Chemical Bonding Material Applied To Wound Edges Patents (Class 606/214)
  • Patent number: 11389346
    Abstract: Skin compression devices are disclosed that are formed of a shape memory material and that have multiple tensioning members. Disposal of one or more skin compression devices on the skin of a subject increases the temperature of the shape memory material and causes the tensioning members to bend inward, thereby compressing the area of skin disposed between the tensioning members; this compression shields the compressed skin from tensile loading. Methods of production and use of the skin compression devices are also disclosed.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: July 19, 2022
    Assignee: DePuy Synthes Products, Inc.
    Inventor: Ryan DeWall
  • Patent number: 11357536
    Abstract: A device set and a method for producing a micro-graft matrix with a plurality of punched full-thickness skin parts (12) from skin includes a film set of at least one first film (1) and one second film (2), which adhere to and are peelable from one another; an adhesive (10) to stick the first film (1) onto the skin; a cutting device with an adapter to provide a predefined distance to the skin and to make a plurality of hollow-cylindrical cuts vertical to the film set down to a predetermined depth in the skin underneath, the film set being respectively cut and divided, so that an outer portion of the second film can be peeled off and inner portions remain; and a third film (3), stuck in contact with the second film (2). The punched full-thickness skin parts can be extracted from the skin as the micro-graft matrix using the third film (3).
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: June 14, 2022
    Inventors: Markus Depfenhart, Jörg Müller, Hoc-Kiem Trieu, Matthias Spanic
  • Patent number: 11318040
    Abstract: Delivery systems and methods for forming and delivering biomaterials from two components are described herein. In particular, apparatus and methods for performing controlled delivery of multicomponent delivery of biomaterials into or onto a body part, such as a body lumen are described. More specifically, in some embodiments, the apparatus and methods are directed towards controlled delivery of micro-volumes of biomaterials into or onto a target location, the micro-volumes being defined as 0.001 mL-1 mL (or 1 ?L-1,000 ?L) of volume.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: May 3, 2022
    Assignee: Contraline, Inc.
    Inventors: Gregory Grover, Kevin S. Eisenfrats
  • Patent number: 11239198
    Abstract: A chip bonding method and a bonding device. The chip bonding method is used for bonding a chip to a display module, the display module includes a substrate and a functional layer on the substrate, the substrate includes a first substrate portion and a second substrate portion, the functional layer is on the first substrate portion, and an electrode is on an upper side of the second substrate portion. The chip bonding method includes: forming a light absorbing film layer on a side of the second substrate portion facing away from the electrode; coating a conductive adhesive film on the electrode, and placing the chip on the conductive adhesive film; and irradiating, by using a laser beam, a side of the second substrate portion facing away from the electrode.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: February 1, 2022
    Inventors: Lili Wang, Haiwei Sun, Zhenxing Tang, Feng Qu, Jing Liu, Chao Liu, Chuhang Wang, Qiangwei Cui, Ke Meng, Linhui Gong
  • Patent number: 11224438
    Abstract: A method of implanting an occlusive device in a perforator vessel may include introducing a needle through skin of a patient, and advancing the needle into a perforator vessel, the perforator vessel extending between a superficial vein and a deep vein. The method may further include distally advancing a delivery component from within the needle until a distal end of the delivery component extends into the deep vein and releasing a distal portion of the occlusive device into the deep vein. The needle may then be proximally withdrawn from the perforator vessel such that the device is exposed within the vessel, and the proximal portion of the device may be released into the superficial vein such that the device blocks flow through the vessel.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: January 18, 2022
    Assignee: ArtVentive Medical Group, Inc.
