Abstract: An introduction needle includes a needle piercing portion. The needle piercing portion comprises a needle tooth and a substrate; the needle tooth is fixedly disposed on a portion of a first side surface of the substrate; and when the needle tooth pierces into the skin, the remaining portion of the first side surface of the substrate is configured to abut against an outer surface of the skin.

Abstract: A microarray receptacle which has a first side and a second side. Furthermore, the microarray receptacle includes a carrier structure for connecting the microarray receptacle to an application point. To the carrier structure there is connected a carrier surface which in turn is connected to a microarray. An articulation device is arranged between the carrier surface and the carrier structure, the articulation device making possible movement of the microarray connected to the carrier surface relative to the carrier structure along the extent of the microarray. Further, a microarray receptacle cluster with a plurality of such microarray receptacles.

Abstract: An operating rod for a tattoo device includes: a drive mechanism, configured to drive an injection needle of the tattoo device to move; a first rod body, having a receiving cavity and a first fastening portion, wherein the receiving cavity is configured to receive the drive mechanism, and the first fastening portion is configured to fastened with the injection needle; and a second rod body, connected to at least part of the first rod body in a sleeved manner and configured with a second fastening portion, wherein the second fastening portion is configured to connect to the injection needle.

Abstract: A wireless tattoo device is disclosed. The device includes an electronics housing, a control panel, a power source, and a motor assembly driven by the power source. A motor housing is attached to the electronics housing, and the motor housing defines a passage dimensioned to receive a portion of the motor assembly. A grip defines an opening dimensioned to receive an end of the motor housing. The motor housing is configured to receive a needle cartridge. The motor housing and the grip are rotatable relative to each other such that a depth of the needle cartridge relative to the grip varies based on a relative rotation position between the motor housing and the grip.

Abstract: A needle assembly for a liquid applicator comprises a housing, a needle bundle, and an elastic tubular member. The housing comprises a longitudinal channel having upper and lower open ends. The needle bundle is movably mounted in the channel and configured to be driven by a driving shaft to reciprocatively move between a retracted position and an extended position. The elastic tubular member comprises a first end attached to the housing and a second end attached the needle bundle to bias the needle bundle to move longitudinally towards the retracted position. The tubular member comprises a first portion and a second portion thinner than the first portion, which are separated by a boundary. The boundary extends helically between the first and second ends of the tubular member. The first portion may include one or more helical ridges.

Abstract: A tattoo tool is presented that receives a disposable tattoo cartridge and causes the needles of the cartridge to be constantly extended for manual tattooing. The tattoo tool includes a front cartridge-receiver for receiving a tattoo cartridge and a back handle portion. The cartridge-receiver comprises a cartridge-receiving concavity configured to accept the cartridge and to secure the cartridge in a position in which the cartridge needles are extended to reach beyond the cartridge tip and are maintained in this position. Embodiments are presented in which the tool is a single-piece tool. In other embodiments, the tattoo tool is a two-part tool that includes a front cartridge-receiver and a separable handle that can be removably attached.

Abstract: Tattoo needle unit according to the present invention includes a pocket having a body part; at least one first needle having a first diameter and coupled to the pocket; and at least one second needle having a second diameter larger than the first diameter and coupled to the pocket, wherein, a part of the first needle is exposed out of the body part, and another part of the first needle is disposed inside the body part, and wherein, a part of the second needle is exposed out of the body part, and another part of the second needle is disposed inside the body part. According to the tattoo needle unit according to the present invention, there is an advantage in that it is possible to easily implement a tattoo of a more diverse and natural shape due to the combination of various types of needles.

Abstract: Apparatus for treating dermatological tissue including a user holdable device having an end defining a surface configured to receive and capable of being releasably coupled to a needle module that includes a movable needle assembly having a plurality of needles that is located past the end of the device when the module is releasably coupled to the device. The device includes a motor capable of moving the assembly to deploy the needles to penetrate dermatological tissue to a selectable desired depth. The apparatus includes a signal generator capable of being coupled to the needles to provide a radio frequency signal having a selectable intensity; at least one processor configured to provide a signal to cause the motor to deploy the needles to the desired depth and a signal to cause the signal generator to provide the intensity of the radio frequency signal to the needles; and at least one display.

