Abstract: Devices and methods used to obtain a core tissue samples are disclosed. The devices may be configured to drill into cortical bone and saw a hole into a bone lesion and/or bone marrow while obtaining the core tissue sample. The devices can include a motor and a transmission configured to rotate a trocar having a tip configured for drilling and an outer coax cannula having a cutting tip configured for sawing.

Abstract: The disclosure relates to a spray applicator system for accurately and precisely dosing liquid formulations, including vaccines and probiotic formulations, to caged avian animals. In particular, the disclosure relates to spray applicators, having improved acceptance by the avian animals, relative to more disruptive prior spray applicators. The disclosed automated caged spray applicator system is designed to attach to and function with automated poultry feeding systems, routinely used in poultry house settings.

Abstract: A method for readying a fluid sensor associated with a medical device includes attaching a flow restrictor to a fluid outlet of the fluid sensor. The fluid sensor includes a fluid channel, a fluid inlet at a first end of the fluid channel configured to couple to an outlet of an administrable fluid source, and the fluid outlet at a second end of the fluid channel. Fluid is delivered from the administrable fluid source to the fluid channel through the fluid inlet. A syringe actuation device including a force limiting device may be used to deliver the fluid. The fluid is pressurized in the fluid channel between the fluid inlet and the flow restrictor to wet an interior surface of the fluid channel with the fluid. The flow restrictor is removed from the fluid outlet.

Abstract: A marker system includes a biopsy apparatus having a cannula and a stylet. The cannula has a distal end, the stylet has a distal stylet tip, and the stylet is received in the cannula. A tissue marker is coupled to the distal stylet tip. The tissue marker is configured to be contacted by the distal end of the cannula. The tissue marker is detached from the stylet distal tip by either of a proximal movement of the stylet relative to the cannula or a distal movement of the cannula relative to the stylet.

Abstract: An implantable device has a body that is substantially rigid and has an imageable shape. The body is further bioabsorbable and may contain permanent metallic elements to aid in its imaging. When the device is implanted in a resected cavity in soft tissue, it can cause the cavity to conform substantially to a known imageable shape. The implantable device is further imageable due to its attenuation properties being different from those of soft tissue such that the boundaries of the tissue corresponding to the predetermined shape can be determined.

Abstract: A multiple dose syringe has a first valve defining a first valve opening pressure and a second valve defining a second valve opening pressure. A storage chamber in fluid communication with the second valve stores multiple doses of a substance therein and includes an outlet for dispensing multiple doses of the stored substance therethrough. A compression surface is movable between first and second positions and defines a compression chamber between the compression surface and the first valve. Movement of the compression surface in a direction from the first position toward the second position dispenses substance in the compression chamber through the first valve and out of the syringe. Movement of the compression surface in a direction from the second position toward the first position causes substance to flow from the storage chamber through the second valve and into the compression chamber.

Abstract: Provided are a package of a mounting jig mounted balloon and a balloon mounting method capable of reducing the burden of an operation of mounting a balloon in an insertion part of an endoscope. A balloon includes a first sleeve part, a second sleeve part, and a balloon main body. A balloon mounting jig is formed to be folded flat in a hollow cylindrical shape, and has a main body having a first opening part and a second opening part, and a pair of guide pieces that is provided on the second opening part and face each other. A package of a mounting jig mounted balloon is configured so that the balloon mounting jig and the balloon are contained in the container, in which in the container, the balloon is disposed so that the second sleeve part is disposed inside the folded balloon main body and the pair of guide pieces is disposed inside the first sleeve part and the second sleeve part.

Abstract: A marker delivery device is described and claims. The marker delivery device is used to implant a detectable marker after a biopsy procedure is performed. The marker delivery device includes a cannula comprising a distal end and a marker exit positioned proximate the distal end; an actuator movable to a marker deployment position, wherein the actuator is slidably disposed within the cannula; and a retainment mechanism configured to retain the actuator in the deployment position.

