Search Patents
  • Phosphor mixtures comprising europium-doped ortho-silicates
    Patent number: 9157025
    Abstract: The invention relates to novel phosphor mixtures comprising three or more silicate phosphors. The invention furthermore relates to the use of these mixtures in electronic and electro-optical devices, in particular in light-emitting diodes (LEDs) for backlighting applications. The invention furthermore relates to LEDs comprising the phosphors.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: October 13, 2015
    Assignee: MERCK PATENT GMBH
    Inventors: Holger Winkler, Andreas Benker, Martina Hueber, Monika Kursawe, Ralf Petry, Stefan Tews, Tim Vosgroene
  • Use of tachykinin antagonist and rizatriptan
    Patent number: 5981526
    Abstract: The present invention relates to a method for the treatment or prevention of migraine, which method comprises administration to a patient in need of such treatment an amount of a tachykinin antagonist and an amount of rizatriptan such that together they give effective relief. There is also provided pharmaceutical compositions and products comprising a tachykinin antagonist and rizatriptan.
    Type: Grant
    Filed: October 3, 1997
    Date of Patent: November 9, 1999
    Assignee: Merck Sharp & Dohme Ltd.
    Inventor: Richard John Hargreaves
  • VIAL-TO-SYRINGE CONVERTER AND METHODS OF MAKING AND USING SAME
    Publication number: 20240424218
    Abstract: In some examples, a vial-to-syringe converter includes a plunger rod, an adapter including a body having a piercing spike, a receiver and a lumen extending between the spike and the receiver, the body further including at least one laterally-extending flange, and a needle in communication with the receiver and configured to deliver a medicament to a patient's body.
    Type: Application
    Filed: November 1, 2022
    Publication date: December 26, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Daniel A. Bonanno, Eduardo Cristofolli, Cassie Megna, Wail A. Rasheed, Ophelia L. Wells
  • Antifungal agents
    Patent number: 5770587
    Abstract: There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.
    Type: Grant
    Filed: October 21, 1996
    Date of Patent: June 23, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Angela Basilio, Fernando Pelaez, Maria Teresa Diez, Francisca Vicente, Sandra A. Morris, James E. Curotto, Gerald F. Bills, Sarah J. Dreikorn, Otto D. Hensens, Jerrold M. Liesch, Rosalind G. Jenkins, John R. Thompson
  • Complex compounds having tetradentate ligands and the use thereof in the opto-electronic field
    Patent number: 9553276
    Abstract: The invention describes electronic devices comprising a metal complex compound having at least one tetradentate ligand having N and/or P donors, in particular a ligand having a PPPP, NNNN, PNNP or NPPN structure, and uses of a complex of this type in the electronic field and for the generation of light.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: January 24, 2017
    Assignee: Merck Patent GmbH
    Inventors: Lars Wesemann, Hermann August Mayer, Hartmut Schubert, Sophie Wernitz
  • PROCESS FOR PREPARING SUBSTITUTED PENTACENES
    Publication number: 20120305854
    Abstract: The invention relates to a process of preparing substituted pentacenes, to novel pentacenes prepared by this process, to the use of the novel pentacenes as semiconductors or charge transport materials in optical, electrooptical or electronic devices including field effect transistors (FETs), electroluminescent, photovoltaic and sensor devices, and to FETs and other semiconducting components or materials comprising the novel pentacenes.
    Type: Application
    Filed: August 14, 2012
    Publication date: December 6, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Steven TIERNEY, Martin HEENEY, Clare BAILEY, Weimin ZHANG
  • LONG-ACTION IMPLANT FOR TREATMENT OF INFECTIOUS DISEASES
    Publication number: 20200179273
    Abstract: The present invention relates to long-acting implants useful for the treatment of bacterial infections, particularly mycobacterial infections. The invention also relates to methods of use of such long-acting implants for the treatment of mycobacterial infections such as those caused by Mycobacteria tuberculosis.
