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  • Pyrin gene and mutants thereof, which cause familial Mediterranean fever
    Patent number: 6627745
    Abstract: The invention provides the nucleic acid sequence encoding the protein associated with familial Mediterranean fever (FMF). The cDNA sequence is designated as MEFV. The invention is also directed towards fragments of the DNA sequence, as well as the corresponding sequence for the RNA transcript and fragments thereof. Another aspect of the invention provides the amino acid sequence for a protein (pyrin) associated with FMF. The invention is directed towards both the full length amino acid sequence, fusion proteins containing the amino acid sequence and fragments thereof. The invention is also directed towards mutants of the nucleic acid and amino acid sequences associated with FMF. In particular, the invention discloses three missense mutations, clustered in within about 40 to 50 amino acids, in the highly conserved rfp (B30.2) domain at the C-terminal of the protein. These mutants include M6801, M694V, K695R, and V726A.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: September 30, 2003
    Assignees: The United States of America as represented by the Department of Health and Human Services, Cedars-Sinai Medical Center, University of California, University of Michigan, Women's and Children's Hospital, Heller Institute for Medical Research
    Inventors: Daniel L. Kastner, Ivona Aksentijevichh, Michael Centola, Zuoming Deng, Ramen Sood, Francis S. Collins, Trevor Blake, P. Paul Liu, Nathan Fischel-Ghodsian, Deborah L. Gumucio, Robert I. Richards, Darrell O. Ricke, Norman A. Doggett, Mordechai Pras
  • Call screening service for communication devices
    Patent number: 11184481
    Abstract: One example method of operation may include collecting call metric data over a predefined period of time for identified calls, querying the call metric data to identify whether one or more call filtering criteria parameters require changes, determining one or more call filtering criteria parameters require changes based on a deviation from one or more expected call metric data values included in the call metric data, modifying one or more of the call filtering criteria parameters, and updating an active call scam model stored on a call processing server based on the one or more call filtering parameters.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: November 23, 2021
    Assignee: FIRST ORION CORP.
    Inventors: Mark Hamilton Botner, Collin Michael Turney, Daniel Francis Kliebhan, Robert Francis Piscopo, Jr., Charles Donald Morgan, Jamelle Adnan Brown, Chee-Fung Choy, Samuel Kenton Welch, Nysia Inet George, Andrew Collin Shaddox
  • Call screening service for communication devices
    Patent number: 11729314
    Abstract: One example method of operation may include identifying a call from a caller and destined for a callee, receiving a data message associated with the call, forwarding the data message to a call processing server, processing the data message to identify one or more call parameters, comparing the one or more call parameters to an active call scam model applied by the call processing server, determining a scam score for the call based on the comparing of the one or more call parameters to the active call scam model applied by the call processing server, and determining whether to notify the callee that the call is a scam based on the scam score.
    Type: Grant
    Filed: March 29, 2022
    Date of Patent: August 15, 2023
    Assignee: FIRST ORION CORP.
    Inventors: Mark Hamilton Botner, Collin Michael Turney, Daniel Francis Kliebhan, Robert Francis Piscopo, Jr., Charles Donald Morgan, Jamelle Adnan Brown, Chee-Fung Choy, Samuel Kenton Welch, Nysia Inet George, Andrew Collin Shaddox
  • Call screening service for communication devices
    Patent number: 11290503
    Abstract: One example method of operation may include identifying a call from a caller and destined for a callee, receiving a data message associated with the call, forwarding the data message to a call processing server, processing the data message to identify one or more call parameters, comparing the one or more call parameters to an active call scam model applied by the call processing server, determining a scam score for the call based on the comparing of the one or more call parameters to the active call scam model applied by the call processing server, and determining whether to notify the callee that the call is a scam based on the scam score.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: March 29, 2022
    Assignee: FIRST ORION CORP.
    Inventors: Mark Hamilton Botner, Collin Michael Turney, Daniel Francis Kliebhan, Robert Francis Piscopo, Jr., Charles Donald Morgan, Jamelle Adnan Brown, Chee-Fung Choy, Samuel Kenton Welch, Nysia Inet George, Andrew Collin Shaddox
  • Call screening service for communication devices
    Patent number: 11889021
    Abstract: One example method of operation may include collecting call metric data over a predefined period of time for identified calls, querying the call metric data to identify whether one or more call filtering criteria parameters require changes, determining one or more call filtering criteria parameters require changes based on a deviation from one or more expected call metric data values included in the call metric data, modifying one or more of the call filtering criteria parameters, and updating an active call scam model stored on a call processing server based on the one or more call filtering parameters.
