Volumetric Dispenser (e.g., Pipette) Patents (Class 73/1.74)
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Patent number: 11590947Abstract: A method for controlling a hydrodynamic machine, including the steps of: providing a hydrodynamic machine which includes a bladed primary wheel and a bladed secondary wheel, which together form a working chamber, which can be filled with a working medium from a working medium supply contained in a working medium reservoir, to transfer drive power hydrodynamically from the bladed primary wheel to the bladed secondary wheel by forming a working medium circuit in the working chamber; applying a control pressure to the working medium supply in order to force the working medium from the working medium supply into the working chamber; detecting, at least indirectly, a pressure increase in the working medium reservoir, when the control pressure is applied to the working medium supply; and determining, as a function of the pressure increase that has been detected, a fill level of the working medium supply in the working medium reservoir.Type: GrantFiled: July 9, 2021Date of Patent: February 28, 2023Assignee: Voith Patent GmbHInventors: Dieter Laukemann, Matthias Lehr
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Patent number: 11249099Abstract: A liquid class including control parameters for controlling a laboratory automation device when handling a liquid of a liquid type assigned to the liquid class with a pipette tip of a pipette tip type assigned to the liquid class, and a method for optimizing the liquid class. The method can include initializing a genetic algorithm with a start liquid class by generating a set of liquid classes by modifying control parameters of the start liquid class. The method can further include optimizing the liquid class iteratively with the genetic algorithm by applying liquid classes from the set of liquid classes to the laboratory automation device, which performs at least one aspiration and dispensing measurement for each applied liquid class, as well as additional method acts.Type: GrantFiled: March 20, 2019Date of Patent: February 15, 2022Inventors: Anja Wolter, Michael Keller
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Patent number: 10948335Abstract: A cartridge for evaluating the volume of an aliquot of liquid is described. The cartridge can have one or more well tabs that pivot into a position in which liquid dispensed into a corresponding well is placed in contact with a capillary and surface tension draws the liquid from the well into the capillary. Comparison of the liquid-air interface with markings on or near the capillary, can reveal the volume of liquid dispensed. One or more additional features, such as well tabs that are stable in a substantially vertical orientation and/or a groove for protecting and/or self-aligning the capillary can ensure that the device operates properly.Type: GrantFiled: September 28, 2018Date of Patent: March 16, 2021Assignee: Forward Biotech, Inc.Inventors: Ian K. Glasgow, Jiangbo Tang, Cailee Dean
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Patent number: 10864515Abstract: The automated pipette manipulation system of the present invention allows for the automated manipulation of any pipette commercially available to aspire and dispense liquids in a chemical or biochemical laboratory setting. Measuring the amount of liquid aspired or dispensed by a pipette is conducted by a load sensor that records the starting point of the displacement of a pushbutton of said pipette and a motor that drives the displacement of said pushbutton a predetermined distance past the starting point that corresponds to a predetermined volume of liquid aspired or dispensed by said pipette. The automated pipette manipulation system of the present invention further detects whether a pipette tip is attached to said pipette and then automatically ejects said pipette tip at the end of a liquid handling process.Type: GrantFiled: November 13, 2017Date of Patent: December 15, 2020Inventor: Walid Habbal
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Patent number: 10859592Abstract: Aspiration of a pipette arrangement is initiated. A sensor arrangement senses a least one prevailing first parameter that is dependent from the effect in the pipette arrangement during initiating and upholding the suctioning action. This at least one parameter is analyzed in an analyzing stage. From a result of this analysis and in a determining stage at least one test criterium TC for at least one further parameter as sensed by the sensor arrangement is determined. In a checking stage there is checked whether this further parameter fulfills the at least one test criterium.Type: GrantFiled: January 31, 2017Date of Patent: December 8, 2020Assignee: TECAN TRADING AGInventors: Michael Horsley, Kevin Truempi, Sukesh Gopinathan
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Patent number: 10197435Abstract: A balance including a weighing chamber (16); a draft shield (23), which surrounds the weighing chamber; a climate module (34), which is detachably disposed in the weighing chamber; a processor (32), which is programmed to provide an evaporation rate correction value; a data input unit; and a data transmission path, over which data is exchanged between the climate module and the processor. Also disclosed are a climate module configured to electrically yet detachably couple to a balance, wherein the climate module forms a self-contained modular unit and includes various sensors (52, 54, 62) and a path over which data is transmitted to an external processor, and to a method for calibrating a pipette using a balance, wherein an evaporation rate is determined during the calibration process, and the measurement is corrected in accordance with the determined evaporation rate.Type: GrantFiled: May 9, 2016Date of Patent: February 5, 2019Assignee: SARTORIUS LAB INSTRUMENTS GMBH & CO. KGInventors: Winfried Graf, Christian Elo
