Abstract: A method for preventing infection and maintaining aseptic epidermal areas by preventing contaminated fluid from entering an open epidermal site on a user, comprising the steps of: removably attaching at least one adjustable strap to a reusable non-deforming flexible protective cover comprising a sealing member, covering the open epidermal site with the reusable non-deforming flexible protective cover while maintaining a space between the reusable non-deforming flexible protective cover and the open epidermal site, and tightening the at least one adjustable strap to secure the reusable non-deforming flexible protective cove over the open epidermal site to create a fluid-tight seal between the sealing member and the open epidermal site, thereby preventing contaminated fluid from entering the open epidermal site.