Volumetric Dispenser (e.g., Pipette) Patents (Class 73/1.74)
  • Patent number: 11590947
    Abstract: A method for controlling a hydrodynamic machine, including the steps of: providing a hydrodynamic machine which includes a bladed primary wheel and a bladed secondary wheel, which together form a working chamber, which can be filled with a working medium from a working medium supply contained in a working medium reservoir, to transfer drive power hydrodynamically from the bladed primary wheel to the bladed secondary wheel by forming a working medium circuit in the working chamber; applying a control pressure to the working medium supply in order to force the working medium from the working medium supply into the working chamber; detecting, at least indirectly, a pressure increase in the working medium reservoir, when the control pressure is applied to the working medium supply; and determining, as a function of the pressure increase that has been detected, a fill level of the working medium supply in the working medium reservoir.
    Type: Grant
    Filed: July 9, 2021
    Date of Patent: February 28, 2023
    Assignee: Voith Patent GmbH
    Inventors: Dieter Laukemann, Matthias Lehr
  • Patent number: 11249099
    Abstract: A liquid class including control parameters for controlling a laboratory automation device when handling a liquid of a liquid type assigned to the liquid class with a pipette tip of a pipette tip type assigned to the liquid class, and a method for optimizing the liquid class. The method can include initializing a genetic algorithm with a start liquid class by generating a set of liquid classes by modifying control parameters of the start liquid class. The method can further include optimizing the liquid class iteratively with the genetic algorithm by applying liquid classes from the set of liquid classes to the laboratory automation device, which performs at least one aspiration and dispensing measurement for each applied liquid class, as well as additional method acts.
    Type: Grant
    Filed: March 20, 2019
    Date of Patent: February 15, 2022
    Inventors: Anja Wolter, Michael Keller
  • Patent number: 10948335
    Abstract: A cartridge for evaluating the volume of an aliquot of liquid is described. The cartridge can have one or more well tabs that pivot into a position in which liquid dispensed into a corresponding well is placed in contact with a capillary and surface tension draws the liquid from the well into the capillary. Comparison of the liquid-air interface with markings on or near the capillary, can reveal the volume of liquid dispensed. One or more additional features, such as well tabs that are stable in a substantially vertical orientation and/or a groove for protecting and/or self-aligning the capillary can ensure that the device operates properly.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: March 16, 2021
    Assignee: Forward Biotech, Inc.
    Inventors: Ian K. Glasgow, Jiangbo Tang, Cailee Dean
  • Patent number: 10864515
    Abstract: The automated pipette manipulation system of the present invention allows for the automated manipulation of any pipette commercially available to aspire and dispense liquids in a chemical or biochemical laboratory setting. Measuring the amount of liquid aspired or dispensed by a pipette is conducted by a load sensor that records the starting point of the displacement of a pushbutton of said pipette and a motor that drives the displacement of said pushbutton a predetermined distance past the starting point that corresponds to a predetermined volume of liquid aspired or dispensed by said pipette. The automated pipette manipulation system of the present invention further detects whether a pipette tip is attached to said pipette and then automatically ejects said pipette tip at the end of a liquid handling process.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: December 15, 2020
    Inventor: Walid Habbal
  • Patent number: 10859592
    Abstract: Aspiration of a pipette arrangement is initiated. A sensor arrangement senses a least one prevailing first parameter that is dependent from the effect in the pipette arrangement during initiating and upholding the suctioning action. This at least one parameter is analyzed in an analyzing stage. From a result of this analysis and in a determining stage at least one test criterium TC for at least one further parameter as sensed by the sensor arrangement is determined. In a checking stage there is checked whether this further parameter fulfills the at least one test criterium.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: December 8, 2020
    Assignee: TECAN TRADING AG
    Inventors: Michael Horsley, Kevin Truempi, Sukesh Gopinathan
  • Patent number: 10197435
    Abstract: A balance including a weighing chamber (16); a draft shield (23), which surrounds the weighing chamber; a climate module (34), which is detachably disposed in the weighing chamber; a processor (32), which is programmed to provide an evaporation rate correction value; a data input unit; and a data transmission path, over which data is exchanged between the climate module and the processor. Also disclosed are a climate module configured to electrically yet detachably couple to a balance, wherein the climate module forms a self-contained modular unit and includes various sensors (52, 54, 62) and a path over which data is transmitted to an external processor, and to a method for calibrating a pipette using a balance, wherein an evaporation rate is determined during the calibration process, and the measurement is corrected in accordance with the determined evaporation rate.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: February 5, 2019
