Having Living Cell Patents (Class 623/1.41)
  • Patent number: 11103338
    Abstract: A post-surgical healing accelerator (PSHA) device for tissue and nerve repair at an injury site. The device includes (a) a substrate, (b) a scaffold disposed on a surface of the substrate, and (c) a population of cells attached to the scaffold. The scaffold comprises at least one modified polymer selected from a modified collagen, a modified gelatin, a modified alginate, a modified cellulose, a modified hyaluronic acid, and others, with (i) modifications configured to increase an interaction between the scaffold and the cells, (ii) modifications configured to increase an association of the at least one modified polymer with the substrate, and (iii) a combination of (i) and (ii). The cells attached to the scaffold are configured to carry out tissue and/or nerve repair at an injury site of a subject through at least one of growth, differentiation, and migration following an application of the device to the injury site of the subject.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: August 31, 2021
    Assignee: Imam Abdulrahman Bin Faisal University
    Inventor: Naif Nasser Almasoud
  • Patent number: 11033661
    Abstract: An anti-adhesion material comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing an anti-adhesion material comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; an anti-adhesion material kit comprising decellularized tissues and a biocompatible polymer or fibrin glue; a substitute biomembrane comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing a substitute biomembrane comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; and a substitute biomembrane kit comprising decellularized tissues and a biocompatible polymer or fibrin glue.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: June 15, 2021
    Inventors: Hideki Saga, Takanori Uchida, Shoko Tokorozaki, Ken-ichiro Hiwatari, Haruki Obara, Akio Kishida, Tsuyoshi Kimura, Jun Negishi, Tetsuya Higami, Seiichi Funamoto
  • Patent number: 10888407
    Abstract: A composite implant device for use in a medical application, comprising a synthetically-derived mesh that mimics particular critical aspects of a biologically-derived mesh. The composite implant device can be used for the reinforcement and reconstruction of tissues within the body and can be comprised of a majority of synthetic components and minority of naturally-derived components which mimic the structure and function of a naturally-derived mesh.
    Type: Grant
    Filed: December 10, 2016
    Date of Patent: January 12, 2021
    Assignee: POLY-MED, INC.
    Inventors: Seth Dylan McCullen, Clayton Joseph Culbreath, Michael Aaron Vaughn, Michael Scott Taylor
  • Patent number: 10646896
    Abstract: A construct that supports cell attachment and alignment including a substrate that is incompatible with photolithography conditions, containing a physical pattern in at least part of one surface, the physical pattern optionally bearing a coating of a metal alkoxide, oxide or mixed oxide-alkoxide thereon and a Self-Assembled Monolayer of Phosphonate (SAMP) covalently attached thereto, which phosphonate contains functionality adapted for cell binding. The construct optionally also contains cells attached thereto. Also disclosed are methods of preparing such a construct.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: May 12, 2020
    Assignee: The Trustees of Princeton University
    Inventors: Jeffrey Schwartz, Joshua Spechler, Romain Fardel, Kelly Lim
  • Patent number: 10463769
    Abstract: Provided herein are bioactivated polymer/extracellular matrix (ECM) composites and methods of preparation and use thereof. In particular, heparinized cysteine-polymer/ECM composites, and methods of preparation and use thereof, are provided. In some embodiments, provided herein are compositions comprising a composite of: (a) extracellular matrix (ECM), and (b) a polyester covalently linked to a bioactive agent. In some embodiments, the composite is a homogeneous composite. In some embodiments, the ECM is decellularized ECM. In some embodiments, the ECM is not substantially crosslinked.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: November 5, 2019
    Assignee: Northwestern University
    Inventors: Guillermo A. Ameer, Jason A. Wertheim, Bin Jiang
  • Patent number: 9918879
    Abstract: An improved skin substitute is presented comprised of a silicone layer backed up with a woven nylon fabric layer, the silicone layer possessing a regular pattern of slits that permit the porosity of the skin substitute to be adjusted by clinicians by means of applying tension to the skin substitute that differentially opens the slits. A variety of therapeutic substances can be applied to the skin substitute to promote healing, including aloe and other medicinal preparations. The skin substitute is directed at chronic wound treatment and hernia repair.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: March 20, 2018
