Blood Vessel Patents (Class 623/921)
  • Patent number: 9011518
    Abstract: A stent for placement in a body lumen is fabricated by forming a tube having an un-deployed diameter sized for the tube to be placed on a deployment balloon and advanced through a body lumen to a deployment site. The tube is expandable upon inflation of the balloon to an enlarged diameter sized for the tube to be retained within the lumen at the site upon deflation and withdrawal of the balloon. The tube has a stent axis extending between first and second axial ends of the tube. The tube has an exterior surface and an interior surface. The tube is polished to polish the exterior surface to a smooth surface finish and with at least a portion of the interior surface having a rough surface finish rougher than the surface finish of the exterior surface.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: April 21, 2015
    Assignee: Covidien LP
    Inventor: Paul J. Thompson
  • Patent number: 8859934
    Abstract: A method of removing slag formed during laser cutting a hypotube may include flowing cooling gas into a laser nozzle, directing flow of the cooling gas onto an external surface of the hypotube, and injecting cooling fluid into an inner lumen of the hypotube at a velocity. Flowing the cooling gas and injecting the cooling fluid may at least partially remove slag from the external surface of the hypotube.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: October 14, 2014
    Assignee: Insera Therapeutics, Inc.
    Inventors: Vallabh Janardhan, Vikram Janardhan
  • Patent number: 8409847
    Abstract: Systems and methods are provided for controlling the diameter of a mammalian hybrid coronary bypass graft. The system includes a controller having at least one input for receiving information and feedback information and an output for outputting control signals, including at least one steady flow system control signal; and a pressure/flow loop subsystem coupled to the controller. The pressure/flow loop subsystem includes a specimen holder, an external flow loop system coupled to the specimen holder, a steady flow system, and an output for outputting the feedback information. The pressure/flow loop subsystem receives the control signals and is capable of adjusting a diameter of a specimen in accordance with the control signals, when the specimen holder contains the specimen.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: April 2, 2013
    Assignee: ICE Development Technologies, LLC
    Inventor: Michael Dancu
  • Patent number: 8399243
    Abstract: Developing heart valves are exposed to dynamic strains by applying a dynamic pressure difference over the leaflets. The flow is kept to a minimum, serving only as a perfusion system, supplying the developing tissue with fresh nutrients. Standard heart valves were engineered based on B trileaflet scaffolds seeded with cells isolated from the human saphenous vein. Tissue compaction is constrained by the stent, inducing increasing pre-strain in the tissue. The dynamic strains the tissues are exposed to via the dynamic pressure difference, are estimated using finite element methods based on the mechanical properties of the neo-tissue, in order to get inside into the strain distribution over the leaflet.
    Type: Grant
    Filed: February 1, 2006
    Date of Patent: March 19, 2013
    Assignees: Universitaet Zuerich, Technische Universiteit Eindhoven
    Inventors: Carlijin V. C. Bouten, Anita Mol, Marcel C. M. Rutten, Simon P. Hoerstrup, Frank P. T. Baaijens
  • Patent number: 8329450
    Abstract: An organ support apparatus includes: (a) a fluid circuit defining upstream and downstream legs adapted to be connected to an organ to be supported; (b) a circulation pump connected to the fluid circuit for circulating a process fluid through the fluid circuit and the organ; and (c) a first waveform generator connected to the fluid circuit for impressing a preselected pressure waveform on the process fluid.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: December 11, 2012
    Assignee: Biomedinnovations, LLC
    Inventors: Donald G. Faulkner, John L. Robertson
  • Patent number: 8318414
    Abstract: A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: November 27, 2012
    Assignee: ICE Development Technologies, LLC
    Inventors: Michael B. Dancu, John M. Tarbell
  • Patent number: 8158407
    Abstract: Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can coat a hybrid graft with a confluent monolayer of endothelial cells by immobilizing stem cells on a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft, and placing the hybrid graft in a system embodiment according to the invention under conditions effective to promote the stem cells to form a confluent monolayer on the hybrid graft and in an environment to promote the stem cells to differentiate into endothelial cells.
    Type: Grant
    Filed: January 24, 2008
    Date of Patent: April 17, 2012
    Assignee: ICE Development Technologies, LLC
    Inventor: Michael Dancu
  • Patent number: 8039246
    Abstract: Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft by placing the hybrid hemodialysis access graft or the hybrid femoral artery bypass graft in a system embodiment according to the invention under conditions effective to promote endothelial cells to form a confluent monolayer on the surface of the hybrid graft.
