Search Patents
  • Chemical engines and methods for their use, especially in the injection of highly viscous fluids
    Patent number: 9795740
    Abstract: Chemical engines and processes for their use and construction are described. The chemical engines can provide powerful and compact devices, especially autoinjectors for the rapid, powered injection of viscous medicines. Novel formulations and designs of chemical engines and delivery technologies employing the chemical engines are described.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: October 24, 2017
    Assignee: Eli Lilly and Company
    Inventors: Amy M. Heintz, Corrie Bennison, Christopher H. Muenzer, Timothy M. Blum, Christopher P. McKenzie, Steven M. Madland, Jeffrey L. Ellis, Brian Kaseman
  • Battery efficient method to search for preferred femtocell
    Patent number: 9386431
    Abstract: Mobile user equipment (MUE) can be enabled to search for and camp on a preferred node, such as a home base node (HBN), in a battery-efficient manner even when currently camped on another node, such as a macro base node (MBN). When the MBN provides good channel quality, slow rate background intra- and inter-frequency searches can discover the preferred HBN that would otherwise not be discovered or would consume excessive power with continual searching. When channel quality is fair, slow rate background inter-frequency searches can result in timely switching to the preferred HBN. Location hints that indicate proximity of the preferred HBN can be used to trigger slow rate background searches. Neighboring cell searching of neighbor cell listing (NCL) when in channel quality is fair or poor are maintained to prepare for call reselections to available node.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: July 5, 2016
    Assignee: QUALCOMM Incorporated
    Inventors: Jen Mei Chen, Mehmet Yavuz, Sanjiv Nanda, Manoj M. Deshpande, Fracesco Pica
  • Methods of diagnosing and treating hyperproliferative disorders
    Publication number: 20170226201
    Abstract: The invention relates to compositions and methods for diagnosing and treating hyperproliferative disorders using ligands which specifically recognize the hypusine and/or folate binding region of mature eukaryotic translation initiation factor 5A (hypusine-containing eIF-5A). The invention further relates to methods of identifying molecules which displace immunoreagents binding to mature eIF-5A. Such agents are useful for treating hyperproliferative disorders.
    Type: Application
    Filed: January 2, 2014
    Publication date: August 10, 2017
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Hartmut M. Hanauske-Abel, Myung-Hee Park, Edith C. Wolff, Debra Sheldon-Heller, Bernadette M. Cracchiolo, Anthony Popowicz, Paul M. Clement
  • Vertical fabric vane weight system
    Patent number: 5094287
    Abstract: A vertical fabric vane weight system is used to interconnect a plurality of fabric vanes. The vertical vanes are secured at their top end to a head rail and the botton ends are freely movable. An enclosed pocket is formed adjacent to the bottom of each vertical vane, each vane having a weight positioned in its respective pocket. A continuous chain member interconnects the weights along one edge of the vanes. Clips are used to interconnect the continuous chain to each of the weights and are removable should the chain not be a desirable feature.
    Type: Grant
    Filed: November 1, 1990
    Date of Patent: March 10, 1992
    Assignee: M & B Mini-Blind Corp.
    Inventors: Jose M. Vargas, Mark H. Shanker
  • MULTI FUNCTIONAL TOXINS
    Publication number: 20240117374
    Abstract: Pesticidal proteins are provided that combine two or more modes of action into a single molecule. These pesticidal proteins therefor exhibit greater efficacy and/or durability of resistance, for the purposes of pest control, and can be utilized for pest control by provision in the diet of a pest organism, or by topical application to crop plants and/or pests. Methods and compositions for producing and using such proteins are also provided.
    Type: Application
    Filed: October 30, 2023
    Publication date: April 11, 2024
    Inventors: Timothy K. Ball, Artem G. Evdokimov, Larry A. Gilbertson, Victor M. Guzov, Jeffrey A. Haas, Qing Huai, Sergey Ivashuta, Melissa M. Kemp, Yifei Kong, Thomas M. Malvar, Byron V. Olsen, Parthasarathy Ramaseshadri, Brian E. Weiner
  • Pharmaceutical preparation containing a specific crystal modification of isopropyl-(2-methoxyethyl) 1,4-dihydro-2, 6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
    Patent number: 5599824
    Abstract: The invention relates to pharmaceutical preparations, containing a specific crystal modification (subsequently called "modification II") of isopropyl-(2-methoxyethyl) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (nimodipine) and to a process for its preparation.
