Abstract: The present invention is directed to new de-(acetylglucosaminyl)-di(dehydro)deoxy teicoplanin derivatives which possess antibiotic activity mainly against gram positive bacteria.The new compounds are obtained by chemical modification of a teicoplanin antibiotic substance.
Type:
Grant
Filed:
October 21, 1991
Date of Patent:
November 17, 1992
Assignee:
Gruppo Lepetit S.p.A.
Inventors:
Adriano Malabarba, Pietro Ferrari, Aldo Trani, Giorgio Tarzia
Abstract: Disclosed herein are cyclic peptide derivatives of the formula ##STR1## wherein A is absent or the tripeptide radical Thr.rarw.Gly.rarw.Ala, R.sup.1 is benzyl or benzyl monosubstituted at position 4 of the aromatic ring with halo, hydroxy, lower alkyl or lower alkoxy, R.sup.2 and R.sup.4 each independently is hydrogen or lower alkyl, R.sup.3 is lower alkyl or lower alkyl monosubstituted with a hydroxy, R.sup.5 is lower alkyl, Y is oxo or thioxo and Z is hydroxy or NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 each independently is hydrogen or lower alkyl. The derivatives are useful for treating herpes infections.
Type:
Grant
Filed:
July 3, 1990
Date of Patent:
September 22, 1992
Assignee:
Bio-Mega, Inc.
Inventors:
Julian Adams, John DiMaio, Raymond Plante
Abstract: A new cytostatic depsipeptide, designated "dolastatin 14", was isolated from the Indian Ocean shell-less mollusk Dolabella auricularia. Dolastatin 14 inhibited growth of the PS leukemia with ED.sub.50 0.0018 .mu.g/mL. Pharmaceutical preparations and therapeutic regimens utilizing Dolastatin 14, its synthetic counterpart and pharmaceutically active derivatives are disclosed.
Type:
Grant
Filed:
November 13, 1989
Date of Patent:
August 11, 1992
Assignee:
Arizona Board of Regents acting on behalf of Arizona State University
Inventors:
George R. Pettit, Yoshiaki Kamano, Cherry L. Herald
Abstract: A new and demonstratably active cyclo-octapeptide is isolated from the South Pacific Ocean Hymeniacidon sp. and structurally elucidated. The substance, herein denominated Hymenistatin 1, demonstrated utility by inhibiting tumor growth when measured by the National Cancer Institute P388 leukemia cell line (ED.sub.50 =3.5 .mu.g/mL).
Type:
Grant
Filed:
November 30, 1989
Date of Patent:
July 14, 1992
Assignee:
Arizona Board of Regents, a body corporate of Arizona State University
Abstract: The present invention relates to a peptide having essentially the amino acid sequence of pancreatic secretory trypsin inhibitor (PSTI). The present invention also relates to variants of such peptide wherein one or more of the amino acids in the original sequence are replaced by other amino acids. These peptides show an advantageously modified specificity in their inhibotory action. A method of preparation of the peptides and their pharmaceutical use is also described.
Type:
Grant
Filed:
April 16, 1991
Date of Patent:
June 30, 1992
Assignee:
Bayer Aktiengesellschaft
Inventors:
John Collins, Helmut Blocker, Ronald Frank, Friedhelm Maywald, Hans Fritz, Wolfgang Bruns
Abstract: A novel substance having anthelmintic activity, the PF 1022 substance, which is produced by cultivating a fungal strain capable of producing the substance and recovering the substance from the culture.
Abstract: A cyclic tetrapeptide having the formula (I): ##STR1## wherein n is 4 or 3 and a process for preparing the above cyclic tetrapeptide. The cyclic tetrapeptide of the present invention inhibits transformation of cells caused by oncogenes and possesses activities for recovering to a normal cell and for inhibiting proliferation of carcinoma cells. Therefore, the cyclic tetrapeptide of the present invention is useful for an active ingredient of an antitumor agent.