Having Pores Patents (Class 623/1.39)
  • Patent number: 11179254
    Abstract: A prosthetic heart valve can include an inner support structure, a valve member, and an outer support structure. The inner support structure can have a plurality of first struts coupled together by first pivot joints and forming a first lumen. The valve member can be disposed within the first lumen and coupled to the inner support structure. The valve member can include a plurality of leaflets configured for permitting blood flow through the valve member in one direction. The outer support structure can have a plurality of second struts coupled together by second pivot joints and can form an annulus portion, an outflow portion, and a second lumen. The outflow portion can extend radially outwardly relative to the annulus portion, and the inner support structure and the valve member can be disposed within the second lumen and be coupled to the outer support structure.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: November 23, 2021
    Assignee: Edwards Lifesciences CardiAQ LLC
    Inventor: Jennifer K. White
  • Patent number: 10993803
    Abstract: A leaflet for a prosthetic valve formed of at least one layer that includes a composite material containing at least one expanded fluoropolymer membrane having serpentine fibrils and an elastomer is provided. The fluoropolymer may be polytetrafluoroethylene. In at least one embodiment, the elastic properties are present in an axial direction the leaflet. The leaflets may be single layered or multi-layered. The leaflets may be coupled to a support structure and movable between open and closed configurations relative to the support structure to form a heart valve. The elasticity within the leaflets permits, among other things, the leaflets to bend with a reduced occurrence of wrinkles as the valve opens and closes. The elastic properties of the leaflet also, among other things, improve bending properties and reduce closure stresses, thereby extending the life of the leaflet.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: May 4, 2021
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: William C. Bruchman, Charles F. White
  • Patent number: 10612152
    Abstract: A method of fabricating a nanoporous metal structure, such as a nanoporous metal (NMP) supported Pd catalyst suitable for use in a direct methanol fuel cell (DMFC), is includes the steps of (a) providing a piece of Au55Cu25Si20 alloy glass ribbon with a thickness of 50 ?m, (b) dealloying the piece of alloy glass ribbon by reacting with iron (III) chloride solution to form a free-standing NPM ribbon, (c) depositing a thin film of PdCo of a thickness of 100 nm on the NPM ribbon by RF magnetron sputtering with Pd0.5Co0.5 (atomic percent) as target in an argon atmosphere, and (d) electrochemically dissolving some of the Co on the thin film of PdCo to induce migration of Au from the NPM ribbon to the thin layer of PdCo.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: April 7, 2020
    Assignee: CITY UNIVERSITY OF HONG KONG
    Inventors: Yi Xu, Pak Man Yiu, Chan Hung Shek
  • Patent number: 10548708
    Abstract: An endoprosthesis has an expanded state and a contracted state, the endoprosthesis includes a stent having an inner surface defining a lumen, having an outer surface, and defining a plurality of apertures through the outer surface, wherein the apertures are arranged in a micropattern; and a coating (e.g., polymeric coating) attached to the outer surface of the stent. The coating includes a base and a tissue engagement portion including a second surface facing outwardly from the stent, the tissue engagement portion including a structure that defines a plurality of holes extending inwardly from the second surface toward the base. The holes are arranged in a micropattern. When the endoprosthesis is expanded to the expanded state in a lumen defined by a vessel wall, the structure applies a force that may reduce stent migration by creating an interlock between the vessel wall and the endoprosthesis.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: February 4, 2020
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: William Bertolino, Laura Elizabeth Firstenberg, Claire M. McLeod, Andrea Lai, Sandra Lam, Shannon Taylor
  • Patent number: 10500036
    Abstract: Method and apparatus for mapping the shape and dimensions of a 3-dimensional body, by applying to the 3-dimensional body a stretchable covering configured and dimensioned such that in its stretched condition it tightly engages and conforms to the shape and dimensions of the 3-dimensional body to be mapped. The stretchable covering carries a plurality of reference devices, such as bands and/or markers which are at know or determinable reference locations in an initial condition of the covering, and which change their locations in the stretched condition of the stretchable covering according to the shape and dimensions of the 3-dimensional body covered thereby. The locations of the markers on the stretchable covering are determined after the stretchable covering has been applied to the 3-dimensional body, and are utilized to produce a map of the shape and dimensions of the 3-dimensional body.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: December 10, 2019
    Assignee: DTherapeutics, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 10451637
    Abstract: The present invention provides a synthetic blood vessel and use thereof in drug screening, drug delivery and prognoses of cerebrovascular dysfunction.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: October 22, 2019
    Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Cheryl Wellington, Jerome Robert
  • Patent number: 10354378
    Abstract: A five-index quantitative analysis of OCT angiograms is disclosed. One method of analyzing an anatomical region of interest of a subject includes acquiring vascular image data from the region of interest and generating a binary vasculature map from the vascular image data. A vessel skeleton map and vessel perimeter map are generated from the binary vasculature map. Based on the three generated maps, a vessel area density, vessel skeleton density, vessel perimeter index, vessel diameter index, and vessel complexity can be determined, in addition to detection of any flow impairment zones in the region of interest. These metrics can be used to detect and assess vascular abnormalities from multiple perspectives.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: July 16, 2019
