Search Patents
  • Cerebral dysfunction therapeutic agent, which comprises a dihydropyridine compound
    Patent number: 4782070
    Abstract: The treatment of cerebral dysfunction with a dihydropyridine compounds the formula: ##STR1## R.sup.1 is nitrophenyl and R.sup.2, R.sup.3 and R.sup.4 are each lower alkyl or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 19, 1987
    Date of Patent: November 1, 1988
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takaharu Ono, Toshiharu Kamitani, Minoru Ohtsuka
  • Taliscanin and other aristolactams for treating neurological disorders, Parkinson's disease, Alzheimer disease and impotence
    Patent number: 4782077
    Abstract: A method of treating neurological disorders, in particular Parkinson's disease, is disclosed. The method involves administering an aristolactam, especially Taliscanin, an extract of the root of Aristolochia Taliscana, to an afflicted patient. The dosage is varied in accordance with the patient's response, and generally ranges from 300 to 4000 micrograms per day. Taliscanin has also been shown effective in treating Alzheimer disease and impotence.
    Type: Grant
    Filed: August 20, 1987
    Date of Patent: November 1, 1988
    Assignee: Monoclonetics International, Inc.
    Inventor: Jacinto J. de la Parra
  • Gepirone for alleviation of panic disorders
    Patent number: 4782060
    Abstract: Gepirone and its pharmaceutically acceptable salts are useful in alleviation of panic disorders which can take the form of clinical syndromes comprising, for example, panic attacks, agoraphobia and phobic anxiety.
    Type: Grant
    Filed: July 29, 1987
    Date of Patent: November 1, 1988
    Assignee: Bristol-Myers Company
    Inventors: Neil Kurtz, Roger E. Newton, Davis L. Temple, Jr.
  • Method of treating epilepsy and cerebral concussion
    Patent number: 4782093
    Abstract: A method for treatment of epilepsy and cerebral concussion in mammals by administration of a vasodilator in an effective amount, the vasodilator being bamethan, derivatives thereof, bamethan sulfate, derivatives thereof, 1-epinephrine derivatives having a terminal alkyl substitutent attached to nitrogen and containing at least three carbon atoms, and mixtures thereof. The frequency of epileptic seizures in mammalian patients is substantially reduced by this treatment.
    Type: Grant
    Filed: May 28, 1987
    Date of Patent: November 1, 1988
    Inventor: Mihaly A. Tapolyai
  • Inhibition of interleukin-1 by monocytes and/or macrophages
    Patent number: 4780470
    Abstract: A method of inhibiting the production of interleukin-1 by monocytes in a human in need thereof which comprises administering to such human an effective interleukin-1 production inhibiting amount of a 4,5-diaryl-2(substituted)imidazole.
    Type: Grant
    Filed: August 19, 1986
    Date of Patent: October 25, 1988
    Assignee: SmithKline Beckman Corporation
    Inventors: Paul E. Bender, Don E. Griswold, Nabil Hanna, John C. Lee
  • Use of L-carnitine in the treatment of toxic effects induced by the inhalation of halotane and other halogen-containing general anesthetics
    Patent number: 4780308
    Abstract: Oral or parenteral administration of 10 to 30 mg/kg/day of L-carnitine (or an equivalent amount of a pharmacologically acceptable salt thereof) both during preanesthesia and post-operative phase antagonizes the toxic effects (particularly on kidneys and liver) induced by inhalation of halogen-containing general anesthetics such as, typically, halotane.
    Type: Grant
    Filed: July 2, 1987
    Date of Patent: October 25, 1988
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Noris Siliprandi, Guido Scutari
  • Preparation for the prevention of catabolism
    Patent number: 4780475
    Abstract: Prevention of catabolism and increasing protein synthesis in a subject undergoing stress with compositions containing isoleucine, leucine and valine.