    Assignee: SARTORIUS LAB INSTRUMENTS GMBH & CO. KG
    Inventors: Winfried Graf, Christian Elo
  • Patent number: 9878322
    Abstract: A pipetting unit and a method of using the pipetting unit for pipetting a volume V1 of test liquid for carrying out an in vitro diagnostic test are presented. The method comprises dipping a nozzle of a pipetting unit into a test liquid and aspirating a volume V4 of the test liquid larger than the volume V1 required for carrying out the test. The method further comprises dipping the pipetting unit into a wash liquid and dispensing a volume V2 equal or smaller than V4 minus V1 of the test liquid into the wash liquid. The method further comprises dipping the pipetting unit into a reaction liquid and dispensing the volume V1 of test liquid required for the test.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: January 30, 2018
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Roland Hutter, Roland Stoeckli
  • Patent number: 9625482
    Abstract: A sample analyzer comprises a container setting part on which a liquid container is to be set, a liquid supplying part configured to supply a liquid to the liquid container, an aspiration tube configured to aspirate a sample or a reagent, a movement mechanism configured to move the aspiration tube, a liquid surface sensor configured to detect contact of the aspiration tube with a liquid surface, and a controller configured to execute an aspiration tube adjustment operation. The aspiration tube adjustment operation comprises supplying the liquid to the liquid container by the liquid supplying part, lowering the aspiration tube by the movement mechanism toward the liquid container set on the container setting part, and obtaining information regarding a position in a height direction of the aspiration tube at a time when the aspiration tube has come into contact with the liquid surface.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: April 18, 2017
    Assignee: SYSMEX CORPORATION
    Inventors: Miyuki Yamada, Shuji Kawaguchi, Hiroshi Kurono
  • Patent number: 9599546
    Abstract: Methods for use with chemical analyzers aspirate a sample portion from one location to dispense it at a second location, aspirate another sample portion at that second location and dispense it at the first location, and measure the pressure values experienced inside a probe performing the aspirations and dispenses. By comparing the pressure values (or other values indicative of the viscosity or other relevant properties of the sample), the chemical analyzer can determine if the sample is sufficiently mixed or if the sample components remain separated and the method should be repeated.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: March 21, 2017
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Nathan A. Small, John P. Mizzer
  • Patent number: 9416417
    Abstract: The invention relates to a method of preparing a reaction mixture for Polymerase Chain Reaction (PCR) assay and a solution set for PCR. The method comprises providing a sample solution comprising a biological sample to be amplified in said PCR assay and first colorant providing the solution a first color, providing a reagent solution comprising at least one other substance required for performing said assay and second colorant providing the solution a second color different from the first color, and mixing the sample solution and the first reagent solution for providing a mixed solution to be subjected to the PCR process, the mixed solution having, due to said first and second colorants, a third color different from the first and second colors. The invention significantly aids in pipetting PCR assays.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: August 16, 2016
    Assignee: Thermo Fisher Scientific Baltics UAB
    Inventors: Jaakko Kurkela, Katja Eklin, Sanna Uusivirta
  • Patent number: 9011799
    Abstract: The invention relates to a laboratory sample instrument with a cable holding space in which a printed circuit board cable device is arranged. The printed circuit board cable device has at least one printed circuit board with first and second sides and, arranged in succession, at least one first circuit board section, at least one second circuit board section and at least one third circuit board section, and with a number of conductor tracks arranged in parallel with respect to one another and extending from a first track section arranged in the first circuit board section, via the second circuit board section to the third circuit board section, in which a second track section is arranged, wherein, in the second circuit board section, at least one conductor track is arranged on the first side of the board and at least one track is arranged on the second side.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: April 21, 2015
    Assignee: Eppendorf AG
    Inventor: Burkhardt Reichmuth
  • Patent number: 8932541
    Abstract: Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: January 13, 2015
    Assignee: Beckman Coulter, Inc.