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: February 4, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Alfons Grunenberg, Ahmed Hegasy, Wolfgang M uck, Gerhard Franckowiak, Rango-Rao Kanikanti
  • Control of the charging of pressurized gas-metal electrical storage cells
    Patent number: 4689544
    Abstract: A process and apparatus for controlling the charging of pressurized gas-metal cells such as nickel-hydrogen cells, to prevent detrimental overcharging, wherein the time rate of change of a battery gas pressure index is monitored as a control parameter. When the time rate of change of the index falls below a preselected value, charging is discontinued. The cell gas pressure index can be gas pressure itself, or a quantity which is responsive to, and depends upon gas pressure, such as the deformation of a cell component.
    Type: Grant
    Filed: October 17, 1985
    Date of Patent: August 25, 1987
    Assignee: Hughes Aircraft Company
    Inventors: Steven J. Stadnick, Howard H. Rogers
  • Method and system for presenting a multimedia title that is based on a multi-node structure while preferring nodes with a relatively spare visit history over nodes that have a relatively frequent visit history
    Patent number: 6006262
    Abstract: A method and system for presenting a multimedia title that is based on a multi-node structure while preferring nodes with a relatively spare visit history over nodes that have a relatively frequent visit history.For a multimedia title that is based on an information structure with a finite number of information nodes, first an entry point to the structure is presented to a user. Further, user visits as pertaining to specific nodes are logged, and a visit history of certain nodes is indicated to a user. In particular, the indicating prefers to present nodes with a relatively spare visit history over nodes that have a relatively frequent visit history.
    Type: Grant
    Filed: March 3, 1998
    Date of Patent: December 21, 1999
    Assignee: U.S. Philips Corporation
    Inventors: Graham G. Thomason, Joanne H. D. M. Westerink, Gijsberta M. M. Majoor, Maria d. l. M. Docampo Rama
  • Method and apparatus for storing interface information in a computer system
    Patent number: 5579482
    Abstract: An interface file structure for allowing transfer of information between nodes in a network and a binding process for configuring nodes in the network. The interface offers an advantageous format designed to provide for minimal reading and writing of records while requiring minimal storage space per record. Further, an advantageous format for storing numeric information is disclosed in which information providing the number of buffers allocated and the size of such buffers is stored in a single nibble thus reducing required storage space.
    Type: Grant
    Filed: July 26, 1995
    Date of Patent: November 26, 1996
    Assignee: Echelon Corporation
    Inventors: Robert L. Einkauf, Glen M. Riley, James M. Von De Bur
  • Constrained spirocyclic compounds as CGRP receptor antagonists
    Patent number: 7951795
    Abstract: Compounds of formula I: (wherein variables A1, A2, A3, G1, G2, G3, J, m, n, p, R1, R2, R3, R4 and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: May 31, 2011
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Ian M. Bell, Harold G. Selnick
  • Realtime ultrasonic imaging of perfusion using ultrasonic contrast agents
    Patent number: 6171246
    Abstract: Perfusion of tissue such as the myocardium by a microbubble contrast agent is imaged in realtime by a multiple pulse technique which uses low power transmit pulses which are sufficient to elicit a harmonic response from the microbubbles but are not high enough in power to cause substantial destruction to the microbubbles. In a preferred embodiment the realtime microbubble image sequence is displayed in color, overlaid with a grayscale image of the surrounding tissue in the region being imaged.
    Type: Grant
    Filed: April 29, 1999
    Date of Patent: January 9, 2001
    Inventors: Michalakis Averkiou, Jeffry E. Powers, Matthew Bruce, Danny M. Skyba
  • 90 human secreted proteins
    Publication number: 20030003555
    Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
    Type: Application
    Filed: February 1, 2001
    Publication date: January 2, 2003
    Inventors: Steven M. Ruben, Daniel R. Soppet, Reinhard Ebner, Henrik S. Olsen, Paul E. Young, John M. Greene, Ann M. Ferrie, Guo-Liang Yu, Jian Ni, Craig A. Rosen, Laurie A. Brewer, Fouad Janat
  • System and method for suppression of unwanted noise in ground test facilities
    Patent number: 8939253
    Abstract: Systems and methods for the suppression of unwanted noise from a jet discharging into a duct are disclosed herein. The unwanted noise may be in the form of excited duct modes or howl due to super resonance. A damper member is used to reduce acoustic velocity perturbations at the velocity anti-node, associated with the half-wave resonance of the duct, weakening the resonance condition and reducing the amplitudes of the spectral peaks.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: January 27, 2015
    Assignee: The United States of America as Represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Khairul B. M. Q. Zaman, Michelle M. Clem, Amy F. Fagan
  • Mitotic Kinesin Inhibitors
    Publication number: 20080287414
    Abstract: The present invention relates to tricyclic pyrazoles according to Formula (I) that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
    Type: Application
    Filed: June 27, 2005
    Publication date: November 20, 2008
    Applicant: MERCK & CO., INC.