    Inventor: E. Aubrey Woodroof
  • Patent number: 9623051
    Abstract: Methods for producing compositions of decellularized extracellular matrix (DM) tissue culture are described. The compositions can be used for coating supports such as tissue culture substrates, osteogenic gels, and medical devices.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: April 18, 2017
    Assignee: The Regents of the University of California
    Inventors: J. Kent Leach, Martin Decaris, Archana Bhat
  • Patent number: 9615947
    Abstract: An artificial blood vessel that can be transplanted to blood vessels with a small diameter, can be adjusted to an arbitrary size of a diameter, improves in invasiveness when a graft is taken, and overcomes the problem on the provision of a graft is provided. An artificial blood vessel prepared from a decellularized tubular structure, which is prepared by processing a decellularized, sheet-like blood vessel (decellularized blood vessel sheet) into a roll structure, and a tissue adhesive, wherein a portion which is contacted with blood that flows within the artificial blood vessel consists of the tissue of the tunica intima lined with the tissue of the tunica media whereas a portion of the sheet that overlaps when the sheet is processed into a roll structure (overlap width) consists of the tissue of the tunica media and wherein a tissue adhesive is applied to the overlap width.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: April 11, 2017
    Inventors: Noriko Shinya, Takanori Uchida, Akio Kishida, Tetsuya Higami
  • Patent number: 9545241
    Abstract: It is provided a blood vessel function inspecting apparatus including: a blood vessel diameter measuring portion configured to measure a diameter of a blood vessel; a blood vessel wall thickness measuring portion configured to measure a wall thickness of the blood vessel; and a blood vessel function index value calculating portion configured to calculate a function index value for diagnosing the blood vessel of its function, after releasing of the blood vessel from blood flow obstruction, by dividing an amount of dilatation of said diameter of the blood vessel continuously measured by said blood vessel diameter measuring portion, by the wall thickness measured by said blood vessel wall thickness measuring portion.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: January 17, 2017
    Inventors: Hiroshi Masuda, Chikao Harada, Hidenori Suzuki
  • Patent number: 9533072
    Abstract: Vascular grafts for treating, reconstructing and replacing damaged or diseased cardiovascular vessels that are formed from decellularized extracellular matrix (ECM). The vascular grafts include outer or outer and inner coatings that provide structural reinforcement.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: January 3, 2017
    Inventor: Robert G Matheny
  • Patent number: 9486349
    Abstract: A removable sleeve extends around an expandable stent graft to constrain the expandable stent graft toward a collapsed configuration. The sleeve is held together by a coupling member to constrain the expandable device toward the collapsed configuration for endoluminal delivery to a vascular treatment site. The sleeve is openable by displacing the coupling member away from the sleeve to allow outward expansion of the expandable device toward an expanded configuration. The sleeve is separate from the expandable device so as to be removable from the treatment site after deployment of the expandable device.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: November 8, 2016
    Assignee: W. L. GORE & ASSOCIATES, INC.
    Inventor: Patrick M. Norris
  • Patent number: 9439808
    Abstract: An improved skin substitute is presented comprised of a silicone layer backed up with a woven nylon fabric layer, the silicone layer possessing a regular pattern of slits that permit the porosity of the skin substitute to be adjusted by clinicians by means of applying tension to the skin substitute that differentially opens the slits. A variety of therapeutic substances can be applied to the skin substitute to promote healing, including aloe and other medicinal preparations. A layer of water soluble or water insoluble anti-scar compound is also present, the preferred compound being salinomycin.
    Type: Grant
    Filed: April 25, 2015
    Date of Patent: September 13, 2016
    Inventors: E. Aubrey Woodroof, Richard R. Phipps
  • Publication number: 20150094799
    Abstract: Mufti-sheet laminate structures having a first extracellular matrix (ECM) sheet member having a top cross-linked surface and a second ECM sheet member having a bottom surface, the second ECM sheet member being joined to the first ECM sheet member, wherein the first ECM sheet member top cross-linked surface is disposed proximate the second ECM sheet member bottom surface.