    Inventor: Joshua D. Wiltsie
  • Patent number: 8904882
    Abstract: A method and device for determining the flow rate of a flowing medium according to the plummet principle is characterized by a simplified determination of the calibration data sets in that at least one set of calibration data is recorded with at least one reference medium under at least one reference measurement condition. Then, a position of a plummet which is dependent on the flowing medium is determined under a measurement condition which differs from the reference condition. Here, the set of calibration data is converted from the reference measurement condition to the measurement condition, and from a determined position of the plummet, a measure for the flow rate of the medium is then determined.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: December 9, 2014
    Assignee: KROHNE Messtechnik GmbH
    Inventor: Philipp Mertmann
  • Patent number: 8871157
    Abstract: A handheld electronic pipette including several features aimed at improving ease of use, including a color dot matrix display, an intuitive thumb-operated two-axis controller, and multifunction soft buttons adjacent to the display. A simple and consistent user interface facilitates easy access to various modes of operation, including a manual pipetting mode and a remote mode.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: October 28, 2014
    Assignee: Rainin Instrument, LLC
    Inventors: William D. Homberg, Michael C. Schmittdiel, Haakon T. Magnussen, Andrew Vainshtein, Thomas Allen Bell, Vintory L. Blake Moore
  • Patent number: 8874399
    Abstract: Pipetting errors are detected by: (a) during pipetting, measuring the pressure in the tip of a pipetting device and determining an earlier rate of change of the pressure in the tip; (b) based on the earlier rate of pressure change and a previous pressure value pi, determining an expectation range for the pressure pi+1 at a further moment in time and/or an expectation range for the rate of pressure change ?i+1 based on the pressure at the further moment in time ti+1; (c) at the further moment in time ti+1 measuring the pressure pi+1 in the tip; and (d) determining the occurrence of a pipetting error by comparing the measured pressure pi+1 at the further moment ti+1 in time and/or a rate of pressure change ?i+1 calculated on the basis of the pressure pi+1 at the further moment ti+1 in time.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: October 28, 2014
    Assignee: bioMĂ©rieux S.A.
    Inventors: Thomas Beumer, Bas Fleskens
  • Patent number: 8808625
    Abstract: In a dispensing apparatus for dispensing a liquid, such as a sample solution, on a substrate, such as a glass slide, the dispensing apparatus includes a capillary provided with a distal end and a proximal end, a pump unit configured to pump an operating liquid into the capillary and to pump the operating liquid out of the capillary, and a controller configured to control the pump unit so as to change a position of a liquid surface of the operating liquid in the capillary so that a predetermined volume of liquid is suctioned from the distal end into the capillary and the liquid suctioned in the capillary is discharged from the distal end. As a result, it is possible to precisely dispense extremely small volume amounts of liquids such as a nanoliter.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: August 19, 2014
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Hiroshi Aoki, Hiroaki Tao, Masaki Torimura, Takashi Ikeda
  • Publication number: 20140208824
    Abstract: The invention regards a method for calibrating a sample distribution apparatus for distribution of liquid samples (e.g. a hand held pipettor or a pipetting robot). The method comprises the steps of transferring a volume of liquid from the sample distribution apparatus to a container with a temperature sensor, measuring a first temperature value via, the temperature sensor, changing, the temperature of the liquid in the container, measuring a second temperature value via the temperature sensor, and determining from the first and second temperature values the volume of the liquid in the container.
    Type: Application
    Filed: January 28, 2014
    Publication date: July 31, 2014
    Applicant: INTEGRA BIOSCIENCES AG
    Inventor: Daniel Baechi
  • Patent number: 8747747
    Abstract: A reader for mechanical actuation of fluids within a test cartridge. The instrument interface including multiple independently-controlled plungers aligned to respective fluidic pouches on a test cartridge that is inserted into a testing apparatus embodying the instrument interface. The plungers include tips for applying mechanical force to the respective fluidic pouches.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: June 10, 2014
    Assignee: Abbott Point of Care Inc.
    Inventor: Seth Hunter
  • Publication number: 20140150522
    Abstract: A measurement device containing one or more capillaries to measure the volume of a dispensed fluid and determine the volumetric accuracy of the dispensing device. The measurement device can contain a reservoir containing the fluid to be measured and there may be an additional reservoir for a secondary fluid. A viewing window is necessary to complete a manual measurement and may include a magnifying lens. The liquid well by the capillary inlet may be shaped such that the measurement fluid is directed toward the capillary. The well may have features designed to position the dispensing device toward the capillary, or to position the well proximal to the capillary after it is filled. The well may also have surfaces or coatings which attract or do not attract various types of substances. The measurement device may interface with sensors to output measurement data.