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Patent number: 9878322Abstract: A pipetting unit and a method of using the pipetting unit for pipetting a volume V1 of test liquid for carrying out an in vitro diagnostic test are presented. The method comprises dipping a nozzle of a pipetting unit into a test liquid and aspirating a volume V4 of the test liquid larger than the volume V1 required for carrying out the test. The method further comprises dipping the pipetting unit into a wash liquid and dispensing a volume V2 equal or smaller than V4 minus V1 of the test liquid into the wash liquid. The method further comprises dipping the pipetting unit into a reaction liquid and dispensing the volume V1 of test liquid required for the test.Type: GrantFiled: October 7, 2013Date of Patent: January 30, 2018Assignee: Roche Diagnostics Operations, Inc.Inventors: Roland Hutter, Roland Stoeckli
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Patent number: 9625482Abstract: A sample analyzer comprises a container setting part on which a liquid container is to be set, a liquid supplying part configured to supply a liquid to the liquid container, an aspiration tube configured to aspirate a sample or a reagent, a movement mechanism configured to move the aspiration tube, a liquid surface sensor configured to detect contact of the aspiration tube with a liquid surface, and a controller configured to execute an aspiration tube adjustment operation. The aspiration tube adjustment operation comprises supplying the liquid to the liquid container by the liquid supplying part, lowering the aspiration tube by the movement mechanism toward the liquid container set on the container setting part, and obtaining information regarding a position in a height direction of the aspiration tube at a time when the aspiration tube has come into contact with the liquid surface.Type: GrantFiled: December 19, 2013Date of Patent: April 18, 2017Assignee: SYSMEX CORPORATIONInventors: Miyuki Yamada, Shuji Kawaguchi, Hiroshi Kurono
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Patent number: 9599546Abstract: Methods for use with chemical analyzers aspirate a sample portion from one location to dispense it at a second location, aspirate another sample portion at that second location and dispense it at the first location, and measure the pressure values experienced inside a probe performing the aspirations and dispenses. By comparing the pressure values (or other values indicative of the viscosity or other relevant properties of the sample), the chemical analyzer can determine if the sample is sufficiently mixed or if the sample components remain separated and the method should be repeated.Type: GrantFiled: September 2, 2011Date of Patent: March 21, 2017Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Nathan A. Small, John P. Mizzer
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Patent number: 9416417Abstract: The invention relates to a method of preparing a reaction mixture for Polymerase Chain Reaction (PCR) assay and a solution set for PCR. The method comprises providing a sample solution comprising a biological sample to be amplified in said PCR assay and first colorant providing the solution a first color, providing a reagent solution comprising at least one other substance required for performing said assay and second colorant providing the solution a second color different from the first color, and mixing the sample solution and the first reagent solution for providing a mixed solution to be subjected to the PCR process, the mixed solution having, due to said first and second colorants, a third color different from the first and second colors. The invention significantly aids in pipetting PCR assays.Type: GrantFiled: March 3, 2014Date of Patent: August 16, 2016Assignee: Thermo Fisher Scientific Baltics UABInventors: Jaakko Kurkela, Katja Eklin, Sanna Uusivirta
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Patent number: 9011799Abstract: The invention relates to a laboratory sample instrument with a cable holding space in which a printed circuit board cable device is arranged. The printed circuit board cable device has at least one printed circuit board with first and second sides and, arranged in succession, at least one first circuit board section, at least one second circuit board section and at least one third circuit board section, and with a number of conductor tracks arranged in parallel with respect to one another and extending from a first track section arranged in the first circuit board section, via the second circuit board section to the third circuit board section, in which a second track section is arranged, wherein, in the second circuit board section, at least one conductor track is arranged on the first side of the board and at least one track is arranged on the second side.Type: GrantFiled: August 10, 2012Date of Patent: April 21, 2015Assignee: Eppendorf AGInventor: Burkhardt Reichmuth
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Patent number: 8932541Abstract: Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.Type: GrantFiled: January 23, 2013Date of Patent: January 13, 2015Assignee: Beckman Coulter, Inc.Inventor: Joshua D. Wiltsie