    Type: Application
    Filed: December 10, 2014
    Publication date: April 2, 2015
    Inventor: Robert G. Matheny
  • Publication number: 20150086607
    Abstract: A synthetic construct suitable for implantation into a biological organism that includes at least one polymer scaffold; wherein the at least one polymer scaffold includes at least one layer of polymer fibers that have been deposited by electrospinning; wherein the orientation of the fibers in the at least one polymer scaffold relative to one another is generally parallel, random, or both; and wherein the at least one polymer scaffold has been adapted to function as at least one of a substantially two-dimensional implantable structure and a substantially three-dimensional implantable tubular structure.
    Type: Application
    Filed: September 25, 2014
    Publication date: March 26, 2015
    Inventors: Jed K. JOHNSON, Ross KAYUHA
  • Patent number: 8968391
    Abstract: Methods for ameliorating stent graft migration and endoleak using treatment site-specific cell growth promoting compositions in combination with stent grafts are disclosed. Also disclosed are application of cell growth promoting compositions such as, but not limited to, autologous platelet gel compositions directly to treatment sites during or after stent graft implantation.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: March 3, 2015
    Assignee: Medtronic Vascular, Inc.
    Inventors: Dennis Brooks, Jack Chu, Scott Doig, Trevor Huang, Tessy Kanayinkal
  • Publication number: 20150012083
    Abstract: The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.
    Type: Application
    Filed: September 24, 2014
    Publication date: January 8, 2015
    Inventors: Shannon L.M. Dahl, Laura E. Niklason, Juliana Blum, Justin T. Strader, William E. Tente, Heather L. Prichard, Joseph J. Lundquist
  • Publication number: 20140277354
    Abstract: Disclosed are endovascular stents in which a portion of the stents have a bioactive coating for promoting repair of damaged vessels, systems comprising the stents, and methods of using the stents to promote occlusion of aneurysms and/or repair damaged vessels.
    Type: Application
    Filed: October 6, 2012
    Publication date: September 18, 2014
    Inventors: Jean Paul Allain, Lisa Reece, Zhangcan Yang, Rocco Armonda, Ravindra Kempaiah, Teodoro Tigno
  • Patent number: 8808363
    Abstract: A vascular prosthesis comprising a tubular shaped expandable ECM member and at least one anchoring mechanism. In one embodiment, the anchoring mechanism comprises proximal and distal single or dual-ring anchors. In one embodiment, the anchoring mechanism comprises a multiple-ring anchor. The anchors preferably comprise a biodegradable metal, such as magnesium. The anchors can also comprise a shape memory alloy, such as nitinol, and a cross-linked ECM material. In some embodiments, the ECM member includes a pharmacological agent.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: August 19, 2014
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventors: Michael David Perry, Robert G. Matheny
  • Patent number: 8785196
    Abstract: Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: July 22, 2014
    Assignee: MedRelief Inc.
    Inventors: James W. Kronberg, Timothy Ganey, Stephen L. Gordon
  • Patent number: 8778012
    Abstract: An extracellular matrix (ECM) construct having a biodegradable support scaffold that includes a plurality of biodegradable microneedles that are capable of piercing tissue and anchoring therein, and at least a first layer of first ECM material disposed on the top surface of the support scaffold.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: July 15, 2014
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G. Matheny
  • Publication number: 20140081384
    Abstract: The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e).
    Type: Application
    Filed: November 15, 2013
    Publication date: March 20, 2014
    Inventor: David M. Hoganson
  • Patent number: 8637062
    Abstract: Implant provided with a coating, with the implant being provided with an amino-functionalized parylene coating, an oligonucleotide and/or an oligopeptide having a specific bonding affinity with CD34-positive cells.
