Connector For Nerve Endings Patents (Class 606/152)
  • Patent number: 11065098
    Abstract: Provided is a medical fabric that is thin, and has both high tear strength and low water permeability. The medical fabric is characterized in that multifilament yarns having a total fineness of 7-80 dtex are disposed in the warp and weft, the single yarn fineness of at least one of the multifilament yarns among the warp and weft is 0.5 dtex or less, the twist factor A of the weft is 50-2,000, the thickness is 10-90 ?m, and the water permeability both before and after puncture by a needle is 300 cc/min/cm2 or less.
    Type: Grant
    Filed: January 18, 2016
    Date of Patent: July 20, 2021
    Assignee: Asahi Kasei Kabushiki Kaisha
    Inventors: Akihito Nakazawa, Tokio Okuno
  • Patent number: 11040125
    Abstract: The present invention relates to a neurotrophic factor carrier, particularly to a neurotrophic factor carrier wherein the neurotrophic factor is contained in a porous nerve conduit having micropores formed in microchannels, a method for preparing the same and a method for regenerating a nerve using the same, wherein the neurotrophic factor carrier prepared according to the present invention is applicable to in-vitro and in-vivo researches on nerves.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: June 22, 2021
    Assignee: Wiregene Co., Ltd.
    Inventors: Jung Keun Hyun, Jong-Wan Kim, Jun-Hyeog Jang, Min Soo Kim, Hong Sun Ahn
  • Patent number: 11040498
    Abstract: The present disclosure relates to an apparatus for manufacturing a nerve conduit, more particularly to an apparatus for manufacturing a porous nerve conduit using glass fibers whereby microchannels are formed using the space between the glass fibers and the defective rate and location-dependent variation of each nerve conduit can be minimized through uniform decompression during the manufacture. The nerve conduit manufactured according to the present disclosure can be manufactured to have various diameters and lengths to be applicable to in vitro and in vivo researches on nerves.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: June 22, 2021
    Assignee: RION CO., LTD.
    Inventors: Ki Woong Park, Ku Chan Chung, Jung Keun Hyun, Jong Wan Kim
  • Patent number: 10940235
    Abstract: A biocompatible nerve conduit for nerve re-generation, wherein a porous fiber tube is coated with a bioresorbable hydrogel, with the fibers being formed from a polymer that supports nerve regeneration by preferential adsorption of endogenous proteins and braided with pores in the range from 5 to 200 micrometers using a kink-resistant braiding pattern and the hydro gel coating material and thickness being selected to control the overall porosity, so that nutrients and oxygen can diffuse through said hydrogel coating but the infiltration of fibrous tissue through the coating is prevented.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: March 9, 2021
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Joachim B. Kohn, Basak Clements, Mindy Ezra Sadik
  • Patent number: 10908246
    Abstract: The present invention provides a method for three-dimensional reconstruction of fascicular structure of human peripheral nerve, which comprises the steps of: obtaining human peripheral nerve and preparing a peripheral nerve sample; immersing the peripheral nerve sample into a liquid; setting scan parameters of Micro-MRI, scanning the peripheral nerve sample by Micro-MRI, to acquire image data of the peripheral nerve sample in the liquid environment; and three-dimensional reconstructing a structural model of the peripheral nerve sample based on the image data. By means of the method according to the present invention, high-quality scanned images are obtained without destroying the morphology and physical and chemical properties of peripheral nerve, so as to obtain a precise three-dimensional visualization model of peripheral nerve fascicle.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: February 2, 2021
    Assignee: THE FIRST AFFILIATED HOSPITAL OF SUN YAT-SEN UNIVERSITY
    Inventors: Qingtang Zhu, Jian Qi, Liwei Yan, Zhi Yao, Xiaolin Liu
  • Patent number: 10842494