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Patent number: 8904882Abstract: A method and device for determining the flow rate of a flowing medium according to the plummet principle is characterized by a simplified determination of the calibration data sets in that at least one set of calibration data is recorded with at least one reference medium under at least one reference measurement condition. Then, a position of a plummet which is dependent on the flowing medium is determined under a measurement condition which differs from the reference condition. Here, the set of calibration data is converted from the reference measurement condition to the measurement condition, and from a determined position of the plummet, a measure for the flow rate of the medium is then determined.Type: GrantFiled: January 28, 2013Date of Patent: December 9, 2014Assignee: KROHNE Messtechnik GmbHInventor: Philipp Mertmann
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Patent number: 8871157Abstract: A handheld electronic pipette including several features aimed at improving ease of use, including a color dot matrix display, an intuitive thumb-operated two-axis controller, and multifunction soft buttons adjacent to the display. A simple and consistent user interface facilitates easy access to various modes of operation, including a manual pipetting mode and a remote mode.Type: GrantFiled: May 17, 2011Date of Patent: October 28, 2014Assignee: Rainin Instrument, LLCInventors: William D. Homberg, Michael C. Schmittdiel, Haakon T. Magnussen, Andrew Vainshtein, Thomas Allen Bell, Vintory L. Blake Moore
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Patent number: 8874399Abstract: Pipetting errors are detected by: (a) during pipetting, measuring the pressure in the tip of a pipetting device and determining an earlier rate of change of the pressure in the tip; (b) based on the earlier rate of pressure change and a previous pressure value pi, determining an expectation range for the pressure pi+1 at a further moment in time and/or an expectation range for the rate of pressure change ?i+1 based on the pressure at the further moment in time ti+1; (c) at the further moment in time ti+1 measuring the pressure pi+1 in the tip; and (d) determining the occurrence of a pipetting error by comparing the measured pressure pi+1 at the further moment ti+1 in time and/or a rate of pressure change ?i+1 calculated on the basis of the pressure pi+1 at the further moment ti+1 in time.Type: GrantFiled: September 27, 2010Date of Patent: October 28, 2014Assignee: bioMĂ©rieux S.A.Inventors: Thomas Beumer, Bas Fleskens
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Patent number: 8808625Abstract: In a dispensing apparatus for dispensing a liquid, such as a sample solution, on a substrate, such as a glass slide, the dispensing apparatus includes a capillary provided with a distal end and a proximal end, a pump unit configured to pump an operating liquid into the capillary and to pump the operating liquid out of the capillary, and a controller configured to control the pump unit so as to change a position of a liquid surface of the operating liquid in the capillary so that a predetermined volume of liquid is suctioned from the distal end into the capillary and the liquid suctioned in the capillary is discharged from the distal end. As a result, it is possible to precisely dispense extremely small volume amounts of liquids such as a nanoliter.Type: GrantFiled: August 29, 2008Date of Patent: August 19, 2014Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Hiroshi Aoki, Hiroaki Tao, Masaki Torimura, Takashi Ikeda
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Publication number: 20140208824Abstract: The invention regards a method for calibrating a sample distribution apparatus for distribution of liquid samples (e.g. a hand held pipettor or a pipetting robot). The method comprises the steps of transferring a volume of liquid from the sample distribution apparatus to a container with a temperature sensor, measuring a first temperature value via, the temperature sensor, changing, the temperature of the liquid in the container, measuring a second temperature value via the temperature sensor, and determining from the first and second temperature values the volume of the liquid in the container.Type: ApplicationFiled: January 28, 2014Publication date: July 31, 2014Applicant: INTEGRA BIOSCIENCES AGInventor: Daniel Baechi
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Patent number: 8747747Abstract: A reader for mechanical actuation of fluids within a test cartridge. The instrument interface including multiple independently-controlled plungers aligned to respective fluidic pouches on a test cartridge that is inserted into a testing apparatus embodying the instrument interface. The plungers include tips for applying mechanical force to the respective fluidic pouches.Type: GrantFiled: December 20, 2011Date of Patent: June 10, 2014Assignee: Abbott Point of Care Inc.Inventor: Seth Hunter
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Publication number: 20140150522Abstract: A measurement device containing one or more capillaries to measure the volume of a dispensed fluid and determine the volumetric accuracy of the dispensing device. The measurement device can contain a reservoir containing the fluid to be measured and there may be an additional reservoir for a secondary fluid. A viewing window is necessary to complete a manual measurement and may include a magnifying lens. The liquid well by the capillary inlet may be shaped such that the measurement fluid is directed toward the capillary. The well may have features designed to position the dispensing device toward the capillary, or to position the well proximal to the capillary after it is filled. The well may also have surfaces or coatings which attract or do not attract various types of substances. The measurement device may interface with sensors to output measurement data.Type: ApplicationFiled: December 4, 2013Publication date: June 5, 2014Inventors: Ian K. Glasgow, Kelly Magin, Brian Kolb, Andrea Habura
