Localized Application Patents (Class 607/99)
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Patent number: 7315762Abstract: Devices, systems, and methods can treat incontinence by heating between about 100 and about 800 cubic millimeters of endopelvic fascia for sufficient time to effect substantial collagenous tissue shrinkage. A probe body may directly engage the endopelvic fascia, or may be separated from the endopelvic fascia, heating through (for example) the vaginal wall. In either case, tissue-penetrating electrodes may be inserted from the probe body so as to heat the endopelvic fascia.Type: GrantFiled: January 15, 2004Date of Patent: January 1, 2008Assignee: American Medical Systems, Inc.Inventors: Oren A. Mosher, Carine Hoarau, Abdul M. Tayeb, George L. Matlock, Daniel D. Merrick, Terry E. Spraker
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Patent number: 7285119Abstract: A catheter body includes a proximal portion, an intermediate portion extending from the proximal portion and defining a longitudinal axis, and a distal portion extending from the intermediate portion and terminated by a distal end of the catheter body; the distal portion forms a coil about a central loop axis, which is substantially parallel to the longitudinal axis. A first lumen extends through the proximal and intermediate portions of the catheter body and is terminated at an opening proximal to an ablation section, which is formed along the coil.Type: GrantFiled: October 20, 2003Date of Patent: October 23, 2007Assignee: Medtronic, Inc.Inventors: Mark T. Stewart, James R. Skarda
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Patent number: 7278993Abstract: A surface electrode for ablating tissue is provided. The surface electrode comprises a base, a plurality of tissue penetrating needle electrodes extending from the surface of the base an adjustable distance, and an electrical interface coupled to the plurality of needle electrodes. The adjustability of the needle electrodes allows the depth that the needle electrodes penetrate through tissue to be adjusted.Type: GrantFiled: June 3, 2005Date of Patent: October 9, 2007Assignee: Boston Scientific Scimed, Inc.Inventors: Amy C. Kelly, Steve K. Landreville, Robert J. Garabedian
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Patent number: 7276061Abstract: A tissue ablation device assembly ablates a region of tissue in a body of a patient. The tissue ablation device assembly comprises an elongated body having a proximal end portion and a distal end portion. A tubular porous membrane having a porous wall with an inner surface that defines an inner space is located along the distal end portion of the elongated body. An ablation element is disposed over the porous membrane, with the ablation element having a fixed position with respect to the porous membrane. A fluid passageway extending through the elongated body and communicates with the inner space. The fluid passageway is adapted to be fluidly coupled to a pressurizeable fluid source for delivering a volume of pressurized fluid from the fluid source to the inner space. The porous membrane allows at least a substantial portion of the volume of pressurized fluid to pass through the porous wall for enhancing ablative coupling between the electrode and the region of tissue.Type: GrantFiled: November 6, 2002Date of Patent: October 2, 2007Assignee: Atrionix, Inc.Inventors: Alan K. Schaer, Aurelio Valencia
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Patent number: 7270659Abstract: Systems, apparatus, and methods for treating spinal tissue and other body structures in open and endoscopic spine surgery to relieve symptoms, such as neck or back pain. In particular, the present invention provides methods for the controlled heating of various tissues in or around the vertebral column, including various interspinous tissues, such that spinal ligaments and cartilage surrounding the vertebrae and the facet joints are shrunk or tightened to stabilize the vertebral column of a patient. Thermal energy is applied to the target tissue in a subablation mode of an electrosurgical system to cause shrinkage of the tissue, thereby stiffening the interspinous tissue and stabilizing the vertebral column. In an exemplary embodiment, a high frequency RF voltage can be applied between one or more active electrode(s) and one or more return electrode(s) to heat a target interspinous tissue to within a temperature range at which irreversible shrinkage of the tissue occurs.Type: GrantFiled: September 19, 2005Date of Patent: September 18, 2007Assignee: ArthroCare CorporationInventors: Olivier Ricart, Jean Woloszko, David C. Hovda, Hira V. Thapliyal, Philip E. Eggers
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Patent number: 7270658Abstract: Methods and apparatus for selectively applying electrical energy to a target location within a patient's body, particularly including tissue in the spine. In a method of the invention high frequency (RF) electrical energy is applied to one or more active electrodes on an electrosurgical probe in the presence of an electrically conductive fluid to remove, contract or otherwise modify the structure of tissue targeted for treatment. In one aspect, a dura mater and spinal cord are insulated from the electrical energy by an insulator positioned on a non-active side of the probe. In another aspect, a plasma is aggressively formed in the electrically conductive fluid by delivering a conductive fluid to a distal end portion of the probe and aspirating the fluid from a location proximal of the return electrode.Type: GrantFiled: March 10, 2003Date of Patent: September 18, 2007Assignee: ArthroCare CorporationInventors: Jean Woloszko, David C. Hovda, Hira V. Thapliyal, Philip E. Eggers
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Patent number: 7261711Abstract: A method and apparatus for creating a virtual electrode to ablate bodily tissue. The apparatus includes an outer tube, a first electrode, an inner tube and a second electrode. The outer tube is fluidly connected to a source of conductive fluid and defines a proximal end and a distal end. The distal end includes an opening for delivering conductive fluid from the outer tube. The first electrode is disposed at the distal end of the outer tube for applying a current to conductive fluid delivered from the outer tube. The inner tube is coaxially received within the outer tube and is connected to a source of conductive fluid. The inner tube defines a proximal end and a distal end, with the distal end forming an opening for delivering conductive fluid from the inner tube. Finally, the second electrode is disposed at the distal end of the inner tube for applying a current to conductive fluid delivered from the inner tube.Type: GrantFiled: November 8, 2005Date of Patent: August 28, 2007Assignee: Medtronic, Inc.Inventors: Peter M. J. Mulier, Michael F. Hoey