    Abstract: A nerve repair conduit configured to be secured on first and second portions of a selected nerve. The nerve repair conduit includes a polymeric body having a proximal end, a distal end, an exterior surface and an interior surface defining an interior lumen. In addition, the nerve conduit includes at least one drug reservoir to hold agent(s) that may facilitate nerve regeneration. The drugs diffuse from the drug reservoir(s) into the nerve repair conduit through an outlet (such as a hole or a semipermeable membrane) in proximity to the first and second portions of a selected nerve. The nerve repair conduit may be configured to deliver the agent(s) at a rate having substantially zero-order kinetics and/or at a constant rate over a selected period of time.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: November 24, 2020
    Assignee: University of Utah Research Foundation
    Inventors: Jayant P. Agarwal, Bruce Kent Gale, Himanshu Jayant Sant, Pratima Labroo, Jill Shea
  • Patent number: 10813643
    Abstract: The subject invention pertains to materials and methods for performing breast neurotization with allogeneic or autologous nerves in breast surgeries, such as reconstructive breast surgery. Certain embodiments of the methods comprise harvesting and implanting one or more allogeneic or autologous intercostal nerves 10 to 12 to one or more of the patient's intercostal nerves 2 and/or 3.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: October 27, 2020
    Assignee: AxoGen Corporation
    Inventor: Ivica Ducic
  • Patent number: 10792140
    Abstract: To increase the resistance to liquid and substance flow through a lumen of a tubular organ, a flexible apparatus is appended to an exterior wall of the tubular organ such that it only partially surrounds the tubular organ. Ultimately, tissue ingrowth through the apparatus integrates the apparatus into the wall of the tubular organ. When the apparatus is applied to tubular tissue, flow though the tubular tissue is restricted. The apparatus may also support an optional expandable component, e.g., a balloon-like element that can be selectively inflated and/or deflated to restrict the lumen of the tubular tissue by a desired degree.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: October 6, 2020
    Inventor: Claude Tihon
  • Patent number: 10772633
    Abstract: A nerve repair conduit configured to be secured on first and second portions of a selected nerve. The nerve repair conduit includes a polymeric body having a proximal end, a distal end, an exterior surface and an interior surface defining an interior lumen. In addition, the nerve conduit includes at least one drug reservoir to hold agent(s) that may, for example, facilitate nerve regeneration. The drugs diffuse from the drug reservoir(s) into the nerve repair conduit through an outlet (e.g., a semipermeable membrane) in proximity to the first and second portions of a selected nerve. The nerve repair conduit may be configured to deliver the agent(s) at a rate having substantially zero-order kinetics and/or at a constant rate over a selected period of time (e.g., at least 1 week).
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: September 15, 2020
    Assignee: University of Utah Research Foundation
    Inventors: Jayant P. Agarwal, Bruce Kent Gale, Himanshu Jayant Sant, Keng-Min Lin
  • Patent number: 10568988
    Abstract: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating select portions of a tissue matrix with a cross-linking agent and/or a proteolytic enzyme to produce a tissue matrix with variable mechanical and/or biological properties.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: February 25, 2020
    Assignee: LifeCell Corporation
    Inventors: Gary Monteiro, Christopher T. Wagner, Neil L. Rodriguez, Aubrey Irene Delossantos
  • Patent number: 10493186
    Abstract: An apparatus and system for providing reduced pressure to a defect in a nerve is disclosed. The apparatus comprises a nerve conduit having a generally tubular shape that has walls including a luminal wall surrounding the tissue site to contain fluids within a luminal space between the tissue site to contain fluids within a luminal space between the tissue site and the luminal wall. The apparatus further comprises a manifold having a porous body and a connector for receiving reduced pressure, wherein the manifold is positioned within the luminal space adjacent the tissue site to distribute the reduced pressure to the defect. Additionally, a method for providing reduced pressure to a defect in a nerve is disclosed that includes implanting the nerve conduit and manifold at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: December 3, 2019
    Assignee: KCI Licensing, Inc.