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Patent number: 8726746Abstract: The invention relates to a method for checking the state of a pipette, which pipette includes a suction tube and a pipette tip. According to the invention, ultrasound is coupled into the wall of the suction tube and the damping of the ultrasonic signal is measured as a function of the frequency. The measured frequency-dependent damping is compared with at least one reference measurement or a calibration curve based on the reference measurements, in order to determine whether the pipette is in a functional condition and/or whether the pipette contains or has made contact with fluid. Furthermore, the invention relates to a pipetting method which uses the inventive method for checking the state, a suction tube arrangement for a pipetting device for pipetting fluid, and a pipetting device with which the inventive methods can be carried out.Type: GrantFiled: January 22, 2009Date of Patent: May 20, 2014Assignee: Beckman Coulter, Inc.Inventors: Matthias Wassermeier, Zeno Von Guttenberg, Frido Roehrs
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Patent number: 8632735Abstract: A system for titrating liquids, with a syringe or tip, comprising a holding device and at least one tag and a metering equipment, comprising an additional holding device for holding the syringe or tip on the holding device, a reading device for reading the tag of the syringe or tip held by the additional holding device, a driving device having a motor, which is detachably coupled with a plunger of the syringe when the same is held by the additional holding device, or which is coupled with a plunger which is arranged in a cylinder which is coupled with the tip via a fluid conduit, when the same is held by the additional holding device, an operating device for operating the metering equipment and a control device, connected with the operating device, the reading device and the driving device, which controls the movement of the plunger depending of the tag of the inserted syringe or tip.Type: GrantFiled: January 18, 2007Date of Patent: January 21, 2014Assignee: Eppendorf AGInventors: Heinz-Gerhard Kohn, Karl-Friedrich Andres
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Patent number: 8631682Abstract: The invention relates to a pipette having a piston and a barrel with variable diameter at least in the portion passing by the sealing point.Type: GrantFiled: March 31, 2006Date of Patent: January 21, 2014Assignee: Thermo Fisher Scientific OyInventor: Juha Telimaa
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Patent number: 8584715Abstract: The present invention relates to a method for monitoring the filling of a capsule with a medicament, to a corresponding filling method, to the associated apparatuses, and to a computer program for controlling the method and the apparatus. In the monitoring method, after at least part of the capsule has been filled with a predefined filling mass of a predefined closed contour of the medicament, at least the filling mass in the part of the capsule after the filling operation is recorded using digital imaging in a first step, the contour of the filling mass in the part of the capsule is determined from the digital imaging recording in a second step, and the contour is analysed in a third step in order to assess the filling operation in comparison with the predefined contour. The invention provides for external influences on the image properties to be compensated for by controlling the optical system.Type: GrantFiled: July 7, 2008Date of Patent: November 19, 2013Assignee: Boehringer Ingelheim International GmbHInventors: Peter Stoeckel, Frank Biedenbender, Thomas Kruger
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Patent number: 8580198Abstract: An automatic analyzer analyzes a measurement item by making a sample and reagent react with each other and measuring the reaction result. This apparatus allows parameters associated with reagent dispensing executed by a reagent dispensing mechanism to be set as a dispensing condition for each measurement item or each type of reagent, and controls the reagent dispensing mechanism on the basis of the dispensing condition.Type: GrantFiled: October 25, 2005Date of Patent: November 12, 2013Assignee: Kabushiki Kaisha ToshibaInventor: Takehiko Onuma
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Publication number: 20130283884Abstract: A pipette includes a movable piston and a diaphragm that at least partly defines a fluid chamber enclosing a volume of working fluid. The piston displaces a volumetric amount of the working fluid in the chamber when moved. In response, the diaphragm displaces a smaller volumetric amount of fluid outside the chamber. A deamplification ratio is defined by the ratio of the volume displaced by the diaphragm to the volume displaced by the piston. The deamplification ratio is adjustable by adjusting or changing the diaphragm and/or by adjusting the size of the fluid chamber. The deamplifying pipette enables measuring and dispensing of very small volumes of liquid and is easily adapted to commercially available pipette components. Pipette components such as a pipette tip or adaptor may include a diaphragm to enable deamplification of the nominal volume capacity of a given pipette device.Type: ApplicationFiled: April 30, 2013Publication date: October 31, 2013Applicant: The Regents of the University of MichiganInventors: Justin Douglas Beroz, Anastasios John Hart