    Assignee: University of Washington
    Inventors: Ruikang K. Wang, Chieh-Li Chen, Zhongdi Chu, Qinqin Zhang
  • Patent number: 10251742
    Abstract: An artificial blood vessel is composed of a cylindrical multiple-woven fabric structure allowing only a small amount of blood leakage and can achieve both antithrombogenicity and cellular affinity. The artificial blood vessel includes a cylindrical fabric structure in which a cylindrical fabric whose inside contacts blood is arranged, wherein the cylindrical fabric is a fabric prepared by interlacing a plurality of warp yarns and a plurality of weft yarns with each other into a cylindrical shape; the warp yarns and the weft yarns constituting the cylindrical fabric include a multifilament yarn having a single yarn fineness of not more than 0.50 dtex, and are bound to an antithrombogenic material; the antithrombogenic material forms an antithrombogenic material layer having a thickness of 1 to 600 nm inside the cylindrical fabric; and the water permeability under conditions where a pressure of 16 kPa is applied to the inner surface is less than 300 mL/cm2/min.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: April 9, 2019
    Assignee: Toray Industries, Inc.
    Inventors: Masaki Fujita, Koji Kadowaki, Yuka Sakaguchi, Kazuhiro Tanahashi, Hiroshi Tsuchikura, Satoshi Yamada
  • Patent number: 9795400
    Abstract: A medical device configured to perform an endovascular therapy can include an elongate manipulation member and an intervention member. The elongate manipulation member can include a distal end portion. The intervention member can include a proximal end portion and a mesh. The proximal end portion can be coupled with the distal end portion of the elongate manipulation member. The mesh can have a plurality of cells in a tubular configuration and being compressible to a collapsed configuration for delivery to an endovascular treatment site through a catheter and being self-expandable from the collapsed configuration to an expanded configuration. The mesh can include an anodic metal and a cathodic metal. The anodic metal and the cathodic metal can each form a fraction of a total surface area of the mesh.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: October 24, 2017
    Assignee: Covidien LP
    Inventor: James Davidson
  • Patent number: 9775933
    Abstract: The invention is an improved biocompatible surface for a variety of medical purposes. The biocompatible surface employs a unique tight microstructure that demonstrates enhanced cellular response in the body, particularly when placed in contact with blood. As a blood contact surface, the present invention can be beneficially employed in a wide variety of implantable devices and in many other devices and equipment that come in contact with blood.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: October 3, 2017
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Keith A. Knisley, Vishnu T. Marla, Rachel Radspinner, Paul A. Silvagni, Jason J. Strid, Michael J. Vonesh
  • Patent number: 9770349
    Abstract: The present invention relates generally to medical devices containing nanoporous surfaces and methods for making same. More specifically, the invention relates to implantable vascular stents or other biomedical devices having at least one dealloyed nanoporous layer that promotes improved cellular adhesion properties that promote healing and long term biocompatibility. In the case of stents, the nanoporous layer promotes re-endothelialization at sites of stent implantation vasculature, improves overall healing, and reduces inflammation and intimal disease progression. The nanoporous layer may be optionally loaded with one or more therapeutic agent to further improve the function of the implanted stent and further augment clinical efficacy.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: September 26, 2017
    Assignee: University of Virginia Patent Foundation
    Inventors: Gary Owens, Whye-Kei Lye, Michael Reed, Joshua Spradlin, Brian Wamhoff, Matthew Hudson, Kareen Looi
  • Patent number: 9642728
    Abstract: A stent for placement in a body lumen is fabricated by forming a tube having an undeployed diameter sized for the tube to be placed on a deployment balloon and advanced through a body lumen to a deployment site. The tube is expandable upon inflation of the balloon to an enlarged diameter sized for the tube to be retained within the lumen at the site upon deflation and withdrawal of the balloon. The tube has a stent axis extending between first and second axial ends of the tube. The tube has an exterior surface and an interior surface. The tube is polished to polish the exterior surface to a smooth surface finish and with at least a portion of the interior surface having a rough surface finish rougher than the surface finish of the exterior surface.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: May 9, 2017
    Assignee: Covidien LP
    Inventor: Paul Thompson
  • Patent number: 9572654
    Abstract: A self-sealing vascular graft, including a substrate with a sealant layer and several optional additional layers, is described. The substrate can be ePTFE and the material used for the sealant and additional layers can be polyurethane. The sealant layer and additional layers may include one or more base layers, one or more foam layers, beading of different sizes and shapes, and ePTFE tape. A flared cuff may be integral to one or both ends of the substrate or may be attached to one or both ends. Various methods of making a self-sealing vascular graft are also described, including methods of disposition, methods of forming, methods of bonding and methods of attaching.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: February 21, 2017
    Assignee: C.R. Bard, Inc.
