Search Patents
  • METHODS OF TREATING SYMPTOMS OF CORONAVIRUS INFECTION WITH TOLL-LIKE-RECEPTOR AGONISTS
    Publication number: 20230310469
    Abstract: The present disclosure relates to methods of treating at least one symptom of a coronavirus infection, or preventing an acute inflammatory response, e.g., a cytokine storm in a coronavirus patient, in particular a SARS-CoV-19 patient, by administering a Toll-Like-Receptor (TLR) agonist, in particular a TLR-7 or TLR-8 agonist.
    Type: Application
    Filed: August 30, 2021
    Publication date: October 5, 2023
    Inventors: Kevin Brown, Kevin Brogle
  • HYPERIMMUNIZED EGG PRODUCT FOR TREATMENT OR PREVENTION OF CORONAVIRUS INFECTION
    Publication number: 20230285547
    Abstract: In one aspect, the present disclosure is directed to a method for preventing or treating a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a hyperimmunized egg product obtained from an egg-producing animal, thereby preventing or treating coronavirus infection in the subject, wherein the hyperimmunized egg product comprises a therapeutically effective amount of one or more antibodies to the coronavirus.
    Type: Application
    Filed: April 28, 2023
    Publication date: September 14, 2023
    Inventors: Subramanian V. IYER, Satishchandran CHANDRASEKHAR, Uday SAXENA, Gopi KADIYALA
  • SOLUBLE TREM-1 AS A MARKER OF SEVERITY OR COMPLICATIONS FOR A SUBJECT SUFFERING FROM A CORONAVIRUS INFECTION
    Publication number: 20230273208
    Abstract: The use of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as a marker in a method for identifying a subject suffering from a disease caused by a coronavirus such as COVID-19 at risk of having or developing a severe form and/or a complication or at risk of death, in a method for assessing the severity of a disease caused by a coronavirus such as COVID-19, and in a method for monitoring a subject suffering from a disease caused by a coronavirus such as COVID-19.
    Type: Application
    Filed: June 7, 2021
    Publication date: August 31, 2023
    Applicants: INOTREM, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE NANCY, UNIVERSITE DE LORRAINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
    Inventors: Jean-Jacques GARAUD, Marc DERIVE, Margarita SALCEDO-MAGGUILLI, Lucie JOLLY, Sébastien GIBOT, David MOULIN, Mihai NETEA, Aline DE NOOIJER
  • DEVICE FOR MICROLITER-SCALE LYMPHATIC DELIVERY OF CORONAVIRUS VACCINES AND METHODS OF USE THEREOF
    Publication number: 20240090908
    Abstract: A fluid delivery device adapted for microliter-scale injections of coronavirus vaccines across a dermal barrier of a patient, for example to the lymphatic system of the patient, is described. The present disclosure also provides methods of administering coronavirus vaccines across a dermal barrier of a patient, for example to the lymphatic system of a patient.
    Type: Application
    Filed: January 21, 2022
    Publication date: March 21, 2024
    Inventors: Russell F. Ross, Henry Hongjun Ji
  • HYPERIMMUNIZED EGG PRODUCT FOR TREATMENT OR PREVENTION OF CORONAVIRUS INFECTION
    Publication number: 20220288193
    Abstract: In one aspect, the present disclosure is directed to a method for preventing or treating a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a hyperimmunized egg product obtained from an egg-producing animal, thereby preventing or treating coronavirus infection in the subject, wherein the hyperimmunized egg product comprises a therapeutically effective amount of one or more antibodies to the coronavirus.
    Type: Application
    Filed: March 11, 2022
    Publication date: September 15, 2022
    Inventors: Subramanian V. IYER, Satish CHANDRAN, Uday SAXENA, Gopi KADIYALA
  • Compositions Against Sars-Coronavirus and Uses Thereof
    Publication number: 20080014204
    Abstract: The present invention provides compositions of binding molecules specifically binding to a coronavirus such as SARS-CoV and capable of neutralizing an infection caused by the virus. The compositions are suitable for diagnosing, preventing and/or treating a condition resulting from a coronavirus such as SARS-CoV.
    Type: Application
    Filed: November 10, 2005
    Publication date: January 17, 2008
    Inventors: Jan Ter Meulen, Edward Van Den Brink, Cornelis De Kruif, Jaap Goudsmit
  • COMPOSITIONS AND METHODS FOR TREATING AND DETECTING CORONAVIRUS INFECTION
    Publication number: 20230183703
    Abstract: The present disclosure provides compositions and methods for treating and detecting coronavirus infection, and in particular embodiments, provides compositions and methods for treating and detecting SARS-CoV-2 infection. The present disclosure also relates to the production of compositions for treating and detecting coronavirus infection, and in particular embodiments, to the production of compositions for treating and detecting SARS-CoV-2 infection.