Abstract: Intra-tympanic injections of therapeutics into the inner ear can be used to treat conditions such as hearing loss. One or more stabilizing devices that define working channels can be temporarily implanted in the tympanic membrane. Purpose-built instruments such as endoscopes, forceps, and injections instruments can be passed through the working channels of the stabilizer devices to access the inner ear where the therapy can be administered. Afterwards, the stabilizing devices can be removed from the tympanic membrane and the tympanic membrane can heal, typically without the need for sutures.

Abstract: A grip apparatus or kit, and methods of use thereof, that includes a grip housing having a cartridge receiving portion and a motor housing mating portion at opposite ends. The cartridge receiving end having dimensioned to receive a needle cartridge. The opposite end dimensioned to receive a motor drive pin of a needling device. The grip apparatus including a resilient barrier within the grip housing, positioned between the cartridge receiving portion and the motor housing mating portion. The resilient barrier comprising a flexible portion that may include alignment structures having concave, convex, stepped configurations, or a combination thereof.

Abstract: A power supply unit for a tattoo machine includes a power operating unit electrically connected to a power supply device. The power operating unit is electrically connected to an operating unit. The power operating unit can output a DC power and can control a current value or a voltage value of the DC power according to operation of the operating unit. A modulating unit is electrically connected to the power operating unit and the operating unit. The modulating unit modulates the DC power according to the operation of the operating unit and outputs a square wave power or the DC power. The modulating unit can control frequency or a work cycle of the square wave power according to the operation of the operating unit. An output end of the DC power supply unit is electrically connected to the tattoo machine to output the square wave power or the DC power.

Abstract: A microneedle array including a plurality of microneedles that include nanocellulose or a nanocellulose composite, methods of producing a microneedle array, a device including a microneedle array, and methods of extracting a dermal biofluid or subdermal biofluid by applying a microneedle array.

Abstract: An apparatus for delivering an active ingredient into skin of an animal at a defined depth, the apparatus including: a microprojection array including a plurality of microprojections having a density of at least 2,000 projections per cm2; and an applicator that drives the microprojection array towards the skin in use so that the microprojection array impacts on the skin with a mass-to-velocity ratio of between 0.0005 g/m/s and 0.1 g/m/s per cm2.

Abstract: A micro-needling system, the system includes a micro-channeling device, a needle tip connector and a variety of micro-needling assemblies. The micro-channeling device is designed to provide reciprocal motion, in and out of skin, for the micro-needling assemblies when applied to skin. A quick connector is provided for easy interchange of the micro-needling assemblies. Benefits of the system include ergonomic holding, versatility of needle arrays and reduced vibration.

Abstract: An injection configuration (10) for connection to a male Luer connector (100) includes a hub (12) having an internal conical taper (14) in fluid interconnection with a hollow needle (16). The internal conical taper has a convergence angle of 6% and a length L of 7.5-10.5 millimeters, and presents an entrance aperture diameter D of between 4.365 and 4.595 millimeters.

Abstract: A cryo formulation-based microneedle device for transdermal delivery of bioactive therapeutic agents. The microneedle device includes: one or more microneedle patches each including an array of miniaturized needles, wherein each miniaturized needle defining a base end and a tip; and a substrate to which the base end of the array of miniaturized needles is attached or integrated thereto; wherein the microneedle patch is in a cryo status; wherein each of the one or more microneedle patch is adapted to be applied on a skin surface, in which the miniaturized needles penetrates into skin; and wherein the miniaturized needles is further arranged to melt so as to release one or more bioactive therapeutic agents into the skin to achieve a targeted therapeutic effect.

Abstract: A cryo formulation-based microneedle device for ocular delivery of bioactive therapeutic agents. The microneedle device includes: one or more microneedle patches each including an array of miniaturized needles, wherein each miniaturized needle defining a base end and a tip; and a substrate to which the base end of the array of miniaturized needles is attached or integrated thereto; wherein the microneedle patch is in a cryo status; wherein each of the one or more microneedle patch is adapted to be applied on cornea of an eye, in which the miniaturized needles penetrates into the eye; and wherein the miniaturized needles is further arranged to melt so as to release one or more bioactive therapeutic agents into the eye to achieve a targeted therapeutic effect.