    Inventors: Tarun J. Edwin, Jamie Abbott, Heidi R. Cole, Chandrashekhar P. Pathak, David L. Bogert, Richard Elton, Fitzroy Brown, Kereshmeh Shahriari
  • Patent number: 9433709
    Abstract: An interventional medical device and manufacturing method thereof. The interventional medical device comprises: a stent body (1); a surface of the stent body (1) being provided with a drug releasing structure (3), and drug in the drug releasing structure (3) being drug for suppressing proliferation of adventitial fibroblasts and a drug for suppressing proliferation of intimal and/or smooth muscle cells. In use, after interventional medical device is implanted into a human body, the drug for suppressing proliferation of adventitial fibroblasts carried thereon can promote the compensatory expansion of the vessel, and the drug for suppressing proliferation of intimal cells and/or smooth muscle cells carried thereon can suppress intimal proliferation of the vessel. The combination of the two kinds of drugs greatly reduces the occurrence rate of in-stent restenosis.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: September 6, 2016
    Assignee: SHANGHAI MICROPORT MEDICAL (GROUP) CO., LTD.
    Inventors: Dadong Zhang, Xu Cai, Chengyun Yue, Junfei Li, Yan Hu, Peng Huang, Zhirong Tang, Qiyi Luo
  • Patent number: 9421177
    Abstract: Imidamide (amidine) analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumors.
    Type: Grant
    Filed: August 16, 2010
    Date of Patent: August 23, 2016
    Assignee: University of Virginia Patent Foundation
    Inventors: Kevin R. Lynch, Timothy L. Macdonald, Thomas P. Mathews, Andrew Kennedy, Yugesh Kharel
  • Patent number: 9248121
    Abstract: The present invention is a medical device for controlling the release of an active agent. The medical device has a supporting structure having a porous body disposed therein. At least one elution rate controlling matrix containing an effective amount of at least one active agent is disposed within the pores of the porous body in a manner that protects the matrix from mechanical damage. The medical device may therefore be used for controlled drug release applications. Additionally, the present invention discloses a method for using the medical device for the treatment and prevention of diseases in mammals. This invention further relates to a method for using the medical device for treating and preventing vascular diseases.
    Type: Grant
    Filed: August 15, 2007
    Date of Patent: February 2, 2016
    Assignee: ABBOTT LABORATORIES
    Inventor: Wouter Roorda
  • Patent number: 9011518
    Abstract: A stent for placement in a body lumen is fabricated by forming a tube having an un-deployed diameter sized for the tube to be placed on a deployment balloon and advanced through a body lumen to a deployment site. The tube is expandable upon inflation of the balloon to an enlarged diameter sized for the tube to be retained within the lumen at the site upon deflation and withdrawal of the balloon. The tube has a stent axis extending between first and second axial ends of the tube. The tube has an exterior surface and an interior surface. The tube is polished to polish the exterior surface to a smooth surface finish and with at least a portion of the interior surface having a rough surface finish rougher than the surface finish of the exterior surface.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: April 21, 2015
    Assignee: Covidien LP
    Inventor: Paul J. Thompson
  • Patent number: 8998977
    Abstract: A stent is formed from a wire having an outer member, a radiopaque member lining at least a portion of the outer member inner surface, and a lumen defined by the outer member inner surface or the radiopaque member inner surface. A substance is disposed in the lumen to be eluted through at least one opening disposed through the outer member to the lumen. The radiopaque member may be substantially continuous along the length of the wire or disposed only along portions of the wire such as crowns. In a method for making the stent, a composite wire including an outer member, a radiopaque intermediate member, and a core member is shaped into a stent pattern and processed to remove the core member and optionally portions of the radiopaque intermediate member, without damaging the outer member.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: April 7, 2015
    Assignee: Medtronic Vascular, Inc.