    Type: Application
    Filed: December 4, 2013
    Publication date: June 5, 2014
    Inventors: Ian K. Glasgow, Kelly Magin, Brian Kolb, Andrea Habura
  • Patent number: 8726746
    Abstract: The invention relates to a method for checking the state of a pipette, which pipette includes a suction tube and a pipette tip. According to the invention, ultrasound is coupled into the wall of the suction tube and the damping of the ultrasonic signal is measured as a function of the frequency. The measured frequency-dependent damping is compared with at least one reference measurement or a calibration curve based on the reference measurements, in order to determine whether the pipette is in a functional condition and/or whether the pipette contains or has made contact with fluid. Furthermore, the invention relates to a pipetting method which uses the inventive method for checking the state, a suction tube arrangement for a pipetting device for pipetting fluid, and a pipetting device with which the inventive methods can be carried out.
    Type: Grant
    Filed: January 22, 2009
    Date of Patent: May 20, 2014
    Assignee: Beckman Coulter, Inc.
    Inventors: Matthias Wassermeier, Zeno Von Guttenberg, Frido Roehrs
  • Patent number: 8632735
    Abstract: A system for titrating liquids, with a syringe or tip, comprising a holding device and at least one tag and a metering equipment, comprising an additional holding device for holding the syringe or tip on the holding device, a reading device for reading the tag of the syringe or tip held by the additional holding device, a driving device having a motor, which is detachably coupled with a plunger of the syringe when the same is held by the additional holding device, or which is coupled with a plunger which is arranged in a cylinder which is coupled with the tip via a fluid conduit, when the same is held by the additional holding device, an operating device for operating the metering equipment and a control device, connected with the operating device, the reading device and the driving device, which controls the movement of the plunger depending of the tag of the inserted syringe or tip.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: January 21, 2014
    Assignee: Eppendorf AG
    Inventors: Heinz-Gerhard Kohn, Karl-Friedrich Andres
  • Patent number: 8631682
    Abstract: The invention relates to a pipette having a piston and a barrel with variable diameter at least in the portion passing by the sealing point.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: January 21, 2014
    Assignee: Thermo Fisher Scientific Oy
    Inventor: Juha Telimaa
  • Patent number: 8584715
    Abstract: The present invention relates to a method for monitoring the filling of a capsule with a medicament, to a corresponding filling method, to the associated apparatuses, and to a computer program for controlling the method and the apparatus. In the monitoring method, after at least part of the capsule has been filled with a predefined filling mass of a predefined closed contour of the medicament, at least the filling mass in the part of the capsule after the filling operation is recorded using digital imaging in a first step, the contour of the filling mass in the part of the capsule is determined from the digital imaging recording in a second step, and the contour is analysed in a third step in order to assess the filling operation in comparison with the predefined contour. The invention provides for external influences on the image properties to be compensated for by controlling the optical system.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: November 19, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Peter Stoeckel, Frank Biedenbender, Thomas Kruger
  • Patent number: 8580198
    Abstract: An automatic analyzer analyzes a measurement item by making a sample and reagent react with each other and measuring the reaction result. This apparatus allows parameters associated with reagent dispensing executed by a reagent dispensing mechanism to be set as a dispensing condition for each measurement item or each type of reagent, and controls the reagent dispensing mechanism on the basis of the dispensing condition.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: November 12, 2013
    Assignee: Kabushiki Kaisha Toshiba
    Inventor: Takehiko Onuma
  • Publication number: 20130283884
    Abstract: A pipette includes a movable piston and a diaphragm that at least partly defines a fluid chamber enclosing a volume of working fluid. The piston displaces a volumetric amount of the working fluid in the chamber when moved. In response, the diaphragm displaces a smaller volumetric amount of fluid outside the chamber. A deamplification ratio is defined by the ratio of the volume displaced by the diaphragm to the volume displaced by the piston. The deamplification ratio is adjustable by adjusting or changing the diaphragm and/or by adjusting the size of the fluid chamber. The deamplifying pipette enables measuring and dispensing of very small volumes of liquid and is easily adapted to commercially available pipette components. Pipette components such as a pipette tip or adaptor may include a diaphragm to enable deamplification of the nominal volume capacity of a given pipette device.
