Search Patents
  • Use of pterin derivatives
    Patent number: 4774244
    Abstract: L-erythro-5,6,7,8-tetrahydrobiopterin, L-sepiapterin, 1',2'-diacetyl-5,6,7,8-tetrahydrobiopterin and 6-methyl-5,6,7,8-tetrahydropterin can be used for the therapeutic treatment of patients with Parkinson's disease and of patients with depression.
    Type: Grant
    Filed: January 27, 1988
    Date of Patent: September 27, 1988
    Assignee: Kanagafuchi Chemical Industry Company, Limited
    Inventors: Hans-Christoph Curtius, Heinrich-Georg Muldner, Alois Niederwieser
  • Use of enkephalinase inhibitors as analgesic agents
    Patent number: 4774256
    Abstract: Mercaptoalkanoyl and acylmercaptoalkanoyl compounds of the formula ##STR1## wherein n is an integer from one to fifteen possess enkephalinase inhibition activity and are useful as analgesic agents.
    Type: Grant
    Filed: November 13, 1987
    Date of Patent: September 27, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Norma G. Delaney, Eric M. Gordon, Miguel A. Ondetti
  • Rectally absorbable form of L-dopa
    Patent number: 4771073
    Abstract: The invention relates to compositions and methods of enhancing rectal absorption of L-dopa via the formation of an ester prodrug and optionally with a decarboxylase inhibitor.
    Type: Grant
    Filed: April 17, 1987
    Date of Patent: September 13, 1988
    Assignee: Merck & Co., Inc.
    Inventor: A. J. Repta
  • Use of acetyl L-carnitine for the therapeutical treatment of shock conditions
    Patent number: 4771075
    Abstract: Intravenous administration of a bolus of 3-5 grams of acetyl L-carnitine, followed by 3-5 grams of acetyl L-carnitine via slow infusion in about 12 hours, dramatically restore to normal the arterial pressure and respiratory frequency of a patient in a severe state of shock.
    Type: Grant
    Filed: October 6, 1986
    Date of Patent: September 13, 1988
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventor: Claudio Cavazza
  • Benzoic acid and benzoic acid ester derivatives having antiflammatory and analgesic activity
    Patent number: 4771064
    Abstract: Novel benzoic acid or benzoic acid ester derivatives, pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpetic neuralgia, inflammatory eye disorders, psoriasis, dental pain, and headaches, particularly vascular headache, such as migraine, cluster, mixed vascular syndromes, as well as nonvascular, tension headaches.
    Type: Grant
    Filed: September 21, 1987
    Date of Patent: September 13, 1988
    Assignee: Warner-Lambert Company
    Inventors: Michael F. Rafferty, Graham Johnson
  • Method for alleviation of primary depressive disorders
    Patent number: 4771053
    Abstract: Gepirone and its pharmaceutically acceptable salts are useful in alleviation of certain primary depressive disorders, such as major depression with melancholia and atypical depression.
    Type: Grant
    Filed: March 2, 1987
    Date of Patent: September 13, 1988
    Assignee: Bristol-Myers Company
    Inventors: Jerry M. Cott, Neil Kurtz, Donald S. Robinson
  • Dialytic solution for peritoneal dialysis
    Patent number: 4770879
    Abstract: A dialytic solution for peritoneal dialysis, which dialytic solution is characterized by containing glycerol and a monosaccharide as osmotic pressure regulating agents for regulating the osmotic pressure to a level necessary for the removal of water.
    Type: Grant
    Filed: April 24, 1986
    Date of Patent: September 13, 1988
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Takeshi Okamoto, Mitsuo Iwata, Hiroaki Takahashi
  • Method of treating patients suffering from chronic pain or chronic cough
    Patent number: 4769372
    Abstract: A method of treating patients in chronic pain or suffering from chronic cough over a prolonged period to provide systemic analgesia or central antitussive effect while simultaneously avoiding the onset of intestinal hypomotility. The method includes the oral administration to the patient of dosage units comprising in combination opioid analgesics or antitussives and selected opioid antagonists which are substantially devoid of systemic antagonist activity when administered orally.
    Type: Grant
    Filed: June 18, 1986
    Date of Patent: September 6, 1988
    Assignee: The Rockefeller University
    Inventor: Mary J. Kreek
  • Pharmaceutical compositions and methods for stimulating H.sub.3 histamine receptors
    Patent number: 4767778
    Abstract: The invention relates to a pharmaceutical composition containing histamine derivatives and to a method for treating diseases which involve histamine release and synthesis in the human or animal body.
    Type: Grant
    Filed: August 29, 1986
    Date of Patent: August 30, 1988
    Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Jean-Michel Arrang, Monique Garbarg, Walter Schunack, Jean-Charles Schwartz, Ralph O. Lipp
  • Hypocaloric preparation and intravenous method for hypocaloric treatment of patients
    Patent number: 4767785
    Abstract: Isotonic hypocaloric preparation comprising essential dietary amino acids with or without nonessential dietary amino adies, and xylitol, and method of treating patients ill from renal failure, cancer cachexia and receiving respiratory therapy.
