Material Characteristic Of Corneal Implant Patents (Class 623/5.16)
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Patent number: 10954375Abstract: A robust hydrogel-solid hybrid formed of a substrate material having a nonporous and non-topographically patterned surface and a tough hydrogel bonded to the surface, the tough hydrogel having over 90 wt % water, and the hydrogel being bonded to provide interfacial toughness over 300 Jm?2, and even over 1000 Jm?2. The hydrogel is formed of polyacrylamide or polyethylene glycol diacrylate, which provide long-chain polymer networks, and chitosan, hyaluronan, or alginate, which provide mechanically dissipative components. An anchor, which can be a silane, a sulfide, or an amine, is disposed between the surface and the hydrogel to provide chemical bonding between the surface and the long-chain networks of the hydrogel.Type: GrantFiled: June 2, 2016Date of Patent: March 23, 2021Assignee: Massachusetts Institute of TechnologyInventors: Xuanhe Zhao, Shaoting Lin, Hyunwoo Yuk, Teng Zhang, German A P Hernandez
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Patent number: 10725321Abstract: A contact lens for shaping a cornea of an eye of a patient to treat high cylinder astigmatism may include a peripheral portion, an alignment portion, a treatment portion, a reverse portion, and a staining feature. The peripheral portion may cause migration of epithelial cells from a periphery of a cornea of the eye of the patient towards a center of the cornea of the eye of the patient. The alignment portion may align the contact lens on the cornea. The treatment portion may cause migration of the epithelial cells from the center of the cornea towards the periphery of the cornea. The reverse portion may relieve pressure caused by the migration of the epithelial cells. The staining feature may contact the cornea, thereby reshaping the cornea to treat high cylinder astigmatism. The staining feature may apply a ribbon-shaped staining pattern to the cornea across the contact lens.Type: GrantFiled: November 8, 2019Date of Patent: July 28, 2020Assignee: Liberty Commercial Imports & Exports Services, LLCInventors: Liberty Hai Ho Nguyen, Tim Hung Minh Nguyen
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Patent number: 10258233Abstract: A non-sliding, non-sutured hands-free contact lens assembly for ophthalmic procedures utilizes a number of microstructures strategically placed on the bottom of either the contact lens or the bottom of a contact lens holder ring. After the contact lens, or the contact lens assembled with the contact lens holder ring, is placed on the cornea of the eye and centered, a surgeon applies downward pressure either on the contact lens itself or on the lens holder ring. This secures the lens assembly to the cornea due to increased friction between the microstructures and the tissues of the eye when the microstructures penetrate through the tear film and, optionally, viscous solution film and into the contact with superficial layer of cornea or other parts of the eye, thus temporarily anchoring the contact lens, or lens holder, to the desired surgical site.Type: GrantFiled: February 22, 2018Date of Patent: April 16, 2019Assignee: Drug Delivery Company, LLCInventors: Jeffrey D. Benner, Steven M. Cohen, Christopher Forrest Lumpkin
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Patent number: 10072244Abstract: Disclosed is a method for preparing a heterogenous corneal material, wherein during the whole preparation process, different concentrations of glycerol are used to achieve that the heterogenous corneal graft has the transparent, properties of no viruses and cells; resistance to degradation and immunogenicity of collagen can be further reduced by collagen cross-linking; and under the whole eye saving, cross-linkers 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) and N-hydroxy sulfosuccinimide (NHS) are used for cross-linking, thus enabling the form thereof to be closer to that of a fresh cornea and improving biomechanical properties thereof. The method can prepare a heterogenous corneal material with a high transparency, a low immunogenicity and a good bioactivity and biocompatibility, and can maintain that the three-dimensional structure of collagen is close to that of a fresh cornea.Type: GrantFiled: January 27, 2014Date of Patent: September 11, 2018Assignee: YOUVISION BIOTECH CO., LTD.Inventors: Wei Chen, Qinxiang Zhen, Yongliang Lin
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Patent number: 10045844Abstract: Methods of adjusting an intraocular lens after implantation. In some embodiments the methods include positioning an accommodating intraocular lens within an eye, the intraocular lens comprising an optic portion in fluid communication with a peripheral chamber, wherein movement of a fluid between the peripheral chamber and the optic portion in response to ciliary muscle movement changes the optical power of the lens, and reducing a power of the intraocular lens by causing the fluid to move between the optic portion and the peripheral chamber, wherein the reduction in power of the intraocular lens is not in response to ciliary muscle movement, and wherein the positioning step occurs prior to reducing the power.Type: GrantFiled: July 23, 2008Date of Patent: August 14, 2018Assignee: PowerVision, Inc.Inventors: Terah Whiting Smiley, John H. Shadduck, Victor C. Esch, John A. Scholl, Claudio Argento, Barry Cheskin, David John Smith, Denise H. Burns
