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  • Pharmaceutical composition comprising the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD)
    Patent number: 10729665
    Abstract: This invention relates to a pharmaceutical composition comprising or consisting essentially of the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD). The composition is particularly safe and efficacious for use in the treatment of neurological conditions, characterized by hyper-excitability of the central nervous system, convulsions or seizures such as occur in epilepsy. Preferably the CBDV and the CBD are present with at least one non-cannabinoid component of cannabis such as one or more terpenes or a terpene fraction. More particularly the composition further comprises one or more cannabichromene type compounds. Particularly cannabichromene propyl variant (CBCV) and/or cannabichromene (CBC).
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: August 4, 2020
    Assignees: GW Pharma Limited, Otsuka Pharmaceutical Co., Limited
    Inventors: Benjamin Whalley, Claire Williams, Gary Stephens, Thomas Hill
  • NEW RADIO (NR) HANDOVER, RADIO LINK MONITORING (RLM), BEAM FAILURE DETECTION (BFD), AND CANDIDATE BEAM DETECTION (CBD) WITH CLEAR CHANNEL ASSESSMENT (CCA)
    Publication number: 20230217339
    Abstract: Some aspects relate to apparatuses and methods for implementing mechanisms for performing handover, radio link monitoring (RLM), beam failure detection (BFD), and candidate beam detection (CBD) within the unlicensed spectrum when a listen-before-talk (LBT) failure occurs and/or when a user equipment (UE) performs receiving (RX) beam sweeping. For example, a UE is configured to receive a handover command to connect to a target cell. The UE is further configured to determine a search time and an interruption time uncertainty during a handover procedure initiated by the handover command and in response to a LBT failure or the UE performing a beam sweeping operation. The UE can further determine a handover delay based on the search time and the interruption time uncertainty. In response to a time period for performing the handover procedure exceeding the handover delay, the UE can cease the handover procedure.
    Type: Application
    Filed: September 30, 2022
    Publication date: July 6, 2023
    Applicant: Apple Inc.
    Inventors: Xiang CHEN, Dawei ZHANG, Huaning NIU, Jie CUI, Manasa RAGHAVAN, Qiming LI, Yang TANG
  • Systems and Methods for Using an On-the-fly CBD Estimate to Adjust Fly-Height
    Publication number: 20090154003
    Abstract: Various embodiments of the present invention provide systems and methods for using channel bit density estimates to adjust fly-height. For example, various embodiments of the present invention provide methods for adaptively adjusting fly-height. Such methods include providing a storage medium that includes information corresponding to a process data set, and a read/write head assembly that is disposed a variable distance from the storage medium. The process data set is accessed from the storage medium. A first channel bit density estimate is adaptively calculated based at least in part on the process data set and a second channel bit density estimate that was previously calculated. The variable distance is modified based at least in part on the first channel bit density estimate. A third channel bit density is adaptively calculated based at least in part on the process data set and a fourth channel bit density estimate that was previously calculated.
    Type: Application
    Filed: October 20, 2008
    Publication date: June 18, 2009
    Inventors: George Mathew, Yuan Xing Lee, Hongwei Song, Jefferson E. Singleton
  • Systems and methods for using an on-the-fly CBD estimate to adjust fly-height
    Patent number: 8014099
    Abstract: Various embodiments of the present invention provide systems and methods for using channel bit density estimates to adjust fly-height. For example, various embodiments of the present invention provide methods for adaptively adjusting fly-height. Such methods include providing a storage medium that includes information corresponding to a process data set, and a read/write head assembly that is disposed a variable distance from the storage medium. The process data set is accessed from the storage medium. A first channel bit density estimate is adaptively calculated based at least in part on the process data set and a second channel bit density estimate that was previously calculated. The variable distance is modified based at least in part on the first channel bit density estimate. A third channel bit density is adaptively calculated based at least in part on the process data set and a fourth channel bit density estimate that was previously calculated.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: September 6, 2011
    Assignee: LSI Corporation