    Type: Grant
    Filed: December 22, 1986
    Date of Patent: October 25, 1988
    Inventors: Frank B. Cerra, Ronald J. Amen
  • Aqueous solution containing a quinolone carboxylic acid
    Patent number: 4780465
    Abstract: A stable isotonic aqueous solution of the compound 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline -3-carboxylic acid, or a pharmaceutically-acceptable salt thereof, having a pH of 3 to 6.5 and isotonized with a polyalcohol or boric acid is disclosed.
    Type: Grant
    Filed: May 20, 1987
    Date of Patent: October 25, 1988
    Assignee: Hokuriku Pharmaceutical Co., Ltd.
    Inventors: Kazumi Ogata, Hideo Terayama, Satoshi Takei
  • Analgesic, anti-inflammatory and skeletal muscle relaxant compositions comprising non-steroidal anti-inflammatory drugs and musculoskeletal relaxants and methods of using same
    Patent number: 4780463
    Abstract: Novel pharmaceutical analgesic, anti-inflammatory and skeletal muscle relaxant compositions and methods of using same comprising an analgesically and anti-inflammatory effective amount of at least one non-steroidal anti-inflammatory drug other than aspirin, acetaminophen and phenacetin, in combination with an effective amount of a skeletal muscle relaxant.
    Type: Grant
    Filed: October 30, 1987
    Date of Patent: October 25, 1988
    Assignee: Analgesic Associates
    Inventors: Abraham Sunshine, Eugene M. Laska, Carole E. Siegel
  • Agent against multiple sclerosis
    Patent number: 4778788
    Abstract: The use of a compound having the general formula I ##STR1## in which R.sub.1 is alkyl having from 12 to 18 carbon atoms, R.sub.2 is alkyl having from 1 to 8 carbon atoms, and R.sub.3 is H or alkyl having from 1 to 3 carbon atoms, is described as an agent against multiple sclerosis.
    Type: Grant
    Filed: May 21, 1987
    Date of Patent: October 18, 1988
    Assignee: Max-Planck-Gesellschaft Zur Foerderung der Wissenschaften
    Inventor: Paul G. Munder
  • Pharmaceutical composition for the treatment of infantile autism
    Patent number: 4778794
    Abstract: A pharmaceutical composition for the treatment of infantile autism which contains tetrahydrobiopterin or a derivative thereof as a major effective ingredient and 5-hydroxytryptophan and/or L-DOPA as an optional auxiliary effective ingredient is provided.
    Type: Grant
    Filed: June 4, 1986
    Date of Patent: October 18, 1988
    Assignee: Suntory Limited
    Inventors: Hiroshi Naruse, Masashi Takesada, Osamu Hayaishi, Yasuyoshi Watanabe
  • Inhibition of interleukin-1 production by monocytes and/or macrophages
    Patent number: 4778806
    Abstract: A method of inhibiting the production of interleukin-1 by monocytes and/or macrophages in a human in need thereof which comprises administering to such human an effective interleukin-1 production inhibiting amount of a 2-2'-[1,3-propan-2-onediyl-bis(thio)]bis-1H-imidazole or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 19, 1986
    Date of Patent: October 18, 1988
    Assignee: SmithKline Beckman Corporation
    Inventors: Paul E. Bender, Don E. Griswold, Nabil Hanna, John C. Lee
  • Nasal delivery of caffeine
    Patent number: 4778810
    Abstract: Nasal compositions useful for the delivery of caffeine alone or with other therapeutic agents.
    Type: Grant
    Filed: January 8, 1987
    Date of Patent: October 18, 1988
    Assignee: Nastech Pharmaceutical Co., Inc.
    Inventors: Jeffrey Wenig, Devin N. Wenig
  • Synergistic combination of flupirtin and non-steroidal antiphlogistic
    Patent number: 4778799
    Abstract: Medicines are prepared having a synergistic effect containing a combination of the analgesic Flupirtin and at least one non-steroidal antiphlogistic.
