Search Patents
  • .beta.-adrenergic blocking imidazolylphenoxy propanolamines
    Patent number: 4642311
    Abstract: Substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: May 7, 1984
    Date of Patent: February 10, 1987
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Non-aqueous ivermectin formulation with improved antiparasitic activity
    Patent number: 4853372
    Abstract: Ivermectin, an antiparasitic agent which is insoluble and unstable in water, is formulated in glycerol formal and propylene glycol. These liquid formulations are suitable for parenteral administration for the treatment of parasitic infections and demonstrate improved efficacy and a broadened spectrum over previous formulations.
    Type: Grant
    Filed: November 28, 1986
    Date of Patent: August 1, 1989
    Assignee: Merck & Co., Inc.
    Inventors: James B. Williams, Russell U. Nesbitt
  • Alicyclic compounds as tachykinin receptor antagonists
    Patent number: 5387595
    Abstract: Substituted alicyclic compounds of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma.
    Type: Grant
    Filed: August 26, 1992
    Date of Patent: February 7, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Sander G. Mills, Paul E. Finke, Malcolm MacCoss, Daniel J. Miller, Dennis J. Underwood
  • Liquid-crystalline medium
    Patent number: 6846523
    Abstract: A liquid-crystalline medium of positive dielectric anisotropy and high optical anisotropy, comprising one or more compounds of the formula I and one or more compounds of the formulae II and/or III and its use in electro-optical displays and projection systems, in particular LCoS™ displays and displays based on a birefringence effect, such as OCB displays, is described.
    Type: Grant
    Filed: March 8, 2004
    Date of Patent: January 25, 2005
    Assignee: Merck Patent GmbH
    Inventors: Atsutaka Manabe, Matthias Bremer
  • Intermediates for preparing HMG-CoA reductase inhibitors
    Patent number: 4795811
    Abstract: A process for converting 6-carboxy to 6-hydroxymethyl mevinolin analogs and novel intermediates formed in this process are disclosed.
    Type: Grant
    Filed: June 22, 1987
    Date of Patent: January 3, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Samuel L. Graham, Thomas H. Scholz
  • Gripping apparatus
    Patent number: 5536056
    Abstract: An improved gripping and pinching device particularly useful with laboratory glassware and adaptable for use with a robot or automated system, is disclosed. The device uses flexible tubing as a gripper, eyedropper pincher and as a pinch valve which biases and releases test tubes, vials or the like upon removal and application of a vacuum or pressurizing means.
    Type: Grant
    Filed: August 1, 1994
    Date of Patent: July 16, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Glenn Clarke, Gary S. Kath, Gregory W. King
  • LIQUID-CRYSTALLINE MEDIUM
    Publication number: 20180265786
    Abstract: Liquid-crystalline media containing a) one or more compounds of formula IA, and b) one or more compounds of formula II and c) one or more compounds of formulae III-1 to III-4, their use in electro-optical displays, particularly in active-matrix displays based on the VA, ECB, FFS or IPS effect.
    Type: Application
    Filed: March 16, 2018
    Publication date: September 20, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Chang-Suk Choi, Chang-Jun Yun, Yeon-Jeong Han, Heui-Seok Jin, Yong-Kuk Yun
  • 2 AMINO-3,4-DIHYDRCQUINAZOLINE DERIVATIVES AND THE USE THEREOF AS CATHEPSIN D INHIBITORS
    Publication number: 20150361053
    Abstract: The present invention relates to compounds of the formula (I) and in particular to medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions in the triggering of which cathepsin D is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia.
    Type: Application
    Filed: January 20, 2014
    Publication date: December 17, 2015
    Applicant: Merck Patent GmbH
    Inventors: Markus KLEIN, Christos TSAKLAKIDIS
  • Layer or article comprising polymer particles
    Patent number: 9714384
    Abstract: The invention relates to a layer or article comprising cholesteric liquid crystal polymer particles, which are optionally dispersed in a continuous phase, to cholesteric polymer particles for use in such a layer or article, to methods of preparing such a layer or article, and to the use of such a layer or article as optical element, in windows or electrooptical devices like liquid crystal displays (LCDs).