    Type: Grant
    Filed: September 21, 2007
    Date of Patent: January 28, 2014
    Inventors: Lothar Sellin, Bock-Sun Han, Annelotte Autschbach
  • Patent number: 8632583
    Abstract: An implantable medical device having enhanced endothelial migration features, generally comprises: a structural member including a leading edge and a trailing edge interconnected by a third surface region, the leading edge including a second surface region in a generally curvilinear cross-section, and the trailing edge including a fourth surface region in a generally curvilinear cross-section, whereby blood flow over the second surface region generate shear stress at the second surface region without an eddy region in the second surface region.
    Type: Grant
    Filed: May 9, 2011
    Date of Patent: January 21, 2014
    Assignee: Palmaz Scientific, Inc.
    Inventor: Julio C. Palmaz
  • Publication number: 20130345794
    Abstract: Described herein are engineered multilayered vascular tubes comprising at least one layer of differentiated adult fibroblasts, at least one layer of differentiated adult smooth muscle cells, wherein any layer further comprises differentiated adult endothelial cells, wherein said tubes have the following features: (a) a ratio of endothelial cells to smooth muscle cells of about 1:99 to about 45:55; (b) the tube is compliant; (c) the internal diameter of the tube is about 6 mm or smaller; (d) the length of the tube is up to about 30 cm; and (e) the thickness of the tube is substantially uniform along a region of the tube; provided that the engineered multilayered vascular tube is free of any pre-formed scaffold. Also described herein are methods of forming said tubes and uses for said tubes including methods for treating patients, comprising providing such a tube into to a patient in need thereof.
    Type: Application
    Filed: March 16, 2011
    Publication date: December 26, 2013
    Applicant: ORGANOVO, INC.
    Inventors: Chirag Khatiwala, Keith Murphy, Benjamin Shepherd
  • Patent number: 8613764
    Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: December 24, 2013
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Deborah Kilpatrick, Murthy Simhambhatla, Santosh Prabhu, Shawn Chin Quee
  • Publication number: 20130289715
    Abstract: Exemplary embodiments of the present disclosure provide for multi-layered implantation materials, methods of making a multi-layered implantation material, methods of forming a multi-layered implantation material, methods of forming a multi-layered implantation material having a spiral roll cross-section, and the like.
    Type: Application
    Filed: December 22, 2011
    Publication date: October 31, 2013
    Inventor: Peter McFetridge
  • Patent number: 8562671
    Abstract: The invention relates to scaffolds for artificial heart valves and vascular structures comprising a biocompatible block copolymer. A method and means for producing said scaffold are also provided.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: October 22, 2013
    Assignee: Eidgenossische Technische Hochschule Zurich
    Inventor: Peter Neuenschwander
  • Patent number: 8491457
    Abstract: The invention is directed to methods for preparing artificial blood vessels by preconditioning a matrix seeded with endothelial cells to fluid flow conditions that mimic blood flow.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: July 23, 2013
    Assignee: Wake Forest University Health Services
    Inventors: Anthony Atala, Shay Soker, James Yoo
  • Publication number: 20130172985
    Abstract: Described herein are modified gelatins or the pharmaceutically-acceptable salts or esters thereof comprising at least one actinically crosslinkable group covalently bonded to gelatin. The modified gelatins are useful in producing composites that ultimately can be used to produce three-dimensional engineered biological constructs. The composites are the polymerization product between the modified gelatin and at least one actinically crosslinkable macromolecule. Methods for making the modified gelatins are also described herein.
    Type: Application
    Filed: January 13, 2011
    Publication date: July 4, 2013
    Inventors: Glenn D. Prestwich, Aleksander Skardal, Jianxing Zhang
  • Patent number: 8465542
    Abstract: A modified polyurethane including a lipid substituent pendant from at least one urethane nitrogen and/or at least one carbon atom of the modified polyurethane, methods of preparing modified polyurethanes and the use thereof as an implantable biomaterial.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: June 18, 2013
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Robert J. Levy, Ivan Alferiev, Stanley J. Stachelek
  • Publication number: 20120237560
    Abstract: Embodiments of the present invention provide a composition comprising perivascular stem cells or induced pluripotent cells (iPS) and a NELL-1 factor for cardiac or vascular regeneration and methods of making and using the same.