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Patent number: 8568667Abstract: A handle pipette including at least one cylinder with an upper end and a lower end, said cylinder having a movable piston, an elongate handle (1), by which the pipette can be manually gripped, said handle having an upper part, and in the upper part of the handle, a sideways extending finger support (7), which finger support (7) is at least partly flexible and/or it can be shaped by the user.Type: GrantFiled: November 9, 2011Date of Patent: October 29, 2013Assignee: Thermo Fisher Scientific OyInventors: Mikael Lind, Jouko Mikkonen, Mauno Heinonen, Juha Telimaa
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Patent number: 8512647Abstract: A support pipette including at least one cylinder with an upper end and a lower end, each cylinder having a movable piston, and an elongate handle (1) with an upper part and a lower part, at which handle the pipette can be manually gripped, wherein the lower part (13.1; 13.2; 13.3) of the handle (1) includes a sideways protruding lower support (10.1; 10.2; 10.3; 10.4; 10.5).Type: GrantFiled: November 9, 2011Date of Patent: August 20, 2013Assignee: Thermo Fisher Scientific OyInventors: Juha Telimaa, Mikael Lind
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Patent number: 8491854Abstract: A test tube insert includes a flange having a width greater than a width of a mouth of a larger test tube into which the insert is to be inserted. The flange defines a first central opening. An annulus extends integrally downward from the flange. The annulus includes a fenestrated wall and a floor defining a second central opening. A small test tube body, smaller than the larger test tube, extends integrally downward from the floor of the annulus with the second central opening forming a mouth of the small test tube body. The test tube insert is disposed in the mouth of the larger test tube. Fluid is transferred through the central opening and the fluid fills the small test tube body of the test tube insert and flows through the fenestrated wall once the small test tube body is full into the larger test tube.Type: GrantFiled: November 8, 2010Date of Patent: July 23, 2013Assignee: King Saud UniversityInventor: Abdullah Khalid Al-Rasheed
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Patent number: 8486714Abstract: The invention concerns reagent delivery system for an apparatus for processing of biological samples arranged on microscope slides, comprising a reagent section having one or more reagent containers; a slide section in which at least one microscope slide is arranged; a probe for dispensing a portion of reagent onto a predetermined microscope slide, and means for handling the probe. The probe comprises a continuous prove tubing element extending through a rigid probe member and connecting the probe tip to a pneumatic pressure regulation device. The reagent containers are adapted for cooperation with the probe tip. In this manner a high though-put and a very low carry over of fluid residues is achieved since there is no assembled parts making up the inside volume of the probe in which the fluid may be retained.Type: GrantFiled: April 28, 2008Date of Patent: July 16, 2013Assignee: DAKO Denmark A/SInventors: John A Favuzzi, Merritt M Martin, Jonathan R Sweda, Lauren Bland, Robert L Lathrop, John E Van Bosch, Kristopher S Buchanan
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Patent number: 8475740Abstract: A liquid dispensing apparatus is provided which makes it possible to correctly and easily detect a dispensing operation judgment failure with high accuracy without particularly using a complicated detection mechanism or means. The liquid dispensing apparatus includes a nozzle which sucks a solution in a cassette and dispenses the sucked solution into another cassette; and a cassette holder which holds the another cassette, and the nozzle is used as a first electrode and the cassette holder as a second electrode. Further, the liquid dispensing apparatus has measurement means for measuring a capacitance between the first and second electrodes during a solution dispensing operation.Type: GrantFiled: May 14, 2008Date of Patent: July 2, 2013Assignee: Hitachi High-Technologies CorporationInventors: Atsushi Watanabe, Shigeki Matsubara, Takuya Yamaguchi, Masaaki Odakura
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Patent number: 8470260Abstract: A light beam guided liquid delivery device for tracking the placement of a sample by a liquid delivery device into a receptacle like a milliliter or microliter scale tube, or a microtiter plate, includes a liquid delivery device and a light beam generator. The light beam generator may be positioned on the outside or inside of the liquid delivery device. The light beam generator may be adapted to shoot a light beam below the tip of the liquid delivery device, whereby, a user may track the placement of the tip of the liquid delivery device via the light beam.Type: GrantFiled: April 21, 2010Date of Patent: June 25, 2013Assignee: University of North Carolina at CharlotteInventors: David Andrew Carr, Jennifer W. Weller