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: July 25, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Eduardo Beltran Gracia, Owain Llyr Parri
  • Quinolin-2-one derivatives
    Patent number: 11939314
    Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
    Type: Grant
    Filed: October 12, 2021
    Date of Patent: March 26, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Mathilde Muzerelle, Lars Burgdorf, Margarita Wucherer-Plietker, Paul Czodrowski, Christina Esdar, Christos Tsaklakidis
  • Cyclohexyl sulphones
    Patent number: 6984663
    Abstract: Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: January 10, 2006
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Ian Churcher, Kevin Dinnell, Timothy Harrison, Sonia Kerrad, Alan John Nadin, Paul Joseph Oakley, Duncan Edward Shaw, Martin Richard Teall, Susannah Williams, Brian John Williams
  • CETP inhibitors
    Patent number: 7935727
    Abstract: Compounds having a biphenyl group substituted with a phenyl or heteroaromatic group, as shown in Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis:
    Type: Grant
    Filed: October 13, 2006
    Date of Patent: May 3, 2011
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Yi-Heng Chen, Zhijian Lu, Peter J. Sinclair
  • Liquid crystal medium containing thiophene derivatives
    Patent number: 8906261
    Abstract: The present invention relates to liquid-crystalline media (LC media) comprising thiophene derivatives and to liquid-crystal displays (LC displays) containing these LC media. The media have high optical anisotropy and preferably have a content of thiophene derivatives of 25% by weight or more.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: December 9, 2014
    Assignee: MERCK PATENT GmbH
    Inventors: Michael Wittek, Brigitte Schuler, Axel Jansen
  • ORGANIC COMPOUNDS FOR ELECTROLUMINESCENT DEVICES
    Publication number: 20130053558
    Abstract: The invention relates to compounds of the formula (1), to a method for producing compounds of the formula (1), to the use of the compounds in electronic devices and to electronic devices containing compounds according to formula (1), preferably as electron transport materials, as matrix materials, as electron blocking materials or as emitting materials.
    Type: Application
    Filed: October 14, 2010
    Publication date: February 28, 2013
    Applicant: Merck Patent GmbH
    Inventors: Christof Pflumm, Arne Buesing, Amir Hossain Parham, Rocco Fortte, Holger Heil, Philipp Stoessel, Teresa Mujica-Fernaud
  • LIGANDS FOR NANO-SIZED MATERIALS
    Publication number: 20220127286
    Abstract: The present invention relates to a compound suitable as ligand for binding to the surface of a semiconductor nanoparticle, said compound comprising an anchor group, a linker group and an organic functional group; a semiconductor nanoparticle have said ligand attached to the outermost particle surface; a composition, a formulation and a process for the preparation of said semiconductor nanoparticle; and an electronic device.
    Type: Application
    Filed: February 2, 2020
    Publication date: April 28, 2022
    Applicant: MERCK PATENT GMBH
    Inventors: Itai LIEBERMAN, Manuel HAMBURGER, Christian MATUSCHEK, Thomas EBERLE, Beate BURKHART, Sebastian MEYER
  • Biaxial Film II
    Publication number: 20080113111
    Abstract: The invention relates to an optically biaxial film comprising an anisotropic material with uniform helically twisted structure and a reflection wavelength below 400 nm, to methods and materials for its preparation, to its use as retardation or compensation film in optical devices like liquid crystal displays, and to compensators and liquid crystal displays comprising such a biaxial film.
    Type: Application
    Filed: June 15, 2005
    Publication date: May 15, 2008
    Applicant: MERCK PATENT GMBH
    Inventors: Mark Verrall, Kim Slaney, Owain Llyr Parri, Richard Harding, Shirley Ann Marden
  • Polyhydro derivatives of 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine
    Patent number: 4870080
    Abstract: 10,11-Dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imines and derivatives thereof wherein one or the other or both benzo rings are hydrogenated are active anticonvulsants and atagonists of N-methyl-D-aspartate.
    Type: Grant
    Filed: May 5, 1988
    Date of Patent: September 26, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Theresa R. Lamanec, Terry A. Lyle
  • Process for separating and recovering metal catalysts
    Patent number: 4414401
    Abstract: A process is provided for separating and recovering solid, metal catalysts from reaction mixtures in which they are dispersed, with cross-flow filtration using membrane separation devices. The process is particularly useful for separating gelatinous catalyst sludges, e.g., nickel hydroxide, used in oxidizing diacetone sorbose.
    Type: Grant
    Filed: October 29, 1981
    Date of Patent: November 8, 1983
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Willi Wintermeyer, Rolf Wittmann, Jurgen Butzke
  • Bradykinin B2 receptor modified transgenic non-human animals
    Patent number: 5750826
    Abstract: A transgenic non-human animal with alterations in a bradykinin B2 receptor gene is prepared by introduction of a gene encoding an altered bradykinin B2 receptor into a host non-human animal.
    Type: Grant
    Filed: December 2, 1996
    Date of Patent: May 12, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Joseph A. Borkowski, Howard Y. Chen, John W. Hess, Catherine D. Strader, Myrna E. Trumbauer
  • 4-(pyridyl)- and 4-(oxo-pyridyl)-1,3-benzoxazines
    Patent number: 5036068
    Abstract: Novel benzoxazine derivatives of the formula I ##STR1## wherein R.sup.1 to R.sup.5 have the meanings defined herein, and salts thereof, exhibit effects on the cardiovascular system.
    Type: Grant
    Filed: November 22, 1989
    Date of Patent: July 30, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Manfred Baumgarth, Rolf Gericke, Rolf Bergmann, Jacques De Peyer, Ingeborg Lues
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