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Patent number: 7251531Abstract: Systems, software, devices, and methods are disclosed for therapeutically heating a collagenous structural support tissue within a pelvic support system of a patient body. The present invention may monitor the delivery of energy and dynamically adjust the delivery of energy during the treatment so that an actual treatment time for reaching a target temperature falls within a desired treatment time range of reaching the target temperature. The present invention may also dynamically adjust the power level after the target temperature has been reached so that the tissue is held at the target temperature for a desired dwell time.Type: GrantFiled: January 30, 2004Date of Patent: July 31, 2007Assignee: AMS Research CorporationInventors: Oren A. Mosher, Abdul M. Tayeb
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Patent number: 7238166Abstract: A catheter system for controlling the body temperature of a patient by modifying the temperature of blood flowing within a blood vessel of the patient. The catheter system comprises a catheter body having a heat exchange region in contact with the blood; and a mechanism for moving the heat exchange surface, thereby increasing heat exchange between the heat exchange surface and blood flowing past the heat exchange surface. Various methods of moving the heat exchange surface are disclosed.Type: GrantFiled: May 26, 2004Date of Patent: July 3, 2007Assignee: Radiant Medical, Inc.Inventor: Jeff Callister
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Patent number: 7217268Abstract: An electrosurgical probe (10) comprises a shaft (13) having an electrode array (58) at its distal end and a connector (19) at its proximal end for coupling the electrode array to a high frequency power supply (28). The shaft includes a return electrode (56) recessed from its distal end and enclosed within an insulating jacket (18). The return electrode defines an inner passage (83) electrically connected to both the return electrode and the electrode array for passage of an electrically conducting liquid (50). By applying high frequency voltage to the electrode array and the return electrode, the electrically conducting liquid generates a current flow path between the return electrode and the electrode array so that target tissue may be cut or ablated. The probe is particularly useful in dry environments, such as the mouth or abdominal cavity, because the electrically conducting liquid provides the necessary return current path between the active and return electrodes.Type: GrantFiled: June 24, 2003Date of Patent: May 15, 2007Assignee: ArthroCare CorporationInventors: Philip E. Eggers, Hira V. Thapliyal
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Patent number: 7201750Abstract: An electrosurgical probe (10) comprises a shaft (13) having an electrode array (58) at its distal end and a connector (19) at its proximal end for coupling the electrode array to a high frequency power supply (28). The shaft includes a return electrode (56) recessed from its distal end and enclosed within an insulating jacket (18). The return electrode defines an inner passage (83) electrically connected to both the return electrode and the electrode array for passage of an electrically conducting liquid (50). By applying high frequency voltage to the electrode array and the return electrode, the electrically conducting liquid generates a current flow path between the return electrode and the electrode array so that target tissue may be cut or ablated. The probe is particularly useful in dry environments, such as the mouth or abdominal cavity, because the electrically conducting liquid provides the necessary return current path between the active and return electrodes.Type: GrantFiled: May 18, 1999Date of Patent: April 10, 2007Assignee: ArthroCare CorporationInventors: Philip E. Eggers, Hira V. Thapliyal
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Patent number: 7194294Abstract: The present invention provides multi-functional medical catheters, systems and methods for their use. In one particular embodiment, a medical catheter (100) includes a flexible elongate body (105) having a proximal end (110) and a distal end (120). A plurality of spaced apart electrodes (130–136) are operably attached to the flexible body near the distal end. At least some of the electrodes are adapted for mapping a tissue and, in some embodiments, at least one of the electrodes is adapted for ablating a desired portion of the tissue. The catheter includes a plurality of tissue orientation detectors (140–146) disposed between at least some of the electrodes. In this manner, the medical catheter is capable of tissue mapping, tissue imaging, tissue orientation, and/or tissue treatment functions.Type: GrantFiled: May 2, 2003Date of Patent: March 20, 2007Assignee: Scimed Life Systems, Inc.Inventors: Dorin Panescu, David K. Swanson
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Patent number: 7184811Abstract: A probe that may be used to create circumferential lesions in body tissue and, in some implementations, may also be used to perform mapping functions. The probe includes a collapsible/expandable structure that supports electrodes or other operative elements against the body tissue.Type: GrantFiled: April 4, 2005Date of Patent: February 27, 2007Assignee: Boston Scientific Scimed, Inc.Inventors: Huy D. Phan, David K. Swanson, Josef V. Koblish, Russell B. Thompson, Thomas R. Jenkins
