing between a closed position for closing the male connector attachment/detachment part, and an open position in which a flow path in a male connector communicates with the liquid flow path, by the valve being pressed down from the closed position by the male connector against a biasing force. The valve comprises a head portion that closes the male connector attachment/detachment part when the valve is at the closed position, and a body portion that is connected to a bottom end of the head portion and receives the biasing force. A Young's modulus of the body portion is larger than a Young's modulus of the head portion.

Abstract: A portable enteral feeding apparatus includes a pouch which defines a reservoir for enteral fluid and having an outlet for delivery of enteral fluid from the pouch. An outlet spout has a pouch spigot connected to the pouch outlet and a connector spigot which is adapted for mounting of a connector shaft, in one case a cross fit shaft of an ENFit connector. A valve is mounted to the spout. The connector spigot has a mounting structure for mounting a connector shaft of a PEG feeding system to the connector spigot only when the connector shaft is extended through the valve. An interlock prevents fixing of a connector shaft to the connector spigot if the connector shaft is not extended through the valve.

Abstract: A pinch valve having a clamping member (300) mounted between two side walls (110) of a valve housing, the side walls extending parallel to a hose guide axis and to a plunger guide axis. Each of the side walls has a step (112) extending parallel to the hose guide axis and recessing with respect to the advancing direction of the plunger. The clamping jaws (320) of the pinch valve, upon displacement of the clamping member (300), move over the steps (112) with their outer sides, which face away from the hose guide, bearing against the side walls (110).

Abstract: A medium connector including a passage configured to allow for the flow of medium, and a multi-portion engagement surface positioned about the passage. The multi-portion engagement surface includes a first surface portion, and a second surface portion. The first surface portion is configured to provide an interference fit with a corresponding sealing surface of a mating connector. The second surface portion is configured to provide a clearance fit with the corresponding sealing surface of the mating connector. The ratio of the first surface portion and the second surface portion is selected to regulate an engagement force between the medium connector and the mating connector.

Abstract: A system for facilitating instrument delivery through a peripheral intravenous catheter (“PIVC”) may include a catheter assembly having a catheter adapter, an extension tube extending from a side port of the catheter adapter, a septum disposed in a lumen of the catheter adapter, and a PIVC extending distally from the catheter adapter. The septum may include a first piece and a second piece and may be least partially disposed within a canister. The system may include an extension set, which may include a distal end and a proximal end. The distal end may include a distal connector and a rigid tube. The proximal end may include a proximal connector. The distal connector may be coupled to the proximal end of the catheter adapter. The rigid tube may penetrate the septum in response to the distal connector being coupled to the proximal end of the catheter adapter.

Abstract: A medical female connector (10) for controlling a fluid flow is disclosed, as well as a method for its manufacturing, and medical devices including such a female connector. A tubular plunger (40) and a flexible valve member (60) are inserted into a housing (20). A distal end (42) of the plunger (40) is located at a distance proximally from the distal end (22) of the housing (20). In a flow stop configuration, the flexible valve member (60) seals a flow path (44) through the tubular plunger (40). In a flow configuration, the valve member (60) is compressed by a male connector (90) and deformed by the plunger (40) to allow a fluid flow through the plunger (40). A frusto-conical female sealing surface (24) is arranged to form a seal with the male connector (90). An entrance opening (25) of the housing (20) presents a diameter equal to or larger than the maximum diameter (d1) of the female sealing surface (24).

Abstract: Some embodiments disclosed herein relate to medical connectors with a housing comprising a proximal body member and a base member that form an internal cavity with a proximal abutment surface. An elastomeric seal without a guide member is positioned within the internal cavity. A rigid, hollow elongated portion is located within the internal cavity such that in an open configuration, a tip of the elongated portion is more proximal than a proximal surface of the elastomeric seal.

Abstract: A method for producing a composition, the method being for producing a composition using a stirring device provided with a stirring tank and a stirrer, includes a mixing step of charging a resin, an acid generator, and a solvent into the stirring tank, and a stirring step of stirring the mixture accommodated in the stirring tank, using the stirrer, in which a ratio c of a content of the acid generator to a total mass of the mixture is 0.3% to 2.5% by mass, the stirrer is provided with a rotatable stirring shaft, a plurality of support parts attached to the stirring shaft, and a plurality of stirring elements attached to each of end parts of the plurality of support parts, the shape and the arrangement of the stirring elements are specified, and the positions of the plurality of stirring elements are specified so as to satisfy a specific Expression (1).

