Abstract: This disclosure relates to surgical stapling apparatus for enhancing one or more properties of body tissue that is or is to be repaired or joined. The apparatus includes a staple anvil, a staple cartridge, a driving member for driving the surgical staples from individual staple slots in the staple cartridge and against the staple anvil, and a wound closure material applicator assembly. The applicator assembly includes at least one conduit extending along at least a length of the driving member, anvil and/or cartridge and at least one reservoir in fluid communication with the at least one conduit, the reservoir containing a wound closure material therein. The staples can be coated with a wound closure material.

Abstract: A buttressed anvil assembly is provided for use with a surgical stapling instrument. The buttressed anvil assembly generally includes an anvil member having a strip of buttress material attached thereto by a pair of sutures. A tensioning mechanism is provided to secure or tension the buttress material to the anvil member prior to use and allow for release of the buttress material after stapling of tissue. The tensioning mechanism includes a cinch track engageable with one of the pair of sutures.

Abstract: An end-effector assembly configured to be attached to a surgical instrument. The end-effector assembly comprises a first jaw and a second jaw comprising a staple cavity. At least one of the first jaw and the second jaw is movable relative to the other jaw. The end-effector assembly comprises a staple removably positioned within the staple cavity and an electrically-conductive driver configured to move the staple between a first stored position in which the staple is at least partially positioned within the staple cavity and a second position in which the staple is at least partially deployed from the staple cavity into tissue positioned intermediate the first jaw and the second jaw. The staple comprises an electrode.

Abstract: A surgical device is described herein that can be used to fire different types and sizes of disposable loading units. In a preferred embodiment, the device applies parallel rows of surgical fasteners to body tissue and concomitantly forms an incision between the rows of staples during an endoscopic or laparoscopic surgical procedure. The device can be utilized with disposable loading units configured to apply linear rows of staples measuring from about 15 mm in length to about 60 mm in length and can be used to fire disposable loading units containing surgical clips and individual staples.

Abstract: A surgical stapler includes a handle assembly, an elongated body portion extending distally from the handle assembly, and a head portion disposed adjacent a distal portion of the elongated body portion and including an anvil assembly and a shell assembly. The anvil assembly is movable in relation to the shell assembly between spaced and approximated positions. The shell assembly includes a pusher movable distally to advance staples from the shell assembly into contact with the anvil assembly. First and second alignment pins operatively associated with the pusher have distal ends positioned distally of the pusher, the alignment pins movable between a first non-engaged position spaced from the anvil assembly and a second position in engagement with the anvil assembly.

Abstract: A surgical stapling instrument is provided having systems for securing buttress material to the anvil and staple containing cartridge associated with the surgical instrument. The system includes a retainer configured to engage the anvil or the staple containing cartridge and capture the buttress material between the retainer and the anvil or staple containing cartridge. The disclose retainer engages the anvil or staple containing cartridge in snap fit or friction fit fashion. The buttress material includes a circumferential perforation line enabling the center of the buttress material to be stapled to tissue while the remainder of the buttress material remains with the anvil or staple containing cartridge.

Abstract: A surgical fastener applying apparatus having a first jaw and a second jaw. The first jaw includes a cartridge body having plurality of surgical fasteners disposed therein. The plurality of surgical fasteners include a plurality of first surgical fasteners having a first backspan with a first configuration, and a plurality of second surgical fasteners having a second backspan with a second, different configuration such that the plurality of first surgical fasteners apply a first compressive force to tissue upon formation and the plurality of second surgical fasteners apply a second, different compressive force to tissue upon formation.

Abstract: A graft fixation device combination. The device is useful for affixing a tissue graft to a bone or other body surface. The combination has a fixation device having two implantation members connected by a connecting member. The implantation members have longitudinal passageways therethrough. The combination also has an insertion member in engagement with the distal end of each implantation member.

Abstract: A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to secure the canal ends together. A method for performing anastomosis and staples for performing anastomosis are also disclosed.

Abstract: An exemplary surgical endocutter may include a staple holder; at least one feeder belt having two lateral edges, at least part of at least one feeder belt extending into the staple holder; and staples, wherein each said staple may include a first end frangibly affixed to a corresponding feeder belt, wherein each first end is affixed to the feeder belt at a location laterally spaced from the longitudinal centerline of the feeder belt, and a second free end; and wherein the staples form at least one row, each row including at least two said staples; wherein staples in least one row are staggered relative to said staples in at least one other row.