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Patent number: 7183523Abstract: A wrist rest equipped with a heating device has a base, a heating device and a cushion. The base has a recess and a chamber. The heating device is mounted in and on the base and has a controller, a heating element, a switch and a power source. The controller is mounted in the chamber and controls operation of the heating device. The heating element is mounted in the recess and connected electrically to the controller. The switch is connected electrically to the controller to turn the heating element on and off. The power source is connected electrically to the controller to supply electricity to the heating device. The cushion is mounted in the recess above the heating element and is heated by heat from the heating element to improve the blood circulation in the mouse user's wrist area while a user operates the computer mouse.Type: GrantFiled: November 9, 2005Date of Patent: February 27, 2007Inventor: Chiang-Tsun Lu
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Patent number: 7175619Abstract: Loop structures for positioning diagnostic an therapeutic elements on the epicardium or other organ surface.Type: GrantFiled: February 9, 2004Date of Patent: February 13, 2007Assignee: Boston Scientific Scimed, Inc.Inventors: Josef V. Koblish, Russell B. Thompson, James G. Whayne, David K. Swanson
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Patent number: 7174217Abstract: A system for treating tissue includes a source of conductive and/or magnetic beads, a first member, e.g., a catheter or cannula, coupled to the source of magnetic beads, and a second member, e.g., a catheter or cannula, carrying a magnet on its distal end. The system is used for ablating or otherwise treating tissue within a target tissue region including a blood vessel contacting or passing therethrough. Magnetic beads are introduced into the target tissue region, e.g., using the first member, and a magnetic field is generated within the target tissue region, e.g., using the second member, to cause the magnetic beads to migrate towards a wall of the vessel. Energy is delivered into the target tissue region, e.g., to heat tissue therein, and the magnetic beads may attenuate or enhance treatment of tissue adjacent to the vessel.Type: GrantFiled: September 12, 2005Date of Patent: February 6, 2007Assignee: Scimed Life Systems, Inc.Inventors: Robert F. Rioux, Robert Garabedian
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Patent number: 7166105Abstract: An electrocautery device is disclosed. In accordance with one aspect of the invention, the electrocautery electrode/tip is provided with a hollow, conductive tube terminating at its distal end in a ball point type tip. Fluid, preferably conductive fluid, is applied to the proximal end of the hollow electrode/tip, and expelled from the distal end thereof during electrocautery. The ball point distal tip allows the distal tip to be directly applied to the tissue and “rolled” or slid along the tissue. This allows the distal tip to be moved across the tissue without dragging or snagging on the tissue. In addition, the conductive fluid expelled from the distal tip further lubricates the distal tip as it moves across the tissue. If conductive fluid is used, the conductive fluid emanating from the electrode/tip conducts the RF electrocautery energy away from the distal tip so that it is primarily the fluid, rather than the distal tip that actually accomplishes the cauterizing of tissue.Type: GrantFiled: September 20, 2005Date of Patent: January 23, 2007Assignee: Medtronic, Inc.Inventors: Peter M. J. Mulier, Michael F. Hoey
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Patent number: 7167757Abstract: Devices, systems, and method for treating urinary incontinence generally rely on energy delivered to a patient's own pelvic support tissue to selectively contract or shrink at least a portion of that pelvic support tissue so as to reposition the bladder. Devices and methods apply gentle resistive heating of tissues to cause them to contract without imposing significant injury on the surrounding tissue structures. Alternative heat-applying probes heat tissue structures which comprise or support a patient's urethra. By selectively contracting the support tissues, the bladder neck, sphincter, and other components of the urinary tract responsible for the control of urinary flow can be reconfigured or supported in a manner which reduces urinary leakage.Type: GrantFiled: April 19, 2004Date of Patent: January 23, 2007Assignee: AMS Research CorporationInventors: Frank W. Ingle, Garry L. Carter, Michael D. Laufer
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Patent number: 7156868Abstract: A catheter having a heat transfer device at or near its distal end, wherein the heat transfer device is layered or coated onto or into the catheter wall is described. The heat transfer device is preferably a flexible film having one or more electrical resistor flow paths thereon or therethrough, or is disposed directly onto the catheter wall by a deposition process. The heat transfer device may alternatively be formed by a length of the catheter wall being formed wholly, substantially of partly from doped material able to act as a heat transfer device upon application of power therethrough. The heat transfer device is preferably powered by one or more metal wires co-extruded within the catheter body.Type: GrantFiled: August 25, 2000Date of Patent: January 2, 2007Assignee: Omega Critical Care LimitedInventors: Aws Nashef, Ted Vander Wiede, Robert Macnair, Stephen Wilson, Simon Andrews
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Patent number: 7156845Abstract: A method and apparatus for creating a virtual electrode to ablate bodily tissue. The apparatus includes an outer tube, a first electrode, an inner tube and a second electrode. The outer tube is fluidly connected to a source of conductive fluid and defines a proximal end and a distal end. The distal end includes an opening for delivering conductive fluid from the outer tube. The first electrode is disposed at the distal end of the outer tube for applying a current to conductive fluid delivered from the outer tube. The inner tube is coaxially received within the outer tube and is connected to a source of conductive fluid. The inner tube defines a proximal end and a distal end, with the distal end forming an opening for delivering conductive fluid from the inner tube. Finally, the second electrode is disposed at the distal end of the inner tube for applying a current to conductive fluid delivered from the inner tube.Type: GrantFiled: September 16, 2005Date of Patent: January 2, 2007Assignee: Medtronic, Inc.Inventors: Peter M. J. Mulier, Michael F. Hoey
