Search Patents
  • Compositions and Methods for Adjuvanted Vaccines
    Publication number: 20230321230
    Abstract: Provided herein are, in various embodiments, methods and compositions comprising polynucleotides (e.g., mRNA) for eliciting an immune response. In certain embodiments, the disclosure provides for methods and compositions for enhancing efficacy of infectious disease treatment (e.g., mRNA vaccines). In still further embodiments, the disclosure provides methods and compositions for enhancing one or more vaccines, such as SARS-CoV-2 mRNA vaccines.
    Type: Application
    Filed: March 24, 2023
    Publication date: October 12, 2023
    Inventors: Bowen Li, Allen Jiang, Robert S. Langer, Daniel G. Anderson
  • WIRELESS RECEIVER APPARATUS AND METHOD
    Publication number: 20210075452
    Abstract: Embodiments of the invention include a wakeup receiver (WRX) featuring a charge-domain analog front end (AFE) with parallel radio frequency (RF) rectifier, charge-transfer summation amplifier (CTSA), and successive approximation analog-to-digital converter (SAR ADC) stages. The WRX operates at very low power and exhibits above-average sensitivity, random pulsed interferer rejections, and yield over process.
    Type: Application
    Filed: September 9, 2020
    Publication date: March 11, 2021
    Applicant: Everactive, Inc.
    Inventor: Kuo-Ken Huang
  • QUASI-BALANCED FED ANTENNA STRUCTURE FOR REDUCING SAR AND HAC
    Publication number: 20130069830
    Abstract: The proposed antenna structure has first and second asymmetric radiated-strip structures developed by modifying the structure of a printed T-type monopole. Specifically, by combining the radiated-strip and the shorting-line, the proposed antenna structure is similar to modified Type III balun and dipole fed by microstrip-line structure. Hence, the proposed antenna structure can also be regarded as a “quasi-balanced” antenna structure.
    Type: Application
    Filed: September 19, 2011
    Publication date: March 21, 2013
    Inventors: I-Fong CHEN, Chia-Mei Peng
  • Pre-processing SAR image stream to facilitate compression for transport on bandwidth-limited-link
    Patent number: 9146312
    Abstract: Pre-processing is applied to a raw VideoSAR (or similar near-video rate) product to transform the image frame sequence into a product that resembles more closely the type of product for which conventional video codecs are designed, while sufficiently maintaining utility and visual quality of the product delivered by the codec.
    Type: Grant
    Filed: May 25, 2011
    Date of Patent: September 29, 2015
    Assignee: Sandia Corporation
    Inventors: Bobby G. Rush, Robert Riley
  • Human serum biomarkers of prostate cancer and SARS-CoV
    Patent number: 10345308
    Abstract: Anti-carbohydrate antibodies are detected by (a) contacting an array of oligomannose-serum albumin conjugates immobilized on a substrate with an antibody-containing serum sample under conditions wherein TM10 antibodies bind the oligomannose of the conjugates at at least micromolar affinity; and (b) detecting resultant binding of specific antibodies of the sample to the oligomannose of the conjugates, as indicative of the anti-carbohydrate antibodies.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: July 9, 2019
    Assignee: SRI INTERNATIONAL
    Inventor: Denong Wang
  • MR scanner with a setting mechanism for patient-dependent control of the radio-frequency fields and magnetic fields
    Patent number: 6721588
    Abstract: An MR scanner with a setting mechanism for patient-dependent control of the radio-frequency fields and magnetic fields for adhering to individual SAR and dB/dt limits, has an optical measuring device containing a distance sensor for determining the surface of a patient and for determining a setting signal for the setting mechanism.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: April 13, 2004
    Assignee: Siemens Aktiengesellschaft
    Inventor: Matthias Drobnitzky
  • ANTIBODY CONSTRUCTS TO TARGET T CELL RESPONSES TO SARS-COV PROTEIN EXPRESSING CELLS, THEIR DESIGN AND USES
    Publication number: 20230331844
    Abstract: The present disclosure provides a hybrid ligand molecule. The hybrid ligand molecule has two antibody combining sites. The first antibody combining site binds to an effector cell receptor complex structure of an effector cell. The second antibody combining site is a target cell-specific antibody combining site. The first and second antibody combining sites are linked.