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Patent number: 9877825Abstract: A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the primary component within the perimeter of the capsulorhexis, thus avoiding the need to touch or otherwise manipulate the capsular bag. The secondary component may be manipulated, removed, and/or exchanged for a different secondary component for correction or modification of the optical result, on an intra-operative or post-operative basis, without the need to remove the primary component and without the need to manipulate the capsular bag. The primary component may have haptics extending therefrom for centration in the capsular bag, and the secondary component may exclude haptics, relying instead on attachment to the primary lens for stability. Such attachment may reside radially inside the perimeter of the capsulorhexis and radially outside the field of view to avoid interference with light transmission.Type: GrantFiled: June 8, 2016Date of Patent: January 30, 2018Assignees: ClarVista Medical, Inc., The Regents of the University of Colorado, a body corporateInventors: Malik Y. Kahook, Naresh Mandava, Paul McLean, Robert E. Atkinson
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Patent number: 9370446Abstract: The present invention relates to a method of altering the refractive properties of the eye, the method including applying a substance to a cornea of an eye, the substance configured to facilitate cross linking of the cornea, irradiating the cornea so as to activate cross linkers in the cornea, and altering the cornea so as to change the refractive properties of the eye.Type: GrantFiled: December 6, 2015Date of Patent: June 21, 2016Inventor: Gholam A. Peyman
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Patent number: 8932352Abstract: An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.Type: GrantFiled: November 28, 2012Date of Patent: January 13, 2015Assignee: University of RochesterInventors: Wayne H. Knox, Li Ding, Jay F. Kunzler, Dharmendra Jani
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Patent number: 8901190Abstract: A method for modifying the refractive index of an optical, hydrogel polymeric material. The method comprises irradiating predetermined regions of an optical, polymeric material with a laser to form refractive structures. To facilitate the formation of the refractive structures the optical, hydrogel polymeric material comprises a photosensitizer. The presence of the photosensitizer permits one to set a scan rate to a value that is at least fifty times greater than a scan rate without the photosensitizer in the material, yet provides similar refractive structures in terms of the observed change in refractive index. Alternatively, the photosensitizer in the polymeric material permits one to set an average laser power to a value that is at least two times less than an average laser power without the photosensitizer in the material, yet provide similar refractive structures.Type: GrantFiled: September 27, 2012Date of Patent: December 2, 2014Assignees: University of Rochester, Rochester Institute of TechnologyInventors: Thomas Smith, Wayne H. Knox, Li Ding, Dharmendra Jani, Jeffrey G. Linhardt
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Patent number: 8834916Abstract: An apparatus and a method for removing epithelium from the cornea include a fluid agent for facilitating de-epithelialization of the cornea. A disc includes a biocompatible material operable for covering a predetermined zone of a cornea. The disc is hydrated by the fluid agent, wherein the hydrated disc is pliable for conforming to a surface of the cornea. An application of the hydrated disc to the cornea substantially constrains the fluid agent to the determined zone and softens a corneal epithelium enabling delamination of the epithelium from an underlying stroma.Type: GrantFiled: October 11, 2010Date of Patent: September 16, 2014Inventor: Leonard Newman
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Publication number: 20140257477Abstract: Devices and methods for handling and depositing corneal implants onto corneal tissue. Devices and methods for packaging and storing corneal implants.Type: ApplicationFiled: October 22, 2012Publication date: September 11, 2014Inventors: Gregg Edmond Plambeck, Ned Schneider, Adam Ariely, David Matsuura, Philip Simpson
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Patent number: 8813753Abstract: Systems and methods for detecting an obstructive sleep apnea event are disclosed herein. The systems and methods may use an electrical output generating ionic polymer metal composite sensor attached to a region in an airway passage in an oral cavity. The electrical output may be wirelessly transmitted as a signal for indication of an obstructive sleep apnea event. The signal may be further analyzed for treatment of the obstructive sleep apnea event.Type: GrantFiled: September 22, 2008Date of Patent: August 26, 2014Assignee: Medtronic Xomed, Inc.Inventors: Nikhil D. Bhat, Charisse M. Yung, Anant V. Hegde, George Y. Choi