    Inventor: Leon Rudakov
  • Patent number: 11110201
    Abstract: Tissue compositions and methods of preparation thereof are provided. The tissue compositions can be used to treat or regenerate muscle tissue. The compositions can be configured to provide increased strength compared to other muscle matrices.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: September 7, 2021
    Assignee: LifeCell Corporation
    Inventors: Li Ting Huang, Eric Stec, Nathaniel Bachrach, Hui Xu
  • Patent number: 11090058
    Abstract: Delivery systems for liquid embolics and methods of using them are disclosed. The devices generally include a catheter and one or more retention elements to limit migration of the liquid embolic to non-target sites.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: August 17, 2021
    Assignee: Boston Scientific Scimed, Inc
    Inventors: Joseph Michael Connolly, Gary Pederson, Mary-Claire Anderson, Patrick A. Haverkost, David Raab, Mark Smith
  • Patent number: 11064989
    Abstract: A multi-ply adhesive retraction device is provided which comprises a top layer, a backing layer and a stretchable middle layer between the top and backing layers. A middle-ply adhesive applied to substantially the entirety of the middle layer bottom surface to removably adhere the backing layer to the middle layer bottom surface. The device includes at least one bottom ply tab integral with the device which is operable to remove at least a portion of the backing layer from the middle layer to expose the adhesive of the middle layer. Additionally, the device includes at least one top ply tab which is operable to remove the top layer from the middle layer. The device can be applied pre-operatively, and then the top layer can be removed post-operatively to remain in place during healing of, for example, an incision site.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: July 20, 2021
    Inventors: Thomas R. Galbierz, Michael A. Galbierz
  • Patent number: 11061325
    Abstract: A photosensitive composition activatable by multiphoton absorption usable for the fabrication of a three-dimensional structure which is biodegradable and/or biocompatible and/or bioresorbable. This structure is usable as a matrix for cell culture. The photosensitive composition comprises: gelatin, collagen, a water-soluble photoinitiator, able to be excited by several photons and capable of generating singlet oxygen, optionally a cell adhesion promoter, and water. A process for preparing the photosensitive composition, a process for preparing a three-dimensional structure from the photosensitive composition, the three-dimensional structure obtained by this preparation process and a matrix for cell culture comprising this structure.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: July 13, 2021
    Inventors: Olivier Stephan, Laetitia Gredy
  • Patent number: 11045187
    Abstract: A subcutaneous wound closure assembly having a closure apparatus, an insertion assembly and a retracting structure. The closure apparatus includes a substrate having a central axis and an outer perimeter. Radial ribs having micro needles extend therefrom. The insertion assembly includes an outer sheath and an applicator. Retracting structures in the form of sting members are coupled to the closure apparatus. A method of use is likewise set forth.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: June 29, 2021
    Assignee: BandGrip, Inc.
    Inventors: Fred Smith, Keith Hoglund, Tom Pruter, Michael Lambert
  • Patent number: 11007301
    Abstract: The invention relates to a hemostatic composition comprising a mixture of cellulose-based short and long fibers, preparation and use thereof.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: May 18, 2021
    Assignees: Omrix Biopharmaceuticals Ltd., Ethicon, Inc.
    Inventors: Erez Ilan, Omri Faingold, Nataly Freizus, Ronen Eavri, Dwayne Looney, Sridevi Dhanaraj, James Galloway, Walter Danker
  • Patent number: 11007300
    Abstract: The present invention relates to improved hemostatic compositions comprising cellulose-based fibers supplemented with compounds, preparation and use thereof.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: May 18, 2021
    Assignees: Omrix Biopharmaceuticals Ltd., Ethicon, Inc.