    Type: Application
    Filed: February 10, 2012
    Publication date: September 20, 2012
    Inventors: B. Chia Soo, Kang Ting, Bruno Peault
  • Patent number: 8202725
    Abstract: Tissue engineering methods and biochamber apparatus are provided for making tissue grafts for implantation into a patient. The methods include applying a sustained low magnitude pressure gradient transmurally across a permeable scaffold material using a media containing cells, preferably microvascular epithelial cells, to be deposited on the scaffold for the production of tissue grafts, preferably vascular grafts, to promote accelerated adhesion and maturation of cells on the scaffold material. Biochambers for preparing tubular tissue grafts are provided which contain connectors for holding a graft substrate, proximal and distal tubing for connection to an optional perfusion system, and structure for switching between transmural flow of a cell suspension across the graft substrate and translumenal flow through the lumen of the graft.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: June 19, 2012
    Assignee: Tissue Genesis Incorporated
    Inventors: Paul E. Kosnik, Christopher T. England, Robert G. Dennis, Stuart K. Williams
  • Patent number: 8083726
    Abstract: A method including combining a cellular component with a viability enhancer material wherein the combination will inhibit an interaction between the cellular component and a delivery device; and delivering the cellular component through the delivery device. An apparatus including a delivery cannula having dimensions suitable for percutaneous delivery and a lumen therethrough, wherein a portion of a luminal surface of the cannula includes a coating that is amenable to a cellular component delivered through the delivery cannula. A method including percutaneously introducing a delivery cannula into a blood vessel; advancing a distal portion of the delivery cannula to a treatment site; and delivering a cellular component through a lumen of the delivery cannula, wherein a portion of a luminal surface of the cannula includes a coating that is amenable to a cellular component delivered through the delivery cannula.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: December 27, 2011
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventor: Edwin Wang
  • Publication number: 20110313513
    Abstract: Described herein are devices and methods fabricating devices having nanostructures that allow adhesion or growth of one cell type, such as endothelial cells, more than another cell type, such as smooth muscle cells. In particular, stent covers having such nanostructures are described, and methods for fabricating these stent covers. Also described herein are methods for optimizing the nanostructures forming the devices.
    Type: Application
    Filed: August 29, 2011
    Publication date: December 22, 2011
    Inventor: Alfred David Johnson
  • Patent number: 8048409
    Abstract: The present invention encompasses methods and apparatus for minimizing the risks inherent in endovascular grafting for blood vessel therapy and repair. The invention involves delivering adult stem cells, embryonic stem cells, progenitor cells, fibroblasts, or smooth muscle cells to the diseased blood vessel, in some embodiments in conjunction with a stent graft.
    Type: Grant
    Filed: August 4, 2004
    Date of Patent: November 1, 2011
    Assignee: Medtronic Vascular, Inc.
    Inventor: Michel Letort
  • Patent number: 8025916
    Abstract: A composite stent and a method for making the same are provided.
    Type: Grant
    Filed: December 18, 2006
    Date of Patent: September 27, 2011
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Syed F. A. Hossainy, Orlando Padilla, Daryush Mirzaee, Fuh-Wei Tang
  • Publication number: 20110098799
    Abstract: Disclosed herein are implantable medical device, and in particular, vascular stent having a biocompatible scaffold seeded with endothelial cells. The stent can provide structural support to maintain the openness of a vessel lumen following angioplasty while the biological scaffold seeded with endothelial cells can provide a new, healthy blood vessel wall.
    Type: Application
    Filed: October 27, 2009
    Publication date: April 28, 2011
    Applicant: Medtronic Vascular, Inc.
    Inventors: Kevin Treacy, Lucy O'Keeffe, Patrick Duane, Paul Kenna, Tony O'Halloran
  • Patent number: 7922761
    Abstract: A vascular prosthesis having a tubular structure is provided. The tubular structure is fabricated from at least two layers wherein at least one layer includes a thrombogenic agent.
