Connector For Nerve Endings Patents (Class 606/152)
  • Patent number: 10363041
    Abstract: A nerve guidance conduit includes one or more guidance channels formed as porous polymeric structures. The guidance channels are within an outer tubular structure that includes randomly-oriented nanofibers. The guidance channels may have electrospun nanofibers on their inner and outer surfaces in a parallel alignment with the guidance channels. Such aligned nanofibers may also be present on the inner surface of the outer tubular structure. The outer surfaces of the guidance channels and the inner surface of the tubular structure define additional guidance channels. Such a nerve guidance conduit provides augmented surface areas for providing directional guidance and enhancing peripheral nerve regeneration. The structure also has the mechanical and nutrient transport requirements required over long regeneration periods.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: July 30, 2019
    Assignee: THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY
    Inventors: Xiaojun Yu, Munish B. Shah, Wei Chang
  • Patent number: 10219808
    Abstract: Aspects of the present disclosure are directed toward providing enhanced structural support to an organ. As may be implemented in accordance with one or more embodiments, an apparatus includes structure configured and arranged to partially encircle a tubular organ, having a semi-cylindrical shape with a tapered end and blunt end of the cylinder. A gap region provides a region of the organ that is unrestricted/unsupported. Struts/lattice facilitate ingrowth of tissue, and couple the apparatus to the organ, which allows the apparatus to provide support/restrict flow in the organ without necessarily coupling to any other structure (e.g., with the majority or all of the support provided via the apparatus as coupled onto and terminating on a sidewall of the tubular organ).
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: March 5, 2019
    Inventor: Claude Tihon
  • Patent number: 10004644
    Abstract: A reduced-pressure treatment system includes an isolation device for isolating a tissue site from surrounding tissue for reduced-pressure treatment that is formed from a first material having a first bio-absorption term and at least a second material having a second and different bio-absorption term. The different materials allow the isolation device initially to function well for reduced-pressure treatment and then to experience degradation at a quicker pace which facilitates healing.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: June 26, 2018
    Assignee: KCI Licensing, Inc.
    Inventor: Jonathan Kagan
  • Patent number: 9962162
    Abstract: In one embodiment, a hook fastener has a plurality of hooks and a loop fastener has a plurality of loops to secure tissues sections to one another. At least one of these fasteners has a porous surface to allow tissue ingrowth to secure the fastener to the tissue. In another embodiment, only a single fastener is used, with a section of tissue being treated to engage and mate with the fastener. The disclosed tissue fastening systems can be used for a number of applications. One such example includes fastening tissue sections by wrapping a tissue fastener around the tissue and securing the fastener on itself. A suture may also be secured with the tissue fastener.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: May 8, 2018
    Assignee: P Tech, LLC
    Inventor: Peter M. Bonutti
  • Patent number: 9955973
    Abstract: An apparatus for coaptation of first and second severed nerve segments. The apparatus includes a plurality of nerve-engaging features or coupling members that each connect to another coupling member to form coupling pairs. The coupling pairs are advantageously movable relative to each other to permit nerve swelling, inhibit nerve compression, and facilitate delivery of pharmaceutical agents.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: May 1, 2018
    Assignee: The General Hospital Corporation
    Inventors: Jonathan M. Winograd, Cameron P. Keating, Mark Omobono
  • Patent number: 9925695
    Abstract: A bioresorbable material incorporating magnesium (Mg) wires into NGCs is disclosed. The bioresorbable material includes magnesium, and a biodegradable polymer, for example, poly(lactic-co-glycolic acid (PLGA). The bioresorbable material can include magnesium wires incorporated into a poly(lactic-co-glycolic acid (PLGA) scaffold to provide both directional and biological cues in a fully bioresorbable material. A method of producing a bioresorbable material is also disclosed, which includes placing a plurality of magnesium (Mg) wires on a layer of a poly(lactic-co-glycolic acid (PLGA) solution, placing a second layer of the poly(lactic-co-glycolic acid (PLGA) solution on the plurality of magnesium (Mg) wires, and drying the plurality of magnesium (Mg) wires between the two layers of poly(lactic-co-glycolic acid (PLGA) solution.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: March 27, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Huinan Liu
