Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
Type:
Grant
Filed:
September 30, 1991
Date of Patent:
August 24, 1993
Assignee:
Merck & Co., Inc.
Inventors:
Samuel L. Graham, S. Jane deSolms, Victor M. Garsky