Abstract: A cryo formulation-based microneedle device for transdermal delivery of bioactive therapeutic agents. The microneedle device includes: one or more microneedle patches each including an array of miniaturized needles, wherein each miniaturized needle defining a base end and a tip; and a substrate to which the base end of the array of miniaturized needles is attached or integrated thereto; wherein the microneedle patch is in a cryo status; wherein each of the one or more microneedle patch is adapted to be applied on a skin surface, in which the miniaturized needles penetrates into skin; wherein the miniaturized needles is further arranged to melt so as to release one or more bioactive therapeutic agents into the skin to achieve a targeted therapeutic effect; and wherein the bioactive therapeutic agents includes protein and/or antigens.

Abstract: An applicator for an analyte monitoring device may include an actuatable housing having a body defining a cavity therein and having a distal opening and a side opening. A cuff and a shuttle are received within the cavity and are separately translatable relative to the housing body. A base may removable engage the housing body at the distal opening. The housing body, the cuff, the shuttle, and/or the base may be engaged with one another with one or more releasable coupling features. The base may be removed from an engagement with the housing body, causing the cuff and the shuttle to be aligned and positioned in a configuration in which the analyte monitoring device, held by the shuttle, is ready for insertion into the skin.

Abstract: A system for facial and skin treatment includes a universal skin exfoliating and rejuvenating system that uses dual-function plate mounted onto the front edge of the hand-held system in a multi-step process. One step used in the multi-step process includes of a microdermabrasion procedure using diamond-tipped wands fixed on a dual-function plate to cleanse and exfoliate dead skin that simultaneously removes the dead skin away. In another dual-function process, a plate equipped with micro-needles and skin care products is used to generate collagen for firmer toned skin. The micro-needles are fixed on moving parts or roller, to help with fine lines, wrinkles, and large pores. Also, a dual-function plate is used for skin massage and special serum treatment and application. The handheld system is equipped with a miniature vacuum pump, mini supply containers, and control parts to supply serums and skincare products to the dual-function plates.

Abstract: An applicator for an analyte monitoring device may include an actuatable housing having a body defining a cavity therein and having a distal opening and a side opening. A cuff and a shuttle are received within the cavity and are separately translatable relative to the housing body. A base may removable engage the housing body at the distal opening. The housing body, the cuff, the shuttle, and/or the base may be engaged with one another with one or more releasable coupling features. The base may be removed from an engagement with the housing body, causing the cuff and the shuttle to be aligned and positioned in a configuration in which the analyte monitoring device, held by the shuttle, is ready for insertion into the skin.

Abstract: A tattoo needle structure is provided. A tattoo needle has a plurality of needle tips, an ink holding space is formed by the arrangement of the needle tips, and a multi-component alloy film is deposited on each needle tip of the tattoo needle by sputtering technology, so that when the tattoo needle is dipped into the tattoo ink, the tattoo ink does not stick to the surface of the multi-component alloy film by the hydrophobic property of the multi-component alloy film, and the tattoo ink is contained in the ink holding space by the cohesive property of the tattoo ink. Thus, when the tattoo needle is dipped into the tattoo ink and the tattoo process is performed, the dyeing area of the skin with the tattoo ink is the cross-sectional area of the ink holding space, thereby achieving the technical effect of improving the contouring resolution of a tattoo.

Abstract: In the preferred embodiment of the present invention, a patch of dissolving microneedles loaded with active ingredients to be applied to skin for treating skin conditions is provided. As seen in FIG. 1, the dissolving microneedle patch (10) comprises a substrate (12) and a plurality of microneedles (14) which extends from the substrate. The dissolving microneedle patch (10) is made of a matrix material and at least one active ingredient such as a corticosteroid, namely triamcinolone (TAC). The matrix material is made of bio-compatible materials such as hyaluronic acid (HA), polyvinylpyrrolidone (PVP), or mixture of them, which dissolve rapidly when they are in contact with the inner skin. The active ingredient is loaded onto individual patches with the desirable dosage ranging from 0.01 mg-1.0 mg.