    Inventors: Larry D. Swain, Michael E. Manwaring, Braden King-Fung Leung, Douglas A. Cornet
  • Patent number: 10441304
    Abstract: A sizing forceps is provided for fixing a nerve in place, measuring the diameter of the nerve, and providing an efficient way to resect the nerve. A sizing forceps can have an upper and lower jaw with one or more aligned notches that form apertures for holding a nerve. The apertures can have predetermined sizes that can be used to measure the diameter of a nerve. A slicing slot in the upper and lower jaw allows a nerve within an aperture to be severed to obtain a non-frayed end.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: October 15, 2019
    Assignee: AxoGen Corporation
    Inventors: Curt Deister, Michael Raymond Orrico, Gregory Drach
  • Patent number: 10406346
    Abstract: A method and device for promoting healing of an injury in a living being are provided. Such method and device are based upon an injury covering portion, which portion comprises an electroactive polymer, such as poled polyvinylidine difluoride (PVDF) or a copolymer of PVDF. The electroactive polymer has either pyroelectric properties, piezoelectric properties, or both.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: September 10, 2019
    Assignee: UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA
    Inventors: Lisa A. Scott-Carnell, Emilie J. Siochi, Kam W. Leong
  • Patent number: 10363041
    Abstract: A nerve guidance conduit includes one or more guidance channels formed as porous polymeric structures. The guidance channels are within an outer tubular structure that includes randomly-oriented nanofibers. The guidance channels may have electrospun nanofibers on their inner and outer surfaces in a parallel alignment with the guidance channels. Such aligned nanofibers may also be present on the inner surface of the outer tubular structure. The outer surfaces of the guidance channels and the inner surface of the tubular structure define additional guidance channels. Such a nerve guidance conduit provides augmented surface areas for providing directional guidance and enhancing peripheral nerve regeneration. The structure also has the mechanical and nutrient transport requirements required over long regeneration periods.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: July 30, 2019
    Assignee: THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY
    Inventors: Xiaojun Yu, Munish B. Shah, Wei Chang
  • Patent number: 10219808
    Abstract: Aspects of the present disclosure are directed toward providing enhanced structural support to an organ. As may be implemented in accordance with one or more embodiments, an apparatus includes structure configured and arranged to partially encircle a tubular organ, having a semi-cylindrical shape with a tapered end and blunt end of the cylinder. A gap region provides a region of the organ that is unrestricted/unsupported. Struts/lattice facilitate ingrowth of tissue, and couple the apparatus to the organ, which allows the apparatus to provide support/restrict flow in the organ without necessarily coupling to any other structure (e.g., with the majority or all of the support provided via the apparatus as coupled onto and terminating on a sidewall of the tubular organ).
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: March 5, 2019
    Inventor: Claude Tihon
  • Patent number: 10004644
    Abstract: A reduced-pressure treatment system includes an isolation device for isolating a tissue site from surrounding tissue for reduced-pressure treatment that is formed from a first material having a first bio-absorption term and at least a second material having a second and different bio-absorption term. The different materials allow the isolation device initially to function well for reduced-pressure treatment and then to experience degradation at a quicker pace which facilitates healing.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: June 26, 2018
    Assignee: KCI Licensing, Inc.