    Type: Grant
    Filed: January 25, 2006
    Date of Patent: April 12, 2011
    Assignee: Nicast Ltd.
    Inventors: Alon Shalev, Alexander Dubson
  • Patent number: 7887581
    Abstract: The present relates to artificial vascular grafts and for methods for performing hemodialysis with the same. The grafts comprise an inner surface on which cells genetically altered to express or over-express one or more cell adhesion factors, such as fibulin-5, or one or more cell adhesion factors and one or more cell proliferation growth factors, such as VEGF, are seeded and cultured.
    Type: Grant
    Filed: January 3, 2007
    Date of Patent: February 15, 2011
    Assignee: Multi-Gene Vascular Systems, Ltd.
    Inventor: Moshe Flugelman
  • Patent number: 7875072
    Abstract: A cellular stent carries living therapeutic cellular material for implantation into a human or animal body and allows either localized or systemic delivery of the therapeutic products, while promoting engraftment, either on a tissue surface or its interior. The cells are contained within wells in the stent that are enclosed by inner and outer membranes that seal the cellular material within the stent until it is to be released. The outer membrane is preferably in the form of a thin, hard plastic sheet having a plurality of score lines, perforations, or other lines or weakening provided therein. The membrane may be embedded in a softer perimetral mount which retains it in position until the seal is to be broken. Rupture of the outer membrane ensures penetration of the cells into the interior of tissue or an organ in which the stent is implanted.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: January 25, 2011
    Inventor: Theodore E. Spielberg
  • Publication number: 20110015723
    Abstract: An adjustable stenosis provides a channel comprising an outer wall and an inner wall. The inner wall may comprise resiliently flexible material. A reservoir may be formed by the outer wall and inner wall. The flexibility of the inner wall allows the reservoir to expand into the channel to increase stenosis and to contract toward the outer wall to decrease stenosis. The reservoir may have a default expanded shape or a default contracted shape. The default shape may be maintained unless the pressure or amount of filler material in the reservoir is manipulated. The reservoir may have one or more chambers. The channel may be attached to a natural lumen or a graft or may be placed around the lumen or graft.
    Type: Application
    Filed: September 20, 2010
    Publication date: January 20, 2011
    Inventors: Stanley Batiste, Steven Achstein
  • Publication number: 20100331964
    Abstract: The present invention provides an ex vivo vascular remodeling methods and system by which an excised, small diameter blood vessel can be harvested and expanded to provide viable vascular grafts, as demonstrated at the physical and molecular levels, and as optimized in vivo. The tissue-engineered vessels generated by the present invention closely resemble native vessels in terms of structure, histologically, including endothelial coverage and intricate structural components such as the internal elastic lamina, viability (as measured with MTT assay and TUNEL analysis), and function (vasoactivity, mechanical and biomechanical properties). Thus, the resulting vascular grafts behave in a manner similar to native arteries in terms of mechanical integrity, and provide clinically relevant patency rates when implanted in vivo.
    Type: Application
    Filed: July 27, 2010
    Publication date: December 30, 2010
    Applicant: Trustees of the University of Pennsylvania
    Inventors: Valerie Clerin, Rebecca Gusic, Keith Gooch
  • Publication number: 20100305687
    Abstract: A mat having a highly uniform porosity distribution is produced by consolidating 15 or more layers of melt blown webs (or the like) having different orientations. Control over the porosity is provided by using webs that exhibit a narrow, unimodal distribution of fiber diameters over the bulk of its distribution, such as in the top 80%. A compliance of the mats can be chosen by selecting a number and orientation of the webs. It is thus possible to produce mats that are good candidates for vascular grafts, for example. The uniformity of the porosity within the range of 6 ?m to 30 ?m permits seeding of the vascular graft with endothelial and smooth muscle cells. The mats have the demonstrated ability to retain, and support growth of, smooth muscle cells and endothelial cells.
    Type: Application
    Filed: May 21, 2008
    Publication date: December 2, 2010
    Inventors: Abdellah Ajji, Marie Moreno, Martin Bureau
  • Publication number: 20100204783
    Abstract: Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality.