    Type: Grant
    Filed: March 13, 2023
    Date of Patent: January 30, 2024
    Assignee: FIRST ORION CORP.
    Inventors: Mark Hamilton Botner, Collin Michael Turney, Daniel Francis Kliebhan, Robert Francis Piscopo, Jr., Charles Donald Morgan, Jamelle Adnan Brown, Chee-Fung Choy, Samuel Kenton Welch, Nysia Inet George, Andrew Collin Shaddox
  • Call screening service for communication devices
    Patent number: 11632462
    Abstract: One example method of operation may include collecting call metric data over a predefined period of time for identified calls, querying the call metric data to identify whether one or more call filtering criteria parameters require changes, determining one or more call filtering criteria parameters require changes based on a deviation from one or more expected call metric data values included in the call metric data, modifying one or more of the call filtering criteria parameters, and updating an active call scam model stored on a call processing server based on the one or more call filtering parameters.
    Type: Grant
    Filed: November 23, 2021
    Date of Patent: April 18, 2023
    Assignee: FIRST ORION CORP.
    Inventors: Mark Hamilton Botner, Collin Michael Turney, Daniel Francis Kliebhan, Robert Francis Piscopo, Jr., Charles Donald Morgan, Jamelle Adnan Brown, Chee-Fung Choy, Samuel Kenton Welch, Nysia Inet George, Andrew Collin Shaddox
  • Vehicle wheelchair lift
    Patent number: 4138023
    Abstract: A vehicle wheelchair lift for loading and unloading an occupant confined to a wheelchair. The lift having a wheelchair platform which is folded vertically inside the vehicle and adjacent a vehicle door. When the lift is in use, the vehicle door is opened and the platform is lowered to a horizontal position outside the door opening. The wheelchair occupant is then wheeled onto the lift by a wheelchair attendant and the platform is lowered to the ground surface.
    Type: Grant
    Filed: October 18, 1976
    Date of Patent: February 6, 1979
    Assignee: Collins Industries, Inc.
    Inventors: Donald L. Rohrs, Harold A. Downing, Donald L. Collins
  • System and method for monitoring synchronous blade vibration
    Patent number: 5206816
    Abstract: A system and method are provided for monitoring synchronous blade vibration in a turbo-machine. At least three sensors capable of detecting the arrival of each blade are arranged about the cylinder which surrounds the tips of the blades. The location of the sensors is selected to minimize the influence of errors in the data. To this end, and to simplify the installation of the sensors into the cylinder, the sensors may be non-uniformly spaced. The location of each sensor for purposes of constructing Fourier transforms is determined using the arrival times at the blades at each sensor, expressed as a fraction of a rotor revolution. The transform matrix is constructed for a predetermined discrete set of M harmonics, so that M harmonics are analyzed simultaneously, the number of harmonics which can be simultaneously analyzed is related to the number of sensors used.
    Type: Grant
    Filed: January 30, 1991
    Date of Patent: April 27, 1993
    Assignee: Westinghouse Electric Corp.
    Inventors: Peter D. Hill, Francis S. McKendree, Charles W. Einolf, Jr., Paul F. Rozelle, Roger W. Heinig
  • Substituted pyrazoles as p38 kinase inhibitors
    Publication number: 20040176433
    Abstract: A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders.