    Inventors: George Mathew, Yuan Xing Lee, Hongwei Song, Jefferson E. Singleton
  • Process of expressing and isolating recombinant proteins and recombinant protein products from plants, plant derived tissues or cultured plant cells
    Patent number: 6331416
    Abstract: A process of expressing a recombinant protein in a plant and of isolating the recombinant protein from the plant, the process is effected by (a) providing a plant, a plant derived tissue or cultured plant cells expressing a fusion protein including the recombinant protein and a cellulose binding peptide being fused thereto, the fusion protein being compartmentalized within cells of the plant, plant derived tissue or cultured plant cells, so as to be sequestered from cell walls of the cells of the plant, plant derived tissue or cultured plant cells; (b) homogenizing the plant, plant derived tissue or cultured plant cells, so as to bring into contact the fusion protein with a cellulosic matter of the plant, plant derived tissue or cultured plant cells, to thereby effect affinity binding of the fusion protein via the cellulose binding peptide to the cellulosic matter, thereby obtaining a fusion protein cellulosic matter complex; and (c) isolating the fusion protein cellulosic matter complex.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: December 18, 2001
    Assignees: CBD Technologies Ltd., Yissum Research and Development Company of the Hebrew University of Jerusalem
    Inventors: Ziv Shani, Oded Shoseyov
  • METHOD FOR IMPROVING FINENESS OF SPECIFIED REGION ON SURFACE OF LIGHT-CURABLE 3D PRINTED MODEL
    Publication number: 20240157654
    Abstract: The present application provides eight methods for improving the fineness of a specified region on the surface of a light-curable 3D printed model. In Methods 1-4, an anti-aliasing function is turned on/an image edge blurring function may be turned on entirely for a puppet 3D model, which can make the overall surface of the printed model smooth and flat. In addition, a specified region on the model surface may be circled, and an image sharpening function is turned on/the anti-aliasing function is turned off/the image edge blurring function is turned off to retain a marginal sawtooth effect of the sliced image in the specified region, so that specific feature lines of the printed model surface are obviously prominent, and the fineness of the specific features in the specified region of the model surface can be improved.
    Type: Application
    Filed: July 14, 2021
    Publication date: May 16, 2024
    Applicant: SHENZHEN CBD TECHNOLOGY CO., LTD.
    Inventors: Yu YI, Xinfu XIE, Li LIU, Shaohua LING
  • METHOD OF MAKING POLYESTER FABRIC TREATED WITH A CBD POWDER
    Publication number: 20210348324
    Abstract: This invention relates to a method for making polyester fabric treated with a CBD powder to provide a novel CBD finish on the polyester fabric. The polyester fabric is treated with a CBD powder to provide a novel finish. The treatment process includes a washing step, wherein the treating CBD water is added to a water channel before the finishing step. Then, the polyester fabric is passed through the water channel having the treating CBD water in the ratio of 1:1000, which is one gram of CBD powder to each 1000 grams of water. The flow rate of the treating CBD water has a ratio of 5:1000, which adds 5 grams of CBD powder to each 1000 grams of water in order to apply the correct treatment of CBD water. In addition, the polyester fabric moves at a speed of approximately 20 meters per minute through the water channel, and the bathing treatment has a normal temperature of 30-35° C. The maximum temperature of the drying machine is 220° C., but has a preferred range of 170-220° C.
    Type: Application
    Filed: October 23, 2019
    Publication date: November 11, 2021
    Applicant: SAM SALEM AND SON, LLC
    Inventor: JESSE SALEM
  • Quad bit using hot-hole erase for CBD control
    Patent number: 7113431
    Abstract: The present invention pertains to a technique for erasing bits in a dual bit memory in a manner that maintains complementary bit disturb control of bit-pairs of memory cells wherein each bit of the dual bit memory cell can be programmed to multiple levels. One exemplary method comprises providing a word of memory cells after an initial erasure and programming of the bits of the word to one or more of the higher program levels. A disturb level is determined for each of the bit-pairs of the word. A combined disturb level is then computed that is representative of the individual disturb levels. A pattern of drain voltages is then applied to the word for a number of program passes until a target pattern is stored in the word of memory cells based on the combined disturb level and the unprogrammed bit of the bit-pairs is erased to a single program level.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: September 26, 2006