Abstract: The present disclosure relates to surgical fasteners and more particularly to surgical fasteners coated with wound treatment materials. According to an aspect of the present disclosure, a surgical fastener for use in combination with a surgical fastener applying apparatus is provided. The surgical fastener includes a pair of legs; a crown interconnecting the pair of legs; and a wound treatment material coating at least a portion of the legs and crown.

Abstract: A bioerodible, implantable medical device that includes a supersaturated magnesium alloy. The magnesium alloy includes magnesium and at least one alloying element present in a concentration in excess of the equilibrium solid solubility concentration of the alloying element in hexagonal close-packed magnesium [at 25° C.].

Abstract: A surgical instrument includes a hollow member having a sidewall provided with a window and a closure member movably connected to the hollow member for alternately covering and uncovering the window. The hollow member has a first clamping surface along an edge of the window, while the closure member has a second clamping surface opposing the first clamping surface and disposable substantially adjacent thereto in a clamping or closure configuration of the instrument. The instrument additionally comprises a tissue occlusion component mounted to at least one of the hollow member and the closure member for acting on tissues gripped between the first clamping surface and the second clamping surface, to couple the tissues to each other.

Abstract: The present disclosure relates to surgical instruments, structures and methods for enhancing the properties of tissue to be repaired or joined. According to an aspect of the present disclosure, a surgical stapling apparatus is provided including a wound treatment material dispersion system for delivering wound treatment material to a target surgical site. The dispersion system includes an aperture formed in the anvil assembly oriented to dispense wound treatment material in an outward direction; and a source of wound treatment material in fluid communication with the aperture of the anvil assembly.

Abstract: According to an aspect of the present disclosure, an apparatus for forming an anastomosis between adjacent intestinal sections of tissue is provided. The apparatus includes an anastomosis device having an anvil and a tubular body portion, wherein the anvil is selectively attachable to the tubular body portion by a shaft; and a support structure for deposition between the intestinal sections of tissue. The support structure includes a body defining an aperture therein for receiving the shaft. The body has an outer terminal edge. The support structure includes at least one layer of expandable material disposed at the outer terminal edge of the body.

Abstract: A surgical fastener applying apparatus having a first jaw and a second jaw. The first jaw includes a cartridge body having plurality of surgical fasteners disposed therein. The plurality of surgical fasteners include a plurality of first surgical fasteners having a first backspan with a first configuration, and a plurality of second surgical fasteners having a second backspan with a second, different configuration such that the plurality of first surgical fasteners apply a first compressive force to tissue upon formation and the plurality of second surgical fasteners apply a second, different compressive force to tissue upon formation.

Abstract: The surgical stapling apparatus includes a handle assembly, an elongated body extending distally from the handle assembly, and an articulation mechanism for articulating a tool assembly. The articulation mechanism includes a first gear rotatably mounted on a transmission shaft and configured to engage a second gear, a clutch interconnecting the second gear and a main shaft; and a yoke shaft coupled to the main shaft and adapted to linearly advance a J-channel, the J-channel operatively connected to an articulation link. A motor assembly may rotate the transmission shaft of the articulation mechanism. Alternatively, the articulation mechanism may include an articulation knob. Users may manually rotate the articulation knob to articulate the tool assembly of the surgical stapling apparatus.

Abstract: Disclosed is a surgical stapling apparatus and method of use that includes a cartridge assembly which is capable of being reloaded during a surgical procedure without being removed from the surgical site. This allows a surgeon to continue a surgical operation without withdrawing or removing the surgical stapler for reloading and thus reduces the length of the surgery while allowing the physician to concentrate solely on the surgical procedure rather than dividing attention between the surgical procedure and reloading of the surgical stapler. The surgical stapling apparatus includes an elongate member having a plurality of fasteners arranged in a plurality of longitudinally extending rows which is longitudinally translatable through the cartridge to position the plurality of fasteners relative to a plurality of retention slots extending through an upper surface of the cartridge.