Abstract: The present invention is a big step forward from the traditional method of drawing a tattoo on human skin, which requires a skilled artist to use the tattoo machine comprising a single needle to deposit ink single injection by single injection. The disclosed invention comprises of a customizable needle substrate, a charging unit, an image processor unit, an ink roller and may be an injection device, to print a permanent multicolor image on the human skin using an instantaneous method of injecting the ink at desired depth in a human skin, resulting in an image or tattoo on the human skin. The method also causes less pain in comparison to the traditional method of tattoo making, as the process is relatively quick. Furthermore, the disclosed invention reduces the dependency on a skilled artist to draw a tattoo on the human skin.

Abstract: An animal ear tag is anchorable on an animal's ear by means of a dome and has a housing enclosing an electronics assembly and a battery, and a panel surface on which identification data relating to the animal are directly visible in clearly legible characters, wherein the panel surface is located below the housing when the ear tag is placed on the animal. The center of gravity of the housing and of the parts enclosed by the latter lies inside an area protruding downwards from the spike axis, which area is not higher and 2 cm and, in the horizontal lying normal to the spike axis, is not wider than 1 cm.

Abstract: A surgical tack applier comprising a handle assembly, an inner tube, a plurality of fasteners and a solution is disclosed. The handle assembly includes an actuator associated therewith. The inner tube extends distally from the handle assembly and defines a longitudinal axis. The inner tube is rotatable about the longitudinal axis. The plurality of fasteners are disposed at least partially within the inner tube and are selectively ejectable therefrom. The solution is disposed within the inner tube and is dispensable through a distal opening of the inner tube.

Abstract: A microneedle puncture instrument includes a pinch section including a first pinch element and a second pinch element arrayed in an array direction and configured to individually pinch the skin in a pinch direction, which intersects with the array direction, the first pinch element and the second pinch element being connected to each other with a distance therebetween maintained within a predetermined range; and a puncture section configured to puncture the skin while pinching the skin in the pinch direction at a position between the first pinch element and the second pinch element in the array direction, the puncture section including a microneedle for puncturing the skin and a support portion that supports the microneedle.

Abstract: In conventional structures, a space between a dual cooling tank is vacuum insulated, and a cooling part is cooled via a highly thermally conductive material connected to an inner container. Such structures are affected by heat infiltrating into the highly thermally conductive material and the cooling part. For instance, in cases when liquid nitrogen is used as a coolant, it takes approximately 30 minutes for the temperature to reach ?120° C. Even in cases when a significant amount of time has been spent, the temperature only reaches approximately ?150° C., and thus falls significantly short of the temperature of liquid nitrogen, namely ?196° C.

Abstract: A medical device that may include an elongate member having a proximal end and a distal end, and a lumen disposed through the elongate member is disclosed. The medical device may also include an opening disposed at the distal end of the elongate member in communication with the lumen, and a pushing element disposed with the lumen. The medical device may also include at least one fiducial disposed within the lumen and distal to the pushing element, and a separating mechanism disposed at the distal end of the elongate member. The separating mechanism may be configured to apply a separating force to deploy the at least one fiducial.

Abstract: A capsule assembly for an endograft introducer is disclosed. The assembly comprises: a capsule retriever having a plug portion and a tail portion, the plug portion having a lead-in surface, the tail portion having an elongate body extending proximally from the plug portion to an end stop feature receiver; a capsule tube having an end stop feature at a proximal end thereof and terminating in a distal end, the end stop feature and the end stop receiver arranged such that proximal movement of the capsule tube relative to the plug portion is limited; and a capsule cavity inside the capsule tube, a proximal end of a prosthesis being receivable in the cavity. The capsule tube is slidably movable with respect to the capsule retriever to a position in which the distal end of the capsule tube is adjacent to the lead-in surface of the plug portion.