Abstract: To provide a means which makes it possible to hold a microneedle array without an adhesive sheet and protect tips of microneedles. A foam support sheet for a microneedle array, which has an open cell surface on at least one side, the open cell surface being an arrangement portion for the microneedle array holding the microneedle array with a microneedle side of the microneedle array facing downward; as well as a microneedle array sheet consisting of a microneedle array and a foam support sheet, the foam support sheet having an open cell surface on at least one side, and the microneedle array being arranged on the open cell surface with a microneedle side of the microneedle array facing downward.

Abstract: Disclosed herein are devices (e.g., needles (e.g., hollow needles), hollow staples, articles, apparatuses, and systems), kits, and methods for treating skin and skin conditions, for example, by promoting skin tightening, such as by reducing skin laxity and reducing tissue area or volume.

Abstract: A microneedle structure and a biodegradable microneedle thereof are provided. The biodegradable microneedle defining a central axis includes a first step portion and a second step portion that is taperedly extending from the first step portion along the central axis. The biodegradable microneedle has a total height along the central axis and a maximum internal diameter along a direction perpendicular to the central axis. The total height is within a range of 380-430 ?m, and an aspect ratio defined by the total height divided by the maximum internal diameter is within a range of 1.2-2.2. In a cross section of the biodegradable microneedle having the central axis, a part of the second step portion arranged away from the first step portion having a corner. The corner has an angle within a range of 65-100 degrees and faces toward the first step portion.

Abstract: A compact battery and voltage supply controller apparatus for a tattoo machine is disclosed. The battery and controller are configured to connect the battery to the tattoo machine through replaceable internally received magnetic connection adapters. The toggle switch operated display screen provides easy-to-view status and health of the battery and incremental voltage adjustment using a voltage boost circuit and adjustment knob. The internal battery can be replaced and/or removed and recharged.

Abstract: A microneedling device includes a microneedle cartridge that extends needles at a predetermined angle, rather than perpendicular to the centerline of the device.

Abstract: A system for controlling a tattoo machine configured to push ink includes a computerized processor configured to control a voltage supplied to the tattoo machine. The computerized processor includes programming configured to monitor a hand gesture input, determine a desired command for the tattoo machine based upon the monitored hand gesture input, and control the voltage supplied to the tattoo machine based upon the determined desired command. Monitoring the hand gesture input can include monitoring a touch-free hand gesture sensor.

Abstract: Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue.

Abstract: The disclosure provides an applicator for applying a cosmetic treatment product to the skin or the lips, the applicator comprising at least: an application portion comprising a bundle of needles for applying the cosmetic treatment product and extending along a longitudinal axis, the bundle of needles comprising at least one first set of needles having a distribution that is square in cross-section relative to the longitudinal axis; and a linear drive device connected to the application portion and configured to constrain the bundle of needles to perform reciprocating motion along the longitudinal axis.

Abstract: There is disclosed a materials delivery system for use with a surgical stapling instrument having at least one jaw including a knife slot. The materials delivery system includes a series of treatment material receiving pockets positioned adjacent the knife slot such that a portion of each pocket is open to the knife slot. A source of treatment material is positioned within the pockets such that passage of the knife blade adjacent to the pockets repeatedly coats the knife blade with the treatment material.

Abstract: Pixel array medical devices, systems and methods are described for skin grafting and skin resection procedures. The procedures involve applying a scalpet array to a target skin site. The scalpet array comprises scalpets positioned on an investing plate. Skin pixels are circumferentially incised at a target skin site by applying a load via the scalpet array onto subjacent skin surface that includes the target skin site. Incised skin pixels are captured on an adherent substrate, where the incised skin pixels are extruded through the scalpet array. Bases of incised skin pixels extruded through the scalpet array are then transected.

