Abstract: Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(?S)—, —S(O)—, —S(O)2—, —C(?O)—, —O—, —C(R6)(R7)—, —N(R5)— or —C(?N(R5))—; X is —O—, —N(R5)— or —C(R6)(R7)—; provided that when X is —O—, U is not —O—, —S(O)—, —S(O)2—, —C(?O)— or —C(?NR5)—; U is a bond, —S(O)—, —S(O)2—, —C(O)—, —O—, —P(O)(OR15)—, —C(?NR5)—, —(C(R6)(R7))b— or —N(R5)—; wherein b is 1 or 2; provided that when W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, U is not —S(O)—, —S(O)2—, —O—, or —N(R5)—; provided that when X is —N(R5)— and W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, then U is not a bond; and R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I.

Abstract: The present invention relates to a method for making a polymer wherein during ring opening polymerisation is incorporated into the polymer chain at least one cyclic (alkyl) carbonate monomer having the formula (1) wherein Y is optional and represents the residue of a sulfhydryl reacted group, X represents a functional group reactive with a sulfhydryl group, L=—[CH2]n with n=0-10, or L=—[CH2]p-S—S—[CH2]q with p and q are 0-5 or L=-[PEG]- with PEG is a group that comprises a —[CH2CH2O]m-group with m=1-200, and R2 is hydrogen, methyl or ethyl. Optionally a cyclic (alkyl) acryloyl carbonate, or other additional monomer A may be used as comonomer. The polymer may be formed into a polymer article, such as a polymer film, such as a coating and modified and/or cross linked, to a polymer or polymer article obtainable, and to a biodevice, their use, and to the cyclic (alkyl)carbonates.

Abstract: A mobile power pack includes a cover over a guide track which includes first, second, third, and fourth turning points. A sliding block defines a sliding groove to receive a ball, and the slotted ball interacts with the guide track. An elastic element is connected to the sliding block. When a cable is pulled out, the sliding block slides from the first turning point to the second turning point. When the pull on the cable is released, the elastic element restores to cause the sliding block to move until the ball reaches the third turning point, to lock the cable in position. When the cable is pulled and released, the sliding block slides until the ball reaches the fourth turning point, allowing the cable to be retracted into the body of the power pack.

Abstract: A PLC includes a single-chip, a DC power module, a relay output module, an I/O module, and a pulse output module. The single chip includes a single-chip timer, a hardware watchdog, a 11.0592M crystal, and an A/D converter module. A system program is burned into an EEPROM (Electrically Erasable Programmable Read-Only Memory) of the single-chip. The system program includes a programming module and a control module. A DC power module includes an anti jamming circuit, a first output port, and a second output port. The first output port and the second output port are respectively connected to the anti-jamming circuit, and the single-chip is connected to the first output port. A relay output module is connected to the second output port. An I/O module receives and sends digital signals.

Abstract: A portable mold-temperature control unit includes a local heating system, a first fluid duct, a second fluid duct, and a fluid exchange system. The local heating system includes a local heater for heating fluid that is used to rapidly heat a mold. The first fluid duct carries hot fluid heated by the local heating system. The second fluid duct carries cool fluid that is used to rapidly cool a mold. The fluid exchange system includes an outlet that permits fluid to flow from the first and second fluid ducts to the mold during heating and cooling, respectively. The fluid exchange system also includes an inlet that receives the fluid as it returns from the mold. In one embodiment, the heating system reheats the fluid returning from the mold and reuses it to heat the mold again. In a more particular embodiment, the heating system includes a steam generator that generates steam used to heat the mold.

Abstract: One embodiment of the present invention sets forth a technique for extracting a memory address offset from a 64-bit type-conversion expression included in high-level source code of a computer program. The technique involves receiving the 64-bit type-conversion expression, where the 64-bit type-conversion expression includes one or more 32-bit expressions, determining a range for each of the one or more 32-bit expressions, calculating a total range by summing the ranges of the 32-bit expressions, determining that the total range is a subset of a range for a 32-bit unsigned integer, calculating the memory address offset based on the ranges for the one or more 32-bit expressions, and generating at least one assembly-level instruction that references the memory address offset.