Abstract: The surgical instrument for sealing and/or cutting tissue includes a handle assembly and an end effector assembly operatively connected to the handle assembly. The end effector assembly includes first and second jaw members each including a jaw housing and an electrically conductive surface defining a plurality of bores and an adhesive applicator assembly disposed in one of the jaw members. The electrically conductive surfaces are configured to effect a tissue seal. The adhesive applicator assembly includes a platform defining a reservoir therein and a plurality of needles in communication with the reservoir. The platform is movable between a neutral position in which the plurality of needles are disposed within the jaw housing and an actuated position in which the plurality of needles extend through the respective plurality of bores defined in the electrically conductive surface.

Abstract: A tattooing apparatus, which have a tattoo needle traveling back and forth to a skin to allow a staining solution for tattoo contained in the apparatus to penetrate into the skin and thus to get a tattoo and which can adjust a concentration of the staining solution for tattoo, is disclosed. The tattooing apparatus includes a chamber pressure adjusting member to adjust a degree of opening and closing an inlet of a storing chamber in which the staining solution for tattoo is stored, thus to adjust a pressure in the storing chamber.

Abstract: A device and method for marking a treatment isocenter on a patient's body. One embodiment includes a base including alignment indicia, a marker disposed over the base and positioned relative to the indicia for marking the isocenter on the patient's body and an actuator for actuating the marker and causing a mark indicating the isocenter to be made on the patient's body. The actuator can include a button and a spring coupled to the marker. Compressing the actuator causes the marker to travel through an ink well prior to piercing the patient's skin.

Abstract: Provided, amongst other things, are dyes of formula II: wherein R1, R2, R3 and R4 are independently H or alkyl, so long as one or more is alkyl, and salts of the compound of formula II. Methods of making, inks, surgical markers and methods of marking tissue and the like are further provided.

Abstract: A delivery system, including: a material for storing molecules and/or nanoparticles by substantially binding said molecules and/or nanoparticles to said material; a means for applying an electric field to said material to release said molecules and/or nanoparticles; and a means for applying an ultrasonic signal to said material to transport said molecules and/or nanoparticles through said material to a surface for delivery to an entity.

Abstract: Embodiments of the invention are directed towards a medical device, method and system thereof for the placement or passage of patches, sutures, anchors, tags, tissue sensors and more particularly to a medical device for repairing female pelvic organ or tissue prolapsed region. The device may be used for the placement of stereotactic markers into tissue near joints or tumors for guidance during orthopedic or neurosurgical procedures.

Abstract: A device for characterizing a luminal dimension, such as the aortic annulus, has also been developed. These include a balloon or basket with sensing and transmitting elements for assessing two or three dimensional shape of lumens using a guide wire and catheter. Sheath introducer devices were developed for percutaneous delivery of bioprosthetic valves during various percutaneous procedures, such as TAVI. A marker needle dispenser for pre-marking anatomical features that are either desirable to target or desirable to avoid has been developed. The needle contains a central passage or lumen for loading marker and spacer material. These are characterized by specific spacing, color, shape or diagnostic imaging criteria to facilitate passage through and placement within the vasculature. Hemostatic stents or balloons are used to prevent bleeding and facilitate closure at sites for entry of catheters or introducer sheaths into luminal structures, especially for procedures such as TAVI through the subclavian artery.

Abstract: Embodiments provide apparatus and methods for producing markings in the skin. One embodiment provides an apparatus for marking the skin comprising a housing and reservoir for storing a skin colorant. An electrode is positioned within the housing so as to be electrically coupled to the colorant in the reservoir and is configured to be coupled to a current source and return electrode. A colorant applicator having at least one fluid pathway is coupled to a housing distal end. The applicator proximal end is positioned such that the fluid pathway is coupled with the reservoir. The applicator distal end applies colorant to the skin surface through the fluid pathway as the applicator is moved across the skin. The electrode delivers current from the current source to the skin to transport charged pigment elements of the colorant into the skin using an electromotive driving force to produce a marking in the skin.