    Inventors: Erez Ilan, Omri Faingold, Nataly Freizus, Ronen Eavri, Dwayne Looney, Sridevi Dhanaraj, James Galloway, Walter Danker
  • Patent number: 10973503
    Abstract: Provided are approaches to establish a failsafe barrier to internal bleeding from percutaneous wounds to protect a patient from failed wound closure devices or related complications due to a variety of contributing factors such as state of systemic anticoagulation, errors in surgical procedure, variability in patient anatomy, and the like. Systems include a clotting agent to encase, and thus isolate, substantially the entire wound access area from the rest of the patient and an instrument, such as an intravascular introducer sheath, inserted through a wound at an access site on a vessel, for delivering the clotting agent to the entire enveloping tissue region around the accessed area as a mold cavity to be filled with the clotting agent. With benefits of patient safety, user simplicity, and low healthcare cost driving the effort, autologous whole blood is the preferred injected agent.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: April 13, 2021
    Inventor: Karol Leon Nowakowski
  • Patent number: 10945724
    Abstract: An adhesion device incorporating a plurality of element block assemblies which are partially disposed within an element support body having an engagement surface. Each element block assembly may include an element activation sheet, an element deployment sheet, a plurality of engagement elements, and an element transition mechanism which is operatively coupled to the engagement elements. The element transition mechanism is configured to reversible transition from a neutral configuration wherein the element activation sheet is substantially adjacent to the element deployment sheet, and an expanded configuration wherein the element activation sheet and the element deployment sheet are separated by a transition gap.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: March 16, 2021
    Assignee: Microkoll, Inc.
    Inventor: Steven Craig Anderson
  • Patent number: 10857261
    Abstract: A solidifying prepolymeric implant composition comprising a biocompatible prepolymer and an optional filler. One such implant composition is a polyurethane implant composition comprising an isocyanate, such as hydroxymetbylenediisocyanate (HMDI) and an alcohol, such as polycaprolactonediol (PCL diol). The compositions of the invention are useful for improving bone structure in patients by applying the solidifying implant composition to bone, reinforcing bone structure, improving load bearing capacity and/or aiding healing of microfractures.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: December 8, 2020
    Assignee: 206 ORTHO, Inc.
    Inventors: Jeffrey A. D'Agostino, Andrew J. Carter, Craig M. Jones, Arthur C. Watterson
  • Patent number: 10786255
    Abstract: An apparatus for joining two hollow organ sections includes a staple cartridge component, an anvil component, a knife member, a buttress mount and a buttress member. The staple cartridge component includes a plurality of surgical staples in an annular array. The anvil component is movable relative to the staple cartridge component between spaced apart and approximated positions to adjustably clamp tissue. The knife member is movable relative to the staple cartridge component. The buttress mount is concentrically disposed at least partially within the lumen of the knife member. The buttress mount includes a plurality of spokes radially extending outward and a plurality of legs detachably secured with an inner wall of the knife member. The buttress member is secured with the plurality of spokes of the buttress mount. The buttress member is concentrically aligned with the plurality of surgical staples.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: September 29, 2020
    Assignee: Covidien LP
    Inventors: Gerald Hodgkinson, Paul Scirica, Sally Carter, Richard Stevenson, Arthur Hislop, Thomas Casasanta
  • Patent number: 10625032
    Abstract: The present inventions are directed to spray tips for multidirectional or three-dimensional spraying of an unmixed two-part sealant and/or hemostat comprising a first biocompatible component and a biocompatible second component onto a tissue or wound comprising: a hollow body having inside a first component distribution compartment and a second component distribution compartment, said compartments not in fluid communication with each other. The first component can contain one or more biologic components, preferably fibrinogen and the second component can contain one or more biologic component different from the first biologic component, preferably thrombin and/or thrombin precursors. The present inventions are also directed to methods of spraying the unmixed two-part sealant or hemostat using the spray tip and associated components described above by simultaneously expressing the first component and the second component from the syringes.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: April 21, 2020
    Assignee: Ethicon, Inc.
    Inventors: Ashley DeAnglis, Sridevi Dhanaraj, John F. Goodman
  • Patent number: 10626299
    Abstract: The present invention relates to a fast and elastic adhesive. Said adhesive includes two components, one including a monomer having an alkoxyalkyl ester group, a thickener, a thixotropic agent and a stabilizing agent. In the other component, a plasticizing agent, a thixotropic agent, and an initiating agent are included. This adhesive can be used to practically instantaneously bond substrates that can move relative to one another, or which may be bent or have the ability to absorb an impact, or to seal.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: April 21, 2020
    Inventors: Arnau Pejoan Jiménez, Verónica De La Fuente Molina, Ciaran McArdle
  • Patent number: 10420857
    Abstract: This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: September 24, 2019
    Assignee: DSM IP ASSETS, B.V.
