Search Patents
  • Methods for treatment of polyposis
    Patent number: 8603465
    Abstract: The present invention relates to method for treating medical disorders mediated by mutations in the APC gene by administering an IGF1R inhibitor. Such disorders include, for example, familial adenomatous polyposis (FAP).
    Type: Grant
    Filed: August 6, 2007
    Date of Patent: December 10, 2013
    Assignee: Merck Sharp & Dohme, Corp.
    Inventor: Siu-Long Yao
  • Human wingless-like gene
    Patent number: 7033770
    Abstract: Wnt-8D polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Wnt-8D polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: April 25, 2006
    Assignee: Merck Patent GmbH
    Inventor: Klaus Dücker
  • Scramblase 2
    Patent number: 6914125
    Abstract: Scramblase 2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing scramblase 2 polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: July 5, 2005
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Silke Brandt, Johannes Gleitz, Klaus Duecker
  • Interleukin-B30 proteins
    Patent number: 8765914
    Abstract: Purified genes encoding a cytokine referred to as interleukin-B30 (IL-B30) from a mammal, and reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using the reagents and diagnostic kits are also provided.
    Type: Grant
    Filed: July 22, 2013
    Date of Patent: July 1, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventor: J. Fernando Bazan
  • Histidine phosphatase interacting protein with 120kD
    Patent number: 7176285
    Abstract: PHPIP-120 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed, also disclosed are methods for utilizing PHPIP-120 polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: February 13, 2007
    Assignee: Merck Patent GmbH
    Inventors: Bjoern Hock, Klaus Duecker, Roland Kellner
  • Splice variant of head trauma induced cytoplasmatic calcium binding protein
    Patent number: 6995241
    Abstract: ANIC-BP-1B polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ANIC-BP-1B polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: February 7, 2006
    Assignee: Merck Patentgesellschaft
    Inventors: Klaus Dücker, Izaak den Daas
  • Process for purifying recombinant hepatitis antigens
    Patent number: 5011915
    Abstract: Methods of purifying recombinant surface antigen of hepatitis B virus are disclosed. In one protocol, purification is achieved by selective extraction of the antigen from yeast membranes, followed by solubilization with urea and dithiothreitol.
    Type: Grant
    Filed: October 26, 1987
    Date of Patent: April 30, 1991
    Assignee: Merck & Co., Inc.
    Inventor: Shigeko Yamazaki
  • Histidine phosphatase interacting protein with 240kD
    Patent number: 7193051
    Abstract: PHPIP-240 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PHPIP-240 polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: March 20, 2007
    Assignee: Merck Patent GmbH
    Inventors: Bjoern Hock, Klaus Duecker, Roland Kellner
  • MAMMALIAN CELL SURFACE ANTIGENS; RELATED REAGENTS
    Publication number: 20130324483
    Abstract: Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided.
    Type: Application
    Filed: August 9, 2013
    Publication date: December 5, 2013
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Daniel M. Gorman, Troy D. Randall, Albert Zlotnik
  • Identification of new human gaba transporter
    Patent number: 7034125
    Abstract: Human GABA transporter2 like protein polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing human GABA transporter2 like protein polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: April 6, 2001
    Date of Patent: April 25, 2006
    Assignee: Merck Patent GmbH
    Inventor: Silke Brandt
  • Human survivin interacting protein 1 (SIP-1)
    Patent number: 7166701
    Abstract: Survivin Interacting Protein 1 and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SIP-1 polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: January 23, 2007
    Assignee: Merck Patent GmbH
    Inventors: Bernd Hentsch, Klaus Dücker, Björn Hock
  • Histamine receptor H3 polynucleotides
    Patent number: 7223839
    Abstract: Novel splice variants of the human H3 histamine receptor are described. The splice variants have deletions of portions of the N-terminal of the wild type H3 receptor. The splice variants are useful in methods for identifying agonists, inverse agonists or antagonists of histamine action at the H3 receptor.
    Type: Grant
    Filed: November 4, 2002
    Date of Patent: May 29, 2007
    Assignee: Merck & Co., Inc.
    Inventors: Michael J. Gallagher, Stephen L. Yates
  • Monocyte-derived Nucleic Acids and Related Compositions and Methods
    Publication number: 20130230855
    Abstract: Nucleic acids encoding various monocyte-derived proteins and related compositions, including purified proteins and specific antibodies are described. Methods of using such composition are also provided.
    Type: Application
    Filed: April 19, 2013
    Publication date: September 5, 2013
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: ELIZABETH BATES, NATHALIE FOURNIER, LIONEL CHALUS, PIERRE GARRONE
  • Recombinant human papillomavirus type 18 vaccine
    Patent number: 5820870
    Abstract: The present invention is directed to vaccines for human papillomavirus type 18 and derivatives thereof.
    Type: Grant
    Filed: March 22, 1995
    Date of Patent: October 13, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Joyce, Hugh A. George, Kathryn J. Hofman, Kathrin U. Jansen, Michael P. Neeper
  • Seripancrin
    Patent number: 7011967
    Abstract: Seripancrin polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Seripancrin polypeptides and polynucleotides in diagnostic assays.
    Type: Grant
    Filed: July 4, 2000
    Date of Patent: March 14, 2006
    Assignee: Merck Patent GmbH
    Inventors: Britta Sundermann, Uwe Hofmann, Siegfried Matzku, Oliver Wilbert
  • High throughput assay using fusion proteins
    Patent number: 5776696
    Abstract: This application describes a high throughput assay for screening for compounds which are capable of binding to a fusion protein which consists of a target protein and an FKS506-binding protein.
    Type: Grant
    Filed: September 4, 1996
    Date of Patent: July 7, 1998
    Assignee: Merck & Co., Inc.
    Inventor: Scott P. Salowe
  • Heparanase-2 a member of the heparanase protein family
    Patent number: 6872558
    Abstract: Heparanase-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing heparanese-2 polypeptides and polynucleotides and diagnostic assays.
    Type: Grant
    Filed: September 11, 2000
    Date of Patent: March 29, 2005
    Assignee: Merck Patent GmbH
    Inventors: Klaus Dücker, Christian Sirrenberg
  • Histamine receptor H4 polynucleotides
    Patent number: 7164003
    Abstract: Novel splice variants of the human H4 histamine receptor are described. The splice variants have delections of portions of the N-terminal of the wild type H4 receptor. The splice variants are useful in methods for identifying agonists, inverse agonists or antagonists of histamnie action at the H4 receptor.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: January 16, 2007
    Assignee: Merck & Co. Inc.
    Inventors: Michael J. Gallagher, Stephen L. Yates
  • Dog melanin-concentrating hormone receptor
    Patent number: 7148026
    Abstract: The present invention features polypeptides and nucleic acids related to a dog MCH receptor and uses of such polypeptides and nucleic acids. The dog MCH receptor is a G protein coupled receptor whose activity is stimulated by MCH binding.
    Type: Grant
    Filed: July 17, 2001
    Date of Patent: December 12, 2006
    Assignee: Merck & Co., Inc.
    Inventor: Carina Tan
  • Human receptor tyrosine kinase, KDR
    Publication number: 20030055239
    Abstract: An isolated nucleic acid molecule encoding a novel human receptor type tyrosine kinase gene, KDR, is disclosed. The isolation of this KDR cDNA sequence results in disclosure of purified forms of human KDR protein, recombinant vectors and recombinant hosts which express human KDR.
    Type: Application
    Filed: March 18, 2002
    Publication date: March 20, 2003
    Applicant: Merck & Co., Inc.
    Inventors: Richard L. Kendall, Kenneth A. Thomas, Xianzhi Mao, Andrew Tebben