Abstract: An intracorporeal marker delivery device includes a delivery tube which has a distal tip, a discharge orifice and an inner bore extending to the discharge orifice. A plug is releasably secured within the inner bore. The plug may itself serve as a marker, and may be the sole marker. Markers may be positioned proximal to the plug, and may be detectable by ultrasound, X-ray, magnetic resonance imaging, and other imaging devices, and may include bioactive elements.

Abstract: A marker delivery device is configured for deploying a tissue marker. The marker delivery device includes a handle having a chamber, and a cannula. According to one aspect, the cannula has a flexible portion formed by a slot arrangement having of a plurality of spaced-apart substantially parallel peripheral slots extending through the side wall of the cannula to the lumen. A marker introducer rod is movably disposed in the lumen of the cannula for deploying the mark, and has a flexible region that corresponds to the flexible portion of the cannula. According to another aspect, a retraction mechanism is mounted to the handle and is configured to facilitate a complete retraction of both the cannula and the marker introducer rod into the chamber of the housing of the handle upon an actuation of the retraction mechanism.

Abstract: A device for sampling biological tissue (1) to be used in a label for marking animals includes: a hollow needle (3) having a cutting edge (36) at one end, capable of sampling a biological tissue sample when the sampling device is inserted into the biological tissue; a fixation part (22) of the hollow needle, made as a single piece and including a tank (2) containing a chemical for processing a biological tissue sample, the base of the tank including a partition (211) that is punctured by the needle when a pressure is applied upon the insertion of the sampling device into the biological tissue. After puncturing the partition, the content of the tank flow into the hollow needle and contacts the recovered sample. The end of the hollow needle containing the sample can further be protected by a cap, and the sample remains easily accessible for further analysis.

Abstract: A localizing wire includes an anchor portion that can change shape from a collapsed shape to an expanded shape and thereby anchor within a tissue mass. The localizing wire has an exterior portion that can lie flat against the tissue mass. The localizing wire can be repositioned or withdrawn without the need for the reinsertion of an introducer.

Abstract: Described herein is a marking system for marking animals. The marking system may include a restraining device, a controller, and a marking device. The marking device includes a marking needle of fixed length comprising one or a plurality of needle tips; the restraining device is sized and configured for restraining an animal or animal body part thereof and oriented such that the marking device can make a mark on a substrate portion of the animal body part; and the controller is configured to control the position of the marking device and to make a mark on the substrate portion of the animal body part. Also described herein are media transfer assemblies for use in the disclosed marking system.

Abstract: Embodiments provide apparatus and methods for producing markings in the skin. One embodiment provides an apparatus for marking the skin comprising a housing and reservoir for storing a skin colorant. An electrode is positioned within the housing so as to be electrically coupled to the colorant in the reservoir and is configured to be coupled to a current source and return electrode. A colorant applicator having at least one fluid pathway is coupled to a housing distal end. The applicator proximal end is positioned such that the fluid pathway is coupled with the reservoir. The applicator distal end applies colorant to the skin surface through the fluid pathway as the applicator is moved across the skin. The electrode delivers current from the current source to the skin to transport charged pigment elements of the colorant into the skin using an electromotive driving force to produce a marking in the skin.

Abstract: A site marker delivery system is provided. The site mark delivery system includes an outer cannula having an open distal end. The outer cannula defines an inner lumen in which an inner cannula may be received. A marker is also positioned within the inner lumen of the outer cannula. The inner cannula further includes a trigger mechanism that when actuated injects the marker through the open distal end of the outer cannula into a biopsy site.

Abstract: A method and system for determining the orientation of a surgical tool with respect to a bone of a patient, and a device for positioning a sensor are disclosed. The bone has at least three predetermined reference locations.

Abstract: The present invention provides a method for labeling a living organism by laser engraving, the method comprising fixing the living organism to a fixation device, coating whole or a part of body surface of the living organism with a paint operable to react with a laser; and reacting the paint with the laser to make a label by color alteration of the paint.