    Inventor: Jonathan Kagan
  • Patent number: 9962162
    Abstract: In one embodiment, a hook fastener has a plurality of hooks and a loop fastener has a plurality of loops to secure tissues sections to one another. At least one of these fasteners has a porous surface to allow tissue ingrowth to secure the fastener to the tissue. In another embodiment, only a single fastener is used, with a section of tissue being treated to engage and mate with the fastener. The disclosed tissue fastening systems can be used for a number of applications. One such example includes fastening tissue sections by wrapping a tissue fastener around the tissue and securing the fastener on itself. A suture may also be secured with the tissue fastener.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: May 8, 2018
    Assignee: P Tech, LLC
    Inventor: Peter M. Bonutti
  • Patent number: 9955973
    Abstract: An apparatus for coaptation of first and second severed nerve segments. The apparatus includes a plurality of nerve-engaging features or coupling members that each connect to another coupling member to form coupling pairs. The coupling pairs are advantageously movable relative to each other to permit nerve swelling, inhibit nerve compression, and facilitate delivery of pharmaceutical agents.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: May 1, 2018
    Assignee: The General Hospital Corporation
    Inventors: Jonathan M. Winograd, Cameron P. Keating, Mark Omobono
  • Patent number: 9925695
    Abstract: A bioresorbable material incorporating magnesium (Mg) wires into NGCs is disclosed. The bioresorbable material includes magnesium, and a biodegradable polymer, for example, poly(lactic-co-glycolic acid (PLGA). The bioresorbable material can include magnesium wires incorporated into a poly(lactic-co-glycolic acid (PLGA) scaffold to provide both directional and biological cues in a fully bioresorbable material. A method of producing a bioresorbable material is also disclosed, which includes placing a plurality of magnesium (Mg) wires on a layer of a poly(lactic-co-glycolic acid (PLGA) solution, placing a second layer of the poly(lactic-co-glycolic acid (PLGA) solution on the plurality of magnesium (Mg) wires, and drying the plurality of magnesium (Mg) wires between the two layers of poly(lactic-co-glycolic acid (PLGA) solution.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: March 27, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Huinan Liu
  • Patent number: 9895234
    Abstract: A spinal cord device comprises a body formed of a biocompatible, biodegradable matrix. The body includes proximal, cranial and distal, caudal surfaces for connection to two ends of an injured spinal cord after removal of an injured section and has through channels with openings in the cranial and caudal surfaces for connection of descending motor pathways and ascending sensory pathways. The device has a transversal diameter (Dt), an anteroposterior diameter (Da) and a length (L), wherein Dt is from 9 to 13 mm and the ratio anteroposterior diameter/transverse diameter (RAPT) is from 0.5 to 1.0 and wherein the position and dimension of the channels, RAPT value, and cranial surface area and/or caudal surface area of the device are adopted to the shape, level, dimension of white and gray matter, and size of the injured spinal cord for optimal connection between spinal cord tracts. Kits and methods employ such devices.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: February 20, 2018
    Assignee: BIOARCTIC NEUROSCIENCE AB
    Inventors: Arvid Frostell, Per Mattsson, Mikael Svensson
  • Patent number: 9820747
    Abstract: Described herein is conduit material that causes minimal inflammatory reaction, and serves as a structural guide for regenerating nerve tissue (e.g., axons). Thus, the invention is directed to methods of treating a nerve injury in an individual in need thereof. The methods employ an isolated, naturally occurring epineural sheath, and can be used, for example, to regenerate nerve tissue in an individual in need thereof. Also provided herein is a device for harvesting an epineural sheath.
    Type: Grant
    Filed: April 2, 2009
    Date of Patent: November 21, 2017
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Maria Siemionow, Krzysztof Siemionow
  • Patent number: 9750851
    Abstract: An implantable medical device including at least one double-walled microsphere containing an active agent, and a biodegradable polymer layer containing the at least one double-walled microsphere.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: September 5, 2017
    Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Lauren Elizabeth Kokai, Kacey Gribbin Marra
  • Patent number: 9592254
    Abstract: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating select portions of a tissue matrix with a cross-linking agent and/or a proteolytic enzyme to produce a tissue matrix with variable mechanical and/or biological properties.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: March 14, 2017
    Assignee: LifeCell Corporation
    Inventors: Gary Monteiro, Christopher T. Wagner, Neil L. Rodriguez, Aubrey Irene Delossantos
  • Patent number: 9585666