  • Patent number: 9895234
    Abstract: A spinal cord device comprises a body formed of a biocompatible, biodegradable matrix. The body includes proximal, cranial and distal, caudal surfaces for connection to two ends of an injured spinal cord after removal of an injured section and has through channels with openings in the cranial and caudal surfaces for connection of descending motor pathways and ascending sensory pathways. The device has a transversal diameter (Dt), an anteroposterior diameter (Da) and a length (L), wherein Dt is from 9 to 13 mm and the ratio anteroposterior diameter/transverse diameter (RAPT) is from 0.5 to 1.0 and wherein the position and dimension of the channels, RAPT value, and cranial surface area and/or caudal surface area of the device are adopted to the shape, level, dimension of white and gray matter, and size of the injured spinal cord for optimal connection between spinal cord tracts. Kits and methods employ such devices.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: February 20, 2018
    Assignee: BIOARCTIC NEUROSCIENCE AB
    Inventors: Arvid Frostell, Per Mattsson, Mikael Svensson
  • Patent number: 9820747
    Abstract: Described herein is conduit material that causes minimal inflammatory reaction, and serves as a structural guide for regenerating nerve tissue (e.g., axons). Thus, the invention is directed to methods of treating a nerve injury in an individual in need thereof. The methods employ an isolated, naturally occurring epineural sheath, and can be used, for example, to regenerate nerve tissue in an individual in need thereof. Also provided herein is a device for harvesting an epineural sheath.
    Type: Grant
    Filed: April 2, 2009
    Date of Patent: November 21, 2017
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Maria Siemionow, Krzysztof Siemionow
  • Patent number: 9750851
    Abstract: An implantable medical device including at least one double-walled microsphere containing an active agent, and a biodegradable polymer layer containing the at least one double-walled microsphere.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: September 5, 2017
    Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Lauren Elizabeth Kokai, Kacey Gribbin Marra
  • Patent number: 9592254
    Abstract: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating select portions of a tissue matrix with a cross-linking agent and/or a proteolytic enzyme to produce a tissue matrix with variable mechanical and/or biological properties.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: March 14, 2017
    Assignee: LifeCell Corporation
    Inventors: Gary Monteiro, Christopher T. Wagner, Neil L. Rodriguez, Aubrey Irene Delossantos
  • Patent number: 9585666
    Abstract: A nerve guidance conduit includes a spiral structured porous sheet decorated with channels on its surface and electrospun nanofibers in a parallel alignment with the channels and an outer tubular structure including randomly-oriented nanofibers. Such a structure provides augmented surface areas for providing directional guidance and augmented surfaces for enhancing and peripheral nerve regeneration. The structure also has the mechanical and nutrient transport requirements required over long regeneration periods. To prepare a nerve guidance conduit, porous polymer sheet is prepared by a solvent casting method while using a template of thin rods to form parallel channels on a surface of the sheet. Aligned nanofibers are deposited on the sheet parallel to the channels. The polymer sheet is then wound to form a spiral structure. A dense layer of randomly-oriented nanofibers may be deposited on the outside of the spiral.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: March 7, 2017
    Assignee: THE STEVENS INSTITUTE OF TECHNOLOGY
    Inventors: Xiaojun Yu, Wei Chang
  • Patent number: 9555235
    Abstract: A scaffold defines a plurality of channels, into which axons of a severed nerve may regenerate, such as after limb amputation. Each channel includes a corresponding electrode. Regenerating axons may make electrical contact with the electrodes. Each channel is at least partially filled with a growth factor selected to selectively stimulate axon regeneration. Adjacent channels may include different growth factors, so as to attract different types of axons, for example efferent axons and afferent axons, to each of the adjacent channels. The growth factors may be distributed in the channels so as to present a gradient across a geometry of each channel. This gradient provides enhanced differentiated geometric guidance to the axons, thereby yielding better specificity, in terms of which axons regenerate into which channels. Topography, such as geometric patterns in walls, ceilings and floors of the channels, may also be used to selectively encourage axon regeneration into the channels.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: January 31, 2017
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Anilkumar H. Achyuta, Bryan L. McLaughlin, James Hsiao
  • Patent number: 9498221
