With At Least One Abnormal Peptide Link In The Ring (c07k-7/54) Patents (Class 930/DIG536)

Digests

The cyclisation not occurring through the 2,4-diamino-butanoic acid (c07k-7/56) (Class 930/DIG537)
The cyclisation occurring through the 4-amino group of the 2,4-diamino butanoic acid (c07k-7/60) (Class 930/DIG542)
  • Cyclic peptides for treating herpes infections
    Patent number: 5258493
    Abstract: Disclosed herein are cyclic peptide derivatives of the formula ##STR1## wherein A is absent or the tripeptide radical Thr.rarw.Gly.rarw.Ala, R.sup.1 is benzyl or benzyl monosubstituted at position 4 of the aromatic ring with halo, hydroxy, lower alkyl or lower alkoxy, R.sup.2 and R.sup.4 each independently is hydrogen or lower alkyl, R.sup.3 is lower alkyl or lower alkyl monosubstituted with a hydroxy, R.sup.5 is lower alkyl, Y is oxo or thioxo and Z is hydroxy or NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 each independently is hydrogen or lower alkyl. The derivatives are useful for treating herpes infections.
    Type: Grant
    Filed: March 16, 1992
    Date of Patent: November 2, 1993
    Assignee: Bio-Mega/Boehringer Ingelheim Research Inc.
    Inventors: Julian Adams, John DiMaio, Raymond Plante
  • Phosphorylated cyclic lipopeptide
    Patent number: 5198421
    Abstract: There is disclosed a monophosphorylated cyclic lipopeptide compound obtained by biophosphorylating a cyclic lipopeptide related to echinocandins and having a peptide skeleton bearing several hydroxy groups wherein in the phosphorylated cyclic lipopeptide, the phosphate group is attached to the hydroxy group of the 4-hydroxyproline component of the lipopeptide. The compounds are useful for the control of fungi and parasites.
    Type: Grant
    Filed: April 26, 1991
    Date of Patent: March 30, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Shieh-Shung T. Chen, David J. Mathre, Brian R. Petuch, Robert A. Reamer
  • Cyclic peptides for treating herpes infections
    Patent number: 5149778
    Abstract: Disclosed herein are cyclic peptide derivatives of the formula ##STR1## wherein A is absent or the tripeptide radical Thr.rarw.Gly.rarw.Ala, R.sup.1 is benzyl or benzyl monosubstituted at position 4 of the aromatic ring with halo, hydroxy, lower alkyl or lower alkoxy, R.sup.2 and R.sup.4 each independently is hydrogen or lower alkyl, R.sup.3 is lower alkyl or lower alkyl monosubstituted with a hydroxy, R.sup.5 is lower alkyl, Y is oxo or thioxo and Z is hydroxy or NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 each independently is hydrogen or lower alkyl. The derivatives are useful for treating herpes infections.
    Type: Grant
    Filed: July 3, 1990
    Date of Patent: September 22, 1992
    Assignee: Bio-Mega, Inc.
    Inventors: Julian Adams, John DiMaio, Raymond Plante
  • Isolation and structural elucidation of the cytostatic cyclodepsipeptide dolastatin 14
    Patent number: 5138036
    Abstract: A new cytostatic depsipeptide, designated "dolastatin 14", was isolated from the Indian Ocean shell-less mollusk Dolabella auricularia. Dolastatin 14 inhibited growth of the PS leukemia with ED.sub.50 0.0018 .mu.g/mL. Pharmaceutical preparations and therapeutic regimens utilizing Dolastatin 14, its synthetic counterpart and pharmaceutically active derivatives are disclosed.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: August 11, 1992
    Assignee: Arizona Board of Regents acting on behalf of Arizona State University
    Inventors: George R. Pettit, Yoshiaki Kamano, Cherry L. Herald
  • PF 1022 substance, method of treating helminthic parasitic infection and anthelmintic composition
    Patent number: 5116815
    Abstract: A novel substance having anthelmintic activity, the PF 1022 substance, which is produced by cultivating a fungal strain capable of producing the substance and recovering the substance from the culture.
    Type: Grant
    Filed: February 6, 1990
    Date of Patent: May 26, 1992
    Assignee: Meiji Seika Kaisha Ltd.
    Inventors: Masayuki Takagi, Tadaaki Okada, Naotoshi Akai, Takashi Yaguchi, Shinji Miyadoh, Takashi Shomura, Toru Sasaki, Masaji Sezaki, Takao Shimizu, Masashi Niida
  • Endothelin antagonistic cyclic pentapeptides
    Patent number: 5114918
    Abstract: Cyclic pentapeptides of the formula:cyclo (-X.sup.1 -X.sup.2 -X.sup.3 -X.sup.4 -X.sup.5 -) (I)wherein X.sup.n (n=1-5) represents amino acid residues. These compounds are useful as hypotensive drugs.
    Type: Grant
    Filed: December 20, 1990
    Date of Patent: May 19, 1992
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takashi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaru Nishikibe, Masaki Ihara, Mitsuo Yano
  • Antibiotic, mersacidin, a process for the preparation thereof and the use thereof as a pharmaceutical
    Patent number: 5112806
    Abstract: Mersacidin, a cyclic peptide of the formula I ##STR1## has antibiotic activity.
    Type: Grant
    Filed: August 15, 1989
    Date of Patent: May 12, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Sukumar Chatterjee, Sugata Chatterjee, Bimal N. Ganguli, Deepak K. Chatterjee, Rajendra K. H. Jani, Richard H. Rupp, Hans-Wolfram Fehlhaber, Herbert Kogler, Gerhard Seibert, Volker Teetz