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Patent number: 7104986Abstract: The present invention provides systems and methods for selectively applying electrical energy to a target location within a patient's body, particularly including tissue in the spine. The present invention applies high frequency (RF) electrical energy to one or more electrode terminals in the presence of electrically conductive fluid to contract collagen fibers within the tissue structures. In one aspect of the invention, a system and method is provided for removing a vertebral disc in preparation for implanting a prosthetic disc or removing a portion of the vertebral disc such as the nucleus pulposus in preparation for placing a prosthetic nucleus within the annulus of the disc. The present invention also teaches shrinking residual tissue in preparation for placing the implants.Type: GrantFiled: May 12, 2003Date of Patent: September 12, 2006Assignee: ArthroCare CorporationInventors: David C. Hovda, Brian Martini, Zsuzsi Conforti, Jean Woloszko
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Patent number: 7070596Abstract: Apparatus and methods for advancing and retracting a medical instrument within an introducer device, wherein the instrument includes a distal tip, a distal linear portion, a first distal curve, a substantially linear inter-curve portion, and a second proximal curve. The length of the distal linear portion and the angle of the first curve determine the position of the distal tip within a lumen of the introducer device, such that the distal tip occupies a substantially central transverse location within the lumen and the distal tip avoids contact with the introducer device. The length of the inter-curve portion and the angle of the second curve determine deflection of the distal tip from a longitudinal axis of the shaft when the second curve is extended distally beyond a distal end of the introducer device. Also, methods and apparatus for treating an intervertebral disc by ablation of disc tissue.Type: GrantFiled: October 3, 2000Date of Patent: July 4, 2006Assignee: Arthrocare CorporationInventors: Jean Woloszko, Theodore C. Ormsby, John J. Quackenbush, Brian Martini
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Patent number: 7066935Abstract: Delivery elements, including needle electrodes and sheaths of tissue ablation devices, containing a conductivity-enhancing agent are discussed. The delivery elements contain a body member and optionally one or more coating layers. The conductivity-enhancing agent is disposed on or in the body member and/or at least one of the one or more coating layers. The conductivity-enhancing agent is capable of eluting from the delivery element when the delivery element is contacted with bodily tissue or fluid and increases conductivity of the tissue, making tissue ablation more efficient.Type: GrantFiled: April 30, 2004Date of Patent: June 27, 2006Assignee: Medtronic, Inc.Inventors: John M. Swoyer, Yelena G. Tropsha, Julie M. Woessner, Mark A. Christopherson
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Patent number: 7043306Abstract: A heat therapy device and therapy system is provided comprising a plurality of acupressure knobs having superconductive and far-infrared emitting material attached to it. This therapy device is slightly bent up at both ends for comforting the patients. The therapy system is configured more than one therapy device comprising: upper and lower bodies, control boxes, upper control panels connected to the upper control boxes, motors installed under the upper and lower bodies, pulleys installed at the opposite the motors, upper and lower rails installed between the motors and pulleys, timing belts positioned between the upper rails and the lower rails that directly connected to the motors and pulleys; upper and lower mobile units coupled with the timing belts and seated on the upper and lower rails, each mobile unit installed with the multiple heat therapy devices, and other heat therapy devices formed the left and right sides of upper rails.Type: GrantFiled: June 27, 2003Date of Patent: May 9, 2006Assignee: Migun Medical Instrument Co., Ltd.Inventor: Mi-Ja Park
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Patent number: 7041098Abstract: A catheter includes a plurality of primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes an electrode located at the working end of the catheter. Separation is maintained between the primary leads such that each primary lead can individually receive power of selected polarity. The primary leads are constructed to expand outwardly to place the electrodes into apposition with a hollow anatomical structure. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure. The diameter of the hollow anatomical structure is reduced by the heating effect, and the electrodes of the primary leads are moved closer to one another. Where the hollow anatomical structure is a vein, energy is applied until the diameter of the vein is reduced to the point where the vein is occluded. In one embodiment, a balloon is inflated to occlude the structure before the application of energy.Type: GrantFiled: June 3, 2002Date of Patent: May 9, 2006Assignee: VNUS Medical Technologies, Inc.Inventors: Brian E. Farley, Dawn A. Henderson, Christopher S. Jones, Mark P. Parker, Joseph M. Tartaglia
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Patent number: 7041095Abstract: A medical device, and related method, use epicardial ablators and detectors for intraoperative epicardial approaches to ablation therapy of cardiac conduction pathways. An epicardial gripper is sized to grasp the cardiac circumference or smaller structures on the epicardial surface of the heart. Ablators are disposed on the arms of the gripper for epicardial ablation of cardiac conduction tissue. In another embodiment of the invention, an electrode system includes a flexible, adjustable probe forming a loop for epicardial ablation. Ablators are provided on one or multiple surfaces of the probe for epicardial ablation of cardiac conduction tissue. In yet another embodiment of the invention, an endocardial ablator detection system provides an indicator adjacent an ablator on an endocardial catheter, and a detector on an epicardial probe.Type: GrantFiled: October 28, 2003Date of Patent: May 9, 2006Assignee: New England Medical CenterInventors: Paul J. Wang, Hassan Rastegar