Abstract: A sustained-release pharmaceutical composition of topiramate, which is free of binding agent. The sustained-release pharmaceutical composition of topiramate is a sustained-release pellet, comprising a blank pellet core, a drug layer, and a sustained-release coating layer.

Abstract: A heat assisted magnetic recording (HAMR) transducer on a slider and including first and second opposing surfaces, wherein the first surface is aligned to an air bearing surface (ABS) of the slider and the second surface is aligned to a surface of the slider opposite the ABS, a target waveguide having an entrance at the second surface, the target waveguide being configured to direct energy provided by a light source from the entrance toward the first surface, wherein the target waveguide expands in cross-section area with distance from the entrance to form an inverse taper waveguide, a plurality of assistant waveguides each having an entrance at the second surface, wherein the plurality of assistant waveguides are configured to direct energy to the plurality of output devices.

Abstract: The present disclosure relates to a method and apparatus for troubleshooting based on log similarity. In one embodiment, there is provided a method for troubleshooting based on log similarity, comprising: extracting log patterns from multiple log files in response to having collected the multiple log files from at least one system with troubles, the log pattern describing a regular expression to which a log message in a log file among the multiple log files conforms; building a pattern repository using the log patterns; mapping each of the multiple log files to an n-dimensional vector based on the pattern repository; and clustering multiple n-dimensional vectors to which each of the multiple log files is mapped into at least one group, wherein each of the at least one group indicates one trouble type of the at least one system. In another embodiment, there is provided a corresponding apparatus.

Abstract: The present invention relates to a touch technology field, provides a touch detecting method for a touch sensor, the method comprises the following steps: putting the touch sensor into a mutual capacitance mode and a self capacitance mode alternatively, and scanning and detecting the rows and columns of a capacitance array of the touch sensor; when a touch state is preliminarily judged as a multi-touch according to a scanning and detecting result in the mutual capacitance mode, implementing envelopment analysis for data obtained by sampling in the self capacitance mode, determining whether the touch state in the mutual capacitance mode is a single touch or the multi-touch, outputting one touch coordinate if the touch state is the single touch; and outputting a plurality of touch coordinates if the touch state is the multi-touch. The present invention also provides a touch detecting system and a touch terminal for the touch sensor.

Abstract: Embodiments of the present invention disclose a method and apparatus for speeding up Web page access, pertaining to the network field. The method includes: acquiring a URL address initiated by a user; judging whether the URL address is stored in a preset cache database, where the cache database stores a plurality of mapping relationships between URL addresses and cache data; and when it is judged that the URL address is stored in the preset cache database, acquiring cache data corresponding to the URL address from the cache database, processing the cache data, and rendering the Web page. According to the embodiments of present invention, logic for implementing the cache database is added at the browser end. In this way, no matter a Web server or a proxy server complies with the HTTP.

Abstract: Provided is a lithium ion battery including a battery can, a battery core received in the battery can, electrolyte filled in the battery can, and a battery cover assembled to the battery can. The battery can or the battery cover is provided with a pressure relief valve, and the pressure relief valve is coupled with a mesh cover defining a number of through holes therein. According to the present invention, when thermal runaway occurs to the lithium ion battery, the pressure relief valve breaks timely. Only gases and electrolyte vapor can pass through the mesh cover. Solid particles cannot pass through the mesh cover. Therefore, ignition of the flammable gases, the electrolyte vapor and the high temperature solid particles in the surrounding air afar from the pressure relief valve is avoided and the safety performance of the lithium ion battery can be improved remarkably.

Abstract: The present disclosure relates to boron-based 4-hydroxytamoxifen and endoxifen prodrugs and the synthesis of the same. Further, the present disclosure teaches the utilization of the boron-based 4-hydroxytamoxifen and endoxifen prodrugs in a treatment for breast cancer.