    Inventors: Ryan Bienvenu, James Mitchell, Dustin Thompson
  • Patent number: 8968390
    Abstract: The present invention relates to covered endoprosthetic devices. Covered endoprosthetic devices comprise an endoprosthesis and a sheath. The sheath comprises a central portion and outer portions, wherein the central portion preferentially restricts or causes a restriction of blood flow. Blood flow can be reduced by the central portion of the sheath by varying the permeability of the sheath or by having projections on the sheath that slow blood flow. Permeability may be provided by perforations or holes in the material of the sheath or by varying the polymer structure that makes up the sheath itself. The outer portions of the sheath do not substantially reduce blood flow. Methods of using sheath-covered endoprosthetic devices of the invention to treat aneurysms, especially aneurysms in proximity to small perforator vessels or arteries, are also encompassed.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: March 3, 2015
    Assignee: Medinol Ltd.
    Inventor: Jacob Richter
  • Patent number: 8920490
    Abstract: A medical device is provided with a porous region including a reservoir zone including a polymer and a protective zone between adjacent tissue and the reservoir zone that restricts the tissue from direct contact with the polymer.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: December 30, 2014
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Rajesh Radhakrishnan, Liliana Atanasoska, Scott R. Schewe, Ken Merdan
  • Patent number: 8911857
    Abstract: The disclosure describes a coating for medical implants, in particular, vascular stents, said coating comprising silicon dioxide, towards medical implants with a coating containing silicon dioxide and towards a method for their production. The coating can contain additional admixtures and have functionalization coats. The substrate of the coating is produced from a durable material, preferably from a stainless steel.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: December 16, 2014
    Assignee: Axetis AG
    Inventor: Carlo Civelli
  • Patent number: 8895099
    Abstract: Endoprostheses and methods of making endoprostheses are disclosed. For example, endoprostheses are described that include an endoprosthesis body, a biodegradable metallic tie layer, and a polymer coating about the endoprosthesis body. The biodegradable tie layer and the polymer coating can have a high peel strength from the body.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: November 25, 2014
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Liliana Atanasoska, Angela Kostrewa, Matthew Cambronne, James Q. Feng, Rajesh Radhakrishnan
  • Publication number: 20140336747
    Abstract: Implants for treating insufficient blood flow to a heart muscle with transmyocardial revascularization are disclosed. Methods of treating insufficient blood flow to a heart muscle with the implant are also disclosed. The implant can have a body with an inner lumen that supports a channel in the heart muscle to allow for increased blood flow through the lumen upon implantation. The implant can include active agents to prevent or inhibit thrombotic closure of the channel, to promote vascularization, or both.
    Type: Application
    Filed: April 15, 2014
    Publication date: November 13, 2014
    Inventors: Richard Rapoza, Nadine Ding, Yunbing Wang, Stephen Pacetti, Derek Mortisen
  • Publication number: 20140288638
    Abstract: The present invention relates to a medical device, particularly a vascular graft or an arteriovenous (AV) graft for haemodialysis. The medical device comprises a layer of porous silk fibroin matrix and a layer of knitted silk fibres. The invention further relates to processes of manufacture of such medical devices and methods of use of such devices.
    Type: Application
    Filed: August 10, 2012
    Publication date: September 25, 2014
    Inventors: David Philip Knight, Stephanie Lesage
  • Publication number: 20140277397
    Abstract: A vascular occlusion device for effectively occluding blood flow and pressure to a vascular defect while simultaneously not occluding blood flow and pressure to adjacent vasculature is provided. The vascular occlusion device can include a tubular member that has variable porosity regions along its length. The tubular member can be formed of a plurality of filaments that have different cross-sectional shapes along their length that are indexed to the variable porosity regions along the length of the tubular member.