    Type: Application
    Filed: May 14, 2021
    Publication date: June 15, 2023
    Applicant: HOWARD UNIVERSITY
    Inventor: Hemayet ULLAH
  • METHOD FOR THE PROPHYLAXIS OR TREATMENT OF CORONAVIRUS INFECTION USING AN IMMUNOMODULATOR AND VACCINE COMPOSITIONS COMPRISING THE SAME
    Publication number: 20210346491
    Abstract: The present disclosure provides a method for the treatment or prophylaxis of coronavirus infection, comprising administering a therapeutically effective amount of an immunomodulator to a subject in need thereof or at risk of coronavirus infection. A vaccine composition comprising a pharmaceutically effective amount of an immunomodulator is also provided.
    Type: Application
    Filed: May 7, 2021
    Publication date: November 11, 2021
    Inventors: YU-SHEN HSU, SSU-WEI KANG, MING-I CHANG
  • IDEBENONE FOR THE TREATMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) IN PATIENTS DIAGNOSED WITH A CORONAVIRUS INFECTION
    Publication number: 20230127518
    Abstract: The present invention relates to idebenone for treating Acute Respiratory Distress Syndrome (ARDS) associated with a viral infection, particularly a coronavirus infection, such as Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
    Type: Application
    Filed: March 19, 2021
    Publication date: April 27, 2023
    Inventors: Giampiero DE LUCA, Alessandro BERTI
  • Anti-coronavirus agent
    Publication number: 20070026087
    Abstract: An antiviral agent is provided which is effective in treating coronaviruses and can be formed into various products whose efficacy sustainability is promising. In particular, the present invention provides an antiviral agent which is effective in treating a coronavirus, comprising a silver ion carrier; a product capable of inactivating a coronavirus, comprising the same; and a method of inactivating a coronavirus. The silver ion carrier is at least one selected from a compound represented by the following formula (1), potassium titanate, potassium uranate, potassium vanadate, potassium niobate, sodium tangustate, magnesium molybdate, calcium pentaborate, aluminosilicate, aluminum phosphate, nickel hexacyanoferrate, sepiolite, montmorillonite, silica gel, zeolite, ?-alumina, titanium oxide hydrate, hydroxyapatite and a glassy carrier. AgaAbM2c(PO4)d.
    Type: Application
    Filed: October 31, 2003
    Publication date: February 1, 2007
    Applicant: Toagosei Co., Ltd.
    Inventors: Koji Sugiura, Yasuharu Ono
  • MODIFIED S1 SUBUNIT OF THE CORONAVIRUS SPIKE PROTEIN
    Publication number: 20200354410
    Abstract: The present invention relates i.a. to a recombinant avian coronavirus spike protein or fragment thereof comprising a mutation at amino acid position 267 to Cysteine. Further, the present invention relates to an immunogenic composition comprising an avian coronavirus with such spike protein.
    Type: Application
    Filed: May 6, 2020
    Publication date: November 12, 2020
    Inventors: Annika KRAEMER-KUEHL, Thomas Min STEPHAN, Hans-Christian PHILIPP
  • Physical methods for living tissue inactivation and detection, and physical methods in use for the detection and inactivation of living bodies (like Ebola and 2019 Coronavirus) in living systems and non-living systems thereof
    Patent number: 11564587
    Abstract: A system for detecting presence of coronavirus in a subject, the system including a first pad for placing a first hand, the pad including a contact to measure conductance of the subject's body, a conductance meter connected to the contact, a second pad for placing a second hand, a source of electromagnetic radiation for irradiating the second pad. A system for detecting presence of coronavirus in a subject, the system including a chip with a plurality of wires disposed on or in the chip, a conductance meter arranged to measure conductance between the wires, and biological material associated with the coronavirus disposed on or in the chip. Related apparatus and methods are also described.
    Type: Grant
    Filed: August 18, 2021
    Date of Patent: January 31, 2023
    Inventor: Dorit Arad
  • CORONAVIRUS-KILLING AND SCALP CARE DEVICE USING CARBON HEATING MAT
    Publication number: 20230218430
    Abstract: Provided is a coronavirus-killing and scalp care device using a carbon heating mat. Carbon heating mats are applied to a coronavirus-killing face cover and a scalp cover which are coupled to or separated from each other as necessary, and a filter part for accommodating a scent material is formed around a nose and mouth portion of the coronavirus-killing face cover. Therefore, a temperature of the scalp is raised to boost immunity, prevent hair loss, and the like, heat is introduced into the human body during breathing through the nose and mouth to kill various disease-causing pathogens (particularly, coronaviruses) in the human body, and a scent material filling the filter part is fumigated by heat generated by the carbon heating mats and introduced into the human body through breathing to prevent and cure diseases.