Abstract: Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device, removing a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device, and rotating a locking clip on the first aseptic coupling device to compress a first seal member of the first aseptic coupling device with a second seal member of the second aseptic coupling device to form a sterile fluid passageway.

Abstract: This document describes fluid handling couplings. For example, this document describes fluid handling couplings that include manually openable valves and that are configured for aseptic fluid handling usage. In some embodiments, the valves are manually openable by rotation of a collar of the fluid handling couplings.

Abstract: A coupling member for a closed fluid transfer system includes a housing having a fluid connection and a coupling side. The housing includes a longitudinal axis extending from the fluid connection toward the coupling side and a spike having a fluid opening. The fluid opening is arranged in an end portion of the spike facing the coupling side. A sealing member receptacle is arranged in the housing on the coupling side, and a sealing member is arranged in the sealing member receptacle. The housing includes a housing portion that at least partially surrounds the sealing member receptacle and a threaded portion. The coupling housing with the sealing member is guided by a guiding structure and movable in the direction of the longitudinal axis via the threaded portion between a position with maximum distance to the fluid connection and a position with minimum distance to the fluid connection.

Abstract: A valve including an antimicrobial agent can be used with needleless access connectors. The valve can have an insert that includes an antimicrobial coating thereon and/or the valve can have physical features, such as a series of tunnels or groves or a patterned surface, containing an antimicrobial formulation and/or the valve can be made of a material that includes an antimicrobial agent.

Abstract: Fluid connector systems including first and second connector portions couplable together to form a fluid pathway therethrough, and can resist fluid flow through the connector when the connector portions are separated from each other. A connector portion can include a connector housing, a luer portion, and a deformable valve member. The deformable valve member is disposed within the connector housing and includes a spherical portion extending partially through a valve opening of the connector housing. The spherical portion defines a slit, and the deformable valve member is configured to selectively prevent fluid flow from the housing volume through the valve opening and to deform to expand the slit and permit fluid flow from the housing volume through the valve opening.

Abstract: A device for connection to a medical connector, the device includes a cap, a container and a peelable seal. The cap configured to define a chamber to contain an absorbent material and disinfectant or antimicrobial agent. The cap includes one or more threads adapted to engage with a female luer connector. The cap is adapted to engage a male luer connector in a press-fit connection. The peelable seal prevents the disinfectant or the antimicrobial agent from exiting the chamber.

Abstract: A catheter for positioning a guidewire across an occluded portion of a vessel includes an elongate catheter body, an integrated rotatable distal tip, a proximal handle region, and a catheter lumen extending through the elongate catheter body. The elongate body has a distal region configured to be bent to a set angle. The integrated rotatable distal tip includes one or more channeled flutes extending around the distal tip that are configured to be rotated in a first direction to dissect tissue and a second direction for bluntly contacting tissue. A proximal handle region includes a control for rotating the distal tip in either the first or second directions. The catheter lumen is configured to pass a guidewire.

Abstract: Disclosed embodiments of introducer devices provide hemostatic sealing and allow a delivery catheter to be inserted through the introducer seals without the use of a separate loader device that covers a medical device that is mounted on the catheter. Some disclosed introducers comprise a housing, a distal sheath extending distally from the housing and adapted to be inserted into a patient's vasculature, a distal hemostatic seal mounted within the housing and a proximal hemostatic seal mounted within the housing, and a slidable tube positioned within the housing that is movable longitudinally relative to the distal hemostatic seal between a proximal position and a distal position, wherein in the proximal position a distal end of the tube is positioned proximal to the distal hemostatic seal with the distal hemostatic seal closed, and wherein in the distal position the distal end of the tube extends through the distal hemostatic seal.

Abstract: A syringe assembly includes (1) a syringe barrel defining a chamber; (2) a plunger mounted in the chamber and moveable with respect to the barrel; and (3) a cap assembly containing a cap and an absorbent material is removably attached to the plunger. A strip package includes at least two cap assemblies. Each of the cap assemblies includes a cap holder and an antiseptic cap positioned in the cap holder. The antiseptic cap includes a sidewall defining a chamber and an antiseptic substance within the chamber. A strip extends over at least two cap assemblies. The strip includes a first seal engaged to the cap holder and a second seal engaged to the antiseptic cap.