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Patent number: 8628572Abstract: Provided herein is an endothelial scaffold comprising, consisting of, or consisting essentially of decellularized corneal stroma. In some embodiments, the scaffold has cultured endothelial cells seeded thereon. Methods of treating a patient in need of corneal endothelial transplant are also provided, including implanting the scaffold as described herein onto a cornea of the patient (e.g., by deep keratectomy).Type: GrantFiled: February 25, 2010Date of Patent: January 14, 2014Assignee: Wake Forest University Health SciencesInventors: Shay Soker, J. Koudy Williams, Patrick Laber, Margaret Greven, Keith A. Walter
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Patent number: 8500803Abstract: An ocular implant including a hydrophobic pseudo-endothelial implant and a binding agent applied thereto, the binding agent capable of bonding the implant to a posterior portion of a cornea such that the implant serves as a water barrier enabling dehydration of the cornea.Type: GrantFiled: February 7, 2012Date of Patent: August 6, 2013Assignee: Mor Research Applications Ltd.Inventor: Ofer Daphna
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Patent number: 8377121Abstract: Annular cornea implant for inserting into a cornea pocket of the human eye via a narrow, tunnel-shaped access, with the end shape of the cornea implant depending on the shortsightedness or astigmatism to be corrected. To enable the cornea implant to be implanted in the cornea pocket in a simple manner and in an optimum position, the implant has a shape memory which is impressed on the basis of the geometry and/or material of the implant, and is designed in such a way that the deformability from a starting shape enables the insertion of the cornea implant into the cornea pocket via the narrow access, and the cornea implant has an adjustment force in the end shape thereof, which enables an essentially independent unfolding of the cornea implant in the cornea pocket.Type: GrantFiled: December 5, 2011Date of Patent: February 19, 2013Inventor: Albert Daxer
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Patent number: 8337553Abstract: The invention is directed to an optical device comprising refractive optical structures, wherein the refractive structures are characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material.Type: GrantFiled: July 30, 2010Date of Patent: December 25, 2012Assignee: Bausch & Lomb IncorporatedInventors: Wayne H. Knox, Li Ding, Jay F. Kunzler, Dharmendra M. Jani, Candido D. Pinto
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Publication number: 20120232648Abstract: A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.Type: ApplicationFiled: April 6, 2012Publication date: September 13, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: Malik Y. Kahook, Naresh Mandava, Robin Shandas, Bryan Rech
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Patent number: 8236053Abstract: Ophthalmic device materials comprising 2-amino benzophenone UV-absorbing compounds are disclosed. The ophthalmic device materials are particularly useful in intraocular lenses.Type: GrantFiled: October 8, 2009Date of Patent: August 7, 2012Assignee: Novartis AGInventor: Charles Freeman
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Publication number: 20120191184Abstract: A device for transplanting a graft such as a layer or layers of cultivated, autologous, allogenic or xenogenic cells to cover an accidental or surgical wound. The graft is cultivated and carried on a bed of collagen or other dissolvable or releasable material mounted on a protective substrate molded to conform to the profile of the wounded area and provided with a lateral attachment zone. The device facilitates the graft cultured in vitro to the recipient surface.Type: ApplicationFiled: March 30, 2012Publication date: July 26, 2012Inventor: Paul Hong-Dze Chen
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Publication number: 20120136437Abstract: An ocular implant including a hydrophobic pseudo-endothelial implant and a binding agent applied thereto, the binding agent capable of bonding the implant to a posterior portion of a cornea such that the implant serves as a water barrier enabling dehydration of the cornea.Type: ApplicationFiled: February 7, 2012Publication date: May 31, 2012Inventor: Ofer Daphna
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Patent number: 8109997Abstract: An ocular implant including a hydrophobic pseudo-endothelial implant and a binding agent applied thereto, the binding agent capable of bonding the implant to a posterior portion of a cornea such that the implant serves as a water barrier enabling dehydration of the cornea.Type: GrantFiled: January 18, 2009Date of Patent: February 7, 2012Assignee: Eyeon Medical Ltd.Inventor: Ofer Daphna