    Type: Application
    Filed: April 30, 2013
    Publication date: October 31, 2013
    Applicant: The Regents of the University of Michigan
    Inventors: Justin Douglas Beroz, Anastasios John Hart
  • Patent number: 8568667
    Abstract: A handle pipette including at least one cylinder with an upper end and a lower end, said cylinder having a movable piston, an elongate handle (1), by which the pipette can be manually gripped, said handle having an upper part, and in the upper part of the handle, a sideways extending finger support (7), which finger support (7) is at least partly flexible and/or it can be shaped by the user.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: October 29, 2013
    Assignee: Thermo Fisher Scientific Oy
    Inventors: Mikael Lind, Jouko Mikkonen, Mauno Heinonen, Juha Telimaa
  • Patent number: 8512647
    Abstract: A support pipette including at least one cylinder with an upper end and a lower end, each cylinder having a movable piston, and an elongate handle (1) with an upper part and a lower part, at which handle the pipette can be manually gripped, wherein the lower part (13.1; 13.2; 13.3) of the handle (1) includes a sideways protruding lower support (10.1; 10.2; 10.3; 10.4; 10.5).
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: August 20, 2013
    Assignee: Thermo Fisher Scientific Oy
    Inventors: Juha Telimaa, Mikael Lind
  • Patent number: 8491854
    Abstract: A test tube insert includes a flange having a width greater than a width of a mouth of a larger test tube into which the insert is to be inserted. The flange defines a first central opening. An annulus extends integrally downward from the flange. The annulus includes a fenestrated wall and a floor defining a second central opening. A small test tube body, smaller than the larger test tube, extends integrally downward from the floor of the annulus with the second central opening forming a mouth of the small test tube body. The test tube insert is disposed in the mouth of the larger test tube. Fluid is transferred through the central opening and the fluid fills the small test tube body of the test tube insert and flows through the fenestrated wall once the small test tube body is full into the larger test tube.
    Type: Grant
    Filed: November 8, 2010
    Date of Patent: July 23, 2013
    Assignee: King Saud University
    Inventor: Abdullah Khalid Al-Rasheed
  • Patent number: 8486714
    Abstract: The invention concerns reagent delivery system for an apparatus for processing of biological samples arranged on microscope slides, comprising a reagent section having one or more reagent containers; a slide section in which at least one microscope slide is arranged; a probe for dispensing a portion of reagent onto a predetermined microscope slide, and means for handling the probe. The probe comprises a continuous prove tubing element extending through a rigid probe member and connecting the probe tip to a pneumatic pressure regulation device. The reagent containers are adapted for cooperation with the probe tip. In this manner a high though-put and a very low carry over of fluid residues is achieved since there is no assembled parts making up the inside volume of the probe in which the fluid may be retained.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: July 16, 2013
    Assignee: DAKO Denmark A/S
    Inventors: John A Favuzzi, Merritt M Martin, Jonathan R Sweda, Lauren Bland, Robert L Lathrop, John E Van Bosch, Kristopher S Buchanan
  • Patent number: 8475740
    Abstract: A liquid dispensing apparatus is provided which makes it possible to correctly and easily detect a dispensing operation judgment failure with high accuracy without particularly using a complicated detection mechanism or means. The liquid dispensing apparatus includes a nozzle which sucks a solution in a cassette and dispenses the sucked solution into another cassette; and a cassette holder which holds the another cassette, and the nozzle is used as a first electrode and the cassette holder as a second electrode. Further, the liquid dispensing apparatus has measurement means for measuring a capacitance between the first and second electrodes during a solution dispensing operation.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: July 2, 2013
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Atsushi Watanabe, Shigeki Matsubara, Takuya Yamaguchi, Masaaki Odakura
  • Patent number: 8470260
    Abstract: A light beam guided liquid delivery device for tracking the placement of a sample by a liquid delivery device into a receptacle like a milliliter or microliter scale tube, or a microtiter plate, includes a liquid delivery device and a light beam generator. The light beam generator may be positioned on the outside or inside of the liquid delivery device. The light beam generator may be adapted to shoot a light beam below the tip of the liquid delivery device, whereby, a user may track the placement of the tip of the liquid delivery device via the light beam.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: June 25, 2013
    Assignee: University of North Carolina at Charlotte
    Inventors: David Andrew Carr, Jennifer W. Weller
  • Patent number: 8434345
    Abstract: An apparatus for improving the procedure for quantifying the volume of liquid dispensed by a liquid-dispensing mechanism of an analytical instrument. The apparatus of this invention comprises (a) at least one weigh cup; (b) at least one standard mass; (c) at least one transducer assembly to convert a value of weight to an electrical response; and (d) at least one electronic circuit for converting the electrical response to a measurement of volume. This invention provides a method for calibrating readings of the volume of liquid dispensed by a liquid-dispensing mechanism of an analytical instruments so that absolute measurements of the volume of liquid dispensed can be obtained.
