Abstract: Ophthalmic lenses are described including an ophthalmic base, and a plurality of electro-active elements, such as dynamic micro-lenses or micro-prismatic apertures. Each electro-active element may be configured to dynamically change optical power. The ophthalmic lens may be configured such that an optical power of the ophthalmic lens focuses mostly one image at one time on the retina of the eye of the wearer. The ophthalmic lens may be, for example, a spectacle lens, other types of specialty lenses such as used for gaming and the like, a contact lens, an intra-ocular lens, and intra-ocular optic, etc. Each electro-active element may include liquid crystal, such as dichroic, non-dichroic, nematic, and/or cholesteric liquid crystal. The electro-active elements may comprise non-dichroic liquid crystal, and gaps between the electro-active elements may include a dichroic liquid crystal, or the electro-active elements may be shaped and arranged in a substantially conformal pattern.

Abstract: Antennas and antenna systems may be designed and configured for incorporation into mechanical devices, including medical devices, such as ophthalmic devices, including contact lenses. These antennas and antenna systems may be utilized to transmit data from the mechanical device to a receiver, to receive data from a transmitter, and/or to inductively charge an electromechanical cell or the like incorporated into the mechanical device.

Abstract: Apparatus is provided having an intraocular device for implantation entirely in a subject's eye, the intraocular device including: a photosensor array having a plurality of photosensors, each photosensor detects ambient photons and generates a signal in response thereto. A spatial density of the photosensors in a central portion of the array is greater than a spatial density of the photosensors in an outer portion of the array. The intraocular device additionally includes a plurality of stimulating electrodes and driving circuitry coupled to the photosensors, and configured to drive the electrodes to apply electrical pulses to a retina of the eye in response to the signals from the photosensors. Other applications are also described.

Abstract: This invention describes Ophthalmic Devices with media inserts that have nanostructured Metasurface elements upon or within them. In some embodiments passive ophthalmic devices of various kinds may be formed. Methods and devices for active ophthalmic devices based on Metasurface structures may also be formed.

Abstract: A presbyopia correcting intraocular lens implant for implanting in a human eye includes an implant body having a central lens enclosure and at least one stability tab extending therefrom. At least one ciliary body sensor senses movement of the eye's ciliary body. An electronic module is embedded in the implant body and includes a microprocessor communicative with the ciliary body sensor. A dynamic lens assembly is housed in the central lens enclosure and has a dynamic range of continuous accommodation. The lens implant also includes a renewable intraocular power supply.

Abstract: A foldable accommodating intraocular lens (AIOL) for implantation in a human eye, the AIOL including a hollow flattened sphere shaped housing including a shape memory optical element and a tubular casing mounted on the housing for reciprocation relative thereto for selectively compressing the shape memory optical element between a non-compressed shape and a compressed shape whereby the AIOL has a continuously variable Diopter strength.

Abstract: An emitter-detector pair sensor may be incorporated into a powered or electronic ophthalmic lens. The emitter-detector pair sensor may be configured to determine the distance from the sensor to an object in its path. Based upon this information, a system controller of the ophthalmic lens may output a signal to an actuator of the ophthalmic lens to control a variable power optic of the ophthalmic lens.

Abstract: A pupil position and convergence detection system for an ophthalmic lens comprising an electronic system is described herein. The pupil position and convergence detection system is part of an electronic system incorporated into the ophthalmic lens. The electronic system includes one or more batteries or other power sources, power management circuitry, one or more sensors, clock generation circuitry, control algorithms and circuitry, and lens driver circuitry. The pupil position and convergence detection system is utilized to determine pupil position and use this information to control various aspects of the ophthalmic lens.

Abstract: An electronic or powered ophthalmic lens includes one or more systems having one or more batteries or other power sources, power management circuitry, one or more sensors, clock generation circuitry, control algorithms and circuitry, and lens driver circuitry. These systems may change the state of the powered ophthalmic lens. In systems having one or more sensors, a decision making process is required to substantially reduce the possibility of changing the state of the powered ophthalmic lens based upon inaccurate, incomplete or erroneous information supplied by the sensors, changing physiologic conditions , as well as noise and/or interference from internal and external sources.