    Abstract: An implantable medical device including at least one double-walled microsphere containing an active agent, and a biodegradable polymer layer containing the at least one double-walled microsphere.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: November 22, 2016
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Lauren E. Kokai, Kacey Gribbin Marra
  • Patent number: 9476026
    Abstract: Provided is an electroactive structure and method for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a biocompatible synthetic piezoelectric polymeric material, wherein the matrix of fibers is seeded with the isolated differentiable cells and forms a supporting scaffold for growing the isolated differentiable cells, and wherein the matrix of fibers stimulates differentiation of the isolated differentiable cells into a mature cell phenotype on the structure.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: October 25, 2016
    Assignee: New Jersey Institute of Technology
    Inventors: Treena Arinzeh, George Collins, Yee-Shuan Lee
  • Patent number: 9421085
    Abstract: The device (1) comprises a first snare (10) and a second snare (20), each of these snares comprising a contractable hollow elongated body (11, 21) which defines a longitudinal central axis (X10, X20) and which reduces its cross section when two opposed first (12, 22) and second (13, 23) ends thereof are axially moved away from each other. The first end (12) of the first snare (10) and the first end (22) of the second snare (20) are each open and adapted to be fitted and tightened around, respectively, two stumps (T1, T2) of a soft tissue (T) to be repaired. The second end (13) of the first snare (10) and the second end (23) of the second snare (20) are adapted to the axially pulled so that the second end of each of the two snares is passed alongside or through the body (11, 21) of the other snare.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: August 23, 2016
    Assignee: Tornier, Inc.
    Inventors: Randip R. Bindra, Dale R. Peterson, Kevin L. Ohashi
  • Patent number: 9386990
    Abstract: The subject invention provides materials and methods for effective nerve repair. In a preferred embodiment, the subject invention provides nerve repair methods comprising the steps of applying a fibrin glue between severed nerve stumps, coapting the nerve stumps, and applying a polyethylene glycol (PEG) hydrogel to encase the coapted nerve stumps.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: July 12, 2016
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: David F. Muir, James B. Graham, Debbie Neubauer
  • Patent number: 9351882
    Abstract: An apparatus and system for providing reduced pressure to a defect in a nerve is disclosed. The apparatus comprises a nerve conduit having a generally tubular shape that has walls including a luminal wall surrounding the tissue site to contain fluids within a luminal space between the tissue site to contain fluids within a luminal space between the tissue site and the luminal wall. The apparatus further comprises a manifold having a porous body and a connector for receiving reduced pressure, wherein the manifold is positioned within the luminal space adjacent the tissue site to distribute the reduced pressure to the defect. Additionally, a method for providing reduced pressure to a defect in a nerve is disclosed that includes implanting the nerve conduit and manifold at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: May 31, 2016
    Assignee: KCI Licensing, Inc.
    Inventors: Larry Swain, Michael Manwaring, Braden Leung, Douglas Cornet
  • Patent number: 9334476
    Abstract: Provided is an electroactive structure for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a biocompatible synthetic piezoelectric polymeric material, wherein the matrix of fibers is seeded with the isolated differentiable cells and forms a supporting scaffold for growing the isolated differentiable cells, and wherein the matrix of fibers stimulates differentiation of the isolated differentiable cells into a mature cell phenotype on the structure.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: May 10, 2016
    Assignee: New Jersey Institute of Technology
    Inventors: Treena Arinzeh, George Collins, Yee-Shuan Lee
  • Patent number: 9283386
    Abstract: Provided is a neural device including a nanowire and a support layer. Further, provided is a neural device including: a substrate, at least one nanowire which is fixed on the substrate at a lengthwise end thereof to extend vertically and inserted into nerves to obtain electrical signals from nerve fibers or apply electrical signals to the nerve fibers; and a support layer which is formed on the substrate and which surrounds and supports at least one portion of the nanowire.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: March 15, 2016
    Assignee: Industry-Academic Cooperation Foundation, Yonsei University
    Inventors: Seung Han Park, Jong Ill Hong, Jae Young Choi, Heon Jin Choi, Jae Chul Pyun
  • Patent number: 9179976
    Abstract: The disclosure describes methods of winding collagen fiber to make medical constructs and related collagen fiber tube and patch devices.