    Assignee: Spansion LLC
    Inventors: Darlene Hamilton, Alykhan Madhani, Fatima Bathul, Satoshi Torii
  • Method of making polyester fabric treated with a CBD powder
    Patent number: 11186944
    Abstract: This invention relates to a method for making polyester fabric treated with a CBD powder to provide a novel CBD finish on the polyester fabric. The polyester fabric is treated with a CBD powder to provide a novel finish. The treatment process includes a washing step, wherein the treating CBD water is added to a water channel before the finishing step. Then, the polyester fabric is passed through the water channel having the treating CBD water in the ratio of 1:1000, which is one gram of CBD powder to each 1000 grams of water. The flow rate of the treating CBD water has a ratio of 5:1000, which adds 5 grams of CBD powder to each 1000 grams of water in order to apply the correct treatment of CBD water. In addition, the polyester fabric moves at a speed of approximately 20 meters per minute through the water channel, and the bathing treatment has a normal temperature of 30-35° C. The maximum temperature of the drying machine is 220° C., but has a preferred range of 170-220° C.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: November 30, 2021
    Assignee: Sam Salem and Son, LLC
    Inventor: Jesse Salem
  • PROCESS FOR PRODUCING A NANO-CBD MICROEMULSION SYSTEM
    Publication number: 20190365647
    Abstract: The present invention relates to a process of producing a nano-CBD microemulsion system includes: (i) preparing a dispersal phase by dissolving CBD in an ethanol solvent in a ratio between mass of CBD:volumn of ethanol solvent as 8:10 at a speed of 300 to 500 rpm with heating to a temperature ranging from 40 to 60° C. within 4 to 8 hours; (ii) preparing a carrier by heating a liquid PEG (polyethylene glycol) accounted for 40-60% by mass of the mixture of PEG and water to a temperature from 60 to 80° C., stirring homogeneously; (iii) adding the carrier to the dispersal phase in a ratio by mass of 40:60, continuing heating the dispersal phase to a temperature of 40 to 60° C., stirring at a speed of 400 to 800 rpm; (iv) elmusifying as follows: when the temperature arrives at 100° C., adding ACRYSOL K-140 to the mixture of the carrier and dispersal phase obtained in step (iii) in a ratio by mass of 40:60, continuing to stir at a speed of 500 to 700 rpm, at a temperature of about 100° C.
    Type: Application
    Filed: August 11, 2019
    Publication date: December 5, 2019
    Inventor: Hai Nam Lai
  • Composition and Method for Transdermal Delivery of Cannabidiol (CBD) and 9-Tetrahydrocannabinol (THC)
    Publication number: 20210251912
    Abstract: A transdermal delivery composition for the delivery to skin and the penetration of the skin includes: (a) a therapeutic effective amount of a cannabinoid mixture, wherein the cannabinoid mixture comprises cannabidiol (CBD) and ?9-tetrahydrocannabinol (THC) at a weight ratio of about 1:20 to about 20:1; (b) a hydrophilic polymer/hydrophobic polymer adduct in an amount sufficient to hold the cannabinoid composition and provide a sustain release of the cannabinoid mixture after application to skin tissue over a time period of at least 6 hours; (c) a penetrant component in an amount sufficient to assist with a transdermal penetration of the cannabinoid mixture through skin tissue once the composition has been applied to skin tissue; (d) a surfactant component in an amount sufficient to stabilize the polymer adduct and release the cannabinoid mixture from the transdermal delivery composition upon application to skin tissue; and (e) at least about 70 wt. % water.
    Type: Application
    Filed: February 8, 2021
    Publication date: August 19, 2021
    Inventor: James A. Roszell
  • Composition and Method for Transdermal Delivery of Cannabidiol (CBD) and Tetrahydrocannabinol (THC)
    Publication number: 20230138946
    Abstract: A transdermal delivery composition for the delivery to skin and the penetration of the skin includes: (a) a therapeutic effective amount of a cannabinoid mixture, wherein the cannabinoid mixture comprises cannabidiol (CBD) and ?9-tetrahydrocannabinol (THC) at a weight ratio of about 1:20 to about 20:1; (b) a hydrophilic polymer/hydrophobic polymer adduct in an amount sufficient to hold the cannabinoid composition and provide a sustain release of the cannabinoid mixture after application to skin tissue over a time period of at least 6 hours; (c) a penetrant component in an amount sufficient to assist with a transdermal penetration of the cannabinoid mixture through skin tissue once the composition has been applied to skin tissue; (d) a surfactant component in an amount sufficient to stabilize the polymer adduct and release the cannabinoid mixture from the transdermal delivery composition upon application to skin tissue; and (e) at least about 70 wt. % water.