    Type: Grant
    Filed: November 26, 1986
    Date of Patent: August 30, 1988
    Inventor: Michael Georgieff
  • Antiinflammatory compositions and methods
    Patent number: 4766117
    Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of antiinflammatory piroxicam, or a pharmaceutically acceptable salt thereof, with analgesic acetaminophen, antidepressant doxepin, bronchodilator pirbuterol, minor tranquilizer diazepam, or antihypertensive trimazosin.
    Type: Grant
    Filed: December 12, 1986
    Date of Patent: August 23, 1988
    Assignee: Pfizer Inc.
    Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
  • Pyroglutamic acid esters used as dermal penetration enhancers for drugs
    Patent number: 4762851
    Abstract: The invention relates to pyroglutamic acid esters used as dermal penetration enhancers for therapeutic agents having poor skin permeation.
    Type: Grant
    Filed: November 29, 1985
    Date of Patent: August 9, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Jose Alexander, Takeru Higuchi
  • Novel pharmaceutical compositions improving oxygenation of the brain and a process for their production
    Patent number: 4762855
    Abstract: 2,2-Bisphenoxy-dimethyl-aminoethane to improve brain disfunction.
    Type: Grant
    Filed: November 4, 1986
    Date of Patent: August 9, 1988
    Assignee: Albert Rolland S.A.
    Inventors: Jean-Claude Levy, Pierre Bessin, Jean-Pierre Labaune
  • Selective method for blocking 5HT2 receptors
    Patent number: 4762842
    Abstract: Method of blocking 5HT without effect on alpha receptors with 1-loweralkyl-6-straight chain alkyl-8.beta.-hydroxycycloalkyloxycarbonylergolines.
    Type: Grant
    Filed: October 5, 1987
    Date of Patent: August 9, 1988
    Assignee: Eli Lilly and Company
    Inventors: Marlene L. Cohen, Ray W. Fuller, William L. Garbrecht, Kathleen R. Whitten
  • Regimen for treating osteoporosis
    Patent number: 4761406
    Abstract: A method for treating or preventing osteoporosis utilizing a cyclic regimen comprising alternating for two or more cycles the administration of a bone resorption inhibiting polyphosphonate and a no treatment (rest) period. Further disclosed is a kit for use in implementing this method of treatment.
    Type: Grant
    Filed: June 6, 1985
    Date of Patent: August 2, 1988
    Assignee: The Procter & Gamble Company
    Inventors: Lawrence Flora, Benjamin F. Floyd
  • Enkephalinase and endorphinase inhibitors as anti-craving compositions
    Patent number: 4761429
    Abstract: A new class of anti-craving compositions is provided by substances which inhibit breakdown of endogenous substances such as enkephalins and/or endorphins. An anti-alcohol craving effect is observed with an enkephalin breakdown inhibitor. Specifically, D-phenylalanine, DL-phenylalanine, D-leucine, DL-leucine, and hydrocinnamic acid, each an encephalin breakdown inhibitor, significantly lowered alcohol intake in animals and humans. The anti-alcohol desire effect is observed in animals genetically prone to choose alcohol over water solutions.
    Type: Grant
    Filed: July 22, 1985
    Date of Patent: August 2, 1988
    Inventors: Kenneth Blum, Arthur H. Briggs, Jack E. Wallace
  • Treatment of demyelinating diseases
    Patent number: 4760092
    Abstract: Method of treating demyelinating diseases such as multiple sclerosis by treatment with colchicine or colchiceine.
    Type: Grant
    Filed: December 3, 1986
    Date of Patent: July 26, 1988
    Assignee: The Rockefeller University
    Inventor: Herman J. Weinreb
  • Analgesic compositions and method
    Patent number: 4760070
    Abstract: An improved method of treating pain in warm-blooded animals, including humans, by administering a central analgesic and adenine simultaneously or successively at times of a few seconds up to two hours and novel analgesic compositions comprising an analgesically effective amount of a central analgesic and adenine free of side effects.
    Type: Grant
    Filed: November 12, 1986
    Date of Patent: July 26, 1988
    Assignee: Roussel Uclaf
    Inventors: Francoise Delevallee, Roger Deraedt
  • Cosmetic sticks
    Patent number: 4759924
    Abstract: Transparent soap gel cosmetic stick compositions comprising a polyhydric aliphatic alcohol, a hydro-alcoholic soluble emollient, water and soap. Such cosmetic sticks possess good cosmetics as well as clarity.
    Type: Grant
    Filed: August 16, 1983
    Date of Patent: July 26, 1988
    Assignee: The Procter & Gamble Company
    Inventors: John P. Luebbe, James A. Davis
  • Method and agents for inhibiting protein aging
    Patent number: 4758583
    Abstract: The present invention relates to compositions and methods for inhibiting protein aging. Accordingly, a composition is disclosed which comprises an agent or compound capable of inhibiting the formation of advanced glycosylation end products of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. Suitable agents may contain an active nitrogen-containing group, such as a hydrazine group, and may further be at least partially derived from amino acids. Particular agents comprise aminoguanidine, .alpha.-hydrazinohistidine and lysine. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
    Type: Grant
    Filed: November 14, 1985
    Date of Patent: July 19, 1988
    Assignee: The Rockefeller University
    Inventors: Anthony Cerami, Peter C. Ulrich, Michael Brownlee