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: May 7, 2013
    Assignee: Abbott Laboratories
    Inventors: Kurt M. Klosterman, Ganesh Rajagopal, Larry R. Jibson, James L. Dempski, Paul A. Matuszewski, Jeffrey W. Stewart, Jeffrey R. Swanson, David M. Tipotsch, Randall E. Youngs, Noman A. Abunimeh
  • Patent number: 8307693
    Abstract: An injector system for use in injecting a fluid into a patient includes a communication system adapted to receive data from at least a first sensor that measures a value first variable. The communication system is also adapted to receive data from a calibrated sensor that measures a value the first variable. The injector system further includes a calibration system adapted to calibrate output from the first sensor in response to output from the calibrated sensor. An injector for use in injecting a fluid into a patient, includes a first sensor that measures a value first variable, a communication port adapted to receive data from a calibrated sensor that measures the value the first variable, and a controller adapted to compare data from the calibrated sensor with data from the first sensor and to calibrate output from the first sensor. The devices, systems and methods of the present invention are applicable to systems other than injection systems.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: November 13, 2012
    Assignee: Medrad, Inc.
    Inventors: Martin J. Uram, Michael G. Frazier, Kenton E. Adams
  • Patent number: 8307722
    Abstract: There are provided a method of detecting dispensed quantity in which without the need of detecting a surface of liquid accommodated in a container, a liquid quantity can be detected only by measuring pressure change; and a relevant liquid suction monitoring dispensing apparatus.
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: November 13, 2012
    Assignee: Universal Bio Research Co., Ltd.
    Inventors: Hideji Tajima, Michinori Koizuka, Hiroshi Suzuki, Susumu Kimura
  • Patent number: 8277757
    Abstract: A pipette tip mounting shaft includes outwardly circumferentially extending locking lobes over which the pipette tip collar is mounted. The locking lobes preferably include an inclining ramp portion that gently flexes and distorts the pipette tip collar out-of-round as the mounting shaft is inserted into the pipette tip, rather than the stretching tip collar. Each locking lobe also includes a declining ramp portion which extends upward along the mounting shaft. The peak of the lobes is preferably curved. When the pipette tip is fully mounted on the mounting shaft, a locking ring on the inside surface of the tip collar engages the declining ramp of the lobes to provide an over-center engagement, however, the required ejection force is small.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: October 2, 2012
    Assignee: Integra Biosciences Corp.
    Inventors: Terrence Kelly, Richard Cote, Gregory Mathus
  • Patent number: 8273009
    Abstract: A device for aspirating sample media into a pipette for use in a micro-manipulation procedure includes a ring member having an opening sized for receiving a digit of an operator, and an aspirating bulb engaged with the ring member. The aspirating bulb has an open end sized for receiving an end of the pipette, and includes a compressible chamber capable of creating a suction force suitable for aspirating the sample media into the pipette. The aspirating bulb is oriented along the ring member such that the chamber is compressible by a digit on the same hand of the operator as the digit receivable in the ring member.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: September 25, 2012
    Assignee: Cook Medical Technologies LLC
    Inventors: Dustin John Arabia, Chad E. Unger
  • Patent number: 8265796
    Abstract: A network of fluid dispenser systems is disclosed where a Host/Server is a virtual controller for a number of fluid dispensers systems. The virtual controller may exchange information with local dispenser systems, that incorporate virtual controlling functions. The information may be dispensing processes, information regarding quality and reliability, problems and/or helpful information, and applications. An application may include synchronizing multiple dispensing syringe assemblies. The information may be exchanged in real time during fluid dispensing where any issues may be shared and resolved quickly even in remote locales. Information may be distributed among the disparate locations.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: September 11, 2012
    Assignee: Fishman Corporation
    Inventor: W. Scott Beebe
  • Patent number: 8227258
    Abstract: A liquid delivery apparatus is provided for depositing liquid materials onto prescribed areas. The apparatus includes a sensing and delivery pin and a photo sensor. The apparatus is sized to deliver a droplet of liquid material to the surface of a target area without coming into contact with the target surface. The apparatus is also capable of drawing geometric features, such as lines and grids of liquid material. The photo sensor measures the intensity of light during a processing cycle. Measured reflected-light intensity can be compared in real-time to a reference curve which is based on test process cycles representing the light intensity expected when the process proceeds in the preferred fashion to produce a normal spot having an expected droplet size. The light intensity measurements can also be fitted with a mathematical function such as an asymmetric double sigmoidal curve.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: July 24, 2012