    Type: Grant
    Filed: January 24, 2008
    Date of Patent: October 18, 2011
    Assignee: ICE Development Technologies, LLC
    Inventor: Michael Dancu
  • Patent number: 8034608
    Abstract: Hybrid synthetic grafts and embodiments of systems and methods for producing hybrid vascular grafts that can yield implantable grafts that combine synthetic grafts with living cells. Embodiments of systems can include a pressure/flow loop subsystem having an external flow loop system coupled to a specimen holder, where the pressure/flow loop subsystem is capable of adjusting at least two dynamic conditions in the specimen holder or a diameter of a specimen in the specimen holder. Embodiments of methods can promote endothelialization of a hybrid hemodialysis access graft or a hybrid femoral artery bypass graft by placing the hybrid hemodialysis access graft or the hybrid femoral artery bypass graft in a system embodiment according to the invention under conditions effective to promote stem cells to form a confluent monolayer on the hybrid graft.
    Type: Grant
    Filed: January 24, 2008
    Date of Patent: October 11, 2011
    Assignee: ICE Development Technologies, LLC
    Inventor: Michael Dancu
  • Patent number: 7968329
    Abstract: A method of yielding a functional human hybrid coronary bypass graft is provided. The method includes conditioning a hybrid synthetic tubular structure having stem cells and/or endothelial cells on at least one surface to yield the functional human hybrid coronary bypass graft. Specifically, the method includes placing the hybrid synthetic tubular structure in a system capable of producing three dimensional dynamic conditions for a sufficient time to yield said functional human hybrid coronary bypass graft.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: June 28, 2011
    Inventor: Michael Dancu
  • Patent number: 7964387
    Abstract: A method of yielding a functional human hybrid hemodialysis access graft is provided. The method includes conditioning a hybrid synthetic tubular structure having stem cells and/or endothelial cells on at least one surface to yield the functional human hybrid hemodialysis access graft. Specifically, the method includes placing the hybrid synthetic tubular structure in a system capable of producing three dimensional dynamic conditions for a sufficient time to yield said functional human hybrid hemodialysis access graft.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: June 21, 2011
    Inventor: Michael Dancu
  • Patent number: 7851200
    Abstract: A bioreactor and a method for growing engineered tissue provide facing surfaces in a vessel for containing cell-culture media. The facing surfaces are equidistant and define a gap therebetween while providing substrates for cell tissue growth. By maintaining conditions within the vessel conducive to cell tissue growth and moving the surfaces relative to one another within such cell culture media, tissue growing thereupon is subjected to physiological flow and shear stress, preferably through the use of oscillating motion, and engineered tissue is produced.
    Type: Grant
    Filed: August 7, 2006
    Date of Patent: December 14, 2010
    Inventor: Robert B. More
  • Patent number: 7662898
    Abstract: A biocompatible material having excellent biocompatibility such as small interaction with a component of a living body such as a protein or blood cell. A biocompatible material comprising a polymer obtained by polymerizing a monomer composition comprising an amino acid-type betaine monomer represented by the formula (I): wherein R1 is a hydrogen atom or a methyl group; R2 is an alkylene group having 1 to 6 carbon atoms; each of R3 and R4 is independently an alkyl group having 1 to 4 carbon atoms; R5 is an alkylene group having 1 to 4 carbon atoms; and Z is an oxygen atom or an —NH group; and a polymerizable monomer represented by the formula (II): wherein R1 is as defined above; and R6 is a monovalent organic group, in a weight ratio, i.e. amino acid-type betaine monomer/polymerizable monomer, of from 1/99 to 100/1. The biocompatible material can be suitably used, for example, in food, a food additive, a medicament, a quasi-drug, a medical device, cosmetics, a toiletry article, or the like.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: February 16, 2010
    Assignee: Osaka Organic Chemical Ind., Ltd.