Abstract: An endoscopic surgical instrument includes a flexible tube, a grasping and fastening end effector coupled to the distal end of the tube, and a manual actuator coupled to the proximal end of the tube. The manual actuator is coupled to the end effector by a plurality of flexible cables which extend through the tube. The tube contains a lumen for receiving a manipulable endoscope and the end effector includes a passage for the distal end of the endoscope. The end effector has a store for a plurality of male fastener parts, a store for a plurality of female fastener parts, a rotatable grasper, a rotatable fastener head for aligning a female fastener part and a male fastener part with tissues therebetween, and a firing member for pressing a male fastener part through tissues grasped by the grasper and into a female fastener part.

Abstract: A surgical device comprising an anvil, a cartridge assembly, a dynamic clamping member, a clamp ring and a drive mechanism is disclosed. The cartridge assembly is configured to house a plurality of fasteners at least partially therein. The anvil and cartridge assembly are movable in relation to each other between open and approximated positions. The dynamic clamping member is slidably positioned to translate at least partially through the cartridge assembly to eject fasteners therefrom. The dynamic clamping member engages the anvil and the cartridge assembly. The clamp ring is movable from a retracted position to an advanced position at least partially encircling proximal portions of the anvil and cartridge assembly for preventing a gap between proximal portions of the anvil and cartridge assembly from exceeding a predetermined distance. The drive mechanism includes a single actuator for driving both the clamp ring and the dynamic clamping member.

Abstract: A loading unit for use with a surgical stapling apparatus is provided and includes a tool assembly having a cartridge assembly and an anvil assembly that are movable in relation to one another; a surgical buttress releasably secured to a tissue contacting surface of the anvil assembly and/or the cartridge assembly, wherein each surgical buttress is secured to the anvil assembly and/or the cartridge assembly by at least one anchor; a release assembly associated with the anvil assembly and/or the cartridge assembly; and a drive assembly slidably translatable through the tool assembly between proximal and distal positions, wherein the drive assembly actuates the release assembly to thereby release the anchor to free the surgical buttress from the anvil assembly and/or the cartridge assembly.

Abstract: A staple having a crown, a deformable leg extending from the crown, and a spring extending from the crown configured to compress tissue between the spring and the deformable member. Owing to the flexibility of the spring, the staple can accommodate a wide range of tissue thicknesses while still compressing the tissue captured therein. As a result, a single staple design can be used in a wide variety of surgical procedures thereby reducing the amount of staple designs that must be provided to the surgeon. In at least one embodiment, the staple includes a crushable member. This crushable member can include a plastically deformable first portion and an elastically deformable second portion. The present invention can also include, in various embodiments, a crown, a first deformable member extending from the crown, and means for compressing the tissue against the first deformable member.

Abstract: In one embodiment, a medical device includes a tissue anchor, and elongate member, a first needle, and a second needle. The tissue anchor has a first arm portion, a second arm portion, and a base portion extending between the first arm portion and the second arm portion. The first needle extends from the elongate member. The first needle defines a lumen configured to receive the anchor member of the first arm portion of the tissue anchor. The second needle extends from the elongate member. The second needle defines a lumen configured to receive the anchor member of the second arm portion of the tissue anchor.

Abstract: The present disclosure describes a surgical fastener applying apparatus that includes an elongate body portion having proximal and distal ends, an end effector including a first movably coupled to a second jaw that is positioned at the distal end of the elongate body portion, and an introducer member. The introducer member has proximal and distal portions, and is configured and dimensioned for releasable connection with the end effector. The introducer member is at least partially formed from a flexible material, and is configured and dimensioned to separate target tissue from collateral tissue prior to positioning of the target tissue between the first and second jaws of the end effector.

Abstract: A surgical apparatus may include an end effector comprising a staple holder including a housing therein, and an anvil connected to the staple holder, where the end effector is movable between an open configuration and a clamped configuration; a feeder belt having two lateral edges, at least part of which is held within the housing; a plurality of staples, where each staple has a first end frangibly connected to the feeder belt and a second, free end; where at least one staple is oriented relative to the corresponding feeder belt in a direction angled relative to the transverse direction; and wherein the staples form at least one row, each row including at least two staples; and an overtube movable relative to the staple holder and anvil.

Abstract: A surgical device for applying a plurality of surgical staples is provided. The device includes a staple fastening assembly attached to a surgical instrument. The staple fastening assembly includes a pair of cooperating jaws, a jaw operating mechanism, and a gap sensor. A staple magazine having a plurality of staples and an anvil member having a plurality of staple pockets are attached to the jaws. The staple magazine includes a staple crimping cam and a staple dimpling cam that are operatively coupled to the surgical instrument. The jaw operating mechanism is operatively connected to a drive assembly in the surgical instrument for moving the jaws for automatically setting a tissue gap between the cooperating jaws. The gap sensor cooperates with the jaw operating mechanism for controlling staple formation.