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Patent number: 7041099Abstract: An elongate, malleable ablation probe including an elongate malleable body (38) and a plurality of longitudinally spaced apart electrodes (40) disposed at a distal end thereof. The electrodes (40) are separated one from another by insulative material. In one embodiment, a malleable insert is provided for insertion into a flexible longitudinal sleeve, the flexible longitudinal sleeve conforming to the shape of the malleable insert upon such insertion. In other embodiments, a malleable core is surrounded by a flexible body, the electrodes (40) being mounted to the body.Type: GrantFiled: March 24, 2003Date of Patent: May 9, 2006Assignee: Western Sydney Area Health ServiceInventors: Stuart Thomas, David Ross, Arianwen Rees, Robert Patterson, Michael Daly, Ilija Koevski
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Patent number: 7039469Abstract: A device and method for treating an infarct scar on a heart comprising an electric cable with proximal and distal ends; a handle with proximal and distal ends with the proximal end connected to the distal end of the cable; a stem with proximal and distal ends with the proximal end of the stem connected to the distal end of the handle; a heating element with a first surface for contacting infarct scar tissue connected to the distal end of the stem wherein the heating element comprises at least two electrodes and at least one temperature sensor positioned on the first surface for sensing a temperature of infarct scar tissue adjacent to the sensor; an energy source connected to the electrodes via the electric cable; and a regulator connected to the energy source and the temperature sensor of the infarct scar tissue, for controlling the temperature of the infarct scar tissue from about 60 degrees C. to about 99 degrees C.Type: GrantFiled: April 9, 2003Date of Patent: May 2, 2006Inventors: Michael D. Laufer, Suresh K. Wadhwani, Edward J. Nance, Payam Adlparvar, Thomas F. Kordis
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Patent number: 7008420Abstract: The high frequency surgical instrument includes the electrical connection portion configured to detachably connect the connection cord designed for an external high frequency power source, to the slider, and the instrument has such a structure in which the contact pin configured to lead the connection cord backward in substantially parallel with the advancing and retreating direction of the slider is provided in substantially parallel with the advancing and retreating direction of the slider while the connection cord is connected to the electric connection portion.Type: GrantFiled: December 9, 2003Date of Patent: March 7, 2006Assignee: Olympus CorporationInventor: Tsutomu Okada
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Patent number: 6997941Abstract: A device is described that may be positioned at a location in an intervertebral disc for diagnosis or treatment of the disc. Treatment may include, for example, applying energy or removing material, and may decrease intradiscal pressure. Radiofrequency energy may be applied. A percutaneous method of repairing a fissure in the annulus pulposus comprises placing an energy source adjacent to the fissure and providing sufficient energy to the fissure to raise the temperature to at least about 45-70° C. and for a sufficient time to cause the collagen to weld. An intervertebral fissure also can be treated by placing a catheter with a lumen adjacent to the fissure and injecting sealant into the fissure via the catheter, thereby sealing the fissure. An intervertebral fissure additionally can be treated by providing a catheter having a distal end, a proximal end, a longitudinal axis, and an intradiscal section at the catheter's distal end on which there is at least one functional element.Type: GrantFiled: March 17, 2003Date of Patent: February 14, 2006Assignee: Oratec Interventions, Inc.Inventors: Hugh R. Sharkey, John Ashley, Joel Saal, Jeffrey A. Saal, Le Trong Le
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Patent number: 6980862Abstract: A system and method for approaching the intervertebral disc through a percutaneous insertion from the back of a patient for thermal or electromagnetic treatment of an intervertebral disc, includes an elongated probe member having a guidable region adjacent its distal end with an undulating groove defined in its outer surface. The undulating groove is dimensioned to facilitate bending of the guidable region in at least one radial direction of movement relative to a longitudinal axis of the thermal probe. Preferably, the guidable region includes a plurality of undulating grooves, whereby adjacent undulating grooves are longitudinally spaced with respect to each other. The undulating grooves each define a sinusoidal configuration which may be arranged about an undulating axis extending in oblique relation to the longitudinal axis. The guidable region also includes a longitudinally extending backbone which resists bending of the guidable region in a radial direction of movement.Type: GrantFiled: May 16, 2003Date of Patent: December 27, 2005Assignee: Sherwood Services AGInventors: Raymond Fredricks, John Shanahan
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Patent number: 6978183Abstract: A manually activated Peltier device was placed in direct contact with a cortical slice. Seizures terminated within seconds of the onset of cooling, sometimes preceding a detectable drop in temperature measured near the top of the slice. Activation of the Peltier did not stop seizures when slices were no longer in direct physical contact with the device, indicating that this was not a field effect. When cooling was shut off and temperature returned to 33° C., the bursting sometimes returned, but a longer term suppressive effect on seizure activity could be observed. In two experiments, a custom computer program automatically detected seizure discharges and triggered a TTL pulse to activate the Peltier. In these experiments the Peltier automatically terminated the slice bursting in less than four seconds. When the Peltier device was placed in contact with the normal, exposed cortex of a newborn pig, we found that the cortical temperature rapidly decreased from 36° C. to as low as 26° C., at a depth of 1.Type: GrantFiled: May 4, 2001Date of Patent: December 20, 2005Assignee: The Washington UniversityInventor: Steven M. Rothman