Abstract: A gaze direction tracking system for an ophthalmic lens comprising an electronic system is described herein. The gaze direction tracking system is part of an electronic system incorporated into the ophthalmic lens. The electronic system includes one or more batteries or other power sources, power management circuitry, one or more sensors, clock generation circuitry, control algorithms and circuitry, and lens driver circuitry. The gaze direction tracking system is utilized to determine pupil position and use this information to control various aspects of the ophthalmic lens.

Abstract: The invention relates to a device (1) for the vision correction of an eye (6), comprising: a converter (3, 3A, 3B, 5A, 5B) which can generate an electrical and/or magnetic and/or electromagnetic signal in response to the mechanical energy generated by a movement of the eye; and a soft lens (2) intended to be aligned with the eye. The converter is positioned in relation to the lens such that the electrical and/or magnetic and/or electromagnetic signal generated during the movement of the eye causes the optical properties of the lens to change. The invention is characterised in that the lens (2) includes a polymer material (7) containing a material (4) having a refractive index that can vary under the action of the electrical and/or magnetic and/or electromagnetic signal generated during a movement of the eye.

Abstract: An intraocular system is presented that may include an electro-active element having multiple independently controllable zones or pixels, and a controller capable of being remotely programmed. The system or element may be flexible, such that it can be folded for insertion into the eye. The system may include various energy storage and charging mechanisms to provide power to the lens and/or the controller.

Abstract: An implantable fluidic valve actuated by osmotic pressure gradient and methods of operating it are provided. The valve includes: an input fluid channel; an output fluid channel in fluid communication with the input fluid channel at an aperture; and a semi-permeable membrane forming a portion of a sealed chamber. The semi-permeable membrane may have an outer surface forming a wall of the input fluid channel, and an inner surface forming a wall of the sealed chamber, the membrane being configured to allow diffusion of a solvent into and out of the sealed chamber; and a first electrode and a second electrode disposed within the sealed chamber configured to receive a voltage. A pump including the above elements and a check valve is provided. An ocular implant including an inlet tube sized to receive aqueous humor and an intra-ocular pressure control system having a fluidic valve as above is also provided.

Abstract: Ophthalmic devices with dynamic electro-active elements offer variable optical power and/or depth of field that restore lost accommodation in individuals suffering from presbyopia or aphakia. An illustrative device senses physiological processes indicative of the accommodative response and actuates a dynamic electro-active element to provide the desired change in optical power and/or depth of field. The illustrative device includes two application-specific integrated circuits (ASICs) for processing the accommodative response and actuating the electro-active element: a high-voltage ASIC that steps up a low voltage from a power supply to a higher voltage suitable for actuating the electro-active element, and another ASIC that operates at low voltage (and therefore consumes little power) and controls the operating state of the high-voltage ASIC. Because each ASIC operates at the lowest possible voltage, the illustrative ophthalmic device dissipates less power than other ophthalmic devices.

Abstract: An intraocular lens is adapted for insertion into a capsular bag having a zonular contact region. The intraocular lens comprises a shape changing optical element and an accommodating element comprising at least one force transmitting element and a plurality of spaced apart contacting elements each adapted to contact a portion of the zonular contact region and transmit compressive displacement radially inward at an oblique angle to the optical element and configured to cooperate with at least one of the ciliary muscle of the mammalian eye, the zonules of the mammalian eye and the vitreous pressure in the eye to effect an accommodating shape and a disaccommodating shape change to the optical element.

Abstract: An intraocular lens is adapted for insertion into a capsular bag having a zonular contact region. The intraocular lens comprises a shape changing optical element and an accommodating element comprising at least one force transmitting element and a plurality of spaced apart contacting elements each adapted to contact a portion of the zonular contact region and transmit compressive displacement radially inward at an oblique angle to the optical element and configured to cooperate with at least one of the ciliary muscle of the mammalian eye, the zonules of the mammalian eye and the vitreous pressure in the eye to effect an accommodating shape and a disaccommodating shape change to the optical element.

Abstract: According to a first aspect, the invention relates to an intraocular variable focus implant comprising a non-conducting liquid with a melting temperature above 0° C., a conducting liquid, a liquid interface formed by the non-conducting and conducting liquids, a first electrode in contact with the conducting liquid, a second electrode insulated from the conducting liquid, wherein the liquid interface is movable by electro wetting according to a change in a voltage applied between the first and second electrodes.

