Search Patents
  • Method of thrombin inhibition
    Patent number: 5939392
    Abstract: The invention relates to new competitive tripeptide inhibitors of trypsin-like serine proteases, their synthesis, pharmaceutical compositions containing the compounds as active ingredients, and the use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory inhibitors for prophylaxis and treatment of related diseases.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 17, 1999
    Assignee: Astra Aktiebolag
    Inventors: Karl Thomas Antonsson, Ruth Elvy Bylund, Nils David Gustafsson, Nils Olov Ingemar Nilsson
  • Cholestyramine pellets and methods for preparation thereof
    Patent number: 10441604
    Abstract: The invention relates to small cholestyramine pellets that can be prepared by extrusion. The pellets have a high cholestyramine loading and are stable enough to be coated with one or more coating layers. The invention also relates to a process for the preparation of such pellets and to a multiparticulate drug delivery system comprising such pellets.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: October 15, 2019
    Assignee: Albireo AB
    Inventors: Per-Göran Gillberg, Nils Ove Gustafsson, Nils-Olof Lindberg, Jessica Elversson
  • Cholestyramine pellets and methods for preparation thereof
    Patent number: 10610543
    Abstract: The invention relates to small cholestyramine pellets that can be prepared by extrusion. The pellets have a high cholestyramine loading and are stable enough to be coated with one or more coating layers. The invention also relates to a process for the preparation of such pellets and to a multiparticulate drug delivery system comprising such pellets.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: April 7, 2020
    Assignee: Albireo AB
    Inventors: Per-Göran Gillberg, Nils Ove Gustafsson, Nils-Olof Lindberg, Jessica Elversson
  • Pharmaceutical composition
    Patent number: 6117857
    Abstract: The invention relates to a pharmaceutical composition comprising an antiviral compound selected from the group consisting of foscarnet, acyclovir, valaciclovir, penciclovir and famciclovir, in admixture with galactolipids and a polar solvent. The pharmaceutical composition can be used in a prophylactic and/or curative treatment of herpesvirus infections in mammals including man, by topical or parenteral administration.
    Type: Grant
    Filed: March 8, 1996
    Date of Patent: September 12, 2000
    Assignee: Astra Aktiebolag
    Inventors: Anders Nils-Erik Carlsson, Bengt Goran Herslof, Stefan Karl Lundquist, Goran Nils Gunnar Nilsson
  • Starting materials in the synthesis of thrombin and kinogenase inhibitors
    Patent number: 5723444
    Abstract: The invention concerns the compounds of the formulas: ##STR1## and protected forms and salts thereof which serve as starting materials in an improved method of synthesizing thrombin and kininogenase inhibitors. The invention further concerns an improved method for synthesizing the inhibitors which utilizes the compounds.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 3, 1998
    Assignee: Astra AB
    Inventors: Karl Thomas Antonsson, Ruth Elvy Bylund, Nils David Gustafsson, Nils Olov Ingemar Nilsson
  • CHOLESTYRAMINE PELLETS, ORAL CHOLESTYRAMINE FORMULATIONS, AND USES THEREOF
    Publication number: 20200046757
    Abstract: The invention relates to a population of pellets, each pellet comprising cholestyramine and at least about 5% w/w of an acrylate copolymer. The invention also relates to an oral formulation for targeted delivery of cholestyramine to the colon, comprising a plurality of cholestyramine pellets and wherein said pellets are coated with a colon release coating. The invention also relates to the use of this formulation in the treatment of bile acid malabsorption.
    Type: Application
    Filed: August 9, 2019
    Publication date: February 13, 2020
    Inventors: Per-Göran Gillberg, Nils Ove Gustafsson, Nils-Olof Lindberg, Jessica Elversson
  • METHOD FOR OPTIMIZING NILS OF EXPOSED LINES
    Publication number: 20050259237
    Abstract: A method for optimizing NILS of exposed lines includes providing a photomask layout which has a first straight line and a second straight line parallel with the first straight line and is applied to a Quasar 90 illumination, and adding a first assist pattern between the first and second straight lines, wherein the first assist pattern has a plurality of geometric patterns with similar size arranging as a line parallel with the first straight line.
    Type: Application
    Filed: May 19, 2004
    Publication date: November 24, 2005
    Inventor: Yuan-Hsun WU
  • Molten metal immersion pouring spout
    Patent number: 4640447
    Abstract: An immersion pouring spout for introducing molten metal, such as steel, into an ingot mold is provided with a top head and a cylindrical pouring tube including a protective external jacket attached by cement to the pouring tube and extending the entire length of the pouring tube. The jacket material has a thermal conductivity that is less than the thermal conductivity of the pouring tube material.
