Peptides Containing The Sequence (cys-tyr-a-gln-asn-cys-pro-b -gly Nh2), With A Being Ile Or Phe, B Being Leu Or Arg Or Lys Or S-s Bridge 1-6, E.g., Oxytocin, Vasopressin, Or A Related Peptide (c07k 99/02) Patents (Class 930/DIG565)

Digests

With all amino acids in l-form (c07k-99/02a) (Class 930/DIG566)
With at least one amino acid in d-form (c07k-99/04) (Class 930/DIG567)
  • Oxytocin antagonist
    Patent number: 5373089
    Abstract: A novel compound is disclosed for inhibiting the effects of oxytocin in a female mammal. As an analog of oxytocin the compound is named [(S)PMP.sup.1,D-Trp.sup.2,Pen.sup.6,Arg.sup.8 ] oxytocin. This compound can be administered to pregnant women to arrest premature labor while avoiding unwanted side effects due to antagonism of the antidiuretic hormone, vasopressin.
    Type: Grant
    Filed: April 26, 1993
    Date of Patent: December 13, 1994
    Assignee: Northwestern University
    Inventors: George Flouret, Laird Wilson