Abstract: A method of controlling a tattoo machine power supply (14), comprises detecting a user interaction with the tattoo machine power supply (14); based on said user interaction, generating an activation signal; wirelessly transmitting the activation signal; and setting the tattoo machine power supply (14) in an active state, in which it is responsive to remote control commands.

Abstract: An acupuncture device and a needle wakening method are disclosed. The acupuncture device includes a plurality of acupuncture needles, and each acupuncture needle includes a needle body and a needle handle; an end of the needle body is a needle tip, and the other end of the needle body is fixedly connected with the needle handle. The acupuncture device further includes a driving device, and the driving device includes a driving component and a first timing component; the first timing component is configured for setting an interval of time to start the driving component, and the driving component is configured for driving the acupuncture needle to rotate alternately in forward and reverse directions when the interval of time is arrived.

Abstract: Provided is an automatic hair transplanter for transplanting follicles including a housing having a space therein and having an aperture in a front surface, a cartridge installed behind the aperture and having a plurality of holes containing each of needle and rod assemblies, a cartridge driver configured to sequentially cause centers of the needle and rod assemblies to correspond to the center of the aperture by causing the cartridge to make a rectilinear motion or a rotary motion, a needle-and-rod assembly pressurizer configured to pressurize the back end of a needle and rod assembly whose center corresponds to the center of the aperture, and a manipulator having a switch for controlling operations of the cartridge mover and the needle-and-rod assembly pressurizer.

Abstract: A tattooing device is designed for ingraining a design on the skin. The tattooing device includes an electric drive motor with a rotatable motor pin. The motor pin defines an axis of rotation. A rotatable actuator cam is operatively connected to the motor pin, and comprises a cam post axially offset from the motor pin and the axis of rotation. An elongated drive shaft is operatively connected to the cam post, such that rotation of the actuator cam effects simultaneous substantially linear reciprocating movement of the drive shaft. A needle assembly is operatively connected to the drive shaft, and adapted for carrying a pointed tattooing needle for penetrating the skin.

Abstract: A wireless tattoo applicator system includes a wireless tattoo applicator having a frame, a wireless receiver mechanically coupled to the frame, at least one coil mechanically coupled to the frame, an armature pivotally coupled to the frame adjacent the at least one coil, a spring mounted to the frame and applying a force to the armature in a first direction, a needle assembly mechanically coupled to the armature and free to move in a reciprocating manner, a battery power supply mechanically coupled to the frame and selectively electrically couplable to the at least one coil and operable, when coupled to the at least one coil, to energize the at least one coil to create a magnetic field causing the armature to be pulled in a second direction opposite the first direction, and a control circuit communicatively coupled to the receiver and operable to couple and decouple the battery power supply from the at least one coil at a selectable frequency.

Abstract: A device for manufacturing a brachytherapy array having a planar base which includes a working area comprising at least one planar major surface defining a first array of apertures, and a holding mechanism for holding a planar surgical mesh over the working area of said planar base. Also, a method for forming a brachytherapy array using this device.

Abstract: A volume of platelet-rich blood product is obtained from a volume of anti-coagulated blood to prepare a composition for promoting the growth of hair follicles within skin. A portion of the skin is traumatized to form a treatment area in which stem cells within the hair follicles are activated. A protein matrix is formed from the platelet-rich blood product composition to entrap growth factors. The platelet-rich blood product composition is infused into the treatment area to form a complex between the protein matrix and the growth factors so that the stem cells attach to the complex and proliferate within the hair follicles.

Abstract: A tattooing apparatus includes a tattoo needle; and upward and downward moving means to transmit a rotating force of a driving motor to the tattoo needle. The upward and downward moving means consists of a cam structure to convert a rotary movement by the rotating force of a driving motor into a linear movement, and includes a bearing member for rolling contact to reduce vibrations and noises.

Abstract: Apparatus is provided for sealing a vascular puncture by causing a reduction in the circumference of the puncture tract through delivery of a closure agent into tissue surrounding the puncture tract. A resultant inflammatory response and volumetric increase cause the tissue to swell into the puncture tract, thereby sealing it.