    Inventors: Hiromi Kitano, Makoto Genmei, Yoshiyuki Saruwatari, Takahiro Mukaiyama
  • Patent number: 7485138
    Abstract: Described are medical devices which are or can be used to form tubular medical devices, and related methods. Preferred devices include tubular grafts of biomaterial having lumen walls which present no seam edge that traverses the entire length of the lumen, illustratively including devices having lumen walls which have a discontinuous seam presenting multiple seam edges. Such a device may include a tubular structure formed by inserting a plurality of extensions of a biomaterial sheet through a plurality of corresponding apertures of the sheet.
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: February 3, 2009
    Assignee: Cook Biotech Incorporated
    Inventors: Neal E. Fearnot, Michael C. Hiles
  • Patent number: 7468052
    Abstract: An improved method and devices for preventing restenosis are provided. The method may include delivering a stent configured to contain a stenosis to a body vessel. The method may also include using atherectomy at the site prior to stent delivery. In one embodiment, the stent has a proximal end, a distal end, and a center portion arranged such that the diameters of the proximal and distal ends are greater than the diameter of the center portion. In one embodiment, the atherectomy device includes a housing to prevent injury to the unaffected areas of the body vessels but the cutter is extendible beyond the housing. In one embodiment, the stent may be impregnated with at least one drug after stent deployment.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: December 23, 2008
    Inventors: Balbir S. Brar, Harvinder Sahota
  • Patent number: 7348175
    Abstract: A microprocessor controlled and instrumented bioreactor for conditioning intravascular tissue engineered medical products. One bioreactor design including an integrated pump to provide a relatively small volume of fluid nutrient. The microprocessor control providing measurement and control of the fluid flow and tissue displacement and subsequent determination of material properties. One design includes a flexible joint providing motion of the treated tissue in the axial, bending and torsional direction.
    Type: Grant
    Filed: February 19, 2003
    Date of Patent: March 25, 2008
    Assignee: St3 Development Corporation
    Inventors: Kent Vilendrer, Troy Nickel
  • Patent number: 7332689
    Abstract: An apparatus for tacking a multi-lumen tubular assembly together comprises a laser, an optical member and a placement tray for retaining the tubular assembly. A portion of the optical member defines a window that is substantially transparent to laser energy emitted from the laser. The window has a substantially concave shaped surface. The placement tray and the window surface define a processing area for positioning at least a portion of the tubular assembly. The processing area receives the laser energy that is emitted from the laser and passed through the window of the optical member. The tubular assembly is defined by an outer tubular member disposed about at least a portion of at least one inner tubular member. The laser energy transmitted into the processing area is transmitted substantially through the outer tubular member and is substantially absorbed by at least one region of the least one inner tubular member.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: February 19, 2008
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Steven P. Mertens, Afsar Ali, Thomas J. Holman, Leo M. Klisch
  • Patent number: 7279183
    Abstract: Treatment with magnesium produces a inhibition of acute stent thrombosis under high-shear flow conditions without any hemostatic or significant hemodynamic complications.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: October 9, 2007
    Assignee: Cedars-Sinai Medical Center
    Inventors: Sanjay Kaul, Prediman K. Shah
  • Patent number: 7094418
    Abstract: A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant.
    Type: Grant
    Filed: November 17, 2004
    Date of Patent: August 22, 2006
    Assignee: SurModics, Inc.
    Inventors: Stephen J. Chudzik, David L. Clapper
  • Patent number: 7077860
    Abstract: An implantable stent is coated with a material that attracts heparin and with which heparin forms a bond. The stent is exposed to a heparin containing solution just prior to implantation or is first implanted and then exposed to heparinized blood. As heparin becomes detached from the stent, the implantation site is exposed to heparin to restore an effective level and thereby prevent thrombosis.
    Type: Grant
    Filed: June 24, 2004
    Date of Patent: July 18, 2006
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: John Y. Yan, Randy Chan
  • Patent number: 7063942
    Abstract: A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one pump for circulating the fluid within the system. Fluid can be tissue culture medium or blood analog fluid, and the vessel may include mammalian cells attached to its inside. A drive system, comprising two reciprocating drive shafts that are coupled by a cam, enables the uncoupling of pulsatile flow and pulsatile pressure to provide independent control over wall shear stress and circumferential strain. The shaft drives two pumps that are 180 degrees out-of-phase and are connected upstream and downstream of the vessel, and effect this uncoupling.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: June 20, 2006
    Inventors: Michael B. Dancu, John M. Tarbell
  • Patent number: 6849262
    Abstract: This invention relates to methods of coating the lumenal surface of a blood vessel, or other tissue cavity, and to compositions suitable for use in same.
