Peptides Containing The C-terminal Sequence (x-cys-phe-gly-phe-gly-gly Arg-a-asp-arg-ile-gly-ala-gln-ser-gly-leu-gly-cys-y) With X Being Nh, Y Being -oh, Nh, Or Part Of The Sequence -asn-ser-phe-arg-tyr-arg-arg- And A Being Met Or Ile, E.g., Atriopeptine; Atrial Natriuretic Peptides And Proteins (anp) (c07k-99/00c) Patents (Class 930/DIG553)
  • Patent number: 5091366
    Abstract: Analogs of the 17-membered ring portion of ANF wherein the cysteine moiety is replaced with dipeptidyl moieties, specifically, Phe-Pro, NMP-Pro, Pro-Pro, Val-Pro, Lys-Pro, Ile-Pro, Arg-Pro, HAr-Pro, Dly-Pro, Arg-Pro, Lys-BAr, Arg-Pro, CyA-CyA, Cys-Cys, or with .alpha.-aminoheptanoic acid result in analogs of ANF having increased potencies and metabolic stability.
    Type: Grant
    Filed: June 4, 1990
    Date of Patent: February 25, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Ruth F. Nutt, Terrence M. Ciccarone, Stephen F. Brady, Daniel F. Veber