Abstract: The present invention is directed to substituted azoanthracene derivatives or pharmaceutically acceptable salts thereof that modulate the human GLP-1 receptor and that may be useful in the treatment of diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial, such as diabetes mellitus type 2. The invention is also directed to pharmaceutical compositions comprising these compounds and to the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial.

Abstract: Processes are provided for forming film adhesives (10). The processes include applying an adhesive (18), such as a Bisphenol A epoxy resin, to a membrane (14), and partially curing the adhesive (18). The resulting film adhesives (10) can be shipped and stored at room temperature. The film adhesives (10) can be used to bond components such as, but not limited to printed wireboards (11, 12) and other substrates. A structural bond between the components can be formed by fully curing the resin (18) while the resin (18) is in contact with at least one of the components.

Abstract: A composite film useful for image supporting media, including: a first layer containing a thermoplastic polymer and optionally containing a whitening agent; a second layer containing a thermoplastic polymer and a whitening agent; a third layer containing a thermoplastic polymer and a cavitating agent, wherein the third layer is a cavitated layer; optionally a fourth layer containing a thermoplastic polymer and optionally a whitening agent; and optionally a fifth layer containing a thermoplastic polymer and optionally a whitening agent; wherein the second layer is between the first layer and the third layer, the third layer is between the second layer and the optional fourth layer, and the optional fourth layer is between the third layer and the optional fifth layer. Embodiments may have the advantage(s) of improved outer surface characteristics, compressibility, thermal insulation, whiteness, and/or stiffness.

Abstract: The subject disclosure is directed towards data deduplication (optimization) performed by phases/modules of a modular data deduplication pipeline. At each phase, the pipeline allows modules to be replaced, selected or extended, e.g., different algorithms can be used for chunking or compression based upon the type of data being processed. The pipeline facilitates secure data processing, batch processing, and parallel processing. The pipeline is tunable based upon feedback, e.g., by selecting modules to increase deduplication quality, performance and/or throughput. Also described is selecting, filtering, ranking, sorting and/or grouping the files to deduplicate, e.g., based upon properties and/or statistical properties of the files and/or a file dataset and/or internal or external feedback.

Abstract: A system of rotate-to-advance medical devices including catheters, dilators, occluders, stents, suprapubic catheters and camera introducers configured with external screw threads and depending substantially on rotation for means of advancement and emplacement in mammalian genitourinary and gastrointestinal passages and organs.

Abstract: The system includes a housing having a light transmission window and produces an extremely-elongated laser beam having an elongation ratio (ER) that is defined as greater than 4.5 for any point within the working range of the laser scanning bar code symbol reading system. A laser scanning mechanism is provided for scanning the extremely-elongated laser beam out the light transmission window and across a scanning field defined external to the housing, in which a bar code symbol is present for scanning by the extremely-elongated laser scanning beam.

Abstract: A method and system to allow wireless devices, such as wirelessly-equipped digital cameras, to gain wireless packet-data connectivity and to interact with a media management server, such as a photo server. A wireless carrier distributes multiple devices all having the same set of radio access data (e.g., mobile identification number and electronic serial number), and all having shared or unique pre-registration data. Any such device can then readily use the shared radio access data to acquire radio connectivity and can then use the pre-registration data to gain access to the media management server. The first time such a device connects with the media management server using the pre-registration data, the server will engage in a online account registration session with the device and provision the device with post-registration data that the device can thereafter use to access the online account.

Abstract: An impeller includes a hub, and a plurality of blades supported by the hub, the blades being arranged in at least two blade rows. The impeller has a deployed configuration in which the blades extend away from the hub, and a stored configuration in which at least one of the blades is radially compressed, for example by folding the blade towards the hub. The impeller may also have an operational configuration in which at least some of the blades are deformed from the deployed configuration upon rotation of the impeller when in the deployed configuration. The outer edge of one or more blades may have a winglet, and the base of the blades may have an associated indentation to facilitate folding of the blades.

Abstract: Methods and devices are provided for performing various procedures using interchangeable end effectors. In general, the methods and devices allow a surgeon to remotely and selectively attach various interchangeable surgical end effectors to a shaft located within a patient's body, thus allowing the surgeon to perform various procedures without the need to remove the shaft from the patient's body. In an exemplary embodiment, multiple end effectors can be introduced into a body cavity. The end effectors can be disassociated or separate from one another such that they float within the body cavity. A distal end of a shaft can be positioned within the body cavity and it can be used to selectively engage one of the end effectors. In particular, the device can be configured to allow each end effector to be remotely attached and detached from the distal end of the shaft.

Abstract: A wetness sensor includes a self-supporting substrate and an electrically conductive trace carried by the substrate. The trace is patterned to provide at least a portion of a tuned RF circuit, which may be disposed on only one side of the substrate and characterized by an impedance or resistance. The trace is not self-supporting. The substrate is adapted to dissolve, swell, or otherwise degrade when contacted by a target fluid. Such degradation produces a drastic change in the operation of the RF circuit, which can be interpreted by a remote reader as a “wet” condition. Contact of the substrate by the target fluid may change the impedance or resistance of the RF circuit by at least a factor of 5, 10, 100, or 1000, and/or may cause the trace to disintegrate so as to provide the RF circuit with an open circuit, and/or may substantially render the RF circuit inoperative.