    Type: Grant
    Filed: February 7, 2002
    Date of Patent: February 1, 2005
    Assignee: Cryolife, Inc.
    Inventors: Jeremy Ollerenshaw, Umit Yuksel, Kirby S. Black
  • Publication number: 20040260377
    Abstract: In accordance with embodiments of the present invention, a method for preparing a shape memory alloy endoprosthesis, displaying strain induced martensite phenomenon, for delivery includes inserting a shape memory alloy endoprosthesis into a delivery device, inducing a first strain within a first region of the shape memory alloy endoprosthesis, inducing a second strain within a second region of the shape memory alloy endoprosthesis, and sterilizing the delivery device while maintaining the first strain and the second strain induced within the shape memory alloy endoprosthesis. In accordance with other embodiments of the present invention, an apparatus for delivering a shape memory alloy endoprosthesis includes an inner core having a first diameter, an outer body having a second diameter greater than the first diameter, and a calibrated endcap attached to the inner core.
    Type: Application
    Filed: June 17, 2003
    Publication date: December 23, 2004
    Applicant: Medinol, Ltd.
    Inventors: Joseph Michael Flomenblit, Nathalie Boris Budigina
  • Patent number: 6729356
    Abstract: A graft provided with a flexible sealing member to substantially prevent blood from leaking between the graft a lumen into which the graft is placed. In one embodiment, the flexible sealing member may be pressed against the vascular wall by an outwardly biased spring means attached to the sealing member. In other embodiments, the sealing member may be self-positioning upon deployment of the graft. The sealing member also may be formed into the shape of a toroid, which may be filled with thrombogenic material causing blood permeating into the toroid-shaped space to coagulate therein and hold the sealing member in place. It is also contemplated that the sealing member be formed from tufts of frayed yarn protruding circumferentially from the outer surface of the graft. A method of manufacturing such tufted yarn sealing members is also disclosed.
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: May 4, 2004
    Assignee: Endovascular Technologies, Inc.
    Inventors: Steven G. Baker, Tamara L. Trayer, Arnold M. Escano, Mark LeMere, Elizabeth A. McDermott
  • Patent number: 6699282
    Abstract: An implanted device such as a stent is provided which is capable of holding an induced charge or sufficient magnitude that the device may, by electrostatic means, attract the bioactive material to itself. The charge, either positive or negative, or relative to the bioactive material sufficiently positive or negative, is deposited into the implantable device via an exterior induction coil. The implantable device itself becomes an introduced “dosage form”, becoming part of a biologically closed electric circuit, through which the bioactive material is attracted to the implanted device.
    Type: Grant
    Filed: March 6, 2003
    Date of Patent: March 2, 2004
    Assignee: Gelsus Research and Consulting, Inc.
    Inventor: Nicholas A. Sceusa
  • Patent number: 6692772
    Abstract: Treatment with magnesium produces a inhibition of acute stent thrombosis under high-shear flow conditions without any hemostatic or significant hemodynamic complications.
    Type: Grant
    Filed: July 18, 2001
    Date of Patent: February 17, 2004
    Assignee: Cedars-Sinai Medical Center
    Inventors: Sanjay Kaul, Prediman K. Shah
  • Patent number: 6605114
    Abstract: A method for delivering heparin, wherein an implantable stent is coated with a material that attracts heparin and with which heparin forms a bond. The stent is exposed to a heparin containing solution just prior to implantation or is first implanted and then exposed to heparinized blood. As heparin becomes detached from the stent, the implantation site is exposed to heparin to restore an effective level and thereby prevent thrombosis.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: August 12, 2003
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: John Y. Yan, Randy Chan
  • Patent number: 6602287
    Abstract: A glycocalyx-like material is applied to a stent in order to mimic the outer surface of the cells lining arteries and veins to prevent thrombogenesis. The glycocalyx material is applied over a base layer of a fluorocarbon that is applied directly to the stent surfaces.