    Inventors: Timothy A Ringeisen, William Christopher Wattengel
  • Patent number: 10357591
    Abstract: Otologic materials and methods are provided. For example, a cell-adhesive, biodegradable hydrogel scaffold loaded with time-released drugs for repairing chronic tympanic membrane perforations is disclosed, methods of making same and administering same are provided. This hydrogel may promote vascular in-growth and epithelial cell growth of the tympanic membrane with the purpose of closing the perforation and providing a barrier between the external and middle ear. The hydrogel is initially a liquid polymer that only gels upon exposure to specific conditions, such as exposure to light. This scaffold may simultaneously induce repair of the tympanic membrane while preventing or alleviating middle ear infection, thus filling a void in current tympanic membrane perforation therapies.
    Type: Grant
    Filed: December 28, 2014
    Date of Patent: July 23, 2019
    Assignee: Tulane Educational Fund
    Inventors: Elaine Horn-Ranney, Parastoo Khoshakhlagh, Michael Moore, Jesse Ranney
  • Patent number: 10183132
    Abstract: The present invention is directed to an integrated delivery device that is operable with one hand and provides co-delivery of a liquid medicant and a powder medicant onto a tissue or wound from a liquid medicant expression subunit and a powder medicant expression subunit. Each expression subunit having an actuator for the liquid medicant and the powder medicant contained therein that are positioned in close proximity to one other at a proximate end of said expression subunits and delivery cannulas for each of said expression subunits that positioned in close proximity to one other at a distal end of said expression subunits. The present invention also relates to method for using such integrated devices.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: January 22, 2019
    Assignee: Ethicon LLC
    Inventors: Yi-Lan Wang, Leo B. Kriksunov
  • Patent number: 10022411
    Abstract: The present invention relates generally to agents and devices for promoting hemostasis and, more particularly, to an extract of a plant-based “Traditional Chinese Medicinal” product and devices incorporating such agents for the delivery thereof to bleeding wounds.
    Type: Grant
    Filed: September 20, 2013
    Date of Patent: July 17, 2018
    Assignee: Ethicon, Inc.
    Inventors: Yi-Lan Wang, Xintian Ming
  • Patent number: 10004487
    Abstract: A vascular closure device includes a vessel locating device, a sealant delivery device, a detachable sealing tip, and a suture. The vessel locating device includes an expandable portion configured to extend through and temporarily seal a vessel puncture from within a vessel. The sealant delivery device is configured to deliver a first volume of flowable sealant to the vessel puncture along an exterior of the vessel. The detachable sealing tip is carried at a distal end of the vessel locating device. The suture is connected to and extends proximally from the detachable sealing tip. The detachable sealing tip is configured for release within the first volume of flowable sealant upon withdrawal of the vessel locating device through the first volume of flowable sealant. The suture is anchored at a location proximal of the detachable sealing tip.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: June 26, 2018
    Assignee: St. Jude Medical Puerto Rico LLC
    Inventors: Deanna Porter, Zhengrong Zhou
  • Patent number: 9913758
    Abstract: A method of closing a wound with a dressing. The method including: restraining at least a portion of the dressing corresponding to the wound into a first shape; adhering first and second portions of the dressing across the wound; removing the restraint from the dressing while the first and second portions are adhered to the skin by removing a member from the dressing to allow at least the portion to move towards a second shape and apply a force tending to close the wound.