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Patent number: 6972016Abstract: An electrophysiology (EP) device suitable for ablating tissue within a patient's body lumen. The EP device of the invention generally comprises an elongated shaft having a distal shaft section with a helical shape and at least one electrode on an exterior portion thereof. One aspect of the invention comprises a method of performing a medical procedure, such as treating a patient for atrial arrhythmia, by forming a lesion using an EP device embodying features of the invention.Type: GrantFiled: May 1, 2001Date of Patent: December 6, 2005Assignee: CaRDiMa, Inc.Inventors: Richard E. Hill, III, Alex L. Lim, Tim Huynh, Eric K. Y. Chan
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Patent number: 6966322Abstract: An implantable medical device, perhaps a pacemaker lead, has a medical unit and a casing at least partially enclosing the medical unit. The casing is formed of a base polymer having surface modifying pendant groups formed of an acrylamide polymer or an acrylamide copolymer, perhaps polyisopropyl acrylamide. The base polymer may be a polyurethane, polyimide, fluoropolymer or polyolefin, for example.Type: GrantFiled: April 19, 2002Date of Patent: November 22, 2005Assignee: Medtronic, Inc.Inventors: Rick D. McVenes, Kenneth B. Stokes, Michael J. Ebert, James M. Anderson
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Patent number: 6962589Abstract: A method and apparatus for creating a virtual electrode to ablate bodily tissue. The apparatus includes an outer tube, a first electrode, an inner tube and a second electrode. The outer tube is fluidly connected to a source of conductive fluid and defines a proximal end and a distal end. The distal end includes an opening for delivering conductive fluid from the outer tube. The first electrode is disposed at the distal end of the outer tube for applying a current to conductive fluid delivered from the outer tube. The inner tube is coaxially received within the outer tube and is connected to a source of conductive fluid. The inner tube defines a proximal end and a distal end, with the distal end forming an opening for delivering conductive fluid from the inner tube. Finally, the second electrode is disposed at the distal end of the inner tube for applying a current to conductive fluid delivered from the inner tube.Type: GrantFiled: January 8, 2004Date of Patent: November 8, 2005Assignee: Medtronic, Inc.Inventors: Peter M. J. Mulier, Michael F. Hoey
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Patent number: 6961620Abstract: A system for treating tissue includes a source of conductive and/or magnetic beads, a first member, e.g., a catheter or cannula, coupled to the source of magnetic beads, and a second member, e.g., a catheter or cannula, carrying a magnet on its distal end. The system is used for ablating or otherwise treating tissue within a target tissue region including a blood vessel contacting or passing therethrough. Magnetic beads are introduced into the target tissue region, e.g., using the first member, and a magnetic field is generated within the target tissue region, e.g., using the second member, to cause the magnetic beads to migrate towards a wall of the vessel. Energy is delivered into the target tissue region, e.g., to heat tissue therein, and the magnetic beads may attenuate or enhance treatment of tissue adjacent to the vessel.Type: GrantFiled: September 16, 2003Date of Patent: November 1, 2005Assignee: Boston Scientific SciMed, Inc.Inventors: Robert F. Rioux, Robert Garabedian
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Patent number: 6955173Abstract: This invention is a method for treating a patient diagnosed with atrial arrhythmia by forming a circumferential conduction block along a circumferential path of tissue in a pulmonary vein wall that circumscribes the pulmonary vein lumen and transects the electrical conductivity of the pulmonary vein such that conduction is blocked along the longitudinal axis of the vein wall and into the left atrial wall. The method is performed to treat a patient with a focal arrythmogenic origin along the pulmonary vein wall by either ablating the focal origin or by isolating the focal origin from the atrial wall with the circumferential conduction block. The circumferential conduction block is also formed in a pulmonary vein in order to bridge the adjacent ends of two linear lesions, wherein each linear lesion is formed to extend between the pulmonary vein and another adjacent pulmonary vein in a less-invasive “maze”-type procedure.Type: GrantFiled: August 30, 2002Date of Patent: October 18, 2005Assignee: The Regents of the University of CaliforniaInventor: Michael D. Lesh
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Patent number: 6949097Abstract: A catheter body of a catheter assembly includes a proximal portion, an intermediate portion extending from the proximal portion, a distal portion extending from the intermediate portion, and a locating device including a distal tip extending from the distal portion of the catheter body. The intermediate portion defines a longitudinal axis and the distal portion forms a loop including one or more loop segments formed around a central loop axis. The central loop axis is substantially parallel with the longitudinal axis and the one or more loop segments include at least one ablation electrode coupled thereto and adapted to create a lesion, the lesion electrically isolating a vessel from a chamber for treatment of a cardiac arrhythmia. The distal tip of the locating device is substantially parallel with the central loop axis.Type: GrantFiled: April 16, 2003Date of Patent: September 27, 2005Assignee: Medtronic, Inc.Inventors: Mark T. Stewart, William J. Flickinger, David E. Francischelli, Rahul Mehra, Xiaoyi Min