Abstract: The present disclosure describes a surgical fastener applying apparatus that includes an elongate body portion having proximal and distal ends, an end effector including a first movably coupled to a second jaw that is positioned at the distal end of the elongate body portion, and an introducer member. The introducer member has proximal and distal portions, and is configured and dimensioned for releasable connection with the end effector. The introducer member is at least partially formed from a flexible material, and is configured and dimensioned to separate target tissue from collateral tissue prior to positioning of the target tissue between the first and second jaws of the end effector.

Abstract: An apparatus comprises a surgical instrument having a proximal end and a distal end. The proximal end may comprise a handle. The distal end may comprise a cutter and a stapler. The apparatus may further comprise a staple for use with the stapler. The staple may comprise an inner channel extending along at least a portion of the length of the staple. The apparatus may further comprise an agent contained in the inner channel, which may be used to coagulate a surgical site where surgical instrument is used. The agent may facilitate coagulation of the fluids at a surgical site once the staples are anchored to the surgical site.

Abstract: A surgical instrument including a first portion and a second portion, wherein the second portion can be sterilized separately from the first portion. The first portion can comprise an anvil, a staple cartridge channel and/or staple cartridge, and a movable cutting member. The second portion can comprise electronic components configured to control the surgical instrument and/or record data collected during the use of the surgical instrument. The first portion can be sterilized using a gamma radiation sterilization process while the second portion can be sterilized using a different sterilization process, such as steam, ethylene oxide, ozone, and/or hydrogen peroxide sterilization processes, for example. As a result, the first and second portions can be sterilized separately and delivered in two separate containers. The second portion can be stored within a sealed bag and can include an electrical terminal which can penetrate the bag and communicate with the first portion.

Abstract: A surgical method for treating a tissue structure having a wall and a lumen may include providing a substantially rigid anvil and a flexible tip affixed to and extending from the distal end of that anvil; making an incision in the wall of the tissue structure; inserting the flexible tip and at least a portion of the rigid anvil through the incision into the lumen of the tissue structure; and deforming at least one connector, introduced from outside the wall of the tissue structure, against the portion of the rigid anvil located within the lumen of the tissue structure.

Abstract: Surgical stapling methods and tools which allow a surgeon to create several different predetermined amounts of tissue constriction using the same staple (11) loaded in such a tool (31). A stapling tool (31) holding one or more staples in an effector section (35) contains a mechanism for spreading the pointed ends of a staple to one of several spaced apart distances as controlled by an actuator-indicator (43). Depending upon the distance the pointed ends have been spread when the staple is implanted into tissue (51), the amount of constriction accomplished by the staple is varied. An improved staple construction (61) of increased rigidity is also shown.

Abstract: A fastener cartridge can comprise a compressible, collapsible, and/or crushable cartridge body and fasteners embedded within the cartridge body which can be utilized to fasten tissue. In use, the fastener cartridge can be positioned in a first jaw of a surgical fastening device, wherein the first jaw can be positioned opposite a second jaw, or anvil. The anvil can be engaged with the fastener cartridge to compress, collapse, and/or crush the cartridge body and deform, or otherwise deploy, the fasteners contained therein. As the fasteners are deformed or deployed, the fasteners can capture at least a portion of the cartridge body therein along with at least a portion of the tissue being fastened. In various embodiments, the fastener cartridge and/or the first jaw can comprise retention features which can allow the fastener cartridge to be selectively inserted into the first jaw in a first orientation or a second orientation.

Abstract: A surgical staple comprising a first deformable leg, a second deformable leg and a backspan having first and second transverse portions spaced apart to create a gap therebetween. The backspan further includes a third transverse portion spaced distally from the first and second transverse portions and distally of the gap. A first non-linear backspan portion extends between the first transverse portion and the first end portion of the third transverse portion and a second non-linear backspan portion extends between the second transverse portion and the second end portion of the third transverse portion.