    Type: Application
    Filed: March 12, 2013
    Publication date: September 18, 2014
    Inventor: Juan A. Lorenzo
  • Publication number: 20140249620
    Abstract: A flow diverter is described and fabricated using ultra-thin porous thin-film Nitinol, and is configured for implantation to a treatment site within a vessel for significant reduction in an intra-aneurismal flow velocity and vorticity. Using small size pores in a coverage area of only 10%, a 90% reduction in flow velocity into a pseudo-aneurysm can be achieved, with an almost immediate cessation of flow into an anatomical feature such as aneurysm sac in vivo. The size of the holes can be tailored to be any shape and range in size from 1-400 ?m using photolithography and from 5-1000 nm using ebeam lithography.
    Type: Application
    Filed: November 3, 2012
    Publication date: September 4, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
  • Patent number: 8808360
    Abstract: The present invention provides apparatus and methods for a conduit, such as an implantable conduit for a vessel. The conduit may comprise a main member and a side-branch member. The conduit may be implanted with the side-branch member initially disposed within the main member. When positioned, the side-branch member may then be extended from within the main member and into a vessel side-branch. The materials for the conduit may include circumferentially distensible and/or low recoil materials. The materials for the conduit may be constructed by various techniques and may include materials with enhanced flexibility and kink resistance.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: August 19, 2014
    Assignee: DSM IP Assets B.V.
    Inventor: Alvaro J. Laguna
  • Patent number: 8801777
    Abstract: An intravascular device for keeping open a previously constricted site within a vessel and for minimizing tissue debris at such a site from closing off the vessel is provided. The device includes an expandable substantially tubular body having a distal end and a proximal end. The device also includes a flexible netting system that is circumferentially disposed about the body, and extends beyond at least one of the distal end or proximal end. The netting system can expand along with the body to minimize release of tissues debris at the site from closing the lumen of the vessel. The netting system can include a plurality of pores to permit communication between fluid flow within the vessel and the vessel wall, and at least one pharmacotherapeutic agent for the treatment or prevention of certain conditions. A method for placing the device at a site of interest is also provided.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: August 12, 2014
    Inventor: David Elmaleh
  • Publication number: 20140194533
    Abstract: The present invention provides a biocompatible and biodegradable elastomer, comprising a hard segment and a soft segment. The hard segment is formed by reacting diisocyanate and a chain extender; and the soft segment is comprising a biodegradable oligomer diol, wherein the biodegradable oligomer diol is selected from the group consisting of polycaprolactone diol, polyethylene butylene adipate diol (PEBA diol), poly-L-lactic acid diol (PLLA diol), polylactic acid diol and any combination thereof. The biocompatible and biodegradable elastomer of present invention can be used to produce vascular graft, cell carrier, drug carrier or gene carrier.
    Type: Application
    Filed: December 31, 2013
    Publication date: July 10, 2014
    Applicant: National Taiwan University
    Inventors: Shan-hui Hsu, Kun-Che Hung, Shenghong A. Dai, Chun-Yi Lu
  • Patent number: 8715340
    Abstract: Embodiments of a uniformly porous membrane covering an endoprosthetic device, for example, a stent used to treat an aneurysm, are described. Some embodiments have a pore size and spacing that provides a material ratio of between 70-80% in the deployed state. Material ratio is the proportion of the total porous segment of the membrane that corresponds to membrane material, the remainder being pores. In some embodiments, pore size ranges from about 10-100 ?m. In some embodiments, pores are equidistantly spaced with pore spacing in a range of about 40-100 ?m. The combination of pore size and spacing are effective to provide a membrane that substantially prevents flow to the aneurysm, while maintaining flow to perforator vessels. In some embodiments the membrane includes permanently attached agents that promote attachment of endothelial cells or progenitors and healing of the aneurysm, or reduce immune responses detrimental to the healing process.
    Type: Grant
    Filed: April 9, 2007
    Date of Patent: May 6, 2014
    Assignee: Merlin MD Pte Ltd.
    Inventors: Leon Rudakov, Tsui Ying Rachel Hong, Michael O'Connor
  • Patent number: 8685427
    Abstract: A medical device for placement in a body of a mammal is provided. The medical device comprises (1) a polymeric matrix forming the device and defining a lumen through the device, the matrix comprising polymer macromolecules and defining spaces between the polymer macromolecules; (2) a drug contained within at least some of the spaces of the matrix; and (3) a material contained within at least some of the spaces of the matrix to affect diffusion of the drug out of the polymeric matrix when the medical device is placed in the body of the mammal.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: April 1, 2014
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Jianmin Li, Weenna Bucay Couto
  • Publication number: 20140067047
    Abstract: A stent or other prosthesis may be formed by coating a single continuous wire scaffold with a polymer coating. The polymer coating may consist of layers of electrospun polytetrafluoroethylene (PTFE). Electrospun PTFE of certain porosities may permit endothelial cell growth within the prosthesis.