Abstract: Various aspects of the subject disclosure relate to a compounder system having a cartridge that includes fluid pathways controllable by valves of the cartridge. A pump component within the cartridge is actuable to move fluid through the controllable fluid pathways. The cartridge includes a needleless fluid port and a needleless vent port for fluid coupling to a vial via a vial puck. The vial puck includes corresponding needleless fluid and vent ports and a cannula. The cannula is extendible, by insertion of a protrusion on the cartridge into a shaft of the vial puck, into the vial to couple the vial to the needleless fluid and vent ports.

Abstract: A medical connector for minimizing discomfort to a patient may include a substantially rigid inner body and a flexible outer body having a patient interfacing surface and coupled to at least a portion of the substantially rigid inner body. The patient interfacing surface may include a cushion material. The cushion material may be interposed between the substantially rigid inner body and the patient's skin when the medical connector is attached to the patient.

Abstract: A medical connector can include a body having a fluid path with an inlet port, an outlet port, a luer portion, and a post extending through a fluid path. An arm having a latch member is coupled to the body to engage a ridge or thread on an exterior surface of a reciprocal connector. The arm may also include an extension. When the connector is in an open position, the latch member restricts retraction of the reciprocal connector from the outlet port. A seal is coupled to the body and includes a flap extending across the outlet port or a bellows to compress along an axis. In a closed position, the post restricts flow through the luer portion. In an open position, the post permits flow through the luer portion.

Abstract: A connector is disclosed that includes comprising a body having a tubing portion, a luer portion axially opposite the tubing portion and connected thereto, and an inner circumferential surface defining an internal bore of the connector. The inner circumferential surface extends axially between the tubing portion and the luer portion, and the internal bore being is in fluid communication with the tubing portion and the luer portion. The inner circumferential surface includes a plurality of splines extending axially along a length of the inner circumferential surface in the tubing portion of the connector. The inner circumferential surface is configured to engage an external surface of a tubing in a coupled configuration. In the coupled configuration edges of the splines grip and engage the external surface of the tubing to retain the tubing in the body.

Abstract: A coupling system for a closed fluid transfer system includes a coupling member that features a coupling member housing. The coupling member housing includes a housing portion that at least partially surrounds a sealing member receptacle in an axial direction with respect to the longitudinal axis and which includes a coupling member housing threaded portion on the inner surface facing the sealing member. The coupling system also includes a mating coupling member for coupling with the coupling member. The mating coupling member includes a mating coupling member housing that has a mating coupling member guiding structure. The coupling member housing threaded portion of the coupling member is configured such that the mating coupling member guiding structure and the sealing member receptacle structure are jointly and movably guided, in particular in a predetermined positional relation to each other, by the coupling member housing threaded portion.

Abstract: A venous access port assembly having a base, a peripheral surface, and a septum. The base defines an interior reservoir. The peripheral surface includes integrally molded X-ray discernable indicia identifying that the assembly is rated for power injection. The X-ray discernable indicia may extend through a height of the peripheral surface from a top surface to a bottom surface thereof. According to one aspect, the peripheral surface may be formed from X-ray discernable material, and the X-ray discernable indicia may be formed from the X-ray discernable material, or they may be formed by voids in the X-ray discernable material. According to another aspect, the peripheral surface may be formed from a radiotransparent or radiolucent material and applied with a radiopaque agent, and the X-ray discernable indicia may be one or more voids in the radiopaque agent or may be portions of the peripheral surface applied with the radiopaque agent.

Abstract: A fluid path connector for a medical fluid delivery system, the fluid path connector including a first connector element comprising a body, a first lumen, a first flexible leg, and a second flexible leg, and a second connector element comprising a body defining an undercut, a second lumen, a channel defined in the body, and at least one sealing element positioned within the channel, in which the first flexible leg comprises a first flange and the second flexible leg comprises a second flange, and in which, upon engagement of the first connector element with the second connector element, the first flange and the second flange engage with the undercut of the body of the second connector element to prevent disengagement of the first connector element and the second connector element.