Abstract: MRI techniques are widely and successfully applied in medicine and biophysics because MRI provides good contrast between different soft tissues without ionizing radiation. MRI protocols are optimized in four aspects: imaging parameters, k-space strategies, RF system calibration and contrast inhomogeneity correction. The signal intensities of normal and disease tissues are simulated, for example, using Bloch equations for an imaging sequence with tissue MR parameters. The relationships between imaging parameters and tissue contrasts are calculated using the numerically simulated signal intensities. The optimal imaging parameters and/or k-space strategies are determined to maximize image contrast and minimize artifacts with acceptable spatial-temporal resolution based on characterization of the imaging hardware. The RF system is optionally calibrated to improve the accuracy of the imaging parameters and reduce inter-scanner variability.

Abstract: The present disclosure provides an electrochemical device, which comprises a plurality of cells which are stacked in a step configuration, electrode tabs of the same polarity of the plurality of cells are electrically connected together. Compared with only using a single wound-type cell or only using a single laminated-type cell, the plurality of cells stacked in the step configuration of the present disclosure can more flexibly adapt to an irregular inner space of an electronic device using the electrochemical device, so that the inner space in the electronic device is fully used, the performance of the electrochemical device for use in the electronic device is improved, and the manufacturing process is more simple, flexible and efficient.

Abstract: The present invention relates to a system and method for monitoring lubricant of an engine. The system for monitoring lubricant of an engine comprises: a lubricant sensor, which measures lubricant quantity of the engine; a data acquisition unit, which collects the lubricant quantity of the engine from the lubricant sensor at a fixed time interval; and a message generation unit, which generates lubricant quantity monitoring messages according to the lubricant quantity of the engine collected by the data acquisition unit.

Abstract: A method includes generating a test model based on at least one of test group dependencies and test group constraints and generating a resource base. the method includes generating a cost model and generating a resource allocation plan based on the test model, the resource base, and the cost model.

Abstract: A connecting assembly includes a first connecting device, a second connecting device, a guide member, and a locking assembly. The first connecting device defines a first through hole. The second connecting device defines a second through hole, and has a latching member protruding from the inner surface of the second connecting device and extending into the second through hole. The guide member defines a first guiding slot and a second guiding slot coupled to the first guiding slot. The first connecting device is fixed to the guide member. The locking assembly has a bar, a locking block, and a sliding block. The locking block is fixed to the top of the bar. The sliding block protrudes from the lateral side of the bar and is received in the first guiding slot.

Abstract: Systems and methods are provided for providing improved de-noising image content by using directional noise filters to accurately estimate a blur kernel from a noisy blurry image. In one embodiment, an image manipulation application applies multiple directional noise filters to an input image to generate multiple filtered images. Each of the directional noise filters has a different orientation with respect to the input image. The image manipulation application determines multiple two-dimensional blur kernels from the respective filtered images. The image manipulation application generates a two- two-dimensional blur kernel for the input image from the two-dimensional blur kernels for the filtered images. The image manipulation application generates a de-blurred version of the input image by executing a de-blurring algorithm based on the two-dimensional blur kernel for the input image.

Abstract: A light roofing system is formed of a substrate layer and a waterproof surface layer. The waterproof surface layer comprises a functional coating layer made of functional paint and a waterproof layer made of waterproof paint, the functional paint comprises a base material and functional materials, and the functional materials comprise an inorganic flaky material, an inorganic high-rigidity wear-resistant material, and polymer powder with good toughness. The addition amount of the inorganic flaky material accounts for 1% to 8% of the total weight of the functional paint, the addition amount of the inorganic high-rigidity wear-resistant material accounts for 2% to 15% of the total weight of the functional paint, and the addition amount of the polymer powder with good toughness accounts for 1% to 8% of the total weight of the functional paint.