    Type: Application
    Filed: February 25, 2003
    Publication date: September 9, 2004
    Inventors: Ashok S. Naraian, Michael Clare, Paul W. Collins, Joyce Zuowu Crich, Rajesh Devraj, Daniel L. Flynn, Lifeng Geng, Matthew J. Graneto, Cathleen E. Hanau, Gunnar J. Hanson, Susan J. Hartmann, Michael Hepperle, He Huang, Francis J. Koszyk, Shuyuan Liao, Suzanne Metz, Richard A. Partis, Thao D. Perry, Shashidhar N. Rao, Shaun Raj Selness, Michael S. South, Michael A. Stealey, John Jeffrey Talley, Michael L. Vazquez, Richard M. Weier, Xiangdong Xu, Ish K. Khanna, Yi Yu, Win Naing, Syaulan Yang
  • Substituted pyrazoles as p38 kinase inhibitors
    Patent number: 7153959
    Abstract: A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
    Type: Grant
    Filed: February 25, 2003
    Date of Patent: December 26, 2006
    Assignee: Pharmacia Corporation
    Inventors: Ashok S. Naraian, Michael Clare, Paul W. Collins, Joyce Zuowu Crich, Rajesh Devraj, Daniel L. Flynn, Lifeng Geng, Matthew J. Graneto, Cathleen E. Hanau, Gunnar J. Hanson, Susan J. Hartmann, Michael Hepperle, He Huang, Francis J. Koszyk, Shuyuan Liao, Suzanne Metz, Richard A. Partis, Thao D. Perry, Shashidhar N. Rao, Shaun Raj Selness, Michael S. South, Michael A. Stealey, John Jeffrey Talley, Michael L. Vazquez, Richard M. Weier, Xiangdong Xu, Ish K. Khanna, Yi Yu, Win Naing, Syaulan Yang
  • Substituted pyrazoles as p38 kinase inhibitors
    Patent number: 7071198
    Abstract: A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
    Type: Grant
    Filed: May 5, 2004
    Date of Patent: July 4, 2006
    Assignee: Pharmacia Corporation
    Inventors: Ashok S. Naraian, Michael Clare, Paul W. Collins, Joyce Zuowu Crich, Rajesh Devraj, Daniel L. Flynn, Lifeng Geng, Matthew J. Graneto, Cathleen E. Hanau, Gunnar J. Hanson, Susan J. Hartmann, Michael Hepperle, He Huang, Ish K. Khanna, Francis J. Koszyk, Shuyuan Liao, Suzanne Metz, Win Naing, Richard A. Partis, Thao D. Perry, Shashidhar N. Rao, Shaun Raj Selness, Michael S. South, Michael A. Stealey, John Jeffrey Talley, Michael L. Vazquez, John Walker, Richard M. Weier, Xiangdong Xu, Syaulan Yang, Yi Yu
  • Substituted pyrazoles as p38 kinase inhibitors
    Patent number: 6979686
    Abstract: A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula (IA), wherein R1, R2, R3 and R4 are as described in the specification.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: December 27, 2005
    Assignee: Pharmacia Corporation
    Inventors: Ashok S. Naraian, Michael Clare, Paul W. Collins, Joyce Zuowu Crich, Rajesh Devraj, Daniel L. Flynn, Lifeng Geng, Matthew J. Graneto, Cathleen E. Hanau, Gunnar J. Hanson, Susan J. Hartmann, Michael Hepperle, He Huang, Francis J. Koszyk, Shuyuan Liao, Suzanne Metz, Richard A. Partis, Thao D. Perry, Shashidhar N. Rao, Shaun Raj Selness, Michael S. South, Michael A. Stealey, John Jeffrey Talley, Michael L. Vazquez, Richard M. Weier, Xiangdong Xu, Ish K. Khanna, Yi Yu, Win Naing, John Walker, Syaulan Yang
  • Method of and apparatus for applying solder to metallic blanks
    Patent number: 4230257
    Abstract: A method of and apparatus for applying beads of solder to a metallic plate as an integral part thereof for subsequent attachment to another component in an assembly operation.