    Type: Application
    Filed: October 2, 2013
    Publication date: March 6, 2014
    Applicant: Merit Medical Systems, Inc.
    Inventors: Zeke Eller, John William Hall, Robert S. Kellar, Rachel Lynn Simmons, Robert J. Radford, Bart Dolmatch
  • Publication number: 20140039606
    Abstract: A method for treating a bifurcation or trifurcation aneurysm (201) occurring on a first artery, the first artery and a second artery joining to a third artery, the method comprising: inserting a medical device (202) such that it is at least partially located in the first artery and is at least partially located in the third artery; expanding the medical device (202) from a first position to a second position, said medical device (202) is expanded radially outwardly to the second position such that the exterior surface of said medical device (202) engages with the inner surface of the first and third arteries so as to maintain a fluid pathway through said arteries; and positioning the medical device (202) such that a membrane (203) of the medical device (202) is located against an aneurysm neck of the aneurysm (201) to obstruct blood circulation to the aneurysm (201) when the medical device (202) is expanded to the second position, and at least a portion of the membrane (203) is secured to the medical device (
    Type: Application
    Filed: August 5, 2013
    Publication date: February 6, 2014
    Inventors: Leon RUDAKOV, Michael O'CONNOR, Deepak GANDHI
  • Patent number: 8632580
    Abstract: Medical devices, such as endoprostheses, and methods of making the devices are disclosed. The medical device can include a stent body and a cover including a deposited metallic film. The medical device can be delivered using a delivery device along a tortuous body passage to a treatment site without damaging the medical device, delivery device, or the body passage. In some cases, the stent body is a flexible helical stent body, which may be threaded through one or more fenestrations of the cover. The cover may include longitudinally extending slits or seams, which help the cover to pass through small radii passages without buckling.
    Type: Grant
    Filed: December 29, 2004
    Date of Patent: January 21, 2014
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Masoud Molaei, Alexander Leynov, Robert Z. Obara
  • Patent number: 8586125
    Abstract: A method of manufacturing an implantable medical device, such as a drug eluting stent, is disclosed. The method includes subjecting an implantable medical device that includes a polymer to a thermal condition. The thermal condition can result in reduction of the rate of release of an active agent from the device subsequent to the implantation of the device and/or improve the mechanical properties of a polymeric coating on the device.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: November 19, 2013
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Syed F. A. Hossainy, Yiwen Tang, Manish B. Gada
  • Patent number: 8574616
    Abstract: The present invention relates to a method for manufacturing an implant, in particular an intraluminal endoprosthesis, having a body containing metallic material, preferably iron. The following manufacturing method is provided for promotion of the anti-inflammatory effect of the implant: (i) providing the body of the implant; (ii) producing an at least partially closed pore structure in a portion of the structure of the implant body close to the surface; and (iii) incorporating NOX into the cavities of the pore structure. Also described is an implant manufactured in this manner.
    Type: Grant
    Filed: June 2, 2010
    Date of Patent: November 5, 2013
    Assignee: BIOTRONIK VI Patent AG
    Inventors: Ullrich Bayer, Claus Harder, Elisabeta Burean
  • Patent number: 8562671
    Abstract: The invention relates to scaffolds for artificial heart valves and vascular structures comprising a biocompatible block copolymer. A method and means for producing said scaffold are also provided.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: October 22, 2013
    Assignee: Eidgenossische Technische Hochschule Zurich
    Inventor: Peter Neuenschwander
  • Publication number: 20130274868
    Abstract: Devices and methods for treatment of a patient's vasculature with some embodiments configured for delivery with a microcatheter for treatment of the cerebral vasculature of a patient. Some embodiments include thin permeable membranes configured to occlude blood flow therethrough.
    Type: Application
    Filed: March 11, 2013
    Publication date: October 17, 2013
    Inventors: BRIAN J. COX, Dean Schaefer, Robert F. Rosenbluth
  • Patent number: 8518105
    Abstract: A method and apparatus to treat regions of a vessel is described. A protein elastin-based polymer is released from the apparatus to coat the vessel lining as a primary therapy or an adjunct therapy with the delivery and deployment of a stent with or without drug coating. The protein elastin-based polymer may include a triblock structure having an elastin pentapeptide as the flanking block and a hydrophilic variant of the pentapeptide as the middle block. Both the flanking and middle blocks can be modified to change the structural and chemical properties of the polymer. In particular, the protein elastin based polymer is adapted to perform at least one of controlling release of a treatment agent, stimulating endothelial cell growth and stabilizing the vulnerable plaque to prevent rupture of the vulnerable plaque.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: August 27, 2013
    Assignee: Abbott Cardiovascular System Inc.
