Abstract: Provided herein are methods for alleviating symptoms in a subject having a neurodegenerative disorder, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) or to its Plexin-B1 or Plexin-B2 receptors.

Abstract: A trailer mounted proportional brake controller for a towed vehicle and a method of controlling the brakes of a towed vehicle is described. The brake control unit may control the brakes of a towed vehicle. The brake control unit may include a power control unit and a hand control unit. The power control unit may be connected to the brakes of the towed vehicle and the power control unit may be capable of selectively controlling the brakes of the towed vehicle based on a set of braking parameters. The hand control unit may be configured to remotely communicate with the power control unit. The hand control unit may be capable of transmitting information to the power control unit to adjust at least one of the braking parameters and receiving information from the power control unit.

Abstract: A method for providing real-time monitoring of and advice relative to user's personal finances is provided. One or more financial goals are received from a user. Financial data associated with the user and stored in one or more financial information data sources is accessed. The accessed financial data is analyzed based upon the one or more financial goals. One or more financial recommendations are provided based on the analyzed financial data and responsive to an occurrence of a user event related to an expenditure of user's funds.

Abstract: Receiver circuitry is disclosed that can take circuit branches offline to possibly adapt an offset value. In one embodiment, a circuit in a receiver has at least two branches. Each branch includes an adjustor to adjust the branch signal by an offset value. Selection circuitry takes one of the branches offline by selecting the output of that branch as an offline value, and by selecting the output of one or more of the other branches as a data decision value. The selection circuitry changes which branch is taken offline during the operation of the circuit. When a branch is taken offline, an offset value associated with that branch may be updated, if necessary.

Abstract: Examples of generating power through the flow of water are disclosed. In one example, remote water meter monitoring system includes an energy converter and a sensor. The energy converter is in fluid connectivity with water flowing through a pipe, the energy convertor being driven by a mechanical energy of water flowing through the pipe to convert the mechanical energy into an electrical energy for charging a battery connected to the energy converter. The sensor detects a level of a property of the water, the sensor being powered by the battery connected to the energy converter.

Abstract: A seafloor bulk mining tool for production cutting of a seafloor bench. The tool uses a tracked locomotion system to travel across a seafloor bench. Power and control interfaces receive power and control signals from a surface source. The tool has a drum cutter for cutting the bench, and a sizing grill adjacent the drum cutter for sizing cuttings as they are produced by the drum cutter. A drum shroud may also be provided to help contain cuttings. A suction inlet can be used to capture cuttings as they are produced, for example in conjunction with a spade and augers.

Abstract: An acoustic device having a neck loop that is constructed and arranged to be worn around the neck. The neck loop includes housing that defines an acoustic volume, a first acoustic driver located at a first distal end of the housing and acoustically coupled to the housing, and a second acoustic driver located at a second distal end of the housing, opposite the first distal end and acoustically coupled to the housing.

Abstract: Described herein are devices, systems, and methods for determining the composition of liquids, including the identity of one or more drugs in the liquid, the concentration of the drug, and the type of diluent using immittance spectroscopy. These devices, systems and methods are particularly useful for describing the identity and, in some variations, concentration of one or more components of a medical liquid such as intravenous fluid.

Abstract: In a method of producing isotopes in a light water power reactor, one or more targets within the reactor may be irradiated under a neutron flux to produce one or more isotopes. The targets may be assembled into one or more fuel bundles that are to be loaded in a core of the reactor at a given outage. Power operations in the reactor irradiate the fuel bundles so as to generate desired isotopes, such as one or more radioisotopes at a desired specific activity or stable isotopes at a desired concentration.

Abstract: An apparatus may include an interface to receive a multiplicity of user information samples at a respective multiplicity of instances; a processor circuit, and an entropy multiplexer for execution on the processor circuit to generate a pseudo random number based upon a pseudo random number seed and pseudo random number algorithm for each user information sample of the multiplicity of user information samples. Other embodiments are described and claimed.

Abstract: A pressure nitrided stainless steel hybrid ball bearing having an inner ring, an outer ring, and rolling elements disposed therebetween. The pressure nitrided stainless steel hybrid bearing has one or more component(s) made from a pressure nitrided stainless steel material. The pressure nitrided stainless steel hybrid bearing used with a refrigerant lubrication for chiller applications leads to a very long useful life time.

Abstract: A method for drag reducing low molecular weight liquids is provided. More specifically, a method to separate drag reducers from low molecular weight liquids, such as hydrocarbons and anhydrous ammonia, is provided.