Abstract: Some embodiments disclosed herein relate to a medical connector having a backflow resistance module configured to prevent fluid from being drawn into the connector when a backflow inducing event occurs. In some embodiments, the backflow resistance module can include a variable-volume chamber configured to change in volume in response to a backflow-inducing event and a check valve configured to resist backflow. In some embodiments, the medical connector can include a fluid diverter configured to direct fluid flowing through the medical connector into the variable volume chamber to prevent fluid stagnation therein. In some embodiments, the medical connector includes a body member, a base member, a seal member, a support member, and a valve member.

Abstract: A robotic system and method are provided for transfer of fluid between a container accessible via a container-septum and a fluid transfer assembly accessible via a fluid transfer connector septum. The robotic system includes a controller and a manipulator controllable by the controller to manipulate at least one of the container and the fluid transfer assembly. The controller is configured to operate the manipulator to secure contact between the container-septum and the fluid transfer connector septum during at least a portion of the transfer of the fluid.

Abstract: A connection including a first profile having a first end and a first lumen, the first profile including a first polymeric material and a second profile having a second end and a second lumen, the second profile including a second polymeric material, a metal, or combination thereof, wherein the first end and the second end are coincidently welded via an ionized gas treatment.

Abstract: A needleless connector may include a housing having an inlet port, an outlet port, and an inner surface defining an internal cavity extending between the inlet and outlet ports, and a compressible valve reciprocally disposed within the internal cavity. In a closed state, a top section of a head portion of the compressible valve may have a planar shape configured to contact and seal against the inner surface of the housing. In an open state, where the compressible valve is subject to an axial force, the top section of the head portion may be lodged between two pinch points between opposing walls of an inwardly angled portion of the internal surface. Additionally, in the open state, the top section of the head portion may have a non-planar shape defining a fluid path extending at least partially between opposing walls on an outwardly angled portion of the internal surface.

Abstract: A syringe adapter includes a housing having a first end and a second end with the first end configured to be secured to a first container, a cannula having a first end and a second end with the second end positioned within the housing, and a collet having a first end and a second end with at least a portion of the collet received within the housing. The collet includes a body defining a passageway, a seal member received by the passageway, and an arcuate, resilient locking member connected to the body of the collet. The collet is movable from a first position where the locking member is open to receive a mating connector to a second position where radially outward movement of the locking member is restricted.

Abstract: Some embodiments disclosed herein relate to medical connectors with a housing comprising a proximal body member and a base member that form an internal cavity with a proximal abutment surface. An elastomeric seal without a guide member is positioned within the internal cavity. A rigid, hollow elongated portion is located within the internal cavity such that in an open configuration, a tip of the elongated portion is more proximal than a proximal surface of the elastomeric seal. A distal portion of the elastomeric seal is seated radially within a region surrounded by a plurality of longitudinally extending protrusions.

Abstract: Disclosed herein are catheter assemblies and methods thereof that address various aspects of at least the retrograde tunneling technique. The catheter assemblies include, but are not limited to, catheter assemblies configured for vascular access, catheter assemblies configured for priming, catheter assemblies configured for tunneling, and mechanisms for connecting catheter tubes to their respective catheter assemblies. The methods include, but are not limited to, priming, tunneling, and connecting catheter tubes to their respective catheter assemblies.

Abstract: A valve system comprises: a valve body; a valve cap; and a valve plug between the valve body and valve cap is compressed radially and axially, and a central bore extends wholly through the valve body and valve cap and partially through the valve plug. The valve system is welded to a packet which can contain a hair color formula. One or more of the packets are then used in a cartridge compatible with a dispensing device.

Abstract: A robotic system and method are provided for transfer of fluid between a container accessible via a container-septum and a fluid transfer assembly accessible via a fluid transfer connector septum. The robotic system includes a controller and a manipulator controllable by the controller to manipulate at least one of the container and the fluid transfer assembly. The controller is configured to operate the manipulator to secure contact between the container-septum and the fluid transfer connector septum during at least a portion of the transfer of the fluid.

Abstract: A disinfection tip is described for disinfecting a threaded connector of a syringe.

Abstract: A connection includes: a first profile having a first end, the first profile including a first polymeric material comprising a thermoset material; and a second profile having a second end, the second profile including a second polymeric material, a metal, or combination thereof, wherein the first end and the second end are coincidently bonded without a bonding material at an interface of the first end and the second end.