Abstract: A prosthesis is provided, which includes anterior and posterior lenses spaced from one another and aligned along an optical axis, and an optic body supporting the lenses in spaced relation to one another to establish a chamber between the lenses. Optically transmissive primary and secondary fluids are contained in the chamber. Orienting the optical axis in a horizontal orientation for far vision positions the optical axis through the primary fluid. Orienting the optical axis for near vision at a range of effective downward angles relative to the horizontal orientation positions the optical axis to extend through the primary fluid and the secondary fluid. The prosthesis may further include an internal plate between the lenses, which may be offset at an oblique angle relative to perpendicular to the optical axis. Related methods are also provided.

Abstract: An implantable MEMS package for the treatment of an ocular condition is provided. The MEMS package includes an outer portion; an active portion attached to the outer portion, the active portion including a fluid regulating element having a moving element; and a fluidic channel at an interface of the outer portion and the active portion. The fluidic channel is formed in at least one of the outer and active portions and permits fluid communication from the MEMS package to the fluid regulating element. A method for forming a MEMS package as above is also provided. An ocular implant for treating glaucoma including an inlet tube for receiving aqueous humor; a MEMS package as above, coupled to the inlet tube; a control system to control the MEMS package; and an outlet tube for draining aqueous humor at a drainage location, is provided.

Abstract: An implantable ophthalmic device with one or more optical elements coupled to one or more shape-memory members provides dynamically variable optical power to restore lost accommodation in individuals suffering from presbyopia or aphakia. Running current from a power supply through the shape-memory members causes the shape-memory members to heat up. Once the current heats the shape-memory members past a forward phase-transition temperature, the shape-memory members change shape, which, in turn, causes the optical element(s) to move, yielding a corresponding change in effective optical power. Cooling the shape-memory members (e.g., by reducing or stopping the flow of current) below a reverse phase-transition temperature causes the shape-memory members to return to their original shape, which, in turn, restoring the optical element(s) to their original positions and returning the effective optical power to its original level.

Abstract: An accommodating intraocular lens for providing a range of accommodative vision contains an optic and a haptic. The haptic includes a plurality of arms coupled to a compressible inner structure. The compressible inner structure of the haptic is configured to exert a compressive force on the optic in response to an ocular force to provide accommodation. The compressible inner structure can include a plurality of arcuate segments that join to form a ring in the fully compressed state or a sinusoidal ring having a varying radial dimension.

Abstract: An implantable, compressible, accommodating intra-ocular lens (IOL) coupled to at least one sensor which detects a signal created by the ciliary muscle. A ciliary sulcus ring can house the at least one sensor, and the sensor can include miniaturized electrodes (ciliary muscle probes) for implanting into the ciliary muscle of the subject. A potentiometer/microcomputer can modulate the ciliary muscle signal detected by the sensor(s) into an electrical signal, and a transmitter sends this electrical signal to a micromotor, which causes compression of the IOL via an annular support ring system, causing a change in the IOL shape. The IOL can be part of an IOL complex including a compressible, accommodating IOL, an external lens membrane, and an annular support ring system. The annular support ring system provides a foundation for the micromotor to compress the IOL.

Abstract: The present invention includes at least an intraocular lens, and a system and method of customizing at least one characteristic for an intraocular lens, in accordance with a regression that indicates the postoperative spherical aberration at the iris plane of a patient aphakic eye, in order to obtain a desired postoperative condition. The lens, system and method of customizing at least one characteristic of an intraocular lens may include measuring at least one biometric parameter of an eye at a desired light level, determining a desired postoperative condition of the eye, obtaining a corneal spherical aberration and an anterior chamber depth of the eye, and empirically calculating a spherical aberration at an iris or pupil plane of the eye, based on a regression formula comprising at least the corneal spherical aberration and the anterior chamber depth, and cross products thereof.

Abstract: Certain exemplary embodiments can provide a system, machine, device, manufacture, circuit, composition of matter, and/or user interface adapted for and/or resulting from, and/or a method and/or machine-readable medium comprising machine-implementable instructions for, activities that can comprise and/or relate to, via a device implanted in a mammal, sensing a ciliary muscle movement and/or force and/or converting the ciliary muscle movement and/or force to a signal and/or a predetermined form of power.