    Inventors: Syed Faiyaz Ahmed Hossainy, Mikael Trollsas, Thierry Glauser, Yiwen Eveleen Tang, Eugene T. Michal
  • Publication number: 20130204347
    Abstract: The invention relates to medical devices and methods of using them. The devices are prostheses which can be percutaneously deliverable with (or on) an endovascular catheter or via other surgical or other techniques and then expanded. The prostheses are configured to have a lattice resistant to dilation and creep, which is defined by a plurality of openings. The prosthesis may also optionally have a stent disposed proximal to the lattice. In exemplary embodiments, the fluoropolymer is expanded polytetrafluoroethylene. The composite materials exhibit high elongation while substantially retaining the strength properties of the fluoropolymer membrane. In at least one embodiment, the lattice is made of a composite material that includes a least one fluoropolymer membrane including serpentine fibrils and an elastomer. A lattice including a generally tubular member formed of a composite material including a least one fluoropolymer membrane containing serpentine fibrils and an elastomer is also provided.
    Type: Application
    Filed: March 14, 2013
    Publication date: August 8, 2013
    Applicant: W. L. GORE & ASSOCIATES, INC.
    Inventor: W. L. Gore & Associates, Inc.
  • Publication number: 20130204355
    Abstract: A medical device includes a porous article of expanded polytetrafluoroethylene (ePTFE) having a microstructure of nodes interconnected by fibrils, and a coating including an antimicrobial material at the surface of the porous article, wherein the microstructure at a surface of the porous article is only partially coated with the antimicrobial material.
    Type: Application
    Filed: February 11, 2011
    Publication date: August 8, 2013
    Applicants: SPIRE BIOMEDICAL, AESCULAP AG
    Inventors: Helmut Goldmann, Dennis Langanke, Richard W. Oliver
  • Patent number: 8500751
    Abstract: A method for treating a bifurcation or trifurcation aneurysm (201) occurring on a first artery, the first artery and a second artery joining to a third artery, the method comprising: inserting a medical device (202) such that it is at least partially located in the first artery and is at least partially located in the third artery; expanding the medical device (202) from a first position to a second position, said medical device (202) is expanded radially outwardly to the second position such that the exterior surface of said medical device (202) engages with the inner surface of the first and third arteries so as to maintain a fluid pathway through said arteries; and positioning the medical device (202) such that a membrane (203) of the medical device (202) is located against an aneurysm neck of the aneurysm (201) to obstruct blood circulation to the aneurysm (201) when the medical device (202) is expanded to the second position, and at least a portion of the membrane (203) is secured to the medical device (
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: August 6, 2013
    Assignee: Merlin MD Pte Ltd
    Inventors: Leon Rudakov, Michael O'Connor, Deepak Gandhi
  • Publication number: 20130184807
    Abstract: Articles comprising an expanded polytetrafluoroethylene membrane having serpentine fibrils and having a discontinuous coating of a fluoropolymer thereon are provided. The fluoropolymer may be located at least partially in the pores of the expanded fluoropolymer membrane. In exemplary embodiments, the fluoropolymer is fluorinated ethylene propylene. The application of a tensile force at least partially straightens the serpentine fibrils, thereby elongating the article. The expanded polytetrafluoroethylene membrane may include a microstructure of substantially only fibrils. The articles can be elongated to a predetermined point at which further elongation is inhibited by a dramatic increase in stiffness. In one embodiment, the articles are used to form a covered stent device that requires little force to distend in the radial direction to a first diameter but is highly resistant to further distension to a second diameter (stop point).
    Type: Application
    Filed: November 13, 2012
    Publication date: July 18, 2013
    Applicant: W. L. Gore & Associates, Inc.
    Inventor: W. L. Gore & Associates, Inc.
  • Publication number: 20130184810
    Abstract: A medical appliance or prosthesis may comprise one or more layers of rotational spun nanofibers, including rotational spun polymers. The rotational spun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Rotational spun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis. Additionally, one or more cuffs may be configured to allow tissue ingrowth to anchor the prosthesis.