    Type: Grant
    Filed: June 6, 2011
    Date of Patent: November 10, 2015
    Assignee: MiMedx Group, Inc.
    Inventors: Leon Paulos, Mengyan Li, Daniel Hernandez, Thomas J. Koob
  • Patent number: 9108042
    Abstract: The present invention provides a device for stimulating neural regeneration and/or neurite outgrowth and a fabrication method thereof. A photovoltaic component having a substrate, a first conductive layer, an active layer and a second conducting stacked in sequence is formed. The photovoltaic component is encapsulated by an encapsulant with a portion of the first conductive layer and the second conductive layer exposed from the encapsulant. The device is configured to be rolled to form a guiding tube having two open ends and to be placed at a damaged portion of a nerve. When the device is illuminated by light, a photovoltage exists between the first conductive layer and the second conductive layer for producing an electric current, so as to stimulate neural regeneration and repair the damaged portion of a nerve.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: August 18, 2015
    Assignee: National Chiao Tung University
    Inventors: Fang-Chung Chen, Ming-Kai Chuang, Kim-Shih Tan
  • Publication number: 20150142026
    Abstract: The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. In certain embodiments, the electrospun fiber compositions comprising one or more biologically active agents are on the surface of a film, or a tube. The tubes comprising the electrospun fiber compositions of the invention can be used, for example, as nerve guide conduits.
    Type: Application
    Filed: January 26, 2015
    Publication date: May 21, 2015
    Inventors: Ahmet Hoke, Sing Y. Chew, Ruifa Mi, Kam W. Leong
  • Patent number: 8998934
    Abstract: Provided is an apparatus that includes a nerve conduit and a nested manifold for providing a reduced pressure. Also provided is a system that includes a source of reduced pressure, a nerve conduit and nested manifold, and a conduit for providing fluid communication between the manifold and the source of reduced pressure. Additionally provided is a method that includes implanting the above nerve conduit and manifold at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: April 7, 2015
    Assignee: KCI Licensing, Inc.
    Inventors: Larry D. Swain, Michael E. Manwaring, Douglas A. Cornet, Braden K. Leung
  • Patent number: 8992552
    Abstract: Provided is an apparatus that includes a nerve conduit, a manifold and a support structure for providing a reduced pressure. Also provided is a system that includes a source of reduced pressure, a nerve conduit, a manifold, a support structure and a conduit for providing fluid communication between the manifold support and the source of reduced pressure. Additionally provided is a method that includes implanting the above nerve conduit, manifold and support structure at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: March 31, 2015
    Assignee: KCI Licensing, Inc.
    Inventors: Larry Swain, Michael Manwaring, Braden K. Leung, Douglas A. Cornet
  • Patent number: 8986733
    Abstract: The subject invention pertains to compositions and methods for promoting repair of damaged nerve tissue. The compositions and methods of the subject invention can be employed to restore the continuity of nerve interrupted by disease, traumatic events or surgical procedures. Compositions of the subject invention comprise one or more chondroitin sulfate proteoglycan (CSPG)-degrading enzymes that promote axonal penetration into damaged nerve tissue. The invention also concerns methods for promoting repair of damaged nerve tissue using the present compositions and nerve tissue treated according to such methods. The invention also pertains to kits for nerve repair.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: March 24, 2015
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: David F. Muir
  • Patent number: 8968764
    Abstract: A keratin hydrogel matrix serves as an effective acellular scaffold for axonal regeneration and facilitates functional nerve recovery.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: March 3, 2015
    Assignee: Wake Forest University Health Sciences
    Inventor: Mark E. Van Dyke
  • Publication number: 20150032137
    Abstract: A biphasic material and devices comprising the same are provided for the development of conductive conduits that may be used for the treatment of peripheral nerve injury. These devices or conduits are designed such that repeated electric field gradients can be initiated to promote neurite and axonal outgrowth. Conducting conduits using doped synthetic and/or natural polymers create specifically patterned high and low conducting segmented materials, which are mechanically used to produce the electrical properties needed for nerve conduits. These electrical properties stimulate neurite outgrowth and axonal repair following a peripheral nerve transection.