    Inventors: Jeffrey M. Bergman, Paul J. Coleman, Mark E. Fraley, Robert M. Garbaccio, George D. Hartman, Chunze Li, Lou Anne Neilson, Christy M. Olson, Edward S. Tasber
  • Emulsified drug delivery systems
    Patent number: 5952004
    Abstract: A pharmaceutical preparation comprising a stable, surface-active emulsion or dispersion of a pharmaceutical agent incorporated into an emulsion (i) having a hydrophobic discontinuous phase of a long chain carboxylic acid or ester or alcohol thereof dispersed in an aqueous phase or (ii) having a hydrophilic discontinuous phase dispersed in a hydrophobic phase of a long chain carboxylic acid or alcohol thereof. The emulsion with pharmaceutical agent is incorporated into a pharmaceutical carrier suitable for oral delivery.
    Type: Grant
    Filed: August 28, 1995
    Date of Patent: September 14, 1999
    Assignee: Shire Laboratories Inc.
    Inventors: Edward Rudnic, John McCarty, Beth Burnside, Charlotte McGuinness, George Belenduik
  • Disubstituted Octahydropyrrolo[3,4-C]Pyrroles As Orexin Receptor Modulators
    Publication number: 20200048263
    Abstract: Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
    Type: Application
    Filed: October 15, 2019
    Publication date: February 13, 2020
    Inventors: Wenying Chai, Michael A. Letavic, Kiev S. Ly, Daniel J. Pippel, Dale A. Rudolph, Kathleen C. Sappey, Brad M. Savall, Chandravadan R. Shah, Brock T. Shireman, Akinola Soyode Johnson, Emily M. Stocking, Devin M. Swanson
  • HANDLING SYSTEM FOR GROUND-ENGAGING WEAR PARTS SECURED TO EARTH WORKING EQUIPMENT
    Publication number: 20170356167
    Abstract: A handling system for handling ground-engaging wear parts used on earth working equipment includes handling tools to remove and handle wear parts from equipment and/or to install new wear parts. The tools can include a torque or other tool to engage and/or disengage a lock retained by the wear member. The handling system allows an operator maintain a distance from heavy parts being removed or installed, reducing the risk of injury.
    Type: Application
    Filed: June 13, 2017
    Publication date: December 14, 2017
    Inventors: David M. Paul, Rodney K. Clarke, Christopher M. Carpenter, Noah D. Cowgill, Taylor M. Finley, Ryan J. Carpenter
  • Systems and methods for determining a level of reward
    Patent number: 8523670
    Abstract: A gaming system and method which includes enabling a first player at a first gaming device to initiate at least one play of a first game, enabling a second player at a second gaming device to initiate at least one play of a second game, determining, based at least in part on at least one activity of the first player, a benefit, and providing the determined benefit to the second player.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: September 3, 2013
    Assignee: IGT
    Inventors: Jay S. Walker, Geoffrey M. Gelman, James A. Jorasch, Stephen C. Tulley, Steven M. Santisi, Daniel E. Tedesco, Magdalena M. Fincham
  • Octasodium-1,1,2,2,4,4,5,5-cyclohexane octacarboxylate and compositions and methods employing same
    Patent number: 4092348
    Abstract: This disclosure relates to:(a) Compounds having the molecular structure represented by the formula: ##STR1## wherein X = COOM, where M is alkali metal, ammonium or trialkanolamine, and preferably is sodium;(b) solid and liquid detergent compositions incorporating compounds of a) supra, and(c) processes for washing comprising the use of compounds of a) and compositions of b), supra.
    Type: Grant
    Filed: March 3, 1977
    Date of Patent: May 30, 1978
    Assignee: Monsanto Company
    Inventors: Marvin M. Crutchfield, Charles J. Upton
  • Azetidinyl diamides as monoacylglycerol lipase inhibitors
    Patent number: 8697683
    Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Y, Z, R1, and s are defined herein.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: April 15, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Haiyan Bian, Kristen M. Chevalier, Jose Clemente, Peter J. Connolly, Christopher M. Flores, Shu-Chen Lin, Li Liu, John R. Mabus, Mark J. Macielag, Mark E. McDonnell, Philip M. Pitis, Yue-Mei Zhang, Sui-Po Zhang, Bin Zhu
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