Abstract: A device and method for subcutaneously implanting an identification chip into a domestic animal, the identification chip becoming relatively immobile once implanted.

Abstract: A biopsy device for delivering a biopsy marker to a biopsy site is disclosed. The biopsy device can include a marker deployer having a unitary endpiece disposed in a distal end of the cannula. The distal endpiece can be a molded component which includes a distal tip, a marker deployment ramp, and a marker engaging element that aids in retaining the marker in the cannula until the marker is meant to be deployed.

Abstract: The present invention provides a three section skin marking system combining target placement, lancing, marking, cleanup and protective bandaging comprising a positioning target, an ink application pad and a bandage pad, wherein the ink application pad is attached to the positioning target and the bandage pad is attached to the positioning target, wherein the positioning target is an appliqué with a top side and a bottom side and a peripheral border of material with a center portion of the appliqué removed and free of material, wherein the bottom side has an adhesive for adhering to skin of a patient; wherein the application pad comprises an absorbent pad surrounding micro-encapsulated or macro-encapsulated ink for marking the patient's skin; and wherein the bandage pad comprises an absorbent pad and an adhesive strip.

Abstract: An apparatus for implanting a locatable marker at a target site within a tissue mass comprises an insertion device and a marker introducer system that is received within the insertion device. The marker introducer system is anchored in a compressed tissue mass and a locatable marker is deployed from the introducer system after the tissue mass is decompressed.

Abstract: A localizing wire comprises an anchor portion that can change shape from a collapsed shape to an expanded shape and thereby anchor within a tissue mass. The localizing wire has an exterior portion that can lie flat against the tissue mass. The localizing wire can be repositioned or withdrawn without the need for the reinsertion of an introducer.

Abstract: A biopsy marker delivery device are described. The delivery device can include a relatively flexible hollow tube, a pushing member such as a push rod disposed for sliding with the tube, and at least one marker disposed in the tube. A marker blocking member is disposed distal of the distal most marker, and is disposed at least partially within the hollow tube to assist in preventing premature deployment of a marker from the hollow tube. A portion of the blocking member may disposed in the hollow tube, and another portion of the member may be operatively associated with a portion of the package such that when the marker delivery device is removed from the package, the member is removed from the marker delivery device.

Abstract: A marker delivery device includes an elongated delivery cannula which has a distal end section, an inner lumen and a discharge opening in the distal end section in communication with the inner lumen. At least one elongated fibrous marker body is slidably disposed within the inner lumen of the elongated delivery cannula. The at least one elongated fibrous marker body includes a plurality of bioabsorbable polymeric strands. The strands are compressed to a compressed configuration and bound together in the compressed configuration with a polymer binding agent prior to insertion into the elongated delivery cannula. A releasable plug is disposed within a distal portion of the inner lumen and distal to the at least one elongated fibrous marker body so as to at least partially occlude the discharge opening in the distal end section.

Abstract: A method is described for producing printed patches to provide a plurality of color markings and high-contrast markings as aligned arrangements of fiducial points. The printed color markings facilitate optical image processing and the printed high-contrast markings facilitate high-contrast image processing. These fiducial points enable a visible area of interest to be located by a person and associated with relevant high-contrast imaging data. This method includes providing a patch; printing at least one arrangement of color markings on the patch; and printing at least one arrangement of high-contrast markings on the patch. According to further features of certain embodiments the markings are aligned, can designate the same point, or can be disjointed.

Abstract: A localizing wire comprising an anchor portion that can change shape from a collapsed shape to an expanded shape and thereby anchor within a tissue mass. A localizing wire having an exterior portion that can lie flat against the tissue mass. A localizing wire that can be repositioned or withdrawn without the need for the reinsertion of an introducer.