    Abstract: A nerve guidance conduit includes a spiral structured porous sheet decorated with channels on its surface and electrospun nanofibers in a parallel alignment with the channels and an outer tubular structure including randomly-oriented nanofibers. Such a structure provides augmented surface areas for providing directional guidance and augmented surfaces for enhancing and peripheral nerve regeneration. The structure also has the mechanical and nutrient transport requirements required over long regeneration periods. To prepare a nerve guidance conduit, porous polymer sheet is prepared by a solvent casting method while using a template of thin rods to form parallel channels on a surface of the sheet. Aligned nanofibers are deposited on the sheet parallel to the channels. The polymer sheet is then wound to form a spiral structure. A dense layer of randomly-oriented nanofibers may be deposited on the outside of the spiral.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: March 7, 2017
    Assignee: THE STEVENS INSTITUTE OF TECHNOLOGY
    Inventors: Xiaojun Yu, Wei Chang
  • Patent number: 9555235
    Abstract: A scaffold defines a plurality of channels, into which axons of a severed nerve may regenerate, such as after limb amputation. Each channel includes a corresponding electrode. Regenerating axons may make electrical contact with the electrodes. Each channel is at least partially filled with a growth factor selected to selectively stimulate axon regeneration. Adjacent channels may include different growth factors, so as to attract different types of axons, for example efferent axons and afferent axons, to each of the adjacent channels. The growth factors may be distributed in the channels so as to present a gradient across a geometry of each channel. This gradient provides enhanced differentiated geometric guidance to the axons, thereby yielding better specificity, in terms of which axons regenerate into which channels. Topography, such as geometric patterns in walls, ceilings and floors of the channels, may also be used to selectively encourage axon regeneration into the channels.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: January 31, 2017
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Anilkumar H. Achyuta, Bryan L. McLaughlin, James Hsiao
  • Patent number: 9498221
    Abstract: An implantable medical device including at least one double-walled microsphere containing an active agent, and a biodegradable polymer layer containing the at least one double-walled microsphere.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: November 22, 2016
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Lauren E. Kokai, Kacey Gribbin Marra
  • Patent number: 9476026
    Abstract: Provided is an electroactive structure and method for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a biocompatible synthetic piezoelectric polymeric material, wherein the matrix of fibers is seeded with the isolated differentiable cells and forms a supporting scaffold for growing the isolated differentiable cells, and wherein the matrix of fibers stimulates differentiation of the isolated differentiable cells into a mature cell phenotype on the structure.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: October 25, 2016
    Assignee: New Jersey Institute of Technology
    Inventors: Treena Arinzeh, George Collins, Yee-Shuan Lee
  • Patent number: 9421085
    Abstract: The device (1) comprises a first snare (10) and a second snare (20), each of these snares comprising a contractable hollow elongated body (11, 21) which defines a longitudinal central axis (X10, X20) and which reduces its cross section when two opposed first (12, 22) and second (13, 23) ends thereof are axially moved away from each other. The first end (12) of the first snare (10) and the first end (22) of the second snare (20) are each open and adapted to be fitted and tightened around, respectively, two stumps (T1, T2) of a soft tissue (T) to be repaired. The second end (13) of the first snare (10) and the second end (23) of the second snare (20) are adapted to the axially pulled so that the second end of each of the two snares is passed alongside or through the body (11, 21) of the other snare.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: August 23, 2016
    Assignee: Tornier, Inc.
    Inventors: Randip R. Bindra, Dale R. Peterson, Kevin L. Ohashi
  • Patent number: 9386990
    Abstract: The subject invention provides materials and methods for effective nerve repair. In a preferred embodiment, the subject invention provides nerve repair methods comprising the steps of applying a fibrin glue between severed nerve stumps, coapting the nerve stumps, and applying a polyethylene glycol (PEG) hydrogel to encase the coapted nerve stumps.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: July 12, 2016
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: David F. Muir, James B. Graham, Debbie Neubauer
  • Patent number: 9351882
    Abstract: An apparatus and system for providing reduced pressure to a defect in a nerve is disclosed. The apparatus comprises a nerve conduit having a generally tubular shape that has walls including a luminal wall surrounding the tissue site to contain fluids within a luminal space between the tissue site to contain fluids within a luminal space between the tissue site and the luminal wall. The apparatus further comprises a manifold having a porous body and a connector for receiving reduced pressure, wherein the manifold is positioned within the luminal space adjacent the tissue site to distribute the reduced pressure to the defect. Additionally, a method for providing reduced pressure to a defect in a nerve is disclosed that includes implanting the nerve conduit and manifold at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: May 31, 2016
    Assignee: KCI Licensing, Inc.