Abstract: A wetness sensor includes a substrate that carries a tuned RF circuit. The circuit includes a conductive pattern applied to the substrate, a capacitor, and a jumper all disposed on a same side of the substrate. The conductive pattern includes an inductive coil, and an inner and outer terminus. The jumper electrically couples the inner terminus to the outer terminus. The jumper also includes a frangible link which, when contacted by a target fluid, produces a drastic change in the operation of the RF circuit. The drastic change can be interpreted by a remote reader as a “wet” condition. Contact of the frangible link by the target fluid may change the impedance or resistance of the RF circuit by at least a factor of 5, 10, 100, or more, and/or may cause the frangible link to disintegrate to produce an open circuit, and/or may substantially render the RF circuit inoperative.

Abstract: A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte.

Abstract: A device for delivering therapeutic energy to tissue is provided. The device includes a proximal segment and a distal segment having one or more electrodes for delivering the therapeutic energy to the tissue. An articulating segment connects the proximal segment and the distal segment such that the distal segment is articulatable with respect to a longitudinal axis of the proximal segment. In one aspect of the invention, the articulating segment includes a living hinge. In another aspect of the invention, at least one electrically conductive articulating cable runs along the articulating segment, wherein the articulating cable is used both to articulate the distal segment and to deliver the therapeutic energy to the one or more electrodes.

Abstract: An application-specific integrated circuit and related network switch are disclosed. The integrated circuit includes switch circuitry for receiving a 802.11 wireless data frame and forwarding it to a predetermined port. Inspection circuitry is provided for inspecting attributes of the data frame. Decision circuitry is provided for instructing the switch circuitry to forward the data frame based on the attributes, both 802.3 wired and 802.11 wireless.

Abstract: Disclosed are systems and methods for monitoring a fluid for the purpose of identifying microbiological content and/or microorganisms and determining the effectiveness of a microbiological treatment. One method of monitoring a fluid includes containing the fluid within a flow path, the fluid including at least one microorganism present therein, optically interacting electromagnetic radiation from the fluid with at least one integrated computational element, thereby generating optically interacted light, receiving with at least one detector the optically interacted light, and generating with the at least one detector an output signal corresponding to a characteristic of the fluid, the characteristic of the fluid being a concentration of the at least one microorganism within the fluid.

Abstract: The disclosure relates to methods and materials useful for polymerizing a monomer. In one embodiment, for example, the disclosure provides a method for polymerizing a monomer containing a plurality of electrophilic groups, wherein the method comprises contacting the monomer with a nucleophilic reagent in the presence of a guanidine-containing catalyst. The methods and materials of the disclosure find utility, for example, in the field of materials science.

Abstract: Methods and systems to detect droop events on-chip, which may include a sensor circuit located adjacent to a voltage node to convert a corresponding voltage to a digital count or value indicative of the voltage. The sensor circuit may include an n-stage ring oscillator and an asynchronous counter. The sensor circuit may include circuitry to capture and convert a phase associated with a count to a binary fractional value to increase voltage resolution. Multiple counts associated with the node may be evaluated at the node to identify minimum and maximum counts and corresponding time stamps. More complex evaluation and control circuitry may be shared amongst a plurality of sensor circuits and may include circuitry to generate and compare counts to one or more variable thresholds, circuitry to average counts over time, and memory to store state values associated with the sensors.

Abstract: Methods and systems are provided for producing syngas utilizing heat from thermochemical conversion of a carbonaceous fuel to support decomposition of at least one of water and carbon dioxide using one or more solid-oxide electrolysis cells. Simultaneous decomposition of carbon dioxide and water or steam by one or more solid-oxide electrolysis cells may be employed to produce hydrogen and carbon monoxide. A portion of oxygen produced from at least one of water and carbon dioxide using one or more solid-oxide electrolysis cells is fed at a controlled flow rate in a gasifier or combustor to oxidize the carbonaceous fuel to control the carbon dioxide to carbon monoxide ratio produced.

Abstract: The present disclosure generally pertains to systems and methods for swapping span power modules that are used for supplying power to network interface units (NIUs). A span power module in accordance with one exemplary embodiment of the present disclosure has logic capable of communicating with logic of another span power module. When one module is to be swapped for the other module, the module being swapped-in is configured to automatically disable the other module shortly after it has powered up and is supplying electrical power across a span line. The amount of time that both modules supply power to the span line is sufficiently small such that damage to electrical communication equipment receiving power from the span line is prevented.

Abstract: A light source includes a substrate arranged into at least two facing surfaces which form a seam therebetween; and a lighting device with light emitting diode (LED) chips embedded therein in a linear arrangement. The LED chips generate light photons. The lighting device has a first edge and a second edge opposite to the first edge, the light photons within the lighting device that are emitted by the LED chips from a top surface of the LED chips being output from the lighting device at the second edge of the device. The lighting device is sandwiched in the seam between the two facing surfaces, the second edge of the lighting device being exposed when the seam is in an opened position.