    Type: Grant
    Filed: December 8, 1999
    Date of Patent: August 5, 2003
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Deborra Sanders Millare, Steven Z-H Wu
  • Patent number: 6537202
    Abstract: A method for polishing radially expandable surgical stents is disclosed where fluid abrasive media M flows over surfaces of the stent 10 causing the surfaces of the stent 10 to be polished and streamlined. The stent 10 is temporarily provided with cylindrical support ends 20, which are not radially expandable to support the stent 10 during the polishing process. An interior polishing fixture 100 is provided which has cylindrical chambers 135 therein adapted to receive a stent 10 therein. Fluid abrasive media M then flows into bores 108 in the fixture 100 leading to the cylindrical chambers 135 and adjacent the inner diameter surfaces of the stent 10. Surfaces of the stent 10 forming the outer diameter are polished by placing the stent 10 within an exterior polishing fixture 200 which has a cylindrical recess 220 therein.
    Type: Grant
    Filed: May 5, 1998
    Date of Patent: March 25, 2003
    Assignee: Cook Incorporated
    Inventor: John J. Frantzen
  • Patent number: 6491624
    Abstract: A device for exploration of the cardiovascular system of human or animal bodies includes a generally transparent blind tube delimiting a cavity in which can be disposed an optical display device, the open end of the tube being shaped to be ensleeved axially in a sealed manner in the passage of an artery or of a vein having first been at least partially sectioned such that the cavity of the tube in the interior of the artery or of the vein form a common chamber at least partially closeable by a cardiac valve. The tube, maintained in ensleeved position by a suitable securement member, includes at least one supplemental opening for the introduction into the cavity of the tube of a physiological liquid under pressure.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: December 10, 2002
    Inventor: Houari Lotfi
  • Patent number: 6416995
    Abstract: The invention provides a device and process for recellularizing essentially acellular or devitalized tissue grafts, including for example essentially acellular or devitalized vascular tissue grafts, derived from human or animal sources, or as constructed using any number of tissue engineering methodologies. The process includes repopulating and reendothelializing an essentially acellular or devitalized tissue graft. The device is useful for producing a repopulated tissue graft from an essentially acellular or devitalized tissue, as well as for producing an essentially acellular or devitalized tissue graft.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: July 9, 2002
    Assignee: Bio Science Consultants, L.L.C.
    Inventor: Lloyd Wolfinbarger
  • Patent number: 6410044
    Abstract: A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant.
    Type: Grant
    Filed: May 16, 2000
    Date of Patent: June 25, 2002
    Assignee: Surmodics, Inc.
    Inventors: Stephen J. Chudzik, David L. Clapper
  • Publication number: 20010020191
    Abstract: An apparatus is disclosed for differentially treating a medical device. One portion of the device is treated with a first fluid and a separate portion is treated with a second fluid. The second fluid generally is substantially different from the first fluid. The first fluid can be contacted with an flow region of the medical device. The apparatus can include a conduit system, where fluid flowing through the conduit system flows through the flow region. Sheet material can be treated differentially on the opposite surfaces of the sheet. The medical device can include vascular tissue.
    Type: Application
    Filed: March 9, 2001
    Publication date: September 6, 2001
    Inventors: R. Brian Williams, Richard F. Schroeder, Matthew F. Ogle
  • Patent number: 6254631
    Abstract: A stent for placement in a body lumen is fabricated by forming a tube having an un-deployed diameter sized for the tube to be placed on a deployment balloon and advanced through a body lumen to a deployment site. The tube is expandable upon inflation of the balloon to an enlarged diameter sized for the tube to be retained within the lumen at the site upon deflation and withdrawal of the balloon. The tube has a stent axis extending between first and second axial ends of the tube. The tube has an exterior surface and an interior surface. The tube is polished to polish the exterior surface to a smooth surface finish and with at least a portion of the interior surface having a rough surface finish rougher than the surface finish of the exterior surface.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: July 3, 2001
    Assignee: IntraTherapeutics, Inc.
    Inventor: Paul J. Thompson
  • Patent number: 6162247
    Abstract: A heparin-collagen dispersion is provided for impregnating a vascular prosthesis with heparin and collagen. The dispersion is prepared at an alkaline pH to allow the addition of heparin without causing the agglutination of collagen from the dispersion. The impregnation of collagen and heparin within the prosthesis effectively prevents blood loss and thrombus formation after implantation of the prosthesis.
    Type: Grant
    Filed: December 21, 1998
    Date of Patent: December 19, 2000
    Assignee: Meadox Medicals, Inc.
    Inventors: Kevin Weadock, David J. Lentz, Jack Tant