    Type: Grant
    Filed: September 8, 2012
    Date of Patent: March 13, 2018
    Inventors: Jahangir S. Rastegar, Thomas Spinelli
  • Patent number: 9867909
    Abstract: Enzymatically degradable compositions containing biocompatible polymers reactive with glycosaminoglycan compositions having a first glycosaminoglycan having a first degree of acetylation and a second glycosaminoglycan having a second degree acetylation different than the first degree of acetylation.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: January 16, 2018
    Assignee: Sofradim Production
    Inventor: Sébastien Ladet
  • Patent number: 9655604
    Abstract: A closure assembly includes an insertion sheath insertable into a tissue puncture and a tissue puncture closure device insertable through the insertion sheath and into the tissue puncture. The tissue puncture closure device includes a dual lumen delivery tube, a first sealing sleeve, and a second sealing sleeve. The dual lumen delivery tube has a first lumen configured to deliver a volume of sealing material to the tissue puncture, and a second lumen sized for insertion of a balloon location device. The first sealing sleeve is positioned between an outer surface of the dual lumen delivery tube and an inner surface of the insertion sheath to limit backflow of the sealing material into the insertion sheath. The second sealing sleeve is positioned between an outer surface of the balloon location device and an inner surface of the second lumen to limit backflow of the sealing material into the second lumen.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: May 23, 2017
    Inventors: Zachary J. Tegels, Robert M. Vidlund, Martha Escobar, Edward E. Parsonage, Russell D. Terwey
  • Patent number: 9611372
    Abstract: An underfill composition comprises a curable resin, a plurality of filler particles loaded within the resin, the filler particles comprising at least 50 weight % of the underfill composition. The filler particles comprise first filler particles having a particle size of from 0.1 micrometers to 15 micrometers and second filler particles having a particle size of less than 100 nanometers. A viscosity of the underfill composition is less than a viscosity of a corresponding composition not including the second filler particles.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: April 4, 2017
    Assignee: Intel Corporation
    Inventors: Yonghao Xiu, Nisha Ananthakrishnan, Yiqun Bai, Arjun Krishnan
  • Patent number: 9603589
    Abstract: A vascular closure device includes an inflation balloon and a delivery tube. The delivery tube includes an inflation lumen configured to deliver inflation fluid to the inflation balloon, a sealant lumen configured to deliver a sealant to a vessel puncture, and a delivery tip in flow communication with the sealant lumen and having a plurality of outlet openings.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: March 28, 2017
    Inventors: Russell D. Terwey, Zachary J. Tegels, Edward E. Parsonage, Robert M. Vidlund, Martha Escobar
  • Patent number: 9526557
    Abstract: An ablation device includes a handle assembly including a distal end and a probe extending distally from the distal end of the handle assembly. The probe includes a heat-transfer portion and at least one fluid-flow path in fluid communication with the heat-transfer portion. The handle assembly includes at least one fluid reservoir in fluid communication with the at least one fluid-flow path and at least one apparatus configured to cause fluid flow between the at least one fluid reservoir and the heat-transfer portion. The probe is configured to apply thermal energy released by an exothermic chemical reaction that occurs when fluid from the at least one fluid reservoir is caused to flow to the heat-transfer portion.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: December 27, 2016
    Assignee: COVIDIEN LP
    Inventor: Joseph D. Brannan
  • Patent number: 9475632
    Abstract: Provided is a syringe-type ejecting container that is capable of ejecting even a small amount of a content medium. Such an ejecting container includes an ejecting unit and an operation unit. The operation unit includes a syringe having a front end tubular portion, a rod extending through an inside of the front end tubular portion, and an operation shaft that causes the rod to project from the front end tubular portion. The ejecting unit includes a pipe that is mounted to the front end tubular portion and that is filled with a content medium, a plunger that is arranged inside the pipe, a nozzle that is mounted over an outside of a front end of the pipe, and a spin element that is arranged inside the nozzle close to the ejection hole and that is formed with a swirling groove leading to the ejection hole.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: October 25, 2016
    Inventors: Toru Toma, Shigeo Iizuka
  • Patent number: 9445796
    Abstract: Embodiments are described for closing vascular access ports, such as arteriotomies, which involve placement and deployment of an expandable device configured to prevent blood flow across a subject arteriotomy while also keeping disturbance of intravascular flow to a minimum. Suitable prostheses may comprise one or more frames constructed from lengths of flexible materials, such as shape memory alloys or polymers. Such frames may be coupled to sheetlike or tube-like structures configured to spread loads, minimize thrombosis which may be related to intravascular flow, and maintain hemostasis.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: September 20, 2016
    Assignee: PROMED, INC.