    Type: Application
    Filed: March 15, 2013
    Publication date: January 29, 2015
    Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
    Inventors: William D. Wagner, Nicole Levi-Polyachenko, Tabitha Rosenbalm, Louis C. Argenta, Michael J. Morykwas
  • Publication number: 20140379009
    Abstract: A nerve guidance conduit includes a spiral structured porous sheet decorated with channels on its surface and electrospun nanofibers in a parallel alignment with the channels and an outer tubular structure including randomly-oriented nanofibers. Such a structure provides augmented surface areas for providing directional guidance and augmented surfaces for enhancing and peripheral nerve regeneration. The structure also has the mechanical and nutrient transport requirements required over long regeneration periods. To prepare a nerve guidance conduit, porous polymer sheet is prepared by a solvent casting method while using a template of thin rods to form parallel channels on a surface of the sheet. Aligned nanofibers are deposited on the sheet parallel to the channels. The polymer sheet is then wound to form a spiral structure. A dense layer of randomly-oriented nanofibers may be deposited on the outside of the spiral.
    Type: Application
    Filed: June 24, 2014
    Publication date: December 25, 2014
    Applicant: THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY
    Inventors: Xiaojun Yu, Wei Chang
  • Publication number: 20140336681
    Abstract: A nerve repair conduit configured to be secured on first and second portions of a selected nerve. The nerve repair conduit includes a polymeric body having a proximal end, a distal end, an exterior surface and an interior surface defining an interior lumen. In addition, the nerve conduit includes at least one drug reservoir to hold agent(s) that may, for example, facilitate nerve regeneration. The drugs diffuse from the drug reservoir(s) into the nerve repair conduit through an outlet (e.g., a semipermeable membrane) in proximity to the first and second portions of a selected nerve. The nerve repair conduit may be configured to deliver the agent(s) at a rate having substantially zero-order kinetics and/or at a constant rate over a selected period of time (e.g., at least 1 week).
    Type: Application
    Filed: October 16, 2012
    Publication date: November 13, 2014
    Inventors: Jayant P. Agarwal, Bruce Kent Gale, Himanshu Jayant Sant, Keng-Min Lin
  • Publication number: 20140277001
    Abstract: Provided is an apparatus that includes a nerve conduit and a nested manifold for providing a reduced pressure. Also provided is a system that includes a source of reduced pressure, a nerve conduit and nested manifold, and a conduit for providing fluid communication between the manifold and the source of reduced pressure. Additionally provided is a method that includes implanting the above nerve conduit and manifold at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue.
    Type: Application
    Filed: April 14, 2014
    Publication date: September 18, 2014
    Applicant: KCI Licensing, Inc.
    Inventors: Larry D. SWAIN, Michael E. MANWARING, Douglas A. CORNET, Braden King-Fung LEUNG
  • Patent number: 8828025
    Abstract: Methods and devices for providing a minimally-invasive placement of a mechanical structure for reducing the volume of a hollow body organ. Anchors may be secured within the hollow body organ and then cinched together using a tensioning member to form a stricture within the hollow body organ. In another embodiment a tensioning member may be threaded along the hollow body organ and then cinched to reduce the volume. The strictures may be placed anywhere within the hollow body organ, and more than one stricture may be formed within the hollow body organ.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: September 9, 2014
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Denise Marie Demarais, James Gannoe, Craig Gerbi
  • Patent number: 8771349
    Abstract: A device and method is disclosed for preventing glaucomatous optic neuropathy, an affliction of the eye. An incision is made in the scleral region of the eye and an optic nerve head shield is inserted and positioned proximate to the optic nerve head of the eye to form a pressure seal over the optic nerve head of the eye. The optic nerve head shield decreases the pressure differential across the cribiform plate preventing bowing of the cribiform plate and glaucomatous optic neuropathy.