    Type: Application
    Filed: February 16, 2022
    Publication date: July 13, 2023
    Inventor: Billian Ducwong HYUN
  • MESSENGER RNA VACCINES AGAINST WIDE SPECTRUM OF CORONAVIRUS VARIANTS
    Publication number: 20240066113
    Abstract: The present invention relates to the mRNA vaccine of coronavirus spike protein with deletion of glycosites in the receptor binding domain (RBD), the subunit 1 (S1) domain, or the subunit 2 (S2) domain, or a combination thereof. The vaccine elicits broadly protective immune responses coronavirus and variants thereof.
    Type: Application
    Filed: April 12, 2022
    Publication date: February 29, 2024
    Inventors: Chi-Huey WONG, Chung-Yi WU, Che MA, Chen-Yu FAN
  • MODIFIED S1 SUBUNIT OF THE CORONAVIRUS SPIKE PROTEIN
    Publication number: 20230340028
    Abstract: The present invention relates i.a. to a recombinant avian coronavirus spike protein or fragment thereof comprising a mutation at amino acid position 267 to Cysteine. Further, the present invention relates to an immunogenic composition comprising an avian coronavirus with such spike protein.
    Type: Application
    Filed: November 28, 2022
    Publication date: October 26, 2023
    Applicant: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Annika KRAEMER-KUEHL, Thomas Min STEPHAN, Hans-Christian PHILIPP
  • NUCLEIC ACID VACCINE AGAINST THE SARS-COV-2 CORONAVIRUS
    Publication number: 20240024462
    Abstract: The invention relates to an immunogenic or vaccine composition against the 2019 novel coronavirus (SARS-CoV-2), comprising a nucleic acid construct encoding a SARS-CoV-2 coronavirus Spike (S) protein antigen or a fragment thereof comprising the receptor-binding domain, wherein the nucleic acid construct sequence is codon-optimized for expression in human.
    Type: Application
    Filed: September 12, 2023
    Publication date: January 25, 2024
    Inventors: Etienne SIMON-LORIERE, Matthieu PROT, Xavier MONTAGUTELLI
  • RT-PCR DETECTION METHOD AND KIT FOR NOVEL CORONAVIRUS
    Publication number: 20230114907
    Abstract: A real-time fluorescence RT-PCR detection method and a kit for a novel coronavirus 2019-nCoV. Specifically, the present invention relates to a kit and a method for detecting the nucleic acid of an E gene of the novel coronavirus 2019-nCoV. The kit and the method have extremely high sensitivity and specificity, and can significantly improve the accuracy of virus identification.
    Type: Application
    Filed: December 30, 2020
    Publication date: April 13, 2023
    Inventors: Xiwen JIANG, Zhihui LIAO, Jian FAN
  • HIGHLY-NETWORKED CORONAVIRUS IMMUNOGEN COMPOSITION
    Publication number: 20230302083
    Abstract: A method of preventing or treating COVID infection in a subject includes selecting two or more COVED CTL epitopes from a Coronavirus proteome that have a network score that meets a threshold value. An effective amount of a T cell immunogen composition and a pharmaceutically acceptable carrier is administered to the subject. The T cell immunogen composition includes the two or more selected Coronavirus CTL epitopes.
    Type: Application
    Filed: April 20, 2021
    Publication date: September 28, 2023
    Inventors: Gaurav GAIHA, Elizabeth Jeffries ROSSIN
  • Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Peptide Epitopes
    Publication number: 20230263883
    Abstract: Peptide epitopes identified in subjects infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and methods of use thereof for diagnosing, determining prognosis, and treating Coronavirus Disease 2019 (COVID-19), and developing prophylactic or therapeutic vaccines against SARS-CoV-2.
    Type: Application
    Filed: July 8, 2021
    Publication date: August 24, 2023
    Inventors: Stephen J. Elledge, Ellen Shrock, Eric Fujimura
  • METHODS FOR IDENTIFYING CORONAVIRUS CROSS-REACTING ANTIBODIES
    Publication number: 20230151080
    Abstract: The disclosure provides methods for identifying coronavirus cross-reacting antibodies. Such antibodies bind to at least part of the S2 ectodomain of the S protein of at least one common human coronavirus selected from HCoV-NL63, HCoV-OC43, HCoV-229E and HCoV-HKU1 and bind to at least part of the S2 ectodomain of the S protein of at least one highly pathogenic human coronavirus selected from SARS-CoV-1, MERS-CoV and SARS-CoV-2. Antibodies identified by the methods described herein are particularly useful for treating or preventing coronaviral infections, in particular against highly pathogenic coronaviruses such as SARS-CoV-1, MERS-CoV and/or SARS-CoV-2 as well as cross-species transmission of typically non-human coronaviruses.
    Type: Application
    Filed: July 9, 2021
    Publication date: May 18, 2023
    Inventors: Jaap Goudsmit, Marit Johanna Van Gils, Rogier Willem Sanders
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