Search Patents
  • Substituted pyridones having cytokine inhibitory activity
    Patent number: 6403596
    Abstract: There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which exhibit utility for the treatment of cytokine mediated diseases such as arthritis.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: June 11, 2002
    Assignee: Merck & Co., Inc.
    Inventors: Nigel J. Liverton, David A. Claremon, John W. Butcher, Cory R. Theberge
  • DIHYDROPYRAZOLE DERIVATIVES AS TYROSINE KINASE MODULATORS FOR THE TREATMENT OF TUMORS
    Publication number: 20110071153
    Abstract: Compounds of the formula I, in which R1, R2, R3?, R3, R4 and D have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: April 24, 2009
    Publication date: March 24, 2011
    Applicant: Merck Patent Gesellschaft
    Inventors: Dieter Dorsch, Oliver Schadt, Frank Stieber, Andree Blaukat
  • Imidazole compounds and their use as transglutaminase inhibitors
    Patent number: 5030644
    Abstract: Imidazole compounds including imidazoles and imidazolium salts, and their use as transglutaminase inhibitors are disclosed.
    Type: Grant
    Filed: July 31, 1989
    Date of Patent: July 9, 1991
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David C. Remy, David A. Claremon
  • Compounds having cytokine inhibitory activity
    Patent number: 6350744
    Abstract: There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which exhibit utility for the treatment of cytokine mediated diseases such as arthritis.
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: February 26, 2002
    Assignee: Merck & Co., Inc.
    Inventors: David A. Claremon, Gerald S. Ponticello
  • Removal of aldehyde impurity by reactive polystyrene resini
    Patent number: 7563807
    Abstract: A purification method in the preparation of a substituted 8-arylquinoline, wherein the aryl group at the 8-position contains a substituent substituted-alkenyl group, utilizes a polystyrene-based sulfonylhydrazine reactive resin to remove an aldehyde impurity.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: July 21, 2009
    Assignee: Merck & Co. Inc.
    Inventors: Mirlinda Biba, Paul Compton Collins, Christopher Joseph Welch, David A. Conlon, Antoinette Drahus
  • 3-aromatic and 3-heteroaromatic substituted bisnaphthalimides
    Patent number: 5641782
    Abstract: This invention relates to 3-Pyrimidinyl Bisnaphthalimides as Anticancer Agents and pharmaceutically acceptable salts thereof, of the formula: ##STR1## and processes for the preparation of such compounds, pharmaceutical composition containing such compounds, and methods of using such compounds to treat cancer, particularly solid tumor carcinomas, in mammals.
    Type: Grant
    Filed: February 16, 1995
    Date of Patent: June 24, 1997
    Assignee: The DuPont Merck Pharmaceutical Company
    Inventors: Jung-Hui Sun, Steven P. Seitz
  • Use of sigma receptor antagonists for treatment of cocaine abuse
    Patent number: 5180729
    Abstract: The invention relates to a method of treating cocaine abuse or addiction in a mammal which comprises administering to the mammal an effective amount of a sigma receptor antagonist lacking or having relatively weak dopamine receptor-blocking activity, to reduce the pharmacological effects of the cocaine.
    Type: Grant
    Filed: February 22, 1991
    Date of Patent: January 19, 1993
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventor: Leonard Cook
  • Inhibitors of farnesyl-protein transferase
    Patent number: 5854264
    Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: December 29, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Neville J. Anthony, Robert P. Gomez
  • Substituted-1,3,8-triazaspiro[4.5]decane-2,4-diones
    Patent number: 8921555
    Abstract: The present invention relates to substituted 1,3,8-triazaspiro[4.5]decame-2,4-diones useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
    Type: Grant
    Filed: June 7, 2010
    Date of Patent: December 30, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Joan M. Pierce, Jeffrey J. Hale, Shouwu Miao, Petr Vachal
  • SALTS COMPRISING A PYRIMIDINECARBOXYLIC ACID DERIVATIVE FOR COSMETIC USE
    Publication number: 20110152292
    Abstract: The invention relates to novel compounds which comprise, as cationic or as anionic component, a pyrimidinecarboxylic acid derivative, in particular a derivative of ectoin or hydroxyectoin, to a process for the preparation thereof, and to the use thereof as ionic liquid or to the use thereof in pharmaceutical, cosmetic and dermatological formulations.