    Inventors: Richard S. Ginn, Nicanor Domingo, Hans F. Valencia, Robert Elliott DeCou, Scott Yerby
  • Patent number: 9427298
    Abstract: A textile implant, in particular for repairing hernias, the implant including a textile piece having a first face completely or partially covered in a bio-adhesive composition that is hydrosoluble and absorbable and that includes at least one bioadhesive polymer that is hydrosoluble and absorbable, with the adhesive function thereof being activatable in a moist or wet medium. The bio-adhesive composition includes less than 4% by weight of plasticizer.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: August 30, 2016
    Assignee: Bard Shannon Limited
    Inventor: Gilles Solecki
  • Patent number: 9408913
    Abstract: The invention provides methods and compositions for wound treatment and/or blood clot formation, e.g., arresting the flow of blood from an open wound. The methods and compositions provide for promoting and accelerating wound healing and optionally provide for inhibition of microbial infection and/or a local analgesic effect.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: August 9, 2016
    Assignee: Protege Biomedical, LLC
    Inventors: Michael Wuollett, Susan Wuollett
  • Patent number: 9345807
    Abstract: Disclosed is a PLGA (poly(D,L-lactide-co-glycolide)) cell scaffold. The cell scaffold is based on a PLGA scaffold, which is an FDA-approved material with no cytotoxicity, and overcomes the problem with conventional PLGA scaffolds of poor cell adhesion.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: May 24, 2016
    Inventors: Won Bae Jeon, Seong Kyoon Choi
  • Patent number: 9345822
    Abstract: A surgical tissue therapy device includes a sealant layer and a collection chamber. The sealant layer functions so as to create a sealed enclosure, or space between it and the surface of a patient, by forming an airtight seal around a surgical area of skin trauma. The closed incision tissue therapy device also comprises a collection chamber, which may comprise an elongate tubular chamber with a plurality of longitudinally spaced openings. The collection chamber may be configured to be in fluid communication with the sealant layer and the area of skin trauma and functions as to distribute the negative pressure applied to a surgically closed area of skin trauma. Preferably, the pressure under the sealant layer is reduced by expanding the volume of the enclosure space and thereby decreasing the density of air molecules under the sealant layer. The collection material may comprise a material and/or a configuration that permits length changes based upon the length of the corresponding surgical wound or incision.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: May 24, 2016
    Assignee: KCI Licensing, Inc.
    Inventors: Dean Hu, Kenton Fong, Moshe Pinto, Kenneth Wu, Craig McGreevy, Brendan Donohoe
  • Patent number: 9295752
    Abstract: Bioadhesives and crosslinked gels therefrom are disclosed. The bioadhesives can be applied to a vessel for occluding the vessel. The present disclosure also describes kits that comprise the various components for preparing and applying the bioadhesives. Bioadhesives of the present disclosure include: (i) a biopolymer having one or more first chemically reactive amine groups; (ii) a biocompatible crosslinker having at least two second chemically reactive groups that can chemically react with the one or more first chemically reactive amine groups of the biopolymer; and (iii) a biocompatible rheological modifier.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: March 29, 2016
    Assignee: Covidien LP
    Inventor: Gaurav Girdhar
  • Patent number: 9259445
    Abstract: The present invention refers to an Integrated Implant System constituted as a gel-matrix-cells integrated system, that allows providing implants in a brief time period, for covering a great skin extension to be treated, with a successful acceptance in patients with burns, chronic damage or wound skin, needing of a skin grafting.