Abstract: Described herein is a marking system for marking animals. The marking system comprises a restraining device, a controller, and a robot assembly wherein the robot assembly comprises a robotic arm, a marking device attached thereto, and one or more actuators for manipulating the robotic arm and marking with the marking device; the robot assembly and the restraining device are positioned in a fixed manner relative to one another; the restraining device is sized and configured for restraining an animal or animal body part thereof and oriented such that the marking device can make a mark on a substrate portion of the animal body part; and the controller is configured to control the position of the marking device and to make a mark on the substrate portion of the animal body part by actuating the one or more actuators. Also described herein are media transfer assemblies and animal restraints.

Abstract: An intracorporeal marker delivery device includes a delivery tube which has a distal tip, a discharge orifice and an inner bore extending to the discharge orifice. A plug is releasably secured within the inner bore. The plug may itself serve as a marker, and may be the sole marker. Markers may be positioned proximal to the plug, and may be detectable by ultrasound, X-ray, magnetic resonance imaging, and other imaging devices, and may include bioactive elements.

Abstract: A biopsy marker delivery device is described. The delivery device can include a relatively flexible hollow tube, a pushing member such as a push rod disposed for sliding with the tube, and at least one marker disposed in the tube. The inner surface of the tube can be configured to engage the marker at spaced apart locations on the outer surface of the marker.

Abstract: An intracorporeal marker delivery device includes a delivery tube which has a tapered, tissue penetrating distal tip, an inclined discharge orifice in the tapered distal tip and an inner bore extending to the orifice. A plurality of remotely detectable markers, which are formed at least in part of bioresorbable material, are slidably disposed within the inner bore. A plug having an inclined exposed surface, which is formed at least in part of bioresorbable material, is releasably secured within the inner bore of the delivery tube distal to the plurality of remotely detectable markers disposed therein to retain the plurality of remotely detectable markers within the inner bore. The plug is disposed at least in part within the inclined discharge orifice. A plunger is slidably disposed within the inner bore proximal to the plurality of remotely detectable markers.

Abstract: A localizing wire includes an anchor portion that can change shape from a collapsed shape to an expanded shape and thereby anchor within a tissue mass. The localizing wire has an exterior portion that can lie flat against the tissue mass. The localizing wire can be repositioned or withdrawn without the need for the reinsertion of an introducer.

Abstract: A delivery cannula for a site marker deployment device is disclosed. The delivery cannula includes a cannula having a tubular sidewall and at least one slot intersecting through the side wall. Each slot is sized to have a predetermined width so as to be configured to receive at least one filament of a site marker. When the site marker is inserted into the delivery cannula, at least a portion of the filament extends outwardly from the cannula and through the slot. A deployment system is also disclosed.

Abstract: The invention relates to a tool for placing a mark for animal marking, said mark combining by nesting: a male portion (2), including a rod defining a fitting axis and enabling the guidance of an awl (11) for piercing the skin of the animal, and a female portion (5), including a recess for engaging said rod. According to the invention, the tool includes a means for setting said awl (11) in rotation about said fitting axis.

Abstract: A self-contained, self-piercing, and side-expelling marking apparatus for percutaneously placing a imaging marker in a tissue mass.

Abstract: Scrub resistant inks and methods and apparatus for fabrication and use thereof are provided. Scrub-resistant ink compositions may include a dye for marking skin; and a solvent dissolving a marking effective amount of the dye, wherein the solvent comprises about 0.1 to about 90 percent of a polar aprotic solvent. Apparatus for marking patients may include an ink reservoir; an ink dispenser having a fluid connection to the ink reservoir to dispense the ink at a desired rate to mark a patient; and a scrub resistant ink disposed in the ink reservoir. Methods for forming scrub-resistant ink compositions may include providing a marking effective amount of a dye suitable for use in marking skin; and mixing the dye with a first solvent comprising 0.1% to 90% of a polar aprotic solvent. Methods of marking patients may include applying an ink as recited above to a body part of the patient.