    Type: Application
    Filed: October 12, 2021
    Publication date: October 19, 2023
    Inventor: Uwe D. STAERZ
  • WIRELESS RECEIVER APPARATUS AND METHOD
    Publication number: 20210409048
    Abstract: Embodiments of the invention include a wakeup receiver (WRX) featuring a charge-domain analog front end (AFE) with parallel radio frequency (RF) rectifier, charge-transfer summation amplifier (CTSA), and successive approximation analog-to-digital converter (SAR ADC) stages. The WRX operates at very low power and exhibits above-average sensitivity, random pulsed interferer rejections, and yield over process.
    Type: Application
    Filed: September 14, 2021
    Publication date: December 30, 2021
    Applicant: Everactive, Inc.
    Inventor: Kuo-Ken Huang
  • PEPTIDES AND ADJUVANTS FOR AUGMENTATION OF FIBROBLAST THERAPY FOR CORONAVIRUS
    Publication number: 20230127499
    Abstract: Embodiments of the disclosure concern methods and compositions of treating or preventing viral infection, including of SARS-CoV-2, for example. In specific embodiments, one or more adjuvants are delivered to an individual receiving and/or having received fibroblasts and/or fibroblast-derived exosomes. In specific cases, the adjuvants comprise particular peptides, chloroquine and/or hydroxychloroquine, and/or one or more activators of one or more toll like receptors.
    Type: Application
    Filed: March 2, 2021
    Publication date: April 27, 2023
    Inventors: Pete O'HEERON, Thomas ICHIM
  • Magnetite in nanoparticulate form
    Patent number: 9096443
    Abstract: The present invention relates to a process for the polyol-type synthesis of nanoparticulate magnetite starting from mixtures of Fe0 and Fe1III in the presence of a mineral acid. The magnetite particles obtainable from the process have uniform size characteristics and have even presented higher SAR (Specific Absorption Rate) values than those of magnetosomes.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: August 4, 2015
    Assignee: Colorobbia Italia S.P.A.
    Inventors: Marco Bitossi, Giovanni Baldi, Franco Innocenti
  • Bimetallic Catalysts for Selective Ammonia Oxidation
    Publication number: 20100111791
    Abstract: Catalysts, methods, and systems for treating diesel engine exhaust streams are described. In one or more embodiments, the catalyst comprises a molecular sieve having a silica to alumina ratio (SAR) less than about 30, the molecular sieve including ion-exchanged copper and ion-exchanged platinum. Systems including such catalysts and methods of treating exhaust gas are also provided.
    Type: Application
    Filed: November 3, 2008
    Publication date: May 6, 2010
    Applicant: BASF Catalysts LLC
    Inventor: Matthew Tyler Caudle
  • Self reporting method and apparatus for personal pathogen status verification at point of entry into an area of congregation
    Patent number: 11908258
    Abstract: A self-reporting system and system for personal pathogen status verifying allows an entity to control access to an area of congregation (AOC) at one or more points of entry (POE) is a configurable manner. In one embodiment, the system may be used for the SARS-CoV-2 virus, but may be similarly used for other pathogens.
    Type: Grant
    Filed: January 19, 2022
    Date of Patent: February 20, 2024
    Assignee: OPENCLEAR, INC.
    Inventors: Mark Klein, Wendell Brown
  • Providing a Task Notification Based on a Dynamic Attribute of an Entity
    Publication number: 20150149227
    Abstract: Methods and apparatus related to providing an indication to a user that a task may be completed based on the values of one or more dynamic attributes of an entity related to the task. An entity is determined based on information that is associated with the task. An indication related to completion of the task is provided to the user when the value of one or more dynamic attributes of the entity is one or more states.
    Type: Application
    Filed: November 26, 2013
    Publication date: May 28, 2015
    Applicant: Google Inc.
    Inventors: Erwin Can Sar, Timothy Youngjin Sohn, Andrew Tomkins
  • SYSTEMS AND METHODS FOR ADMINISTERING VACCINE COMPOSITION USING MICROCHANNEL DELIVERY ADAPTER DEVICES
    Publication number: 20240139483
    Abstract: The present invention provides a method for generating an immune response in a subject, comprising administering to the subject's skin an immunizing composition from a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pathogen, wherein the composition is administered with a microneedle deliver adapter device, and wherein the immunizing composition comprises a heat killed or attenuated pathogen.