Abstract: This disclosure relates to surgical stapling apparatus for enhancing one or more properties of body tissue that is or is to be repaired or joined. The apparatus includes a staple anvil, a staple cartridge, a driving member for driving the surgical staples from individual staple slots in the staple cartridge and against the staple anvil, and a wound closure material applicator assembly. The applicator assembly includes at least one conduit extending along at least a length of the driving member, anvil and/or cartridge and at least one reservoir in fluid communication with the at least one conduit, the reservoir containing a wound closure material therein. The staples can be coated with a wound to closure material.

Abstract: Devices and methods for applying tension to an area of skin are provided, for example, for follicular unit removal and implant in a hair transplantation procedure. The devices may include a frame with at least two skin contact members that hold to the skin. Also disclosed are various ways to apply a force displacing the skin contact members apart, thus creating tension in the skin. The devices and methods may incorporate suction, and/or barbs or microbarbs. The frame may surround the skin area with tensile forces applied outward in multiple directions or substantially uni-directionally. Adjusting members and indicators may be provided to control and display the tensile force applied to skin. The tensioning devices and methods may be incorporated into a robotic hair transplantation system.

Abstract: This document discloses, among other things, a long reach, side ejecting fastener placement apparatus suitable for use in nasal septal surgery. A first linear member carries a fastener body and a second linear member delivers a fastener retainer or provides support for placement of the fastener body. In various examples, the fastener includes a single stud rivet or includes a two legged staple. A mechanical linkage coupled to the handle provides a linear force for placement and deployment of a fastener.

Abstract: A fastener system includes an open loop member and a receiving plate. The open loop member has first and second legs and a base. Each leg defines a longitudinal axis therethrough. The receiving plate has a body including a pair of spaced apart channels. The body defines a longitudinal axis therethrough. Each channel is positioned to receive a portion of one of the first or second legs.

Abstract: A surgical device includes a first jaw and a second jaw moveable relative to the first jaw between a first position, in which the first and second jaws are aligned within a plane, and a second position, in which the second jaw is in non-parallel correspondence to the plane. The surgical device may include a surgical member, e.g., a cutting and/or stapling element, disposed within the first jaw, and a second driver configured to cause relative movement of the surgical member in a direction parallel to the plane. The first and second jaws may include a camming arrangement that is configured to move the second jaw between the first and second positions. The camming arrangement may include a channel disposed along at least a portion of one or both of the first and second jaws, a ball bearing disposed within the channel.

Abstract: The method for surface inclusions detection in wrought and finished Nitinol products by immersing them in aqueous solution of 1% to 12%, and preferably 6%, sodium hypochlorite at room temperature of around 25° C. for specific period of time, preferably 15 minutes while checking for black flocculent precipitate developing on the surface indicating the presence of an inclusion. The presence of black flocculent precipitate indicates surface inclusions and lack of homogeneousness of material.

Abstract: A medical fastener has a first, pre-deployment shape for loading into a surgical instrument, and a second, post-deployment shape for connecting tissue together, and includes a crown and a pair of legs, each leg substantially transversely extending from a respective end of the crown in the first, pre-deployment shape. A coating, such as a hemostatic agent, is applied to a fastener interior surface defined by interior surfaces of the crown and the pair of legs.

Abstract: The present invention relates to an assembly comprising: a ring having anchoring elements for attaching the ring in a passage surrounded by body tissue, in particular blood vessel tissue. An applicator for fitting the ring in the passage; in which the anchoring elements have an anchoring position in which they protrude with respect to the ring, and in which the anchoring elements comprise a memory material, such as a memory metal or memory polymer, and are designed so that they can be bent from an anchoring position counter to a spring force into a fitting position and can be frozen in this fitting position by a temperature treatment in order to bend the anchoring elements back from the fitting position by the effect of this spring force into the anchoring position when a predetermined threshold temperature is exceeded, and in which the applicator is provided distally with a carrier for carrying the ring.

Abstract: One exemplary surgical apparatus may include: an anvil assembly to which a staple holder assembly detachably connected; feeder belts positioned at least partially within the staple holder assembly; staples separably attached to each feeder belt; a wedge assembly slidable within and along the staple holder assembly, the wedge assembly including an engagement feature; and a deployment handle. Upon closure of the anvil assembly and staple holder assembly relative to one another, the deployment handle engages the engagement feature. The deployment handle is movable along the anvil assembly to drive the wedge assembly relative to the staple holder assembly, feeder belts and staples in order to deform at least one staple to a closed state and separate at least one closed staple from the corresponding feeder belt.