    Type: Application
    Filed: August 2, 2022
    Publication date: May 4, 2023
    Inventor: James A. Roszell
  • PROCESS FOR PRODUCING A NANO-CBD LIPOSOME SYSTEM
    Publication number: 20200000724
    Abstract: The present invention relates to a process of producing a nano-CBD liposome system comprises: (i) preparing a dispersal phase by dissolving CBD in an ethanol solvent in a ratio between mass of CBD:volumn of ethanol solvent as 8:10 by a stirrer at a speed of 300 to 500 rpm and simultaneously heating to a temperature ranging from 40 to 60° C. within 4 to 8 hours; (ii) preparing a liposome carrier consisting of lecithin, olive oil in a ratio by mass of 1:3 mixed in a themostatic bath at a temperature from 40 to 60° C. to ensure that lecithin completely dissolves in oil, stirring homogeneously; (iii) adding the carrier to the dispersal phase in a ratio by mass of 40:60, continuing heating the dispersal phase to a temperature ranging from 40 to 60° C., stirring at a speed of 800 to 1000 rpm for 1 to 2 hours; (iv) cooling the resulting mixture to 25° C. and injecting one volumn of distilled water between 1 and 1.
    Type: Application
    Filed: August 11, 2019
    Publication date: January 2, 2020
    Inventor: Hai Nam Lai
  • Process for producing a nano-CBD liposome system
    Patent number: 10660855
    Abstract: The present invention relates to a process of producing a nano-CBD liposome system comprises: (i) preparing a dispersal phase by dissolving CBD in an ethanol solvent in a ratio between mass of CBD:volumn of ethanol solvent as 8:10 by a stirrer at a speed of 300 to 500 rpm and simultaneously heating to a temperature ranging from 40 to 60° C. within 4 to 8 hours; (ii) preparing a liposome carrier consisting of lecithin, olive oil in a ratio by mass of 1:3 mixed in a themostatic bath at a temperature from 40 to 60° C. to ensure that lecithin completely dissolves in oil, stirring homogeneously; (iii) adding the carrier to the dispersal phase in a ratio by mass of 40:60, continuing heating the dispersal phase to a temperature ranging from 40 to 60° C., stirring at a speed of 800 to 1000 rpm for 1 to 2 hours; (iv) cooling the resulting mixture to 25° C. and injecting one volumn of distilled water between 1 and 1.
    Type: Grant
    Filed: August 11, 2019
    Date of Patent: May 26, 2020
    Inventor: Hai Nam Lai
  • Composition and method for transdermal delivery of cannabidiol (CBD) and ?-tetrahydrocannabinol (THC)
    Patent number: 11439602
    Abstract: A transdermal delivery composition for the delivery to skin and the penetration of the skin includes: (a) a therapeutic effective amount of a cannabinoid mixture, wherein the cannabinoid mixture comprises cannabidiol (CBD) and ?9-tetrahydrocannabinol (THC) at a weight ratio of about 1:20 to about 20:1; (b) a hydrophilic polymer/hydrophobic polymer adduct in an amount sufficient to hold the cannabinoid composition and provide a sustain release of the cannabinoid mixture after application to skin tissue over a time period of at least 6 hours; (c) a penetrant component in an amount sufficient to assist with a transdermal penetration of the cannabinoid mixture through skin tissue once the composition has been applied to skin tissue; (d) a surfactant component in an amount sufficient to stabilize the polymer adduct and release the cannabinoid mixture from the transdermal delivery composition upon application to skin tissue; and (e) at least about 70 wt. % water.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: September 13, 2022
    Assignee: Ovation Science Inc.
    Inventor: James A. Roszell
  • Process for producing a nano-CBD microemulsion system
    Patent number: 11617718
    Abstract: The present invention relates to a process of producing a nano-CBD microemulsion system includes: (i) preparing a dispersal phase by dissolving CBD in an ethanol solvent in a ratio between mass of CBD:volumn of ethanol solvent as 8:10 at a speed of 300 to 500 rpm with heating to a temperature ranging from 40 to 60° C. within 4 to 8 hours; (ii) preparing a carrier by heating a liquid PEG (polyethylene glycol) accounted for 40-60% by mass of the mixture of PEG and water to a temperature from 60 to 80° C., stirring homogeneously; (iii) adding the carrier to the dispersal phase in a ratio by mass of 40:60, continuing heating the dispersal phase to a temperature of 40 to 60° C., stirring at a speed of 400 to 800 rpm; (iv) elmusifying as follows: when the temperature arrives at 100° C., adding ACRYSOL K-140 to the mixture of the carrier and dispersal phase obtained in step (iii) in a ratio by mass of 40:60, continuing to stir at a speed of 500 to 700 rpm, at a temperature of about 100° C.
    Type: Grant
    Filed: August 11, 2019
    Date of Patent: April 4, 2023
    Inventor: Hai Nam Lai
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