    Assignee: New Jersey Institute of Technology
    Inventors: Timothy N. Chang, Qiong Shen
  • Patent number: 8221702
    Abstract: A sample dispensing apparatus and method for dispensing a sample such as blood and urine collected for inspection from one vessel to another are provided wherein the remaining quantity of a primary sample can be reduced without disturbing the primary sample. When clogging by a separating agent is detected during suction of a sample such as blood and urine collected for inspection, the sample dispensing apparatus performs raising of an aliquot head such that an opening at the free end of a nozzle tip does not come out of the sample liquid surface to dissolve clogging; sucking of the sample under the residual pressure; and additionally sucking of a fixed quantity of the sample to reduce the remaining quantity of the sample.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: July 17, 2012
    Assignee: Hitachi-High Technologies Corporation
    Inventors: Akihiro Shimoda, Masahito Kakuno, Eiji Takaya, Junichi Oizumi
  • Patent number: 8141410
    Abstract: The invention is directed to a method for testing batches of tips for pipettes, the method comprising the steps of calibrating a pipette to be tested with a recommended reference tip, fitting the pipette with a tip to be tested and performing a second calibration and recalibrating the pipette with the reference tip.
    Type: Grant
    Filed: August 10, 2007
    Date of Patent: March 27, 2012
    Assignee: Biohit Oyj
    Inventor: Ian Hemmings
  • Patent number: 8091405
    Abstract: The present invention relates to a device (1) for calibrating a pipette or a dispensing system comprising a plate (2), said plate (2) comprising at least one channel (3) with a loading port (4) for receiving a test volume of a fluid at one end of the at least one channel and an opening (5) at the other end of the at least one channel, wherein the at least one channel (3) is constructed as a capillary.
    Type: Grant
    Filed: September 12, 2007
    Date of Patent: January 10, 2012
    Assignee: CSEM Centre Suisse d'Electronique et de Microtechnique SA-Recherche et Developpement
    Inventors: Noa Schmid, Janko Auerswald, Thomas Stöckli, Helmut Knapp
  • Patent number: 8075840
    Abstract: An automatic multi-purpose analyzer performs qualitative and quantitative analysis of biological samples such as blood, urine, etc. and includes a plurality of analysis units connected in series through a transfer line for transferring the sample, wherein failure caused by incorrect surface detection is resolved. The plurality of analysis units are connected in series through a transfer line for transferring a sample, each analysis unit including a pipetting mechanism for pipetting the sample, and wherein each of the analysis units includes a transmission mechanism for transmitting information about the amount of sample, obtained upon sample pipetting by the pipetting mechanism of each analysis unit, to other analysis units.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: December 13, 2011
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Takanori Shimane, Katsuaki Takahashi
  • Patent number: 8033188
    Abstract: A hand-held electronic pipettor includes menu driven software for controlling the information displayed on the user interface display, for inputting information to program the pipettor and for controlling the operation of the pipettor.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: October 11, 2011
    Assignee: Integra Biosciences Corp.
    Inventors: George Kalmakis, Gary Nelson, Gregory Mathus, Terrence Kelly, Joel Novak, Kenneth Steiner, Jonathan Finger
  • Patent number: 7950267
    Abstract: Methods and systems for determining an LPG fuel output characteristic of an LPG injector. The output characteristic of the LPG can be determined by calculating a total mass of LPG injected into a canister of known volume by the injector during a plurality of open/closed cycles of the injector. The pressure differential and temperature in the canister can be used in the calculation of total LPG mass along with a gas constant of the LPG and the volume of the canister. The total LPG mass can then be used to determine the mass of LPG injected by the injector during each open/closed cycle.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: May 31, 2011
    Assignee: Bi-Phase Technologies, LLC
    Inventors: Victor Vandyke, Kevin Michael Wolter, Thomas Arnold Kulenkamp
  • Patent number: 7950265
    Abstract: A system for preventing overflow of a toilet includes a sensor, a processor and an actuator. The sensor senses a parameter caused by fluid dynamics within the toilet during a flush cycle. The parameter may involve vibration, sound, pressure, fluid flow rate or other detectible characteristics of the toilet. The processor uses information regarding the parameter that is gathered by the sensor to evaluate the condition of the flush cycle to determine if an impeded flush condition exists. In the event of an impeded flush condition, the processor directs the actuator to close a valve, which may be the toilet flapper valve in some embodiments. Also disclosed are methods for preventing toilet overflow, detecting an impeded flush condition and calibrating the system.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: May 31, 2011
    Assignee: Limit, Inc.