    Type: Grant
    Filed: February 19, 2008
    Date of Patent: July 8, 2014
    Inventor: Ira Hyman Schachar
  • Patent number: 8758374
    Abstract: The disclosure provides methods for repairing nerves and inhibiting atrophy of a muscle via a side-to side neurorraphy using a bridging element between a first epineurial window on a donor nerve and a second epineurial window on a recipient nerve.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: June 24, 2014
    Assignee: University of Utah Research Foundation
    Inventor: Jayant P. Agarwal
  • Publication number: 20140163587
    Abstract: A nerve guide conduit comprising a first open cover, a second open cover and a connecting portion is provided. The first open cover has a first guiding recess, a first terminal surface and a second terminal surface opposite to the first terminal surface. The first guiding recess is extended to the second terminal surface from the first terminal surface. The second open cover has a second guiding recess, a third terminal surface and a fourth terminal surface opposite to the third terminal surface. The second guiding recess is extended to the fourth terminal surface from the third terminal surface. When the first open cover covers the second open cover, the first guiding recess and the second guiding recess together provide a nerve receiving space. The connecting portion connects the first open cover and the second open cover.
    Type: Application
    Filed: February 8, 2013
    Publication date: June 12, 2014
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventor: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
  • Patent number: 8734474
    Abstract: Provided is an apparatus that includes a nerve conduit and a nested manifold for providing a reduced pressure. Also provided is a system that includes a source of reduced pressure, a nerve conduit and nested manifold, and a conduit for providing fluid communication between the manifold and the source of reduced pressure. Additionally provided is a method that includes implanting the above nerve conduit and manifold at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: May 27, 2014
    Assignee: KCI Licensing, Inc.
    Inventors: Larry D Swain, Michael E Manwaring, Douglas A. Cornet, Braden K Leung
  • Patent number: 8718792
    Abstract: A method and system for re-establishing a pathway in a damaged or severed neural network includes an imaging device, an alignment device and a treatment device. An accurate image of the damaged neural network is created. An alignment device imparts wave energy into a damaged region of the neural network to direct re-growth axons into a remaining endoneurial tube to direct axon growth back to the correct targets to re-establish the severed neural network.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: May 6, 2014
    Assignee: Neuron Networks Restored, LLC
    Inventor: Tamara Tennison
  • Publication number: 20140107590
    Abstract: An apparatus for coaptation of first and second severed nerve segments. The apparatus includes a plurality of nerve-engaging features or coupling members that each connect to another coupling member to form coupling pairs. The coupling pairs are advantageously movable relative to each other to permit nerve swelling, inhibit nerve compression, and facilitate delivery of pharmaceutical agents.
    Type: Application
    Filed: February 27, 2012
    Publication date: April 17, 2014
    Inventors: Jonathan M. Winograd, Cameron P. Keating, Mark Omobono
  • Publication number: 20140100591
    Abstract: A method for manufacturing a nerve regeneration-inducing tube with excellent pressure resistance, shape recovery property, anti-kink property, film exfoliation resistance, resistance to invasion of outer tissues, and leakage resistance. The tubular body is formed by weaving together fibers made up of biodegradable polymer. The outer surface of the tubular body is coated multiple times with a collagen solution. The lumen of the tubular body is filled with collagen. Viscosity of the collagen solution that is first applied to the outer surface of the tubular body is between 2 to 800 cps. Viscosity of the collagen solution that is subsequently applied is higher than viscosity of the first applied collagen solution.