    Type: Application
    Filed: December 23, 2021
    Publication date: May 2, 2024
    Inventors: Sobin Chang, Daniel J. Nevrivy, Saiprasad Sankaranarayan
  • Methods for treating COVID-19
    Patent number: 11654132
    Abstract: The invention relates to methods for treating COVID-19 by targeting the inflammasome/caspase1/pyroptosis axis as a key inflammatory pathway. In particular, the invention relates to treating a patient infected with SARS-CoV-2 with an effective amount of one or more compounds that directly or indirectly inhibit one or more pathways of the inflammasome/caspase1/pyroptosis axis.
    Type: Grant
    Filed: June 29, 2022
    Date of Patent: May 23, 2023
    Assignee: MEDSTAR HEALTH, INC.
    Inventors: Thomas M. Fishbein, Khalid M. Khan, Alexander H. Kroemer
  • SUPERVISED IN HOME TESTING METHOD AND APPARATUS FOR PERSONAL PATHOGEN STATUS VERIFICATION AT POINT OF ENTRY INTO AN AREA OF CONGREGATION
    Publication number: 20220157103
    Abstract: A supervised testing system and system for personal pathogen status verifying allows an entity to control access to an area of congregation (AOC) at one or more points of entry (POE) is a configurable manner. In one embodiment, the system may be used for the SARS-CoV-2 virus, but may be similarly used for other pathogens.
    Type: Application
    Filed: February 2, 2022
    Publication date: May 19, 2022
    Applicant: OpenClear, Inc.
    Inventors: Mark Klein, Wendell Brown
  • Compositions and Use of N-Chlorotaurine for Treatment and Prevention of Respiratory Infections
    Publication number: 20220273594
    Abstract: Composition and methods for treatment or prevention of a respiratory infection in a mammal, including a viral infection, like a coronavirus such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or variants thereof. The compositions and methods include a therapeutically effective amount of about a 1% solution of N-chlorotaurine in water. The methods include administering N-chlorotaurine by nasal spray to the nostrils, by oral spray to the throat, and by nebulizer to the lungs.
    Type: Application
    Filed: February 28, 2022
    Publication date: September 1, 2022
    Inventor: Markus Nagl
  • Analog-to-digital converter with offset calibration
    Patent number: 9882575
    Abstract: An analog-to-digital converter (ADC) circuit including error correction circuitry for correcting offset drifts in an ADC, such as a successive approximation register (SAR) ADC. The offset drifts can be reduced, such as by sampling the offset following an analog-to-digital conversion and subsequently providing an error correction signal based on the sampled offset.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: January 30, 2018
    Assignee: Analog Devices, Inc.
    Inventors: Hongxing Li, Michael C. W. Coln, Michael Mueck
  • GENE CONSTRUCT FOR EXPRESSING MRNA
    Publication number: 20240409954
    Abstract: The present invention relates to a gene construct for expressing an mRNA, and a pharmaceutical composition, a vaccine composition, and a gene therapy composition, each comprising the gene construct. More specifically, the present invention relates to a gene construct including a coronavirus (SARS-COV-2: Severe acute respiratory syndrome coronavirus 2)-derived 5? untranslated region (UTR) and/or 3? untranslated region (UTR), and a pharmaceutical composition, a vaccine composition, and a gene therapy composition, each comprising the gene construct.
    Type: Application
    Filed: October 14, 2022
    Publication date: December 12, 2024
    Inventor: Sunghwan AN
  • NETWORK INTRUSION BASED INTELLIGENT REPLICATION OF MICROSERVICES IN A MULTI CLOUD SERVICE MESH
    Publication number: 20250141906
    Abstract: A network intrusion prevention and protection deployment method, system, and computer program product for providing security in a multi-cloud service mesh, the computer-implemented method including selectively deploying, via an instruction from an administrator, a network intrusion prevention and protection tool in a multi-cloud service mesh.
    Type: Application
    Filed: October 30, 2023
    Publication date: May 1, 2025
    Inventors: Sudheesh S. Kairali, Satyam Jakkula, Sudhanshu Sekher Sar, MADHURI MADHAVAN PILLAI, Sarbajit K. Rakshit
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