    Type: Application
    Filed: June 19, 2009
    Publication date: June 23, 2011
    Applicant: MERCK PATENT GESELLSCHAFT
    Inventors: Michael Howard Rayner-Branes, Thomas Rudolph, William-Robert Pitner, Jens Eichhorn
  • Method for controlling coccidiosis
    Patent number: 5646135
    Abstract: The present invention relates to an improved method for controlling coccidiosis in poultry which comprises administering to poultry on shuttle medication an additional medication prior to switching from the starter compound to the grower compound, and continuing the additional medication for a period after the switching.
    Type: Grant
    Filed: March 12, 1996
    Date of Patent: July 8, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Tamas Tamas, Dan A. Ostlind
  • Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors
    Patent number: 8404685
    Abstract: Compounds of the formula I, in which R1, R2, R3, R3?, R4 and D have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumors.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: March 26, 2013
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Dieter Dorsch, Oliver Schadt, Frank Stieber, Andree Blaukat
  • Pyrmidine derivatives
    Patent number: 5763448
    Abstract: A class of substituted pyrimidine derivatives are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment of disorders of the dopamine system, in particular schizophrenia ##STR1##
    Type: Grant
    Filed: March 18, 1996
    Date of Patent: June 9, 1998
    Assignee: Merck, Sharp & Dohme Limited
    Inventors: William Robert Carling, Ian James Collins, Michael Rowley, Paul David Leeson
  • Compounds that are ERK inhibitors
    Patent number: 8658651
    Abstract: Disclosed are the ERK inhibitors of formula 1.0: (Formula (A1)), and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine ring that can have a bridge or a fused ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula A1.
    Type: Grant
    Filed: September 20, 2010
    Date of Patent: February 25, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Hugh Y. Zhu, Jagdish A. Desai, Alan B. Cooper, Ronald J. Doll
  • FUROPYRIDINE DERIVATIVES
    Publication number: 20130225569
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of rheumatoid arthritis and/or systemic lupus
    Type: Application
    Filed: July 29, 2011
    Publication date: August 29, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Lars Burgdorf, Melanie Schultz, Tatjana Ross, Brian Hodous, Justin Potnick, Amanda E. Sutton, Bayard R. Huck
  • Animal growth promotion
    Patent number: 5162337
    Abstract: Female prenatal, neonatal and postnatal animals are treated with compositions containing steroid biosynthesis inhibitors or antagonists which prevents the conversion of androgens to estrogens. The compositions are useful for improving growth and feed efficiency.
    Type: Grant
    Filed: October 5, 1990
    Date of Patent: November 10, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Alexander Elbrecht, Yi-Tien Yang, Roy G. Smith
  • ANTIPROLIFERATIVE PYRIMIDYL, FUSED PYRIMIDYL AND PYRIMIDYL HYDRAZONES
    Publication number: 20120238575
    Abstract: The present invention is related to a novel series of pyrimidyl or fused pyrimidyl hydrazones. Compounds of Formula (I) wherein A is selected from the group consisting of Formulas (A1), (A2), (A3), (A4), (A5) are useful for the treatment and/or prevention of a proliferative disease.
    Type: Application
    Filed: May 31, 2012
    Publication date: September 20, 2012
    Applicant: MERCK SERONO SA
    Inventors: BRIAN HEALEY, Zhong Zhao, Amanda Sutton, Matthias Schwarz
  • Arylsulfonamide derivatives
    Patent number: 7393873
    Abstract: N-aryl arylsulfonamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: July 1, 2008
    Assignee: Merck & Co., Inc.
    Inventors: Neville J. Anthony, John Jin Lim, Dai-shi Su, Michael R. Wood
  • AZAINDOLE DERIVATIVES
    Publication number: 20110207732
    Abstract: Compounds of the formula (I), in which X1, X2, X3, X4, R1, R2, R3 and R4 have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: September 24, 2009
    Publication date: August 25, 2011
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Timo Heinrich, Hannes Koolman
  • SUBSTITUTED-1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONES
    Publication number: 20120095001
    Abstract: The present invention relates to substituted 1,3,8-triazaspiro[4.5]decame-2,4-diones useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
    Type: Application
    Filed: June 7, 2010
    Publication date: April 19, 2012
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Joan M. Pierce, Jeffrey J. Hale, Shouwu Miao, Petr Vachal