    Type: Application
    Filed: December 13, 2013
    Publication date: April 10, 2014
    Applicant: TOYO BOSEKI KABUSHIKI KAISHA
    Inventors: Fumihiko Kajii, Hidenori Tanaka, Yuta Kawakatsu, Susumu Kashiwabara, Masaki Sato
  • Patent number: 8690900
    Abstract: An apparatus for connecting two elongate body tissues is described. A flexible outer surface has a first outer end longitudinally spaced from a second outer end. A flexible inner surface has a first inner end longitudinally spaced from a second inner end. A first end aperture is defined by a flexible connection between the first outer end and the first inner end. The first end aperture is configured to accept a first elongate body tissue. A second end aperture is defined by a flexible connection between the second outer end and the second inner end. The second end aperture is configured to accept a second elongate body tissue. The outer and inner surfaces are configured for relative eversion operative to longitudinally shift an instantaneous midpoint of the apparatus with respect to a reference location on the inner surface. A method of using the apparatus is also provided.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: April 8, 2014
    Assignee: The Cleveland Clinic Foundation
    Inventor: Isador H. Lieberman
  • Publication number: 20140081297
    Abstract: The present invention is directed to the compositions and methods of preparing hydrogel-grafted nerve guides for peripheral nerve regeneration. Particularly, the present invention describes the nerve guides and methods for preparation of hydrogel-grafted nerve guides with encapsulated neurotrophic factors and a nanofiber mesh lining the inner surface of the guide. The present invention also provides methods for peripheral nerve repair using these hydrogel-grafted nerve guides.
    Type: Application
    Filed: November 15, 2013
    Publication date: March 20, 2014
    Inventors: Ahmet Hoke, Shawn H. Lim, Xingyu Liu, Hai-Quan Mao
  • Patent number: 8617049
    Abstract: An apparatus for regulating the functioning of a patient's organ or duct includes an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member. The fastener is configured to engage the second end of the elongated member so that the elongated member forms a loop around the organ or duct. A tension element is disposed for movement within the elongated member. A symmetrical drive system including a drive element associated with and engaging the tension element for causing the tension element to control the tension applied by the elongated member against a patient's body organ or duct is further provided. In accordance with an alternate embodiment an apparatus for regulating the functioning of a patient's organ or duct including an elongated member having a first end and a second end. A fastener is disposed on the first end of the elongated member.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: December 31, 2013
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Daniel F. Dlugos, Jr., Toralf Bork, Christine H. Chen, Rocco Crivelli, Donna L. Korvick, David T. Krumanaker, Timothy P. Lessek, Amy L. Marcotte, Jeffrey D. Messerly, Daniel J. Mumaw, Anil K. Nalagatla, David N. Plescia, Frederick E. Shelton, IV, Jeffrey S. Swayze, Patrick J. Swindon, Mark Tsonton, Scott A. Woodruff
  • Publication number: 20130345729
    Abstract: A compression and kink resistant tubular implant for nerve repair. The implant includes a tubular biopolymeric membrane and a polymeric supporting filament. Also provided is a shaped compression resistant implant for ridge augmentation in dental surgery. Methods for producing the implants are also provided.
    Type: Application
    Filed: June 22, 2012
    Publication date: December 26, 2013
    Applicant: Collagen Matrix, Inc.
    Inventors: Shu-Tung Li, Debbie Yuen
  • Publication number: 20130331869
    Abstract: A novel electrically conductive polymer composite composed of polycaprolactone fumarate-polypyrrole (PCLF-PPy) for applications in nerve regeneration is disclosed. The synthesis and characterization of PCLF-PPy and in vitro studies showing PCLF-PPy supports both PC12 cell and Dorsal Root Ganglia neurite extension. PCLF-PPy composite materials were synthesized by polymerizing pyrrole in pre-formed scaffolds of PCLF resulting in an interpenetrating network of PCLF-PPy. PCLF-PPy composite materials possess electrical conductivity up to 6 mS cm?1 with compositions ranging from 5-13.5 percent polypyrrole of the bulk material. Surface topographies of PCLF-PPy materials show microstructures with a RMS roughness of 1195 nm and nanostructures with RMS roughness of 8 nm. PCLF-PPy derivatives were synthesized with anionic dopants to determine effects on electrical conductivity and to optimize the chemical composition for biocompatibility.
    Type: Application
    Filed: October 15, 2010
    Publication date: December 12, 2013
    Inventors: M. Brett Runge, Mahrokh Dadsetan, Michael J. Yaszemski
  • Patent number: 8603512
    Abstract: Methods and apparatus are provided for treating an injured or severed nerve pathway, wherein one or more microporous tubes are implanted into the nerve pathway to bridge the injured or severed region. A bioactive matrix including stem cells and nutrients is disposed within the microporous tube to facilitate growth of the stem cells and reestablishment of the sensory and motor conductive pathways through the injured or severed region. The microporous tube protects the bioactive matrix during development of the stem cells, and also retains the end regions in proper alignment during the nerve pathway regeneration.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: December 10, 2013
    Assignee: Nexeon Medsystems, Inc.