Abstract: A surgical staple including a crown comprised of a dissolvable, bioabsorbable, or biofragmentable material, a first deformable member, and a second member. In at least one embodiment, the crown connects the first member and the second member, however, after the crown has been dissolved, the first member is unconnected to the second member and, as a result, the first and second members can move relative to each other. Accordingly, the staple can be rigid during the early stages of healing and can be flexible during the latter stages of healing, for example. In various embodiments, the first and second members of the staple are also comprised of a dissolvable, bioabsorbable, or biofragmentable material. In these embodiments, the first and second members can be constructed so that the crown and first and second members dissolve at different rates and/or dissolve away at different times.

Abstract: A surgical stapling apparatus having a housing with an actuator and an elongated member extending from the housing. An end effector is disposed on one end of the elongated member. The end effector houses a plurality of fasteners that are operatively coupled to a plurality of pusher members. An actuation mechanism is operatively coupled to the actuator; the actuation mechanism includes a longitudinally translatable drive member and an actuation sled. The actuation sled is configured for engaging the plurality of pusher members. A pressure responsive element is also disposed in one of the jaws. The pressure responsive element communicates a signal to a controller. The signal is representative of pressure applied to the pressure responsive element. The controller is configured to activate a feedback response.

Abstract: The present disclosure relates to surgical instruments, structures and methods for enhancing the properties of tissue to be repaired or joined. According to an aspect of the present disclosure, a surgical stapling apparatus is provided including a wound treatment material dispersion system for delivering wound treatment material to a target surgical site. The dispersion system includes an aperture formed in the anvil assembly oriented to dispense wound treatment material in an outward direction; and a source of wound treatment material in fluid communication with the aperture of the anvil assembly.

Abstract: A surgical instrument for surgically joining tissue is disclosed. The surgical instrument includes a handle assembly, an elongated portion extending distally from the handle assembly and defining a longitudinal axis, and an end effector disposed adjacent a distal portion of the elongated portion. The end effector includes a first jaw member and a second jaw member. The first jaw member defines a first axis, which is transverse to the longitudinal axis. The first jaw member is pivotable about the first axis. At least one of the first jaw member and the second jaw member is movable with respect to the other between a spaced-apart and an approximated position.

Abstract: A surgical fastener comprising a clip movable between an open configuration and a closed configuration and a biasing member contacting the clip and biasing the dip to its open configuration when the biasing member is actuated. The biasing member and clip both tend to assume the closed configuration when no external forces are applied to them. A needle may be releasably attached to the clip. Methods for making the fasteners are also disclosed, in which both the clip and the biasing member are set in the closed position.

Abstract: Introducers for introducing a surgical circular stapler into a patient. Various embodiments comprise a hollow flexible sheath that has a distal end and an open proximal end that is sized to receive a stapling head portion of the circular stapler therein. A radially-openable barrel member is attached to a distal end of the hollow flexible sheath to define an opening for receiving the stapling head therein. A rigid cap member is hingably attached to the radially-openable barrel member and is movable between a closed position wherein the rigid cap member covers a distal end of the opening in the barrel member and open position wherein the rigid cap member is movable to a position wherein the distal end of the opening is exposed. A releasable latch member is provided to engage and release opposed ends of the radially-openable barrel member.

Abstract: A multi-part surgical staple assembly is provided to provide uniform compression across stapled tissues. The staple assembly generally includes a staple, a staple plate positionable against a backspan of the staple for engagement with one side of a stapled tissue section and a platen for receipt of tissue penetrating tips of the staple and engageable with an opposite side of a stapled tissue section. The staple plate and platen are provided with holes to receive the legs of the staple. In one embodiment, the staple plate is provided with a biasing member to bias the staple plate away from the backspan of the staple and toward the stapled tissue.

Abstract: A mechanism is provided for crimping and releasing a suture securing a strip of buttress material to an end effector. The mechanism includes a retention member movably mounted within the end effector. The retention member is movable from a first position crimping the suture to the end effector to a second position releasing the suture from the end effector. The mechanism additionally includes a follower member, engageable with the retention member, and movable in response to actuation of a surgical instrument to move the retention member between the first and second positions. A lock mechanism is also provided to secure the retention member in the first position. The follower member operates to disengage the lock mechanism.