Abstract: Disclosed herein are systems, methods, and non-transitory computer-readable storage media for erasing user data stored in a file system. The method includes destroying all key bags containing encryption keys on a device having a file system encrypted on a per file and per class basis, erasing and rebuilding at least part of the file system associated with user data, and creating a new default key bag containing encryption keys. Also disclosed herein is a method of erasing user data stored in a remote file system encrypted on a per file and per class basis. The method includes transmitting obliteration instructions to a remote device, which cause the remote device to destroy all key bags containing encryption keys on the remote device, erase and rebuild at least part of the file system associated with user data, and create on the remote device a new default key bag containing encryption keys.

Abstract: In various embodiments, a surgical stapling instrument can include a handle, a shaft extending from the handle, wherein the shaft defines an axis, and a disposable loading unit which is assembled to the shaft in a direction which is transverse to the shaft axis. Such a connection between the disposable loading unit and the shaft can prevent, or at least inhibit, the disposable loading unit from being unintentionally displaced proximally and/or distally relative to the shaft of the surgical instrument. The surgical stapling instrument and/or disposable loading unit can further include a threaded collar and/or detent assembly configured to hold the disposable loading unit in place. In various embodiments, a disposable loading unit can include a lockout feature which can prevent, or at least inhibit, an expended disposable loading unit from being reassembled to the elongated body of the surgical instrument.

Abstract: Systems, methods, and computer program products for recommending multimedia content for inclusion in a message for transmission from a first computing device to a second computing device, is disclosed. A server may receive a plain text message from the first computing device. The server may then parse the plain text message to create a parsed plain text message comprising one or more words and characters. The server may then query a multimedia content database for multimedia content matching a portion of the parsed plain text message. The matched portion, or portions, of the multimedia content are then presented as recommendations on a user interface of the first computing device, to a user of the first computing device, for inclusion as part of a message for transmission to the second computing device.

Abstract: A modular water based heating and cooling system for providing chilled or heated water to terminal devices in a building to heat/cool individual zones in the building. The system includes a flow control device in fluid communication with a riser chilled water supply line, a riser chilled water return line, a riser heated water supply line, and a riser heated water return line. The flow control device includes first control valves and second control valves. Terminal device supply lines extend from the flow control device and are connected to respective first control valves. Terminal device return lines extend from the flow control device and are connected to respective second control valves. The first control valves and the second control valves cooperate to supply required chilled water or heated water through the terminal device supply lines to terminal devices based on the cooling/heating requirements of the terminal devices.

Abstract: In an enterprise where a database maintains multiple accounts for business customers, a method, system, and computer program product correctly links accounts which are associated with a common business. Business identification information from one or more external data sources is obtained and the format of the business identification data is standardized. Data records of business accounts are compared according to a plurality of rules for matching one business account to another. When two business accounts are found to match according to the business matching rules, a common identifier is applied to both business accounts to flag the two accounts as being associated with the same business entity. One or more hierarchy rules are applied to accounts associated with a common business, to establish a hierarchy among the accounts for purposes of marketing and other business communications.

Abstract: Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X?NRX then n is 1 or 2 and if X?CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.

Abstract: In various embodiments, a surgical stapling instrument can include a handle, a shaft extending from the handle, wherein the shaft defines an axis, and a disposable loading unit which is assembled to the shaft in a direction which is transverse to the shaft axis. Such a connection between the disposable loading unit and the shaft can prevent, or at least inhibit, the disposable loading unit from being unintentionally displaced proximally and/or distally relative to the shaft of the surgical instrument. The surgical stapling instrument and/or disposable loading unit can further include a threaded collar and/or detent assembly configured to hold the disposable loading unit in place. In various embodiments, a disposable loading unit can include a lockout feature which can prevent, or at least inhibit, an expended disposable loading unit from being reassembled to the elongated body of the surgical instrument.

Abstract: An turbocharger includes a parallel twin-impeller compressor and separate inlets into the two impellers. A first or outboard impeller receives one stream of inlet air and a second or inboard impeller receives its own separate stream of inlet air by way of a generally annular inlet volute surrounding the inlet to the second impeller. Air is fed from the inlet volute radially inwardly through a feed passage to the inlet to the second impeller. A plurality of inlet guide vanes are located in the feed passage for the second impeller, the inlet guide vanes creating a swirling air stream into the second impeller. Introduction of swirl to the second impeller alters the flow distribution between the impellers and affects the stability of the overall stage.