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Patent number: 8092526Abstract: Annular cornea implant for inserting into a cornea pocket of the human eye via a narrow, tunnel-shaped access, with the end shape of the cornea implant depending on the shortsightedness or astigmatism to be corrected. The aim of the invention is to enable the cornea implant to be implanted in the cornea pocket in a simple manner and in an optimum position. To this end, the implant has a shape memory which is impressed on the basis of the geometry and/or material of the implant, and is designed in such a way that the deformability from a starting shape enables the insertion of the cornea implant into the cornea pocket via the narrow access, and the cornea implant has an adjustment force in the end shape thereof, which enables an essentially independent unfolding of the cornea implant in the cornea pocket.Type: GrantFiled: March 16, 2007Date of Patent: January 10, 2012Inventor: Albert Daxer
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Patent number: 8079706Abstract: An apparatus is provided for aligning an implant with a visual axis of an eye of a patient. The apparatus has an instrument with an instrument axis and an aperture through which the patient may look along the instrument axis. The implant includes an aperture having an implant axis that can be positioned substantially collinear with the instrument axis. The implant further includes a substantially opaque annulus extending between the aperture and an outer periphery of the implant. The annulus has a nutrient transport structure for conveying nutrients between anterior and posterior surfaces of the implant.Type: GrantFiled: May 3, 2006Date of Patent: December 20, 2011Assignee: AcuFocus, Inc.Inventors: Thomas A. Silvestrini, Bruce A. Christie, Kevin F. Hahnen, Carl F. Knopp
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Publication number: 20110276132Abstract: The patentable subject matter is the method and implant used in refractive error correction, in particular in short-sightedness, hypermetropia, astigmatism and presbyopia treatment consisting in a new method and implant causing changes to the curvature of the front surface of the cornea through a controlled increase in the corneal epithelium thickness, the method being implemented using a special implant in the form of an intraepithelial scaffold having a porous structure.Type: ApplicationFiled: April 29, 2011Publication date: November 10, 2011Inventor: Bartlomiej Kaluzny
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Publication number: 20110184513Abstract: A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.Type: ApplicationFiled: December 20, 2010Publication date: July 28, 2011Inventors: David Myung, Jaan Noolandi, Alan J. Smith, Curtis W. Frank, Christopher N. Ta, Yin Hu, Won-Gun Koh, Michael R. Carrasco, Laura Hartmann
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Patent number: 7959939Abstract: A laminate comprising a transparent collagen I type sheet and a human corneal endothelial cell culture layer provided on the sheet. An endothelial cell culture layer laminate usable in transplantation is provided.Type: GrantFiled: February 17, 2005Date of Patent: June 14, 2011Inventors: Satoru Yamagami, Tatsuya Mimura, Shiro Amano, Keisuke Tanaka, Shunji Hattori, Shinkichi Irie, Yasuhiro Osakabe
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Publication number: 20110125260Abstract: The present invention provides an artificial cornea (keratoprosthesis) that may be implanted into a patient in need thereof. The artificial cornea comprises a rigid transparent central core surrounded by a peripheral skirt comprising a porous hydrogel. Methods of making such artificial corneas are also provided.Type: ApplicationFiled: October 26, 2010Publication date: May 26, 2011Applicant: UNIVERSITY OF WASHINGTONInventor: Tueng T. Shen
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Patent number: 7909867Abstract: The present invention provides materials that have high glucose and oxygen permeability, strength, water content, and resistance to protein adsorption. The materials include an interpenetrating polymer network (IPN) hydrogel that is coated with biomolecules. The IPN hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. Any biomolecules may be linked to the IPN hydrogels, but are preferably biomolecules that support the growth of cornea-derived cells. The material is designed to serve as a corneal prosthesis.Type: GrantFiled: December 13, 2006Date of Patent: March 22, 2011Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: David Myung, Christopher Ta, Curtis W. Frank, Won-Gun Koh, Jaan Noolandi
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Patent number: 7857447Abstract: The present invention provides interpenetrating polymer network hydrogels that have high oxygen permeability, strength, water content, and resistance to protein adsorption. The hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. The telechelic macromonomer preferably has a molecular weight of between about 575 Da and about 20,000 Da. Mixtures of molecular weights may also be used. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. The material is designed to serve as a contact lens.Type: GrantFiled: December 7, 2006Date of Patent: December 28, 2010Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: David Myung, Jaan Noolandl, Christopher Ta, Curtis W. Frank