    Type: Application
    Filed: June 1, 2018
    Publication date: June 11, 2020
    Applicant: Merck Sharp & DohmeCorp
    Inventors: Stephanie Elizabeth Barrett, Seth P. Forster, Marian E. Gindy, Jay A. Grobler, David Brian Olsen, Ryan Stevenson Teller
  • Liquid crystal medium and liquid display
    Patent number: 10450509
    Abstract: Mesogenic media comprising one or more compounds of formulae I or II preferably mesogenic media showing a blue phase, preferably stabilized by a polymer, and their use in electro-optical light modulation elements and their respective use in displays, as well as such devices.
    Type: Grant
    Filed: May 9, 2012
    Date of Patent: October 22, 2019
    Assignee: MERCK PATENT GMBH
    Inventors: Michael Wittek, Norihiko Tanaka, Malgorzata Rillich, Volker Reiffenrath, Axel Jansen
  • Photosensitive siloxane composition and pattern forming method using the same
    Patent number: 11899365
    Abstract: To provide a photosensitive siloxane composition capable of forming a pattern having a desired taper angle and a desired linewidth. [Means] The present invention provides a photosensitive siloxane composition comprising: a polysiloxane having a structure represented by the following formula (ia?): (L is an alkylene or phenylene), a photoactive agent, and a solvent.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: February 13, 2024
    Assignee: Merck Patent GmbH
    Inventors: Naofumi Yoshida, Takashi Fuke, Megumi Takahashi, Katsuto Taniguchi, Toshiaki Nonaka
  • Spheronized self-emulsifying system for hydrophobic and water-sensitive agents
    Patent number: 6630150
    Abstract: A self-emulsifying system comprises i) microcrystalline cellulose and ii) an oily substance, surfactant, and water is useful for providing solid dosage forms of hydrophobic or water sensitive agents when dried or extruded and spheronized.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: October 7, 2003
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Steven William Booth, Ashley Clarke, John Michael Newton
  • Rhodium and iridium complexes
    Patent number: 7589203
    Abstract: The present invention relates to novel organometallic compounds which are phosphorescence emitters. Such compounds can be used as active components (=functional materials) in a series of different types of application which can be classed within the electronics industry in the broadest sense. The inventive compounds are described by the formulae (1) to (32) and (1a) to (8a).
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: September 15, 2009
    Assignee: Merck Patent GmbH
    Inventors: Philipp Stössel, Hubert Spreitzer, Ingrid Bach
  • High level expression of human cyclooxygenase-2
    Patent number: 6689596
    Abstract: The invention discloses a cDNA consisting of human cyclooxygenase-2 cDNA attached to 3′ flanking sequence of human cyclooxygenase-1 methods for increasing the expression of human cyclooxygenase-2 in transformed cells and assays for preferentially and independently measuring cyclogenase-2 in samples.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: February 10, 2004
    Assignee: Merck & Co., Inc.
    Inventors: Gary P. O'Neill, Joseph A. Mancini
  • LIQUID-CRYSTALLINE MEDIUM
    Publication number: 20150166890
    Abstract: The invention relates to the compounds of the formula I and to a liquid-crystalline medium based on a mixture of polar compounds which contains at least one compound of the formula I in which R1, ring A1, L1, L2, L3, L4, L5, L6, L7, L8, Z1 and m have the meanings indicated in claim 1 and to the use of the LC mixtures in electro-optical displays, especially for the self-aligning VA mode.
    Type: Application
    Filed: December 15, 2014
    Publication date: June 18, 2015
    Applicant: Merck Patent GmbH
    Inventors: Graziano Archetti, Izumi Saito, Rocco Fortte, Timo Uebel
  • HETEROCYCLIC COMPOUNDS AS B-RAF INHIBITORS FOR TREATMENT OF CANCER
    Publication number: 20140323519
    Abstract: This invention relates to novel heterocyclic compounds that are useful for treating cancer and other cellular proliferative diseases and/or disorders associated with B-Raf activity. The compounds of the invention may be illustrated by the Formula (I).