    Type: Grant
    Filed: June 7, 2007
    Date of Patent: February 16, 2016
    Inventors: Manuel Eduardo Young Anze, Cristian Andrés Acevedo Gutiérrez, Fernando Antonio Albornoz Marquez, Caroline Ruth Weinstein Oppenheimer, Alexis Roobins Aceituno Alvarez, Donald Irving Brown Gonzalez, Sergio Miguel Tapia Murua
  • Patent number: 9220824
    Abstract: A method of implanting a cardiac device featuring the insertion of an inner seal member through an opening in a pericardium about a living human heart. The inner seal member has a first sealing lip disposed inside the pericardium and surrounding an aperture through the inner seal member. An outer seal member is aligned with the inner seal member. The outer seal member has a second sealing lip disposed outside the pericardium, surrounding an aperture through the outer seal member. The inner seal member is secured to the outer seal member. The firsts sealing lip is engaged against an inner surface of the pericardium. The second sealing lip is engaged against an outer surface of the pericardium. A cardiac device is inserted into the pericardium through the apertures of the inner and outer seal members.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 29, 2015
    Assignee: Adjucor GMbh
    Inventors: Stephen Manuel Wildhirt, Andreas Maier
  • Patent number: 9220486
    Abstract: A system for mixing or reconstituting agents including engageable syringe barrels, one of which having a male engagement region and the other a female engagement region. Each of the male and female engagement regions is provided with a screen. The screens are closely spaced from one another when the first and second syringe barrels are engaged with one another. The screens may take the form of a mesh, a plurality of protuberances, or cantilevered wedges having tapering thicknesses.
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: December 29, 2015
    Inventors: Mark Schweiss, Atif M. Yardimci, Scott R. Ariagno
  • Patent number: 9199007
    Abstract: The present invention relates to the application of a platelet gel for augmenting or restoring the volume of a soft tissue, particularly breast tissue, to biological implants comprising said gel, to a kit for preparing said implants and to a process for preparing said implants.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: December 1, 2015
    Assignees: Banc De Sang I Teixits, Fundacio Institut EN Ciencies De La Salut Germains Trias I Pujol, Universitat Autonoma De Barcelona
    Inventors: Juan Francisco Julián Ibáñez, Jorge Navinés López, Joan Ramon Grífols Ronda
  • Patent number: 9179900
    Abstract: A hemostatic device is provided for sealing a puncture of a vessel. The hemostatic device includes a locator device and an injection tube coupled to the locator device. The locator device includes a device valve that is actuatable to selectively restrict access to a portion of the locator device. The hemostatic device is advanced into the vessel until a first fluid is channeled through the locator device. The device valve is actuated to selectively restrict the first fluid from being channeled through the locator device. A second fluid is injected through the injection tube to facilitate sealing a puncture of the vessel. The hemostatic device is withdrawn from the vessel.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: November 10, 2015
    Assignee: Phillips Medical LLC
    Inventor: Victor Matthew Phillips
  • Patent number: 9173698
    Abstract: Embodiments of the disclosed technology provide systems, devices, and methods of creating an electrosurgical tissue seal that is augmented with a seal-enhancing composition. One embodiment of a device includes a set of opposing electrosurgical jaws configured to be able to close on a targeted tissue-sealing site; the jaws have a reservoir configured to hold a tissue seal-enhancing composition. The reservoir is in communication with a surface of the tissue-sealing site when the jaws are closed on the site, and the electrosurgical device is configured to deliver the tissue seal-enhancing composition to the site during an electrosurgical procedure. The device is further configured to deliver sufficient radiofrequency energy to the site such that the targeted tissue and the tissue seal-enhancing composition at the tissue-sealing site are processed to form a high integrity sealed tissue site.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: November 3, 2015
    Assignee: Aesculap AG
    Inventors: Stephen Van Lue, Joseph Charles Eder, Miriam H. Taimisto
  • Patent number: 9045396
    Abstract: The present invention relates to the discovery of new class of linear and multiarmed hydrolysable linkers and cross linkers for use in the synthesis of biodegradable polymers such as, polyesters, polyurethanes, polyamides, polyureas and degradable epoxy amine resin. The linear and multiarmed hydrolysable linkers of the present invention include symmetrical and/or unsymmetrical ether carboxylic acids, amines, amide diols, amine polyols and isocyanates.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: June 2, 2015
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S Bezwada
  • Patent number: 9039667
    Abstract: A method of arresting blood flow from a bleeding wound including the steps of (1) providing a solid hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery onto a bleeding wound, the tablet defining a proximal portion and a distal portion, (2) applying the proximal portion against the bleeding wound to improve the rate of adhesion to a bleeding wound surface, and then (3) applying pressure against the tablet over the wound site. After the seal is formed from the interaction of blood or exudates with the proximal portion of the tablet, the distal portion of the tablet delaminates from the proximal portion to form a reservoir to stop further bleeding and to provide antimicrobial protection and healing. The tablet may be applied to any surface orientation and take any shape and thickness possible.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: May 26, 2015
    Assignee: Biolife, L.L.C.