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Patent number: 7857849Abstract: A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.Type: GrantFiled: October 4, 2005Date of Patent: December 28, 2010Assignees: The Board of Trustees of the Leland Stanford Junior Iniversity, Santa Clara UniversityInventors: David Myung, Jaan Noolandi, Alan J. Smith, Curtis W. Frank, Christopher Ta, Yin Hu, Won-Gun Koh, Michael R. Carrasco
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Publication number: 20100318185Abstract: Biomedical devices such as contact lenses formed from a polymerization product of a mixture comprising (a) a multi-armed macromonomer comprising multiple side chains attached to a nucleus, wherein each side chain comprises a thio carbonyl thio fragment of the same or different reversible addition fragmentation chain transfer (“RAFT”) agent; and (b) one or more biomedical device-forming monomers are disclosed.Type: ApplicationFiled: June 16, 2009Publication date: December 16, 2010Applicant: Bausch & Lomb IncorporatedInventors: Ivan M. Nunez, Jay F. Kunzler, Jeffrey G. Linhardt, Jennifer Hunt
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Patent number: 7842367Abstract: Opthalmic devices, particularity intraocular lenses (IOL), with improved contrast sensitivity and methods of making same. In one aspect, blue light blocking chromophores (BLBC) are diffused into, e.g. an IOL lens body to create a BLBC gradient in the lens. Orange dyes are preferred BLBCs.Type: GrantFiled: February 8, 2006Date of Patent: November 30, 2010Assignee: Key Medical Technologies, Inc.Inventor: Khalid Mentak
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Publication number: 20100298933Abstract: The invention is directed to an optical device comprising refractive optical structures, wherein the refractive structures are characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material.Type: ApplicationFiled: July 30, 2010Publication date: November 25, 2010Inventors: Wayne H. Knox, Li Ding, Jay F. Kunzler, Dharmendra Jani, Candido D. Pinto
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Publication number: 20100241224Abstract: A corneal cover or corneal implant to be placed within or onto the surface of the cornea is made of bony fish scales and a contact lens is made of bony fish scales.Type: ApplicationFiled: March 3, 2010Publication date: September 23, 2010Applicant: BODY ORGAN BIOMEDICAL CORP.Inventors: Horng-Ji Lai, Chien-Cheng Lin, Shang-Ming Lin
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Publication number: 20100215720Abstract: The present invention refers to an implantable optical system comprising a central optical part and an annular anchoring part, where said annular part comprises animals cells, including human cells, that encourage the integration of the implant into the ocular tissue of the patient, as well as a system for dosing chemical compounds directed at a particular function, creating a stabilising microenvironment for the presence of the implant in the tissue. A method for obtaining said system by polymerisation and its applications in various types of ocular disorders is also described.Type: ApplicationFiled: August 8, 2006Publication date: August 26, 2010Applicant: FUNDACION INASMETInventors: Nerea Garagorri Ganchegui, Iratxe Madarieta Pardo, Beatriz Olalde Graells
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Publication number: 20100198348Abstract: Described are biocompatible materials treated with a biocompatible substance that embeds within pores of the materials so as to alter the transmittance of radiation through the materials. Remodelable materials such as collagenous ECM materials can be so treated to provide implants that are both remodelable and possess an increased capacity to transmit visible light and/or other forms of radiation. Such constructs find particular use in ophthalmic applications and, in particular cases, as corneal implant materials.Type: ApplicationFiled: January 27, 2010Publication date: August 5, 2010Inventors: MICHAEL C. HILES, DAVID A. ZOPF
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Publication number: 20100036488Abstract: A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.Type: ApplicationFiled: April 6, 2009Publication date: February 11, 2010Applicant: ForSight Labs, LLCInventors: Eugene de Juan, JR., Cary J. Reich, Stephen Boyd, Yair Alster, David Sierra, Hanson S. Gifford, Jose D. Alejandro, Richard L. Lindstrom, K. Angela Macfariane, Douglas Sutton, John Anthony
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Publication number: 20090299348Abstract: Photoablatable cornea inlays manufactured from a copolymer of hydrophilic monomer to provide a hydrated material with a refractive index of 1.30 or greater, and a water content from 65% to 90% by weight. The cornea inlay is shaped in the form of a disc or lenticule for placement in the corneal bed of an eye.Type: ApplicationFiled: June 30, 2009Publication date: December 3, 2009Inventors: Dominic V. Ruscio, Jay F. Kunzler, Laurent G. Hoffmann