    Type: Grant
    Filed: October 29, 1984
    Date of Patent: February 3, 1987
    Assignee: Didier-Werke AG
    Inventors: Heinrich Geller, Peter Nold, Heinz Schermer, Ortwin Rave
  • Method for optimizing NILS of exposed lines
    Patent number: 6977715
    Abstract: A method for optimizing NILS of exposed lines includes providing a photomask layout which has a first straight line and a second straight line parallel with the first straight line and is applied to a Quasar 90 illumination, and adding a first assist pattern between the first and second straight lines, wherein the first assist pattern has a plurality of geometric patterns with similar size arranging as a line parallel with the first straight line.
    Type: Grant
    Filed: May 19, 2004
    Date of Patent: December 20, 2005
    Assignee: Nanya Technology Corp.
    Inventor: Yuan-Hsun Wu
  • Imatinib for use in the treatment of stroke
    Patent number: 10953010
    Abstract: Imatinib can be used in the treatment of stroke in a new dosage regime, where Imatinib is administered to the patient at a dose of 650 mg/day or higher for at least 3 consecutive days, and preferably administered in a starting dose of 1000 mg/day or higher on day 1, and at a dose in the interval of 650 mg/day to 1000 mg/day on the subsequent days. A method for the treatment of stroke, a pharmaceutical composition and a kit of parts is/are also disclosed.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: March 23, 2021
    Assignees: Hamra Invest AB, Brain Consultant Nils Gunnar Wahlgren AB
    Inventors: Ulf Eriksson, Nils Gunnar Wahlgren
  • New peptide derivatives
    Publication number: 20050222395
    Abstract: The invention relates to new competitive inhibitors of trypsin-like serine proteases, their synthesis, pharmaceutical compositions containing the compounds as active ingredients, and the use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory inhibitors for prophylaxis and treatment of related diseases, according to the formula wherein A1 represents a structural fragment of formulas A2 represent a structural fragment of formulas B represents a structural fragment of formulas Further described is novel compounds, the new use of compounds and especially new structural fragment in synthesis of pharmaceutical compounds.
    Type: Application
    Filed: March 25, 2005
    Publication date: October 6, 2005
    Applicant: Astrazeneca AB
    Inventors: Karl Antonsson, Ruth Bylund, Nils Gustafsson, Nils Nilsson
  • Peptide derivatives
    Patent number: 6984627
    Abstract: Pharmaceutical preparation containing an effective amount of acetylsalicylic acid and a compound of Formula I. A1—A2—NH—(CH2)n—B wherein A1, A2, n and B are as defined in the specification, which is either the compound as such, or a stereoisomer thereof, and which may be in the form of a physiologically acceptable salt, in association with a pharmaceutical carrier. The combinations are suitable for use in inhibiting thrombin, or in the treatment or prophylaxis of thrombosis or hypercoagulability in patients in need thereof.
    Type: Grant
    Filed: May 8, 2000
    Date of Patent: January 10, 2006
    Assignee: AstraZeneca AB
    Inventors: Karl Thomas Antonsson, Ruth Elvy Bylund, Nils David Gustafsson, Nils Olov Ingemar Nilsson
  • METABOLIC PROFILES
    Publication number: 20120108668
    Abstract: The invention relates to the use of endogenous metabolites to produce a metabolic profile of a disorder or disease in a subject, e.g. an autoimmune disease, in particular rheumatoid arthritis, and the analysis of such metabolic profiles in order to find disturbances in such profiles in a subject which are caused by or correlated with the said diseases or disorders. Such disturbances can be normalised by treatment of the subject with specified compounds, particularly N-(2-chloro-3,4-dimethoxybenzylideneamino)guanidine or an aminoguanidine.
    Type: Application
    Filed: March 24, 2010
    Publication date: May 3, 2012
    Inventors: Erik Torbjörn Lundstedt, Nils Johan Trygg, Jon Robert Gabrielsson, Gunilla Ekström, Nils Johan Trygg, Jon Robert Gabrielsson, Gunilla Ekström
  • METHOD FOR OPERATING A WIND TURBINE
    Publication number: 20190229735
    Abstract: A method for operating a wind turbine configured to supply electrical power to an electrical power supply network via a converter comprises measuring a phase angle and measuring a voltage of the electrical power supply network. A value of at least one parameter for a phase locked loop is determined depending on the measured voltage. The phase locked loop is used to determine a corrected phase angle depending on the measured phase angle and the voltage of the electrical power supply network. The corrected phase angle is input into the converter.