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Patent number: 6949098Abstract: An electrocautery device is disclosed. In accordance with one aspect of the invention, the electrocautery electrode/tip is provided with a hollow, conductive tube terminating at its distal end in a ball point type tip. Fluid, preferably conductive fluid, is applied to the proximal end of the hollow electrode/tip, and expelled from the distal end thereof during electrocautery. The ball point distal tip allows the distal tip to be directly applied to the tissue and “rolled” or slid along the tissue. This allows the distal tip to be moved across the tissue without dragging or snagging on the tissue. In addition, the conductive fluid expelled from the distal tip further lubricates the distal tip as it moves across the tissue. If conductive fluid is used, the conductive fluid emanating from the electrode/tip conducts the RF electrocautery energy away from the distal tip so that it is primarily the fluid, rather than the distal tip that actually accomplishes the cauterizing of tissue.Type: GrantFiled: July 1, 2004Date of Patent: September 27, 2005Assignee: Medtronic, Inc.Inventors: Peter M. J. Mulier, Michael F. Hoey
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Patent number: 6929640Abstract: The present invention provides systems and methods for selectively applying electrical energy to a target location within a patient's body, particularly including tissue in the spine. The present invention applies high frequency (RF) electrical energy to one or more electrode terminals in the presence of electrically conductive fluid to contract collagen fibers within the tissue structures. In one aspect of the invention, a system and method is provided for treating herniated or swollen discs within a patient's spine by applying sufficient electrical energy to the disc tissue to contract or shrink the collagen fibers within the nucleus pulposis. This causes the pulposis to shrink and withdraw from its impingement on the spinal nerve.Type: GrantFiled: February 24, 2000Date of Patent: August 16, 2005Assignee: Arthrocare CorporationInventors: Ronald A. Underwood, Terry S. Davison, Hira V. Thapliyal, Philip E. Eggers
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Patent number: 6916317Abstract: A method of treating cardiac arrhythmia, including guiding a distal end portion of a catheter, the distal end portion having a distal tip and accommodating an elongated configuration of ablation electrodes, from the inferior vena cava into the right atrium of a human heart, guiding the distal end portion from the right atrium into the right ventricle of the heart, deflecting the distal tip into a hook configuration, pulling the catheter towards the inferior vena cava until the hook configuration engages the tricuspid annulus of the heart and the configuration of electrodes engages the isthmus of tissue between the tricuspid annulus and the inferior vena cava of the heart, and activating the configuration of electrodes to produce a substantially continuous lesion on the isthmus of tissue.Type: GrantFiled: September 3, 2002Date of Patent: July 12, 2005Assignee: C.R. Bard, Inc.Inventors: Gary S. Falwell, Ian D. McRury, Michael C. Peterson, Paul J. Wang
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Patent number: 6904303Abstract: A probe that may be used to create circumferential lesions in body tissue and, in some implementations, may also be used to perform mapping functions. The probe includes a collapsible/expandable structure that supports electrodes or other operative elements against the body tissue.Type: GrantFiled: December 11, 2002Date of Patent: June 7, 2005Assignee: Boston Scientific SciMed, Inc.Inventors: Huy D. Phan, David K. Swanson, Josef V. Koblish, Russell B. Thompson, Thomas R. Jenkins
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Patent number: 6899711Abstract: A catheter assembly and method for treatment of cardiac arrhythmia, for example, atrial fibrillation, by electrically isolating a vessel, such as a pulmonary vein, from a chamber, such as the left atrium. The catheter assembly includes a catheter body and at least one electrode. The catheter body includes a proximal portion, an intermediate portion and a distal portion. The intermediate portion extends from the proximal portion and defines a longitudinal axis. The distal portion extends from the intermediate portion and forms a substantially closed loop transverse to the longitudinal axis. The at least one electrode is disposed along the loop. With this configuration, the loop is axially directed into contact with the chamber wall about the vessel ostium. Upon energization, the electrode ablates a continuous lesion pattern about the vessel ostium, thereby electrically isolating the vessel from the chamber.Type: GrantFiled: April 16, 2003Date of Patent: May 31, 2005Assignee: Medtronic, Inc.Inventors: Mark T. Stewart, William J. Flickinger, David E. Francischelli, Rahul Mehra, Xiaoyi Min
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Patent number: 6896672Abstract: Systems and methods are provided for removing fatty tissue underlying a patient's epidermis (e.g., blepharoplasty, brow lifts, eyelid shortening procedures, and the like). These methods include positioning one or more active electrode(s) and one or more return electrode(s) in close proximity to a target site on an external body surface of the patient. A high frequency voltage difference is applied between the active and return electrode(s), and the active electrode(s) are translated across the external body surface to create an incision therein. The bipolar configuration controls the flow of current to within and around the distal end of the probe, which minimizes tissue necrosis and the conduction of current through unwanted paths in the patient. The residual heat from the electrical energy also provides simultaneous hemostasis of severed blood vessels, which increases visualization and improves recovery time for the patient.Type: GrantFiled: May 1, 2000Date of Patent: May 24, 2005Assignee: Arthrocare CorporationInventors: Andrew R. Eggers, Philip E. Eggers, Ronald A. Underwood, Stephen M. Brunell, Hira V. Thapliyal