Abstract: Implantable ophthalmic devices with aspheric lenses and dynamic electro-active elements offer excellent depth of field and image quality while providing high optical throughput. An exemplary implantable ophthalmic device includes an aspheric lens with a negative spherical aberration that varies with radius. The aspheric lens can have peak optical powers at its geometric centers surrounded by a region of varying optical power (with varying slope) that extends radially from its center. When implanted, these aspheric lenses provide an incremental optical power that varies as a function of pupil diameter, which changes with object distance, for viewing far, intermediate, and near objects. The aspheric lens may also bonded or integrally formed with a spherical lens that provides fixed optical power for viewing far objects and/or a dynamic electro-active element that with two or more states (e.g., on and off) for increasing the effective optical power when viewing near objects.

Abstract: A lens driver or lens driver circuitry for an ophthalmic apparatus comprising an electronic system which actuates a variable-focus optic is disclosed herein. The lens driver is part of an electronic system incorporated into the ophthalmic apparatus. The electronic system includes one or more batteries or other power sources, power management circuitry, one or more sensors, clock generation circuitry, control algorithms and circuitry, and lens driver circuitry. The lens driver circuitry includes one or more power sources, one or more high voltage generators and one or more switching circuits.

Abstract: According to a first aspect, the invention relates to an electrically controlled focusing ophthalmic device (43) to be worn by a user, comprising:—at least one active liquid lens comprising a liquid/liquid interface movable by electrowetting under the application of a voltage,—a driver for applying a DC voltage to said active liquid lens, the amplitude of the voltage to be applied being a function of the desired focusing;—a sensor (41) for detecting eyelid closing events and/or microsaccades of the user;—a controller for synchronizing said sensor and the driver, such that the driver may reverse the polarization of the DC voltage during a microsaccade and/or an eyelid closing event of the user.

Abstract: An implantable ophthalmic device with flexible, fluid-filled membranes provide dynamically variable optical power to restore lost accommodation in individuals suffering from presbyopia or aphakia without moving parts or reducing the amount of transmitted light. Actuating the device causes the fluid-filled membrane to change curvature, which produces a corresponding change in optical power. For instance, squeezing the edge of the membrane causes the center of the membrane to bulge by an amount proportional to the squeezing force. Alternatively, heating or applying a voltage to the membrane may cause the liquid in the membrane to undergo a phase transition accompanied by a corresponding change in volume that causes the membrane to inflate so as to change the optical power of the device.

Abstract: Many modem implantable ophthalmic devices include electronic components, such as electro-active cells, that can leak harmful substances into the eye and/or surrounding tissue. In the implantable ophthalmic devices disclosed herein, electronic components are hermetically sealed to facilitate mechanically connecting components of an implantable ophthalmic device. Furthermore, the device includes at least one battery with a surface comprising electrical contact portions, a housing for the at least one battery, a first wafer bonded to the housing such that the housing and the first wafer form a hermetically sealed surface around the battery, and an electronic circuit electrically connected to the electrical contact portions of the battery.

Abstract: This invention discloses methods and apparatus for providing a biomedical device, such as an ophthalmic lens with an energy receptor capable of powering a processing device.

Abstract: In one aspect, an accommodative intraocular lens (IOL) is disclosed that includes an optic having at least a portion formed of a polarizable and/or and electro-active material. Once implanted in a subject's eye, a change in the index of refraction of the polarizable and/or electro-active portion in response to forces applied to the optic via the eye's ciliary muscle can cause a change in the optical power of the optic, thereby allowing accommodation.

Abstract: The present invention relates generally to the restoration or improvement of the quality of human vision and, more particularly to a self-adapting system and method for achieving automatic sharp vision by the human eye of objects for instance at distances between 25 cm and more than 10 meters away. The invention can be situated in at least four technological domains: 1. ophthalmology, in particular the implantation of intraocular lenses. 2. Non-contact biometric signal recording and processing. 3. Electro-optic control of refractive lens power. 4. Wireless energy transfer.