    Type: Application
    Filed: January 18, 2019
    Publication date: July 25, 2019
    Applicants: Nordex Energy GmbH, Woodward Kempen GmbH
    Inventors: Nils-Hendric Schall, Andrzej Geniusz, Nils Hoffmann
  • Filter plate
    Patent number: 5076924
    Abstract: A filter plate (1) is described on which a filter cloth (4) is disposed across the whole top side and glued or welded to the outer sides, and which is used for filtering off particles from a liquid. The plate has a large number of apertures (2), each individual aperture area being at most 2.25 cm.sup.2. The total free open area of the plate is 70-90% of the total plate area and the thickness of the plate is at least 5 mm.
    Type: Grant
    Filed: June 28, 1990
    Date of Patent: December 31, 1991
    Assignee: Hydrotech Nils-Ake Persson AB
    Inventors: Nils-Ake Persson, Klas Ralvert
  • Process and apparatus for the production of cellulose pulps of improved quality
    Patent number: 6391153
    Abstract: A process and apparatus for the preparation of improved cellulose pulps is provided, in which defibered pulp is screened for removal of shives, and fibers with low bonding ability are removed in hydrocyclones, and rejects from the hydrocyclones are treated in refiner. In the process a specific combination of characteristics for the hydrocyclones and the volumetric flow is used in order to prepare pulps which give products of improved qualities, such as higher tensile strength, tear strength, light-scattering, surface smoothness, and especially low shive content.
    Type: Grant
    Filed: July 11, 2000
    Date of Patent: May 21, 2002
    Assignee: Nils Anders Lennart Wikdahl
    Inventor: Nils Anders Lennart Wikdahl
  • Method for operating a wind turbine
    Patent number: 10727843
    Abstract: A method for operating a wind turbine configured to supply electrical power to an electrical power supply network via a converter comprises measuring a phase angle and measuring a voltage of the electrical power supply network. A value of at least one parameter for a phase locked loop is determined depending on the measured voltage. The phase locked loop is used to determine a corrected phase angle depending on the measured phase angle and the voltage of the electrical power supply network. The corrected phase angle is input into the converter.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: July 28, 2020
    Assignees: Nordex Energy GmbH, Woodward Kempen GmbH
    Inventors: Nils-Hendric Schall, Andreas Genius, Nils Hoffmann
  • SYSTEM AND METHOD FOR NIL PICK HANDLING AT A WAREHOUSE
    Publication number: 20190034875
    Abstract: Upon the occurrence of the nil pick, an amount of product that is available in the warehouse is determined as is a demand of the product from the replenishment settings. When the amount of product is sufficient to partially satisfy the demand, first instructions are transmitted to the warehouse instructing the warehouse to send selected amounts of the product to selected retail stores. When the amount of product is insufficient to satisfy any of the demand, a message is sent to a secondary supplier instructing the secondary supplier to ship products to the warehouse. Instructions are transmitted to the warehouse to perform a verification of an accuracy of the replenishment settings.
    Type: Application
    Filed: July 10, 2018
    Publication date: January 31, 2019
    Inventors: Greg A. Bryan, Cristy C. Brooks, David B. Brightwell, Matthew A. Jones, Benjamin D. Enssle, Jesse L. Eaton, Todd D. Mattingly
  • Peptide derivatives as kininogenase inhibitors
    Patent number: 5856307
    Abstract: The invention relates to compounds of the formulaA.sup.1 --A.sup.2 --NH--(CH.sub.2).sub.n --B Formula IandA.sup.1 --A.sup.2 --NH--(CH.sub.2).sub.n --B--D Formula Vas well as stereoisomers and physiologically acceptable salts thereof which act as competitive inhibitors of trypsin-like serine proteases, particularly kininogenases. The invention further relates to pharmaceutical compositions containing the compounds as active ingredients and the use of the compounds as kininogenase inhibitors and in the treatment of diseases related to kinin formation.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 5, 1999
    Assignee: Astra Aktiebolag
    Inventors: Karl Thomas Antonsson, Ruth Elvy Bylund, Nils David Gustafsson, Nils Olov Ingemar Nilsson
  • A LIGHT MODULE AND A METHOD FOR ITS OPERATION
    Publication number: 20220285914
    Abstract: Disclosed herein is a light module and a method for operating the light module. The light module includes a light source; an electronic circuit for driving the light source; where the electronic circuit includes a current source, where the current source is designated for generating and controlling a control current for driving the light source, and a protection controller, where the protection controller is designated for interrupting the control current to the light source in an event in which the current source fails. The light module and the related method address an eye-safe operation of the light module, specifically for a laser light source included by the light module to achieve compliance to laser safety class 1.
    Type: Application
    Filed: July 24, 2020
    Publication date: September 8, 2022
    Inventors: Benjamin Rein, Nils Berner, Philipp Nils Raith
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