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Patent number: 8434345Abstract: An apparatus for improving the procedure for quantifying the volume of liquid dispensed by a liquid-dispensing mechanism of an analytical instrument. The apparatus of this invention comprises (a) at least one weigh cup; (b) at least one standard mass; (c) at least one transducer assembly to convert a value of weight to an electrical response; and (d) at least one electronic circuit for converting the electrical response to a measurement of volume. This invention provides a method for calibrating readings of the volume of liquid dispensed by a liquid-dispensing mechanism of an analytical instruments so that absolute measurements of the volume of liquid dispensed can be obtained.Type: GrantFiled: August 11, 2006Date of Patent: May 7, 2013Assignee: Abbott LaboratoriesInventors: Kurt M. Klosterman, Ganesh Rajagopal, Larry R. Jibson, James L. Dempski, Paul A. Matuszewski, Jeffrey W. Stewart, Jeffrey R. Swanson, David M. Tipotsch, Randall E. Youngs, Noman A. Abunimeh
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Patent number: 8307722Abstract: There are provided a method of detecting dispensed quantity in which without the need of detecting a surface of liquid accommodated in a container, a liquid quantity can be detected only by measuring pressure change; and a relevant liquid suction monitoring dispensing apparatus.Type: GrantFiled: May 19, 2006Date of Patent: November 13, 2012Assignee: Universal Bio Research Co., Ltd.Inventors: Hideji Tajima, Michinori Koizuka, Hiroshi Suzuki, Susumu Kimura
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Patent number: 8307693Abstract: An injector system for use in injecting a fluid into a patient includes a communication system adapted to receive data from at least a first sensor that measures a value first variable. The communication system is also adapted to receive data from a calibrated sensor that measures a value the first variable. The injector system further includes a calibration system adapted to calibrate output from the first sensor in response to output from the calibrated sensor. An injector for use in injecting a fluid into a patient, includes a first sensor that measures a value first variable, a communication port adapted to receive data from a calibrated sensor that measures the value the first variable, and a controller adapted to compare data from the calibrated sensor with data from the first sensor and to calibrate output from the first sensor. The devices, systems and methods of the present invention are applicable to systems other than injection systems.Type: GrantFiled: April 18, 2007Date of Patent: November 13, 2012Assignee: Medrad, Inc.Inventors: Martin J. Uram, Michael G. Frazier, Kenton E. Adams
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Patent number: 8277757Abstract: A pipette tip mounting shaft includes outwardly circumferentially extending locking lobes over which the pipette tip collar is mounted. The locking lobes preferably include an inclining ramp portion that gently flexes and distorts the pipette tip collar out-of-round as the mounting shaft is inserted into the pipette tip, rather than the stretching tip collar. Each locking lobe also includes a declining ramp portion which extends upward along the mounting shaft. The peak of the lobes is preferably curved. When the pipette tip is fully mounted on the mounting shaft, a locking ring on the inside surface of the tip collar engages the declining ramp of the lobes to provide an over-center engagement, however, the required ejection force is small.Type: GrantFiled: September 29, 2009Date of Patent: October 2, 2012Assignee: Integra Biosciences Corp.Inventors: Terrence Kelly, Richard Cote, Gregory Mathus
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Patent number: 8273009Abstract: A device for aspirating sample media into a pipette for use in a micro-manipulation procedure includes a ring member having an opening sized for receiving a digit of an operator, and an aspirating bulb engaged with the ring member. The aspirating bulb has an open end sized for receiving an end of the pipette, and includes a compressible chamber capable of creating a suction force suitable for aspirating the sample media into the pipette. The aspirating bulb is oriented along the ring member such that the chamber is compressible by a digit on the same hand of the operator as the digit receivable in the ring member.Type: GrantFiled: March 4, 2009Date of Patent: September 25, 2012Assignee: Cook Medical Technologies LLCInventors: Dustin John Arabia, Chad E. Unger
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Patent number: 8265796Abstract: A network of fluid dispenser systems is disclosed where a Host/Server is a virtual controller for a number of fluid dispensers systems. The virtual controller may exchange information with local dispenser systems, that incorporate virtual controlling functions. The information may be dispensing processes, information regarding quality and reliability, problems and/or helpful information, and applications. An application may include synchronizing multiple dispensing syringe assemblies. The information may be exchanged in real time during fluid dispensing where any issues may be shared and resolved quickly even in remote locales. Information may be distributed among the disparate locations.Type: GrantFiled: July 14, 2010Date of Patent: September 11, 2012Assignee: Fishman CorporationInventor: W. Scott Beebe