Abstract: To provide a puncture device which prevents components constituting a puncture device from being damaged by buckling (bending) etc., secures safety, and can be handled by a weak user easily. A puncture device 1 is provided with an outer needle 21, an outer needle hub 22 for retaining a base portion of the outer needle, an inner needle 3 whose tip portion is inserted in the outer needle, an inner needle hub 41 for retaining a base portion of the inner needle, an outer pipe 6 fitted inside the inner needle hub so as to be moveable to and fro, and an inner pipe 7 having a gripping device 71A for gripping the outer needle hub and fitted inside the outer pipe 6 so as to be moveable to and fro, and at least the outer pipe 6 is formed of a soft synthetic resin.

Abstract: Surgical tools and kits for performing methods include a grommet with cylindrical shaft, cutting tip, annular flange with suture retaining anchoring fixture; a grommet jig for extending between adjacent grommets and guiding a needle therebetween; a family of needles with single and double pointed ends, reinforced eyelets, stops to limit inadvertent exiting, double shaft construction with a longitudinal gap and sharpened, slicing ends, including a “J” shape embodiment; a bone anchor with ring to secure sutures about a patient's clavicle; a tissue dissector having radially extending cones to nick taut connecting tissues; a tissue rasp having a series of crisscrossing grooves along an end; a tissue mesher comprising one or more blocks having a matrix of holes for clamping a plurality of needles and a supporting framework; and a kit device and a method of surgically inserting an internal mesh brassiere under the breast skin.

Abstract: The present invention relates to a needle module, which comprises a piercing means on a mounting, which can be releasably coupled to the drive unit so that, as a result of a driving force exerted by the drive unit on the mounting, a repeated pushing movement moving the piercing means in and out is transmitted, wherein, according to the invention, the mounting has a safety device which mechanically irreversibly blocks the piercing means after the needle module has been released from the drive unit so that it can no longer be moved out of the needle module. The invention also relates to a device, in particular a hand device, for piercing the skin, comprising a drive unit and the needle module according to the invention.

Abstract: The present invention is to provide a tattoo needle guide tube, which has a tubular body defining a receiving space therein, a first through hole at a top end thereof and a second through hole at a bottom end thereof. Both through holes are in communication with the receiving space, and the outer periphery of the top end can be connected to a main body of an eyebrow tattoo machine, so as to allow a plurality of eyebrow tattoo needles in the main body to pass sequentially through the first through hole and receiving space and have needle tips exposed outside the second through hole. The tattoo needle guide tube is characterized in that the second through hole has a curved shape and is configured and sized to render the needle tips into a curved arrangement, so as for an eyebrow tattooist to make desired hair-like tattoos with ease.

Abstract: The present invention relates to a needle unit for injecting liquids such as medicine or tattooing pigment spread to a skin, into the skin, and a dermatological liquid injection apparatus using the same. The present invention includes a body unit including a driving device, a cam member rotated by the driving device, and a connecting member reciprocally driven by the cam member; a needle unit detachably mounted to a front end of the body unit; and a rubber member installed to the needle unit, for blocking blood and liquid mixture which are discharged from a skin of a patient and flow into the needle unit, from flowing to the body unit during a medical procedure.

Abstract: The present invention provides a device and a system for the delivery of biological material across the biological tissue. The device may be for the programmed delivery of biological material through a needle or a micro-needle or micro-needles or biodegradable micro-needles.

Abstract: The invention relates to a device for inserting pigment into the skin comprising a roller head unit comprising 2 or more distal arms; a rotatable structure comprising needles extending therefrom, attached to said roller head unit between said distal arms; a tubular member attached to the proximal end of said roller head unit; an elastic element placed within the distal portion of the inner lumen of said tubular member; a pin placed within said tubular member proximal to said elastic element.

Abstract: A system and method for providing variable power is disclosed. The system includes a power supply which provides power to at least one instrument. A pedal comprises a variable resistor that is configured to produce a resistance value within a predetermined range based on an amount of pressure which is being applied to the pedal. The voltage being supplied to the instrument is varied in accordance with the resistance value produced at the pedal.