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Publication number: 20090287306Abstract: A method for modifying the refractive index of an optical, hydrogel polymeric material. The method comprises irradiating predetermined regions of an optical, polymeric material with a laser to form refractive structures. To facilitate the formation of the refractive structures the optical, hydrogel polymeric material comprises a photosensitizer. The presence of the photosensitizer permits one to set a scan rate to a value that is at least fifty times greater than a scan rate without the photosensitizer in the material, yet provides similar refractive structures in terms of the observed change in refractive index. Alternatively, the photosensitizer in the polymeric material permits one to set an average laser power to a value that is at least two times less than an average laser power without the photosensitizer in the material, yet provide similar refractive structures.Type: ApplicationFiled: March 4, 2009Publication date: November 19, 2009Inventors: Thomas Smith, Wayne H. Knox, Li Ding, Dharmendra Jani, Jeffrey G. Linhardt
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Publication number: 20090222086Abstract: The present invention provides a resorbable corneal button comprised of a biodegradable polymer which is capable of supporting the growth and expansion of endothelial cells on it surface for use in transplantation healthy corneal endothelial cells to cornea tissue in need of a transplant and a method of using same.Type: ApplicationFiled: October 12, 2006Publication date: September 3, 2009Inventors: Ge Ming Lui, Anthony Lee, Shaossheng Dong, Hank Wuh
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Patent number: 7547445Abstract: A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more multifunctional initiator groups. The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant.Type: GrantFiled: June 27, 2006Date of Patent: June 16, 2009Assignee: SurModics, Inc.Inventors: Stephen J. Chudzik, Joseph A. Chinn
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Publication number: 20090076601Abstract: Annular cornea implant for inserting into a cornea pocket of the human eye via a narrow, tunnel-shaped access, with the end shape of the cornea implant depending on the shortsightedness or astigmatism to be corrected. The aim of the invention is to enable the cornea implant to be implanted in the cornea pocket in a simple manner and in an optimum position. To this end, the implant has a shape memory which is impressed on the basis of the geometry and/or material of the implant, and is designed in such a way that the deformability from a starting shape enables the insertion of the cornea implant into the cornea pocket via the narrow access, and the cornea implant has an adjustment force in the end shape thereof, which enables an essentially independent unfolding of the cornea implant in the cornea pocket.Type: ApplicationFiled: March 16, 2007Publication date: March 19, 2009Inventor: Albert Daxer
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Publication number: 20080262610Abstract: Provided herein are intracorneal inlays for correcting vision impairments by altering the shape of the anterior corneal surface. The physical design of the inlay to induce the desired change of the anterior corneal surface includes consideration of the biomechanical response of the corneal tissue to the physical shape of the inlay. This biomechanical response can differ depending on the thickness, diameter, and profile of the inlay. In one embodiment, inlays having diameters smaller than the pupil are provided for correcting presbyopia. To provide near vision, an inlay is implanted centrally in the cornea to induce an “effect” zone on the anterior corneal surface, within which diopter power is increased. Distance vision is provided by a region of the cornea peripheral to the “effect” zone. In another embodiment, small diameter inlays are provided that induce “effect” zones on the anterior corneal surface that are much larger in diameter than the inlays.Type: ApplicationFiled: April 20, 2007Publication date: October 23, 2008Inventors: Alan Lang, Troy Miller, Ned Schneider, Alexander Vatz, Tonya Brooke Icenogle, Sylvia Franz, Derrick Johnson
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Publication number: 20080182956Abstract: This application is directed toward an improved method of synthesizing cationic siloxane prepolymers as well as a specific cationic siloxane prepolymer having improved compatibility with monofunctional siloxanyl methacrylate monomers and medical devices containing the cationic siloxane prepolymer.Type: ApplicationFiled: January 24, 2008Publication date: July 31, 2008Inventors: Jason K. Stanbro, Ivan M. Nunez, Jay F. Kunzler, Derek A. Schorzman