    Inventor: Mark C. Bates
  • Patent number: 8500763
    Abstract: Devices and methods for protecting the neurovascular structures about the vertebral column are provided. One embodiment of the invention comprises a neuroprotective stent or device adapted for placement in an intervertebral foramen of a vertebral column and configured to resist compression or impingement from surrounding structures or forces. The stent or device may further comprise a flange or hinge region to facilitate attachment of the device to the vertebrae or to facilitate insertion of the device in the foramen, respectively.
    Type: Grant
    Filed: May 18, 2010
    Date of Patent: August 6, 2013
    Assignee: Spinal Elemtents, Inc.
    Inventor: Jason Blain
  • Publication number: 20130190786
    Abstract: A neural implant comprising spider silk, especially a neural implant consisting of natural spider silk fibres. In particular, the present invention makes available spider silk for use for the production of a pharmaceutical composition whose medical indication is defects in nerves that are to be bridged. Thread-like spider silk is arranged essentially in an axial direction within a sheathing formed of spider silk threads. The sheathing can be knitted, woven, laced or braided of spider silk threads.
    Type: Application
    Filed: March 8, 2013
    Publication date: July 25, 2013
    Applicant: Medizinische Hochschule Hannover
    Inventor: Medizinische Hochschule Hannover
  • Patent number: 8491611
    Abstract: A self-retaining neural retraction clip, preferably having controlled retraction level and an off-set retraction means. This device can reduce operative site clutter to enhance disc access while providing consistent and stable dural retraction.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: July 23, 2013
    Assignee: DePuy Synthes Products, LLC.
    Inventors: Tony Tannoury, Michael J O'Neil, Derek Shaw, Hassan Serhan
  • Publication number: 20130184724
    Abstract: The present invention provides a peripheral nerve growth scaffold including poly ?-caprolactone (PCL) and microgrooves on an inner surface of the scaffold, the scaffold being adapted for use in treatment of damaged peripheral nerves. The microgrooves are suitably arranged as a pattern or array and preferably comprise sloping side walls, which arrangement has been found to provide a favourably environment for nerve and Schwann cell growth and proliferation. Experimental results demonstrate directed and aligned growth, which suitably reduces the rate of formation of neuromas. Embodiments comprising a PCL-PLA blend of the sloping side wall and a groove width greater than the spacing between adjacent grooves has been found to be particularly effective for directed cell growth and proliferation.
    Type: Application
    Filed: September 16, 2011
    Publication date: July 18, 2013
    Applicant: THE UNIVERSITY OF MANCHESTER
    Inventors: Sandra Downes, Mingzhu Sun, Seyedeh Atefeh Mobasseri, Giorgio Terenghi
  • Publication number: 20130171116
    Abstract: A neural network is disclosed. The neural network comprises a plurality of optogenetically modified neural cells being three-dimensionally distributed in a hydrogel medium and being disconnected from any solid support having a shear modulus above 1 GPa.
    Type: Application
    Filed: January 3, 2013
    Publication date: July 4, 2013
    Applicant: Technion Research & Development Foundation Ltd.
    Inventor: Technion Research & Development Foundation Ltd
  • Patent number: 8449562
    Abstract: Provided is an apparatus that includes a nerve conduit, a manifold and a support structure for providing a reduced pressure. Also provided is a system that includes a source of reduced pressure, a nerve conduit, a manifold, a support structure and a conduit for providing fluid communication between the manifold support and the source of reduced pressure. Additionally provided is a method that includes implanting the above nerve conduit, manifold and support structure at a site of damaged nerve tissue and applying a reduced pressure to the manifold thereby stimulating repair or regrowth of nerve tissue.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: May 28, 2013
    Assignee: KCI Licensing, Inc.
    Inventors: Larry D. Swain, Michael E. Manwaring, Douglas A. Cornet, Braden K Leung