    Inventors: Larry Swain, Michael Manwaring, Braden Leung, Douglas Cornet
  • Patent number: 9334476
    Abstract: Provided is an electroactive structure for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a biocompatible synthetic piezoelectric polymeric material, wherein the matrix of fibers is seeded with the isolated differentiable cells and forms a supporting scaffold for growing the isolated differentiable cells, and wherein the matrix of fibers stimulates differentiation of the isolated differentiable cells into a mature cell phenotype on the structure.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: May 10, 2016
    Assignee: New Jersey Institute of Technology
    Inventors: Treena Arinzeh, George Collins, Yee-Shuan Lee
  • Patent number: 9283386
    Abstract: Provided is a neural device including a nanowire and a support layer. Further, provided is a neural device including: a substrate, at least one nanowire which is fixed on the substrate at a lengthwise end thereof to extend vertically and inserted into nerves to obtain electrical signals from nerve fibers or apply electrical signals to the nerve fibers; and a support layer which is formed on the substrate and which surrounds and supports at least one portion of the nanowire.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: March 15, 2016
    Assignee: Industry-Academic Cooperation Foundation, Yonsei University
    Inventors: Seung Han Park, Jong Ill Hong, Jae Young Choi, Heon Jin Choi, Jae Chul Pyun
  • Patent number: 9179976
    Abstract: The disclosure describes methods of winding collagen fiber to make medical constructs and related collagen fiber tube and patch devices.
    Type: Grant
    Filed: June 6, 2011
    Date of Patent: November 10, 2015
    Assignee: MiMedx Group, Inc.
    Inventors: Leon Paulos, Mengyan Li, Daniel Hernandez, Thomas J. Koob
  • Patent number: 9108042
    Abstract: The present invention provides a device for stimulating neural regeneration and/or neurite outgrowth and a fabrication method thereof. A photovoltaic component having a substrate, a first conductive layer, an active layer and a second conducting stacked in sequence is formed. The photovoltaic component is encapsulated by an encapsulant with a portion of the first conductive layer and the second conductive layer exposed from the encapsulant. The device is configured to be rolled to form a guiding tube having two open ends and to be placed at a damaged portion of a nerve. When the device is illuminated by light, a photovoltage exists between the first conductive layer and the second conductive layer for producing an electric current, so as to stimulate neural regeneration and repair the damaged portion of a nerve.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: August 18, 2015
    Assignee: National Chiao Tung University
    Inventors: Fang-Chung Chen, Ming-Kai Chuang, Kim-Shih Tan
  • Publication number: 20150142026
    Abstract: The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. In certain embodiments, the electrospun fiber compositions comprising one or more biologically active agents are on the surface of a film, or a tube. The tubes comprising the electrospun fiber compositions of the invention can be used, for example, as nerve guide conduits.
    Type: Application
    Filed: January 26, 2015
    Publication date: May 21, 2015
    Inventors: Ahmet Hoke, Sing Y. Chew, Ruifa Mi, Kam W. Leong
  • Patent number: 8998934
    Abstract: Provided is an apparatus that includes a nerve conduit and a nested manifold for providing a reduced pressure. Also provided is a system that includes a source of reduced pressure, a nerve conduit and nested manifold, and a conduit for providing fluid communication between the manifold and the source of reduced pressure. Additionally provided is a method that includes implanting the above nerve conduit and manifold at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: April 7, 2015
    Assignee: KCI Licensing, Inc.
    Inventors: Larry D. Swain, Michael E. Manwaring, Douglas A. Cornet, Braden K. Leung
  • Patent number: 8992552
    Abstract: Provided is an apparatus that includes a nerve conduit, a manifold and a support structure for providing a reduced pressure. Also provided is a system that includes a source of reduced pressure, a nerve conduit, a manifold, a support structure and a conduit for providing fluid communication between the manifold support and the source of reduced pressure. Additionally provided is a method that includes implanting the above nerve conduit, manifold and support structure at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: March 31, 2015
    Assignee: KCI Licensing, Inc.