    Type: Grant
    Filed: December 1, 1978
    Date of Patent: October 28, 1980
    Assignee: Libbey-Owens-Ford Company
    Inventor: Charles W. Genson
  • Substituted pyrazoles as p38 kinase inhibitors
    Patent number: 6617324
    Abstract: A class of pyrazole derivatives described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: September 9, 2003
    Assignee: G. D. Searle & Company
    Inventors: Ashok S. Naraian, Michael Clare, Paul W. Collins, Joyce Zuowu Crich, Rajesh Devraj, Daniel L. Flynn, Lifeng Geng, Matthew J. Graneto, Cathleen E. Hanau, Gunnar J. Hanson, Susan J. Hartmann, Michael Hepperle, He Huang, Francis J. Koszyk, Shuyuan Liao, Suzanne Metz, Richard A. Partis, Thao D. Perry, Shashidhar N. Rao, Shaun Raj Selness, Michael S. South, Michael A. Stealey, John Jeffrey Talley, Michael L. Vazquez, Richard M. Weier, Xiangdong Xi, Ish K. Khanna, Yi Yu
  • Optimized composite flexbeam for helicopter tail rotors
    Patent number: 5690474
    Abstract: An optimized composite flexbeam (10) having a pitch region (PR) which includes a core laminate (50) of unidirectional fiberglass material (U.sub.F), and face laminates (52) of unidirectional graphite material (U.sub.G) bonded to mating surfaces (50.sub.M) defined by the core laminate (50). The core laminate (50) and face laminates define an aspect ratio which is greater than or equal to 10 and define chamfered edge surfaces (54.sub.S). Each chamfered edge surface (54.sub.S) defines a critical acute angle .alpha. with respect to the flapwise bending neutral axis (X.sub.A) of the pitch region (PR) and defines a lateral edge (54.sub.E) disposed a vertical distance X from the flapwise bending neutral axis (X.sub.A). The critical acute angle .alpha. is between about 14 degrees to about 22 degrees and the vertical distance X is about 12.5% to about 37.5% of the pitch region thickness dimension (T.sub.PR).
    Type: Grant
    Filed: July 18, 1996
    Date of Patent: November 25, 1997
    Assignee: Sikorsky Aircraft Corporation
    Inventors: Francis E. Byrnes, Francis D. Federici, David N. Schmaling
  • STRUCTURE FOR A LATCHUP ROBUST ARRAY I/O USING THROUGH WAFER VIA
    Publication number: 20090152592
    Abstract: A design structure including: an I/O cell and an ESD protection circuit in a region of an integrated circuit chip containing logic circuits; an electrically conductive through via extending from a bottom surface of the substrate toward a top surface of the substrate between the I/O cell and an ESD protection circuit and at least one of the logic circuits.
    Type: Application
    Filed: March 6, 2008
    Publication date: June 18, 2009
    Inventors: Phillip Francis Chapman, David S. Collins, Steven H. Voldman
  • STRUCTURE FOR A LATCHUP ROBUST GATE ARRAY USING THROUGH WAFER VIA
    Publication number: 20090152593
    Abstract: A structure, method and a design structure for preventing latchup in a gate array. The design structure including: a NFET gate array and a PFET gate array in a substrate; an electrically conductive through via extending from a bottom surface of the substrate toward a top surface of the substrate the NFET gate array and PFET gate array, the through via electrically contacting the P-well.
    Type: Application
    Filed: March 6, 2008
    Publication date: June 18, 2009
    Inventors: Phillip Francis Chapman, David S. Collins, Steven H. Voldman
  • LATCHUP ROBUST ARRAY I/O USING THROUGH WAFER VIA
    Publication number: 20090152632
    Abstract: A structure and a method for preventing latchup. The structure including: an I/O cell and an ESD protection circuit in a region of an integrated circuit chip containing logic circuits; an electrically conductive through via extending from a bottom surface of the substrate toward a top surface of the substrate between the I/O cell and an ESD protection circuit and at least one of the logic circuits.
    Type: Application
    Filed: December 14, 2007
    Publication date: June 18, 2009
    Inventors: Phillip Francis Chapman, David S. Collins, Steven H. Voldman
  • Latchup robust array I/O using through wafer via
    Patent number: 7741681
    Abstract: A structure and a method for preventing latchup. The structure including: an I/O cell and an ESD protection circuit in a region of an integrated circuit chip containing logic circuits; an electrically conductive through via extending from a bottom surface of the substrate toward a top surface of the substrate between the I/O cell and an ESD protection circuit and at least one of the logic circuits.
    Type: Grant
    Filed: December 14, 2007
    Date of Patent: June 22, 2010
    Assignee: International Business Machines Corporation
    Inventors: Phillip Francis Chapman, David S. Collins, Steven H. Voldman
  • Multiple effect pyrotechnic shell
    Patent number: D429516
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: August 15, 2000
    Assignee: Jake's Fireworks
    Inventors: Francis Wu, Michael Marietta
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