    Inventors: John Hen, Talmadge Kelly Keene, Mark Travi
  • Patent number: 9028529
    Abstract: The present invention is directed to tissue closure devices for closing a tissue opening, including one or more closure components, each closure component having a first member and a second member, each of the first and second members having a first surface that adheres to a tissue surface proximate to the tissue opening, each of the first and second members having a second surface substantially orthogonal to the first surface, and each of the first and second members having a transitional region between the first surface and the second surface which is contoured to evert an edge of the tissue opening upon the drawing together of the first and second members. The present invention is also directed to systems and kits, dressing systems, and methods for tissue repair and closure.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: May 12, 2015
    Assignee: DermaClip US, LLC
    Inventors: Andrew D. Fox, Daniel J. Riskin, Michael Barenboym
  • Patent number: 9029349
    Abstract: The invention provides a bioadhesive composition comprising a polysaccharide and an energy converter, wherein the energy converter is activated by non-UV light. The composition may be prepared by dissolving the polysaccharide and the energy converter in an aqueous acidic solution. The composition, in the form of a film or a gel, may be used for repairing a discontinuity in an area of tissue or for joining tissue.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: May 12, 2015
    Inventors: Antonio Lauto, Laura Poole-Warren, Leslie John Ray Foster
  • Patent number: 9028528
    Abstract: A seal element for sealing between tissue lumens includes a first material for allowing tissue ingrowth and a second sealant material.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: May 12, 2015
    Assignee: Covidien LP
    Inventors: Michael J. Bettuchi, David N. Fowler, Ahmad Robert Hadba, Christopher J. Criscuolo, John J. Kennedy
  • Publication number: 20150119824
    Abstract: An adhesive applicator for applying medical adhesives, particularly cyanoacrylates, to incisions such as those made during minimally invasive surgery. The applicator employs a pipette tip or similar narrow flow restrictor tip to close the incision and a body of foam to seal the incision. Methods of using the applicator are also disclosed.
    Type: Application
    Filed: April 22, 2014
    Publication date: April 30, 2015
    Applicant: Advanced Medical Solutions (Plymouth) Limited
    Inventor: Richard J. Stenton
  • Patent number: 9012530
    Abstract: The invention is directed to an adhesive strip, particularly an adhesive strip or bandage for use in periodontal treatments. The biocompatible adhesive strip comprises a flexible barrier with a biocompatible adhesive for use in an oral environment, wherein the adhesive is in a non-tacky state when dry and becomes adherent upon contact with liquids.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: April 21, 2015
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Kelly Brook Emerton, Susan J. Drapeau, Daniel Andrew Shimko
  • Patent number: 9011486
    Abstract: Methods, devices and systems are described for treating venous insufficiency in which the vein is compressed at least partially along a treatment zone. A system can be provided including an injection device, such as a glue gun, that is operably connected to a delivery catheter that can be advanced across a treatment zone in the vein. The delivery catheter can be used to deliver one, two, or more boluses of media (e.g., cyanoacrylate) to occlude the vein along different spaced-apart sections of the treatment zone. External compression can also be applied to the vein by a compression element, such as a hand or multifunctional ultrasound transducer, to occlude portions of the vein along the treatment zone prior to or during the introduction of the boluses of media.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: April 21, 2015
    Assignee: Covidien LP
    Inventors: Rodney D. Raabe, Jack Chu, Don Crawford, Jan R. Lau, Zhenyu Zuo