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Patent number: 6889089Abstract: A system for treating a target region in tissue beneath a tissue surface comprises a probe for deploying an electrode array within the tissue and a surface electrode for engaging the tissue surface above the treatment site. Preferably, surface electrode includes a plurality of tissue-penetrating elements which advance into the tissue, and the surface electrode is removably attachable to the probe. The tissue may be treated in a monopolar fashion where the electrode array and surface electrode are attached to a common pole on an electrode surgical power supply and powered simultaneously or successively, or in a bipolar fashion where the electrode array and surface electrode are attached to opposite poles of the power supply. The systems are particularly useful for treating tumors and other tissue treatment regions which lie near the surface.Type: GrantFiled: April 11, 2001Date of Patent: May 3, 2005Assignee: SciMed Life Systems, Inc.Inventors: Robert S. Behl, Eben L. Kermit
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Patent number: 6876884Abstract: A forced air warming unit has a casing that encloses a scroll housing with a curved inside surface. A blower is disposed in the scroll housing inside the curved surface. Inlet and outlet openings are provided in the casing. A circuit board is mounted in the casing, against the scroll housing so that the blower is enclosed in space between the scroll housing and the circuit board. At least one opening is provided through the circuit board into the space in which the blower is disposed. A tapered, elongate, arcuate heater plate is disposed in the scroll housing between the circuit board and the blower, with a relatively wide end near the outlet opening and a second, relatively narrower end near the curved inside surface. Air is conducted in response to operation of the blower through the inlet opening, along a first side of the circuit board through the one or more openings in the circuit board into the scroll housing.Type: GrantFiled: April 10, 2003Date of Patent: April 5, 2005Assignee: Arizant Healthcare Inc.Inventors: Gary L. Hansen, Allen Hamid Ziaimehr, Randall C. Arnold
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Patent number: 6855143Abstract: The present invention comprises electrosurgical apparatus and methods for maintaining patency in body passages subject to occlusion by invasive tissue growth. The apparatus includes an electrode support disposed at a shaft distal end having at least one active electrode arranged thereon, and at least one return electrode proximal to the at least one active electrode. In one embodiment, a plurality of active electrodes each comprising a curved wire loop portion are sealed within a distal portion of the electrode support. The apparatus and methods of the present invention may be used to open and maintain patency in virtually any hollow body passage which may be subject to occlusion by invasive cellular growth or invasive solid tumor growth. Suitable hollow body passages include ducts, orifices, lumens, and the like, with exemplary body passages including the coronary arteries.Type: GrantFiled: December 12, 2000Date of Patent: February 15, 2005Assignee: Arthrocare CorporationInventors: Paul O. Davison, Jean Woloszko
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Patent number: 6852091Abstract: A medical probe device comprises a catheter having a stylet guide housing with one or more stylet ports in a side wall thereof and a stylet guide for directing a flexible stylet outward through the stylet port and through intervening tissue at a preselected, adjustable angle to a target tissue. The total catheter assembly includes a stylet guide lumen communicating with the stylet port and a stylet positioned in said stylet guide lumen for longitudinal movement from the port through intervening tissue to a target tissue. The stylet can be an electrical conductor enclosed within a non-conductive layer, the electrical conductor being a radiofrequency electrode. Preferably, the non-conductive layer is a sleeve which is axially moveable on the electrical conductor to expose a selected portion of the electrical conductor surface in the target tissue. The stylet can also be a microwave antenna. The stylet can also be a hollow tube for delivering treatment fluid to the target tissue.Type: GrantFiled: April 15, 2002Date of Patent: February 8, 2005Assignee: Medtronic Vidamed, Inc.Inventors: Stuart D. Edwards, Ronald G. Lax, Ingemar H. Lundquist, Hugh R. Sharkey
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Inflatable balloon catheter structural designs and methods for treating diseased tissue of a patient
Patent number: 6847848Abstract: Each of various modifications of an integrated-structure inflatable balloon catheter design includes a longitudinal structure having a sharply-pointed insertion needle at a distal end of the longitudinal structure and an inflatable balloon situated intermediate a proximate end and the distal end of the longitudinal structure which is attached to said longitudinal structure. With the inflatable balloon in a deflated state, the insertion needle may be used to puncture the patient's skin and underlying sub-cutaneous tissue and place the deflated balloon in proximity to the diseased sub-cutaneous tissue, The balloon is then inflated to press against and thereby spatially deform the diseased sub-cutaneous tissue, after which the deformed diseased sub-cutaneous tissue may be therapeutically heated. This heating may be sufficient to cause the creation of a permanent cavity in the deformed diseased sub-cutaneous tissue which persists after the catheter is withdrawn.Type: GrantFiled: January 7, 2003Date of Patent: January 25, 2005Assignee: MMTC, INCInventors: Fred Sterzer, Daniel D. Mawhinney -
Patent number: 6840954Abstract: The present invention enhances the effectiveness of treatment of support tissue structures. Generally, such tissue structures support organs and hold the organs in their proper position for appropriate functioning. When such tissue structures become weak, hyper-elastic, and/or excessively lengthy, the organs of are no longer supported in their proper position. This often leads to physical manifestations such as incontinence, hernias, and the like. Remedies often involve thermal treatment of the support tissue structures, such as thermally inducted controlled shrinkage, contraction, or stiffening of the support tissue structure. To enhance such thermal treatment and diminish the possibility of undesirable heating and damage to nearby tissue surfaces, vasoconstrictive agents are used.Type: GrantFiled: December 20, 2001Date of Patent: January 11, 2005Assignee: Solarant Medical, Inc.Inventors: Timothy G. Dietz, Stanley Levy, Jr.