Abstract: Astigmatism is an optical aberration that displaces the eye's vertical focal plane with respect to its horizontal focal plane. This displacement in focal planes, which may be caused by an irregularly shaped cornea and/or crystalline lens, causes images to appear blurry. Astigmatism can be corrected by implanting an optic, such as section of a spherical lens, whose projection onto a plane perpendicular to the optical axis is noncircular (e.g., rectangular or elliptical). Because the optic is noncircular, it provides more optical power along one axis than along another axis. As a result, it introduces an astigmatism that can be used to offset or compensate the eye's corneal and/or lenticular astigmatism when aligned properly with respect to the principal meridians of the cornea and/or crystalline lens.

Abstract: Many modern implantable ophthalmic devices include electronic components, such as electro-active cells, that can leak harmful substances into the eye and/or surrounding tissue. In the implantable ophthalmic devices disclosed herein, electronic components are hermetically scaled within cavities formed by bonding together two or more glass wafers. Bonding the glass wafers together with laser fusion bonding, pressure bonding, or anodic bonding creates a seal that leaks at a rate of less than about 5×10?12 Pa m3 s?1 when subjected to a helium leak test. Hermetically sealed feedthroughs formed of conductive material running through channels in the wafers provide electrical connections to components inside the sealed cavities. In some cases, the conductive material has a coefficient of thermal expansion (CTE) that is roughly equal to (e.g., within 10% of) the CTE of the glass wafers to minimize leakage due to thermally induced expansion and contraction of the conductive material and the glass wafer.

Abstract: An intraocular lens has a polymeric optic defined by a harder posterior layer and a softer anterior layer. Haptics having a fulcrum attached to the posterior layer and a resistance arm attached to the anterior layer are provided. A bias is provided to the haptic to rotate the haptics about the fulcrum and cause the resistance arm to deform the softer anterior layer about the harder posterior layer to increase the optical power of the lens. As the haptic rotates, it axially displaces the optic anteriorly to additionally increase the optical power. The optical power is adjustable in response to stresses induced by the eye. The haptics are subject to a pre-bias that urges the haptics to rotate or bend about the fulcrum. Temporary restraints are provided to the haptics to retain a stressed shape of the lens against the bias during a post-implantation healing period.

Abstract: An implantable, compressible, accommodating intra-ocular lens (IOL) coupled to at least one sensor which detects a signal created by the ciliary muscle. A ciliary sulcus ring can house the at least one sensor, and the sensor can include miniaturized electrodes (ciliary muscle probes) for implanting into the ciliary muscle of the subject. A potentiometer/microcomputer can modulate the ciliary muscle signal detected by the sensor(s) into an electrical signal, and a transmitter sends this electrical signal to a micromotor, which causes compression of the IOL via an annular support ring system, causing a change in the IOL shape. The IOL can be part of an IOL complex including a compressible, accommodating IOL, an external lens membrane, and an annular support ring system. The annular support ring system provides a foundation for the micromotor to compress the IOL.

Abstract: A laser system for modifying the index of refraction of an optical hydrogel material. The laser system comprises a computer program to determine the position and shape of refractive structures to be written into the optical hydrogel material to correct a patient's vision, and a focused laser that generates laser light having a wavelength of from 400 nm to 900 nm, and which operates with an average power of 10 mW to 1000 mW to produce a pulse energy from 0.05 nJ to 1000 nJ with a peak intensity at focus of greater than 1013 W/cm2. The refractive structures exhibit a change in the index of refraction of 0.01 to 0.06 in the optical hydrogel material.

Abstract: This invention discloses methods and apparatus for providing a Variable Optic Insert into an Ophthalmic Lens. An energy source is capable of powering the Variable Optic Insert included within the Ophthalmic Lens. In some embodiments, an Ophthalmic Lens is cast-molded from a silicone hydrogel. The various Ophthalmic Lens entities may include electroactive Liquid Crystal layers to electrically control refractive characteristics.

Abstract: An intraocular lens (10) is configured so that it can be incorporated into the capsule of an eye and its refractive power can be modified by the application of electrical voltages.

Abstract: An implantable system for restoring accommodation capacity includes at least one ring configured to be implanted in a ciliary sulcus and a capacitor with a first capacitor plate and a second capacitor plate. The first capacitor plate is arranged on an implantable ring and the second capacitor plate is connected to a capsular bag.