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Patent number: 7364674Abstract: The corneal implant of the current invention takes the general form of a thin, transparent, flexible, porous, biocompatible film of suitable polymer material. The implant is sufficiently porous, the porosity being imparted by the film being irradiated to produce tracks and the material in those tracks being subsequently removed through an etching process, to allow the adequate flow of gaseous and tissue fluid components through the film. Specific embodiments of the invention are achieved by the addition of features to the general form. The embodiment applicable to corneal reshaping features a surface relief pattern in the implant. The artificial iris embodiment features an imprinted partly to fully opaque or partially reflective annular iris pattern of selected inner and outer diameters.Type: GrantFiled: July 23, 2003Date of Patent: April 29, 2008Assignee: Advanced Optical Technologies, Inc.Inventor: Brian G. Hoover
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Patent number: 7347876Abstract: Transplantation of epithelial stem cells, cultured ex vivo on specifically treated amniotic membrane, yields, with that amniotic membrane, a surgical graft having expanded epithelial stem cells. The method of creating this graft and the graft itself are simple and effective to reconstruct damaged tissue, a preferred example being corneal tissue. The source of the epithelial stem cells can be a very small explant from healthy autologous and allogeneic tissue biopsy. The amniotic membrane is treated such that its extracellular matrix is maintained, but its cells are killed.Type: GrantFiled: April 25, 2001Date of Patent: March 25, 2008Inventor: Ray Jui-Fang Tsai
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Patent number: 6976997Abstract: The invention provides implants suitable for use as an artificial cornea, and methods for making and using such implants. Artificial corneas having features of the invention may be two-phase artificial corneas, or may be three phase artificial corneas. These artificial corneas have a flexible, optically clear central core and a hydrophilic, porous skirt, both of which are biocompatible and allow for tissue integration. A three-phase artificial cornea will further have an interface region between the core and skirt. The artificial corneas have a high degree of ocular tolerance, and allow for tissue integration into the skirt and for epithelial cell growth over the surface of the prosthesis. The use of biocompatible material avoids the risk of disease transmission inherent with corneal transplants, and acts to minimize post-operative inflammation and so to reduce the chance or severity of tissue necrosis following implantation of the synthetic cornea onto a host eye.Type: GrantFiled: June 18, 2003Date of Patent: December 20, 2005Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Jaan Noolandi, Christopher Ta, Philip Huie, Jr., Alan J. Smith, Robert Waymouth, Mark Blumenkranz
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Patent number: 6875232Abstract: Prosthetic implants designed to be implanted in the cornea for modifying the cornea curvature and altering the corneal refractive power for correcting myopia, and myopia with astigmatism, such implants formed of a micro-porous hydrogel material.Type: GrantFiled: January 15, 2002Date of Patent: April 5, 2005Assignee: Anamed, Inc.Inventor: Alok Nigam
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Patent number: 6858033Abstract: An insertion system for an intraocular lens having a deformable optical portion and loop-shaped support portions for supporting the optical portion within an eye includes a holding member for holding the intraocular lens at a standby position in a state in which no stress acts on the optical portion of the lens; a deforming member for deforming the lens to a reduced size; an insertion tube through which the deformed lens is inserted into the eye; a pusher mechanism having a push rod for pushing and inserting the lens into the eye; and a lens moving mechanism for moving the lens from the standby position to an insertion position at which the pusher mechanism can push and insert the lens into the eye. When the lens is moved to the insertion position, the optical portion and the support portions of the lens are placed in different spaces in order to fix the positional relationship between the optical portion and the support portions of the lens.Type: GrantFiled: September 27, 2002Date of Patent: February 22, 2005Assignee: Canon-Staar Co., Inc.Inventor: Kenichi Kobayashi
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Patent number: RE38935Abstract: Ophthalmic lenses, such as intraocular lenses, include crosslinked polymeric materials having a first constituent derived from a first monomeric component selected from the group consisting of 2-phenylpropyl acrylate or methacrylate and mixtures thereof, and a second constituent derived from a second component in an amount effective as a crosslinker in the crosslinked polymeric material. The crosslinked polymeric material has branched chain alkyl groups, in an amount effective to reduce the tackiness of the crosslinked polymeric material relative to a substantially identical crosslinked polymeric material without branched chain alkyl groups.Type: GrantFiled: June 4, 2002Date of Patent: January 10, 2006Assignee: Advanced Medical Optics, Inc.Inventors: Harish C. Makker, Xiugao Liao, Joseph I. Weinschenk, III