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Patent number: 8227258Abstract: A liquid delivery apparatus is provided for depositing liquid materials onto prescribed areas. The apparatus includes a sensing and delivery pin and a photo sensor. The apparatus is sized to deliver a droplet of liquid material to the surface of a target area without coming into contact with the target surface. The apparatus is also capable of drawing geometric features, such as lines and grids of liquid material. The photo sensor measures the intensity of light during a processing cycle. Measured reflected-light intensity can be compared in real-time to a reference curve which is based on test process cycles representing the light intensity expected when the process proceeds in the preferred fashion to produce a normal spot having an expected droplet size. The light intensity measurements can also be fitted with a mathematical function such as an asymmetric double sigmoidal curve.Type: GrantFiled: February 11, 2009Date of Patent: July 24, 2012Assignee: New Jersey Institute of TechnologyInventors: Timothy N. Chang, Qiong Shen
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Patent number: 8221702Abstract: A sample dispensing apparatus and method for dispensing a sample such as blood and urine collected for inspection from one vessel to another are provided wherein the remaining quantity of a primary sample can be reduced without disturbing the primary sample. When clogging by a separating agent is detected during suction of a sample such as blood and urine collected for inspection, the sample dispensing apparatus performs raising of an aliquot head such that an opening at the free end of a nozzle tip does not come out of the sample liquid surface to dissolve clogging; sucking of the sample under the residual pressure; and additionally sucking of a fixed quantity of the sample to reduce the remaining quantity of the sample.Type: GrantFiled: June 20, 2008Date of Patent: July 17, 2012Assignee: Hitachi-High Technologies CorporationInventors: Akihiro Shimoda, Masahito Kakuno, Eiji Takaya, Junichi Oizumi
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Patent number: 8141410Abstract: The invention is directed to a method for testing batches of tips for pipettes, the method comprising the steps of calibrating a pipette to be tested with a recommended reference tip, fitting the pipette with a tip to be tested and performing a second calibration and recalibrating the pipette with the reference tip.Type: GrantFiled: August 10, 2007Date of Patent: March 27, 2012Assignee: Biohit OyjInventor: Ian Hemmings
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Patent number: 8091405Abstract: The present invention relates to a device (1) for calibrating a pipette or a dispensing system comprising a plate (2), said plate (2) comprising at least one channel (3) with a loading port (4) for receiving a test volume of a fluid at one end of the at least one channel and an opening (5) at the other end of the at least one channel, wherein the at least one channel (3) is constructed as a capillary.Type: GrantFiled: September 12, 2007Date of Patent: January 10, 2012Assignee: CSEM Centre Suisse d'Electronique et de Microtechnique SA-Recherche et DeveloppementInventors: Noa Schmid, Janko Auerswald, Thomas Stöckli, Helmut Knapp
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Patent number: 8075840Abstract: An automatic multi-purpose analyzer performs qualitative and quantitative analysis of biological samples such as blood, urine, etc. and includes a plurality of analysis units connected in series through a transfer line for transferring the sample, wherein failure caused by incorrect surface detection is resolved. The plurality of analysis units are connected in series through a transfer line for transferring a sample, each analysis unit including a pipetting mechanism for pipetting the sample, and wherein each of the analysis units includes a transmission mechanism for transmitting information about the amount of sample, obtained upon sample pipetting by the pipetting mechanism of each analysis unit, to other analysis units.Type: GrantFiled: August 28, 2008Date of Patent: December 13, 2011Assignee: Hitachi High-Technologies CorporationInventors: Takanori Shimane, Katsuaki Takahashi
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Patent number: 8033188Abstract: A hand-held electronic pipettor includes menu driven software for controlling the information displayed on the user interface display, for inputting information to program the pipettor and for controlling the operation of the pipettor.Type: GrantFiled: September 17, 2007Date of Patent: October 11, 2011Assignee: Integra Biosciences Corp.Inventors: George Kalmakis, Gary Nelson, Gregory Mathus, Terrence Kelly, Joel Novak, Kenneth Steiner, Jonathan Finger
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Patent number: 7950267Abstract: Methods and systems for determining an LPG fuel output characteristic of an LPG injector. The output characteristic of the LPG can be determined by calculating a total mass of LPG injected into a canister of known volume by the injector during a plurality of open/closed cycles of the injector. The pressure differential and temperature in the canister can be used in the calculation of total LPG mass along with a gas constant of the LPG and the volume of the canister. The total LPG mass can then be used to determine the mass of LPG injected by the injector during each open/closed cycle.Type: GrantFiled: July 30, 2008Date of Patent: May 31, 2011Assignee: Bi-Phase Technologies, LLCInventors: Victor Vandyke, Kevin Michael Wolter, Thomas Arnold Kulenkamp
