Having Biological Reactive Capability Patents (Class 977/836)
  • Patent number: 8889657
    Abstract: The present invention provides phosphonate conjugates and methods of preparing the phosphonate conjugates so as to allow, for example, improved methods and compounds for modifying the surface of a nanoparticle to increase in vivo circulation times and targeted delivery performance.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: November 18, 2014
    Assignee: Mallinckrodt LLC
    Inventor: Thomas E. Rogers
  • Patent number: 8613953
    Abstract: The invention provides a novel method for obtaining solid micro- or nanoparticles with a homogeneous structure. A method is provided for obtaining solid micro- or nanoparticles with a homogeneous structure having a particle size of less than 10 ?m where the processed solid compound has the natural, crystalline, amorphous, polymorphic and other features associated with the starting compound. In accordance with the invention a method which also makes it possible to obtain solid micro- or nanoparticles with a substantially spheroidal morphology is provided.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: December 24, 2013
    Assignees: Consejo Superior de Investigaciones Científicas, Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales Y Nanomedicina
    Inventors: Nora Ventosa Rull, Jaume Veciana Miró, Mary Cano Sarabia, Santiago Sala Vergés
  • Publication number: 20130171225
    Abstract: Embodiments of the invention are directed to a composition having antimicrobial activity comprising particles comprising at least one inorganic copper salt; and at least one functionalizing agent in contact with the particles, the functionalizing agent stabilizing the particle in a carrier such that an antimicrobially effective amount of ions are released into the environment of a microbe. The average size of the particles ranges from about 1000 nm to about 4 nm. Preferred copper salts include copper iodide, copper bromide and copper chloride. Preferred functionalizing agents include amino acids, thiols, hydrophilic polymers emulsions of hydrophobic polymers and surfactants.
    Type: Application
    Filed: June 15, 2012
    Publication date: July 4, 2013
    Inventors: Donald R. Uhlmann, Anoop Agrawal, Murat Akarsu, John P. Cronin
  • Publication number: 20100254914
    Abstract: The disclosure provides elongated nanostructures useful for biological imaging and measurement. More particularly the disclosure provides nanoworms having an increased bioavailability compared to nanospheres.
    Type: Application
    Filed: February 25, 2010
    Publication date: October 7, 2010
    Inventors: Ji-Ho Park, Lianglin Zhang, Austin M. Derfus, Michael J. Sailor, Geoffrey A. Von Maltzahn, Todd Harris, Sangeeta N. Bhatia, Dmitri Simberg
  • Publication number: 20100120132
    Abstract: Embodiments of the invention relate to detecting biological molecules with ultra-sensitivity and convenience. The embodiments are especially directed to utilizing nanoparticles as tags and identifying the tags using dark-field microscopy. The probes containing the nanoparticles can be used in solution or attached to a substrate.
    Type: Application
    Filed: March 31, 2006
    Publication date: May 13, 2010
    Applicant: Intel Corporation
    Inventor: Tae-Woong Koo
  • Publication number: 20100103368
    Abstract: An active contact lens system (100) and method for fabricating an active contact lens (200) are disclosed. The system comprises an active contact lens (110) worn like a conventional contact lens, and comprising a transparent substrate (112) having a circuit formed of one or more of a semi-transparent display (114), a display drive circuit (116), a data communications circuit (118), one or more biosensors (122), an energy transfer antenna (120) and an interconnect network (124). The substrate may be a conventional contact lens material, such as PMMA or RGP, and the display may be formed from a plurality LEDs. A method for fabricating the active contact lens includes fabricating the template (202), forming solder compatible pads (204), assembling the circuit elements (206) and micro-molding the lens (208). The template is fabricated with an interconnect network and shape-specific recesses for receiving the circuit elements. Preferably, the assembly is done using fluidic self-assembly.
    Type: Application
    Filed: September 4, 2009
    Publication date: April 29, 2010
    Inventors: Babak Amirparviz, Harvey Ho, Ehsan Saeedi
  • Patent number: 7309482
    Abstract: The disclosure provides a sunscreen formulation comprising a peptide-based metal oxide sunscreen agent, such as titanium dioxide nanoparticles, and a fluid vehicle.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: December 18, 2007
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Janine Buseman-Williams, Xueying Huang, Hong Wang, Gary Ken Whiting
  • Patent number: 7202541
    Abstract: An apparatus for transverse characterization of materials includes a lower pattern of contacts, separated by spacings, a material, and an upper pattern of a multiplicity of contacts, separated by spacings differing from the spacings of the lower pattern. The transverse characterization method includes receiving lower pattern of a multiplicity of contacts, separated by spacings along a surface, with a material above the surface, successively placing an upper contact near the upper surface of the material in an upper pattern of locations separated by spacings differing from the spacings of the lower pattern, measuring the characteristics between the upper contact and one or more contacts of the lower pattern and evaluating the measured characteristics to previous measurements, wherein the evaluation provides the transverse characterization.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: April 10, 2007
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventor: Patricia A. Beck