    Type: Application
    Filed: November 27, 2009
    Publication date: August 12, 2010
    Inventors: HELEN MARIE NUGENT, Elazer Edelman, Anupam Dalal, Stephen August Bollinger, Scott Epperly
  • Patent number: 7758635
    Abstract: An endovascular stent comprising an expandable framework including a plurality of interconnected segments, and a plurality of entangled cylindrical micelles disposed on the expandable framework. Each of the plurality of cylindrical micelles may be loaded with a therapeutic agent.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: July 20, 2010
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Edward Parsonage
  • Publication number: 20090319033
    Abstract: Adipose tissue has proven to serve as an abundant, accessible, and rich source of endothelial or vascular endothelial cells suitable for tissue engineering. We describe a detailed method for the isolation and purification of endothelial cells using purified enzymes and antibody-based selection. The cells can be obtained from liposuction procedures and used in vascular grafts.
    Type: Application
    Filed: March 7, 2007
    Publication date: December 24, 2009
    Applicant: Humacyte
    Inventors: Laura E Niklason, Yuling Li
  • Patent number: 7622298
    Abstract: Microvessel networks are produced in vitro from tissue-engineered parent vessels sprouting into a supporting matrix, as for example gels, of extracellular matrix proteins. The microvessel systems are integrated into devices that allow for controlled perfusion with fluids. The vessels may include cells from one cell type, for example, endothelial cells, or from combinations of two or more cell types.
    Type: Grant
    Filed: March 24, 2006
    Date of Patent: November 24, 2009
    Assignee: Norits, Inc.
    Inventor: Thomas Neumann
  • Publication number: 20090248145
    Abstract: The present invention provides a method of forming a three-dimensional structure of unidirectionally aligned cells. The method comprises providing a substrate with a microchannel. The microchannel is defined by at least a pair of opposing lateral walls and a base. In at least a portion of the microchannel the distance between the pair of opposing lateral walls is within the micrometer range. A first plurality of cells is seeded in the microchannel and the cells are allowed to proliferate up to at least a density of at least 90%. Thereby contact guidance cues are provided by the pair of opposing lateral walls of the microchannel, such that the cells align unidirectionally. Thereby a first layer of aligned cells is also formed at the base of the microchannel. A second plurality of cells is seeded in the microchannel, which already comprises a first layer of aligned cells.
    Type: Application
    Filed: March 28, 2008
    Publication date: October 1, 2009
    Inventors: Bee Eng Chan, Jie Feng, Jinye Shen, Vincent Chan
  • Publication number: 20090210050
    Abstract: An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent body and are designed to increase turbulence or stagnation in the flow of a liquid, such as blood through the stent, and/or to promote the growth of infiltrating cells in an organized pattern. Alternatively, the invention stent can be populated with living cells prior to implant and can be heatable from an external source of energy, thereby inducing production of therapeutic bioactive agents from ingrowing cells. The invention also provides an implantable heatable stent for transcutaneously monitoring the flow of fluid through a lumen into which the stent is implanted by measuring the rate at which the heated stent cools in response to blood flow when the source of heat is removed.
    Type: Application
    Filed: April 24, 2009
    Publication date: August 20, 2009
    Inventors: Robert A. Van Tassel, David R. Holmes, JR., Robert S. Schwartz
  • Patent number: 7563278
    Abstract: The present invention provides intravascular prostheses and methods of production and use. An implantable device for treating a vascular disease or disorder includes an intravascular prosthesis containing an inhibitor of smooth muscle cell proliferation and a growth factor. The device can be coated with a biodegradable drug-eluting polymer that is impregnated with the inhibitor of smooth muscle cell proliferation and the growth factor. The device is useful for treating or preventing a vascular disease or disorder such as restenosis, by simultaneously inhibiting vessel blockage and enhancing recovery of the vessel wall following an intravascular intervention.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: July 21, 2009
    Assignee: Multi-Gene Vascular Systems Ltd.
    Inventor: Moshe Flugelman