    Inventors: Kevin Bowcutt, Ahmed Shishegar, Matthew Ibarra, Daniel L. Corbin, Dennis Repp, Robert M. Connell, Oscar Dufau, Gregory Blake, Sam Iravantchi
  • Patent number: 7926325
    Abstract: A method for differentiating between a liquid sample having clogs therein and a liquid sample having an abnormally elevated viscosity during a liquid aspiration process by relating the ratio between the maximum negative pressure during aspiration and an equilibrium pressure prior to dispensation to viscosity.
    Type: Grant
    Filed: April 23, 2008
    Date of Patent: April 19, 2011
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Michael Kaplit
  • Patent number: 7917313
    Abstract: The present invention relates to a method for monitoring a fluid transfer process, including the steps: providing an allowable pressure profile; detecting a pressure occurring in the course of the fluid transfer process; comparing detected pressure with the allowable pressure profile and signaling an error, if the detected pressure is not within the allowable pressure profile. The allowable pressure profile is defined by interpolation points, the interpolation points being based on a probability function representing a family of pressure courses of a plurality of fluid transfer processes. The allowable pressure profile can be divided into at least two distinct process sections, each section corresponding to a distinct process phase of the fluid transfer process. The probability function is calculated from a family of test pressure curves and reflects the statistical behavior of the pipette system.
    Type: Grant
    Filed: August 27, 2008
    Date of Patent: March 29, 2011
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Guenter Ziegler, Peter Wenzig
  • Patent number: 7897111
    Abstract: A pipetting device, having a base plate, an elastic sealing plate that covers the outside of the base plate, and a plurality of pipetting channels arranged in a predetermined grid extending through the base plate and the sealing plate. A magazine is loaded in the same grid with the pipette tips, each pipette tip having a shoulder. The magazine is arranged in a magazine holder indirectly frictionally connected via the shoulders and the sealing plate with the base plate, and a drive motor, indirectly connected to the eccentric shafts of two identical eccentric drives that are permanently mounted on the support on the base plate. Each drive has an eccentric pin that is offset by a distance with respect to the axis of the eccentric shaft, and one T-shaped gravitational pendulum is suspended from each of the eccentric pins. The magazine holder is formed by a U-shaped magazine frame with a bearing surface on the inside.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: March 1, 2011
    Assignee: Cybio AG
    Inventor: Uwe Naumann
  • Publication number: 20110000276
    Abstract: The invention relates to a method for checking the state of a pipette, which comprises a suction tube and a pipette tip. According to the invention, ultrasound is coupled into the wall of the suction tube and the damping of the ultrasonic signal is measured as a function of the frequency. The measured frequency-dependent damping is compared with at least one reference measurement or a calibration curve based on the reference measurements, in order to determine whether the pipette is in a functional condition and/or whether the pipette contains or has made contact with fluid. Furthermore, the invention relates to a pipetting method, which uses the inventive method for checking the state, a suction tube arrangement for a pipetting device for pipetting fluid and a pipetting device, with which the inventive methods can be carried out.
    Type: Application
    Filed: January 22, 2009
    Publication date: January 6, 2011
    Applicant: Beckman Coulter, Inc.
    Inventors: Matthias Wassermeier, Zeno Von Guttenberg, Frido Roehrs
  • Patent number: RE47118
    Abstract: Systems and methods for automated inspection of fillet formation along on or more peripheral edges (13a) of a packaged microelectronic device (14) that is attached to a supporting substrate (16), such system (10) including a feedback loop for controlling fillet formation. More specifically, the system (10) includes a dispensing system (18) configured for dispensing underfill material (22) onto the supporting substrate (16). The system (19) further includes an automated optical inspection (AOI) system (19) configured for determining a value of a measurable attribute of the fillet (12), such as whether the fillet (12) is properly dimensioned, i.e., sized and shaped. A feedback loop (66) is included between the dispensing system (18) and automated optical inspection system (19).
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: November 6, 2018
    Assignee: Nordson Corporation
    Inventors: Alec Babiarz, Stephane Etienne, Owen Yikon Sit