    Type: Application
    Filed: January 15, 2013
    Publication date: July 18, 2013
    Applicant: Merit Medical Systems, Inc.
    Inventor: Merit Medical Systems, Inc.
  • Publication number: 20130184808
    Abstract: A medical appliance or prosthesis may comprise one or more layers of rotational spun nanofibers, including rotational spun polymers. The rotational spun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Rotational spun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis. Additionally, one or more cuffs may be configured to allow tissue ingrowth to anchor the prosthesis.
    Type: Application
    Filed: January 15, 2013
    Publication date: July 18, 2013
    Applicant: MERIT MEDICAL SYSTEMS, INC.
    Inventor: MERIT MEDICAL SYSTEMS, INC.
  • Patent number: 8454707
    Abstract: The present invention relates to improved biomedical implantable material comprising a plurality of pores, of which one or more of the pores are interconnected below the surface of the material. The improved biomedical implantable material may be used in biomedical implant devices such as orthopedic implants, spinal implants, neurocranial implants, maxillofacial implants, and joint replacement implants. The present invention also relates to a method of preparing an improved biomedical implantable material, comprising subjecting an implantable material to a pore-forming treatment and optionally further subjecting the material to a surface-modifying treatment. The biomedical implantable material may be used in other applications, which as applications where two surfaces are contacted and bonding between the surfaces is required.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: June 4, 2013
    Assignee: University of Maryland
    Inventor: Sreeramamurthy Ankem
  • Patent number: 8419787
    Abstract: A method and apparatus for reducing blood flow to an aneurysm proximate to a bifurcation having a source blood vessel a first branch vessel and a second branch vessel, the method comprising: providing a first mesh-like tube of bio-compatible material, the first mesh-like tube exhibiting a porosity index pre-selected to skew blood flow about the bifurcation away from the aneurysm; inserting the first mesh-like tube into the source blood vessel and the first branch vessel; and securing the first mesh-like tube to at least one of the source blood vessel and the first branch vessel, whereby blood flowing from the source blood vessel flows without undue impedance to the first branch vessel and the second branch vessel while being skewed away from the aneurysm.
    Type: Grant
    Filed: February 21, 2010
    Date of Patent: April 16, 2013
    Assignee: Surpass Medical Ltd
    Inventors: Ofer Yodfat, Baruch B. Lieber, Ygael Grad, Boaz Nishri
  • Patent number: 8398916
    Abstract: A method and process for at least partially forming a medical device that is at least partially formed of a metal alloy which improves the physical properties of the medical device.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: March 19, 2013
    Assignee: ICON Medical Corp.
    Inventors: Raymond W. Buckman, Udayan Patel, Joseph Furst
  • Patent number: 8388678
    Abstract: According to an aspect of the present invention, implantable or insertable medical devices are provided which contain the following: (a) substrate having one or more depressions that contain at least one therapeutic agent and (b) a porous membrane disposed over the substrate and the one or more depressions, which regulate transport of chemical species between the therapeutic-agent-containing depressions and the exterior of the device. The substrate and the porous membrane are formed of different materials each with a different thermal expansion coefficient. Moreover, one of the substrate and the porous membrane at least partially surrounds the other. Other aspects of the present invention are directed to methods of making such medical devices, and methods of treatment using such medical devices.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: March 5, 2013
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Anurag Singhal, Robert A. Herrmann, Yixin Xu, Young-Ho Song
  • Publication number: 20130030518
    Abstract: The present invention relates generally to the maintenance of blow flood using drug eluting stents and/or other coated medical devices to increased length of time of blood flow. Further, the present invention relates to drug-releasing coated devices for reducing smooth muscle cell proliferation and platelet activity to further limit restenosis utilizing resveratrol and quercetin, polyphenols that are linked to the cardioprotection of red wine consumption. The present invention also provides products and methods for treating or preventing atherosclerosis, stenosis, restenosis, smooth muscle cell proliferation, platelet cell activation and other clotting mechanisms, occlusive disease, or other abnormal lumenal cellular proliferation condition in a location within the body of a patient.
    Type: Application
    Filed: October 2, 2012
    Publication date: January 31, 2013
    Applicants: LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER OFFICE OF RESEARCH, NANOCOPOEIA, INC.
    Inventors: Tammy R. DUGAS, Alok KHANDELWAL, James John KLEINEDLER, III, John Devlin FOLEY