Abstract: An intraocular lens is adapted for insertion into a capsular bag having a zonular contact region. The intraocular lens comprises a shape changing optical element and an accommodating element comprising at least one force transmitting element and a plurality of spaced apart contacting elements each adapted to contact a portion of the zonular contact region and transmit compressive displacement radially inward at an oblique angle to the optical element and configured to cooperate with at least one of the ciliary muscle of the mammalian eye, the zonules of the mammalian eye and the vitreous pressure in the eye to effect an accommodating shape and a disaccommodating shape change to the optical element.

Abstract: The system is able to correct the spherical and cylindrical power as well as other aberrations of the optical pathway of both eyes of a person eliminating the need for multiple heavy glass lenses and mirrors. For correcting the refractive errors, the above described system is equipped with a diachroic mirror interposed in front of the system, to divert part of the light reflecting from the pupil to a Shack-Hartman wave front sensor.

Abstract: A vision prosthesis includes an intra-ocular lens system having a variable focal length; and a controller that causes a change in the focal length thereof.

Abstract: An ophthalmic lens including an electro-active optical element including a substrate; a liquid crystalline material; and at least one first layer. The at least one first layer can include a layer of silicon oxide (SiOx) disposed between the liquid crystalline material and the substrate, and deposited onto a surface of the substrate at an oblique angle in reference to a plane normal to the mean surface of the substrate facing the liquid crystalline material.

Abstract: An adjustable intraocular lens is disclosed comprising at least one optical element and at least one haptic. Rotation of the lens in a plane perpendicular to the optical axis and bounded by an oval boundary adjusts the lens diameter which provides a corresponding adjustment of optical power. Preferably the lens according to the invention is adapted to be manipulated by manipulation means outside the eye, for example, surgical means. Adjustment of the angular position of the intraocular lens results in a corresponding adjustment of the lens diameter which, in turn, leads to a corresponding adjustment of the optical power of the lens.

Abstract: According to a first aspect, the invention relates to an electrically controlled focusing ophthalmic device (43) to be worn by a user, comprising:—at least one active liquid lens comprising a liquid/liquid interface movable by electrowetting under the application of a voltage,—a driver for applying a DC voltage to said active liquid lens, the amplitude of the voltage to be applied being a function of the desired focusing;—a sensor (41) for detecting eyelid closing events and/or microsaccades of the user;—a controller for synchronizing said sensor and the driver, such that the driver may reverse the polarization of the DC voltage during a microsaccade and/or an eyelid closing event of the user.

Abstract: Ophthalmic lenses are described including a deformable layer and a deformable membrane disposed opposite the deformable layer. The lens is configured with at least two regions of adjustable optical power, such as by using a patterned electrode which is used to drive the membrane move axially along an optical path of the lens. A surface of the deformable layer is configured to expand and/or contract based on movement of the membrane along the optical path of the lens, such as by bonding one side of the deformable layer to the membrane and bonding the other side to a fixed optical element layer.

Abstract: Systems and their methods of use for testing intraocular lenses outside of the lens capsule. In some embodiments the systems measure an accommodative response based on a force applied to the intraocular lens.

Abstract: The present invention is a system for mapping a high resolution image to a lower resolution electrode array and, by applying varying stimulus to neighboring electrodes, creating a perceived image greater in resolution than the electrode array. The invention is applicable to a wide range of neural stimulation devices including artificial vision and artificial hearing. By applying a sub-threshold stimulus to two neighboring electrodes where the sum of the stimuli is above the threshold of perception, a perception is created in neural tissue between the two electrodes. By adjusting the stimulus on neighboring electrodes, the location of stimulation can be altered. Further, noise can be applied to the stimulating electrode or its neighboring electrodes to reduce the threshold of stimulation.

Abstract: A lens for correcting human vision, for example an IOL, contact lens or corneal inlay or onlay, that carries and interior phase or layer comprising a pattern of individual transparent adaptive displacement structures. In the exemplary embodiments, the displacement structures are actuated by shape change polymer that adjusts a shape or other parameter in response to applied energy that in turn displaces a fluid media within the lens that actuates a flexible lens surface. The adaptive optic means of the invention can be used to create highly localized surface corrections in the lens to correct higher order aberrations-which types of surfaces cannot be fabricated into and IOL and then implanted. The system of displacement structures also can provide spherical corrections in the lens.