    Inventors: Larry Swain, Michael Manwaring, Braden K. Leung, Douglas A. Cornet
  • Patent number: 8986733
    Abstract: The subject invention pertains to compositions and methods for promoting repair of damaged nerve tissue. The compositions and methods of the subject invention can be employed to restore the continuity of nerve interrupted by disease, traumatic events or surgical procedures. Compositions of the subject invention comprise one or more chondroitin sulfate proteoglycan (CSPG)-degrading enzymes that promote axonal penetration into damaged nerve tissue. The invention also concerns methods for promoting repair of damaged nerve tissue using the present compositions and nerve tissue treated according to such methods. The invention also pertains to kits for nerve repair.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: March 24, 2015
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: David F. Muir
  • Patent number: 8968764
    Abstract: A keratin hydrogel matrix serves as an effective acellular scaffold for axonal regeneration and facilitates functional nerve recovery.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: March 3, 2015
    Assignee: Wake Forest University Health Sciences
    Inventor: Mark E. Van Dyke
  • Publication number: 20150032137
    Abstract: A biphasic material and devices comprising the same are provided for the development of conductive conduits that may be used for the treatment of peripheral nerve injury. These devices or conduits are designed such that repeated electric field gradients can be initiated to promote neurite and axonal outgrowth. Conducting conduits using doped synthetic and/or natural polymers create specifically patterned high and low conducting segmented materials, which are mechanically used to produce the electrical properties needed for nerve conduits. These electrical properties stimulate neurite outgrowth and axonal repair following a peripheral nerve transection.
    Type: Application
    Filed: March 15, 2013
    Publication date: January 29, 2015
    Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
    Inventors: William D. Wagner, Nicole Levi-Polyachenko, Tabitha Rosenbalm, Louis C. Argenta, Michael J. Morykwas
  • Publication number: 20140379009
    Abstract: A nerve guidance conduit includes a spiral structured porous sheet decorated with channels on its surface and electrospun nanofibers in a parallel alignment with the channels and an outer tubular structure including randomly-oriented nanofibers. Such a structure provides augmented surface areas for providing directional guidance and augmented surfaces for enhancing and peripheral nerve regeneration. The structure also has the mechanical and nutrient transport requirements required over long regeneration periods. To prepare a nerve guidance conduit, porous polymer sheet is prepared by a solvent casting method while using a template of thin rods to form parallel channels on a surface of the sheet. Aligned nanofibers are deposited on the sheet parallel to the channels. The polymer sheet is then wound to form a spiral structure. A dense layer of randomly-oriented nanofibers may be deposited on the outside of the spiral.
    Type: Application
    Filed: June 24, 2014
    Publication date: December 25, 2014
    Applicant: THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY
    Inventors: Xiaojun Yu, Wei Chang
  • Publication number: 20140336681
    Abstract: A nerve repair conduit configured to be secured on first and second portions of a selected nerve. The nerve repair conduit includes a polymeric body having a proximal end, a distal end, an exterior surface and an interior surface defining an interior lumen. In addition, the nerve conduit includes at least one drug reservoir to hold agent(s) that may, for example, facilitate nerve regeneration. The drugs diffuse from the drug reservoir(s) into the nerve repair conduit through an outlet (e.g., a semipermeable membrane) in proximity to the first and second portions of a selected nerve. The nerve repair conduit may be configured to deliver the agent(s) at a rate having substantially zero-order kinetics and/or at a constant rate over a selected period of time (e.g., at least 1 week).
    Type: Application
    Filed: October 16, 2012
    Publication date: November 13, 2014
    Inventors: Jayant P. Agarwal, Bruce Kent Gale, Himanshu Jayant Sant, Keng-Min Lin
  • Publication number: 20140277001
    Abstract: Provided is an apparatus that includes a nerve conduit and a nested manifold for providing a reduced pressure. Also provided is a system that includes a source of reduced pressure, a nerve conduit and nested manifold, and a conduit for providing fluid communication between the manifold and the source of reduced pressure. Additionally provided is a method that includes implanting the above nerve conduit and manifold at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue.
    Type: Application
    Filed: April 14, 2014
    Publication date: September 18, 2014
    Applicant: KCI Licensing, Inc.