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Patent number: 7950265Abstract: A system for preventing overflow of a toilet includes a sensor, a processor and an actuator. The sensor senses a parameter caused by fluid dynamics within the toilet during a flush cycle. The parameter may involve vibration, sound, pressure, fluid flow rate or other detectible characteristics of the toilet. The processor uses information regarding the parameter that is gathered by the sensor to evaluate the condition of the flush cycle to determine if an impeded flush condition exists. In the event of an impeded flush condition, the processor directs the actuator to close a valve, which may be the toilet flapper valve in some embodiments. Also disclosed are methods for preventing toilet overflow, detecting an impeded flush condition and calibrating the system.Type: GrantFiled: December 17, 2009Date of Patent: May 31, 2011Assignee: Limit, Inc.Inventors: Kevin Bowcutt, Ahmed Shishegar, Matthew Ibarra, Daniel L. Corbin, Dennis Repp, Robert M. Connell, Oscar Dufau, Gregory Blake, Sam Iravantchi
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Patent number: 7926325Abstract: A method for differentiating between a liquid sample having clogs therein and a liquid sample having an abnormally elevated viscosity during a liquid aspiration process by relating the ratio between the maximum negative pressure during aspiration and an equilibrium pressure prior to dispensation to viscosity.Type: GrantFiled: April 23, 2008Date of Patent: April 19, 2011Assignee: Siemens Healthcare Diagnostics Inc.Inventor: Michael Kaplit
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Patent number: 7917313Abstract: The present invention relates to a method for monitoring a fluid transfer process, including the steps: providing an allowable pressure profile; detecting a pressure occurring in the course of the fluid transfer process; comparing detected pressure with the allowable pressure profile and signaling an error, if the detected pressure is not within the allowable pressure profile. The allowable pressure profile is defined by interpolation points, the interpolation points being based on a probability function representing a family of pressure courses of a plurality of fluid transfer processes. The allowable pressure profile can be divided into at least two distinct process sections, each section corresponding to a distinct process phase of the fluid transfer process. The probability function is calculated from a family of test pressure curves and reflects the statistical behavior of the pipette system.Type: GrantFiled: August 27, 2008Date of Patent: March 29, 2011Assignee: Roche Molecular Systems, Inc.Inventors: Guenter Ziegler, Peter Wenzig
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Patent number: 7897111Abstract: A pipetting device, having a base plate, an elastic sealing plate that covers the outside of the base plate, and a plurality of pipetting channels arranged in a predetermined grid extending through the base plate and the sealing plate. A magazine is loaded in the same grid with the pipette tips, each pipette tip having a shoulder. The magazine is arranged in a magazine holder indirectly frictionally connected via the shoulders and the sealing plate with the base plate, and a drive motor, indirectly connected to the eccentric shafts of two identical eccentric drives that are permanently mounted on the support on the base plate. Each drive has an eccentric pin that is offset by a distance with respect to the axis of the eccentric shaft, and one T-shaped gravitational pendulum is suspended from each of the eccentric pins. The magazine holder is formed by a U-shaped magazine frame with a bearing surface on the inside.Type: GrantFiled: October 13, 2009Date of Patent: March 1, 2011Assignee: Cybio AGInventor: Uwe Naumann
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Publication number: 20110000276Abstract: The invention relates to a method for checking the state of a pipette, which comprises a suction tube and a pipette tip. According to the invention, ultrasound is coupled into the wall of the suction tube and the damping of the ultrasonic signal is measured as a function of the frequency. The measured frequency-dependent damping is compared with at least one reference measurement or a calibration curve based on the reference measurements, in order to determine whether the pipette is in a functional condition and/or whether the pipette contains or has made contact with fluid. Furthermore, the invention relates to a pipetting method, which uses the inventive method for checking the state, a suction tube arrangement for a pipetting device for pipetting fluid and a pipetting device, with which the inventive methods can be carried out.Type: ApplicationFiled: January 22, 2009Publication date: January 6, 2011Applicant: Beckman Coulter, Inc.Inventors: Matthias Wassermeier, Zeno Von Guttenberg, Frido Roehrs
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Patent number: RE47118Abstract: Systems and methods for automated inspection of fillet formation along on or more peripheral edges (13a) of a packaged microelectronic device (14) that is attached to a supporting substrate (16), such system (10) including a feedback loop for controlling fillet formation. More specifically, the system (10) includes a dispensing system (18) configured for dispensing underfill material (22) onto the supporting substrate (16). The system (19) further includes an automated optical inspection (AOI) system (19) configured for determining a value of a measurable attribute of the fillet (12), such as whether the fillet (12) is properly dimensioned, i.e., sized and shaped. A feedback loop (66) is included between the dispensing system (18) and automated optical inspection system (19).Type: GrantFiled: June 16, 2017Date of Patent: November 6, 2018Assignee: Nordson CorporationInventors: Alec Babiarz, Stephane Etienne, Owen Yikon Sit