    Type: Grant
    Filed: September 28, 1987
    Date of Patent: October 18, 1988
    Inventors: Ulrich Tibes, Carl H. Weischer, Helmut Hettche, Hans-Peter Breuel
  • Pharmaceutical compositions having vasodilating and antianoxic activities
    Patent number: 4778798
    Abstract: Pharmaceutical compositions having vasodilating and antianoxic activities containing an ubiquinone or Coenzyme Q.sub.10 and a vasodilating compound selected from the groups of ergotamine, Rauwolfia, vincamine alkaloids, calcium antagonists, .beta.-blockers, papaverine, Ginkgo biloba, xanthine derivatives, ACE inhibitors, cyclospasmol.
    Type: Grant
    Filed: July 31, 1986
    Date of Patent: October 18, 1988
    Assignee: Seuref A.G.
    Inventor: Pierre-Noel Brasey
  • Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
    Patent number: 4777174
    Abstract: Novel analgesic and anti-inflammatory compositions of matter for use in eliciting an analgesic or anti-inflammatory response, said compositions comprising caffeine together with a selected non-narcotic analgesic/nonsteroidal anti-inflammatory drug or a selected narcotic analgesic, or both, are disclosed. When used in combination with the selected drugs, caffeine enhances the analgesic or anti-inflammatory response and also hastens its onset.
    Type: Grant
    Filed: March 2, 1987
    Date of Patent: October 11, 1988
    Assignee: Analgesic Associates
    Inventors: Abraham Sunshine, Eugene M. Laska, Carole E. Siegel
  • Method for treatment of alcohol abuse
    Patent number: 4777173
    Abstract: Buspirone and its pharmaceutically acceptable salts are useful in the treatment of alcohol abuse.
    Type: Grant
    Filed: March 25, 1987
    Date of Patent: October 11, 1988
    Assignee: Bristol-Myers Company
    Inventors: Rajesh Shrotryia, George P. Casten
  • Method to prevent and treat the signs and symptoms of motion sickness
    Patent number: 4777170
    Abstract: Motion sickness is a disorder thought to be caused by the excessive stimulation of the vestibular apparatus caused by angular and linear acceleration and deceleration sometimes resulting in nausea and vomiting. Characteristic signs and symptoms of the condition in addition to nausea and vomiting include yawning, hyperventilation, salivation, pallor, profuse cold sweating, somnolence, aerophagia, dizziness, headache, general discomfort, fatigue, weakness, and inability to concentrate. When prolonged motion sickness is accompanied by vomiting, hypotension, dehydration, inanition and depression may occur. The present invention includes methods for prevention of motion sickness as well as methods for the treatment of the signs and symptoms of motion sickness after their onset.
    Type: Grant
    Filed: February 3, 1987
    Date of Patent: October 11, 1988
    Inventor: William A. Heinrich
  • Method and composition for treating neurological disorders and aging
    Patent number: 4775665
    Abstract: Choline or a choline precursor is administered to a patient together with an amino acid which is a precursor to a neurotransmitter in order to give a synergistic result for the two components.
    Type: Grant
    Filed: September 24, 1987
    Date of Patent: October 4, 1988
    Assignee: Massachusetts Institute of Technology
    Inventor: Richard J. Wurtman
  • Topical analgesic anti-inflammatory composition
    Patent number: 4775667
    Abstract: Topical analgesic anti-inflammatory compositions containing a corticosteroid in addition to the conventional efficacy-proven ingredients are disclosed. They may be embodied in an aerosol, a solution and any other type of composition being convenient for administration. More than the sum of effects of the individual ingredients has been proved. In other words, the effects of the salicylate esters and L-menthol are synergistically enhanced by the addition of the corticosteroid. Particularly, the persistency of the analgesic/anti-inflammatory effects of the conventional ingredients has been proved to be dependent upon the the concentration of the corticosteroid in the composition.
    Type: Grant
    Filed: September 24, 1986
    Date of Patent: October 4, 1988
    Assignee: Shionogi & Co., Ltd.
    Inventors: Izumi Saitoh, Hirokuni Jyoyama, Fujio Asanuma, Katsumi Hirose, Shohei Egawa