    Inventors: Larry D. SWAIN, Michael E. MANWARING, Douglas A. CORNET, Braden King-Fung LEUNG
  • Patent number: 8828025
    Abstract: Methods and devices for providing a minimally-invasive placement of a mechanical structure for reducing the volume of a hollow body organ. Anchors may be secured within the hollow body organ and then cinched together using a tensioning member to form a stricture within the hollow body organ. In another embodiment a tensioning member may be threaded along the hollow body organ and then cinched to reduce the volume. The strictures may be placed anywhere within the hollow body organ, and more than one stricture may be formed within the hollow body organ.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: September 9, 2014
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Denise Marie Demarais, James Gannoe, Craig Gerbi
  • Patent number: 8771349
    Abstract: A device and method is disclosed for preventing glaucomatous optic neuropathy, an affliction of the eye. An incision is made in the scleral region of the eye and an optic nerve head shield is inserted and positioned proximate to the optic nerve head of the eye to form a pressure seal over the optic nerve head of the eye. The optic nerve head shield decreases the pressure differential across the cribiform plate preventing bowing of the cribiform plate and glaucomatous optic neuropathy.
    Type: Grant
    Filed: February 19, 2008
    Date of Patent: July 8, 2014
    Inventor: Ira Hyman Schachar
  • Patent number: 8758374
    Abstract: The disclosure provides methods for repairing nerves and inhibiting atrophy of a muscle via a side-to side neurorraphy using a bridging element between a first epineurial window on a donor nerve and a second epineurial window on a recipient nerve.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: June 24, 2014
    Assignee: University of Utah Research Foundation
    Inventor: Jayant P. Agarwal
  • Publication number: 20140163587
    Abstract: A nerve guide conduit comprising a first open cover, a second open cover and a connecting portion is provided. The first open cover has a first guiding recess, a first terminal surface and a second terminal surface opposite to the first terminal surface. The first guiding recess is extended to the second terminal surface from the first terminal surface. The second open cover has a second guiding recess, a third terminal surface and a fourth terminal surface opposite to the third terminal surface. The second guiding recess is extended to the fourth terminal surface from the third terminal surface. When the first open cover covers the second open cover, the first guiding recess and the second guiding recess together provide a nerve receiving space. The connecting portion connects the first open cover and the second open cover.
    Type: Application
    Filed: February 8, 2013
    Publication date: June 12, 2014
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventor: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
  • Patent number: 8734474
    Abstract: Provided is an apparatus that includes a nerve conduit and a nested manifold for providing a reduced pressure. Also provided is a system that includes a source of reduced pressure, a nerve conduit and nested manifold, and a conduit for providing fluid communication between the manifold and the source of reduced pressure. Additionally provided is a method that includes implanting the above nerve conduit and manifold at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: May 27, 2014
    Assignee: KCI Licensing, Inc.
    Inventors: Larry D Swain, Michael E Manwaring, Douglas A. Cornet, Braden K Leung
  • Patent number: 8718792
    Abstract: A method and system for re-establishing a pathway in a damaged or severed neural network includes an imaging device, an alignment device and a treatment device. An accurate image of the damaged neural network is created. An alignment device imparts wave energy into a damaged region of the neural network to direct re-growth axons into a remaining endoneurial tube to direct axon growth back to the correct targets to re-establish the severed neural network.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: May 6, 2014
    Assignee: Neuron Networks Restored, LLC
    Inventor: Tamara Tennison
  • Publication number: 20140107590
    Abstract: An apparatus for coaptation of first and second severed nerve segments. The apparatus includes a plurality of nerve-engaging features or coupling members that each connect to another coupling member to form coupling pairs. The coupling pairs are advantageously movable relative to each other to permit nerve swelling, inhibit nerve compression, and facilitate delivery of pharmaceutical agents.
    Type: Application
    Filed: February 27, 2012
    Publication date: April 17, 2014
    Inventors: Jonathan M. Winograd, Cameron P. Keating, Mark Omobono