    Type: Application
    Filed: April 20, 2012
    Publication date: October 30, 2014
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: M. Arshad Siddiqui, Lianyun Zhao, Amit K. Mandal
  • Matrix liquid crystal display
    Patent number: 7445818
    Abstract: The invention relates to a matrix liquid crystal display containing integrated non-linear elements and a liquid crystal mixture which has a particularly high resistivity.
    Type: Grant
    Filed: December 18, 2006
    Date of Patent: November 4, 2008
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Georg Weber, Ludwig Pohl, Reinhard Hittich, Herbert Plach, Bernhard Scheuble, Takamasa Oyama, Bernhard Rieger, Hans Adolf Kurmeier, Ekkehard Bartmann
  • Antihistaminic and appetite stimulating 10,11-dihydro-3-carboxycyproheptadine
    Patent number: 4160031
    Abstract: 10,11-Dihydro-3-carboxycyproheptadine is disclosed to have pharmaceutical utility as an appetite stimulant and as an antihistaminic agent. Also disclosed are processes for the preparation of such compound; pharmaceutical compositions comprising such compound; and methods of treatment comprising administering such compound and compositions.
    Type: Grant
    Filed: November 22, 1976
    Date of Patent: July 3, 1979
    Assignee: Merck & Co., Inc.
    Inventor: David C. Remy
  • ANTI-ALPHA-V INTEGRIN ANTIBODY FOR THE TREATMENT OF FIBROSIS AND/OR FIBROTIC DISORDERS
    Publication number: 20190144547
    Abstract: A method can treat a patient suffering from at least one of fibrosis and a fibrotic disorder. The method includes administering a therapeutically effective amount of an anti-?v integrin antibody DI17E6, or a biologically active variant or modification thereof, to the patient.
    Type: Application
    Filed: November 22, 2016
    Publication date: May 16, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Ilhan CELIK, Eike STAUB, Miriam URBAN, Sabine RAAB, Eileen SAMY, Andrew BENDER, Georgianna HIGGINBOTHAM, Yin WU, Daigen XU
  • Potassium salt of an HIV integrase inhibitor
    Patent number: 7754731
    Abstract: Potassium salts of Compound A and methods for their preparation are disclosed, wherein Compound A is of formula: Compound A is an HIV integrase inhibitor useful for treating or prophylaxis of HIV infection, for delaying the onset of AIDS, and for treating or prophylaxis of AIDS.
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: July 13, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Kevin M. Belyk, Henry G. Morrison, Amar J. Mahajan, Daniel J. Kumke, Hsien-Hsin Tung, Lawrence Wai, Vanessa Pruzinsky
  • Esters of 2-(substituted sulfamyl)-6-nitro-benzoic acid and pharmaceutical compositions
    Patent number: 4654369
    Abstract: Amides and esters of 2-(substituted sulfamyl)-6-nitro-benzoic acid, in which the substituents on the sulfamyl nitrogen are non-basic, such as: hydrogen, alkyl, hydroxyalkyl and non-basic heterocycles, which are useful as adjuncts to radiation therapy.
    Type: Grant
    Filed: November 6, 1985
    Date of Patent: March 31, 1987
    Assignee: Merck & Co., Inc.
    Inventor: Walfred S. Saari
  • 1-methoxy-2-phenyl ethenes useful for the preparation of 5-carboxaldehyde-2-3-dihydrobenzoxepines
    Patent number: 7442814
    Abstract: The present invention relates to the compounds of general formula (I) wherein R, R1, R2 are as defined in claim 1. Compounds of formula (I) are particularly useful for preparing 3,3-dimethyl-5-formyl-2,3-dihydrobenzoxepines derivatives.
    Type: Grant
    Filed: April 5, 2005
    Date of Patent: October 28, 2008
    Assignee: Merck Patent GmbH
    Inventors: Twana Saleh, Bernard Boudet
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