Search Patents
  • Anti-spike glycoprotein antibodies and the therapeutic use thereof
    Patent number: 12037383
    Abstract: The present application relates to neutralizing antibodies or antigen-binding fragments thereof against betacoronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), to nucleic acid(s) encoding such neutralizing antibodies or antigen-binding fragments thereof, and to mixture and compositions comprising such antibodies, antigen-binding fragments or nucleic acids. Such neutralizing antibodies or antigen-binding fragments thereof are able to block betacoronavirus entry into cells and/or to induce complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC) and/or antibody-dependent cellular phagocytosis (ADCP) against betacoronavirus-infected cells. Methods and uses of the antibodies, antigen-binding fragments thereof, nucleic acid(s) or compositions, including therapeutic, diagnostic, and preventative methods and uses for betacoronavirus infections and related diseases such as COVID-19, are also described.
    Type: Grant
    Filed: February 23, 2023
    Date of Patent: July 16, 2024
    Assignee: Talem Therapeutics LLC
    Inventors: Ilse Roodink, Yasmina Noubia Abdiche, Jennifer L. Bath
  • LAN emulation broadcast and unknown server
    Patent number: 6546015
    Abstract: A novel BUS entity utilizing the forwarding engine in a conventional LAN switch incorporating an ATM interface. The forwarding engine is adapted to assemble Ethernet frames from ATM cells and to segment Ethernet frames back to ATM cells. The switching fabric in a conventional LAN switch is adapted to perform the segmentation and re-assembly (SAR) function of the BUS whereby ATM cells are assembled into Ethernet frames, switched and segmented back to ATM cells. In operation, one or more Multicast Send VCCs transmit traffic destined for the BUS to the modified LAN switch of the present invention. The switching fabric is configured to switch the received traffic to an appropriate outbound Etheret port. The outbound Ethernet port is looped backed to itself and input to the switching fabric. Switching fabric is configured to output the traffic to the appropriate Multicast Forward VCC for distribution to the LECs.
    Type: Grant
    Filed: October 14, 1999
    Date of Patent: April 8, 2003
    Assignee: 3Com Corporation
    Inventors: Sarit Shani Natanson, Ronit Aizicovich, Henic Roizman, Raphi Hess
  • Psuedo-color display for enhanced visual target detection
    Patent number: 5546091
    Abstract: A pseudo-color display useful for enhanced target detection of two-dimensional images such as SAR data. The system includes a color display apparatus responsive to red, green and blue display control signals, and apparatus responsive to the input image data for remapping the respective input data for each pixel comprising the input image into respective red, green and blue display control signals in accordance with respective nonlinear red, green and blue remapping functions dependent on a single intensity threshold. This apparatus can include respective look-up tables stored in memory for each color, to be addressed by the respective pixel values. The display in one form also includes an image data processor which analyzes the input image data to adaptively select the intensity threshold, and calculate the respective remapping function values.
    Type: Grant
    Filed: November 23, 1994
    Date of Patent: August 13, 1996
    Assignee: Hughes Aircraft Company
    Inventors: Marc D. Haugen, Robin L. Morelock
  • Antenna unit and portable radio system comprising antenna unit
    Publication number: 20060017624
    Abstract: A subject of the present invention is to provide an antenna unit and a portable radio device capable of attaining a wider bandwidth and a lower SAR. In the present invention, an antenna element (12) that has an effective length corresponding to a half wavelength of a transmitting frequency and a parasitic element (13) that has an effective length corresponding to a half wavelength of a receiving frequency are provided, an antenna current is induced in the antenna element (12) at the transmitting frequency upon transmitting a radio wave in a predetermined transmitting frequency band, and another antenna current is induced in the parasitic element (13) by a spatial coupling between the antenna element (12) and the parasitic element (13) at the receiving frequency upon receiving the radio wave in a predetermined receiving frequency band, whereby peak points in an antenna current distribution are scattered into two points.
    Type: Application
    Filed: February 14, 2003
    Publication date: January 26, 2006
    Inventors: Kenya Nagano, Tadashi Oga
  • METHOD OF DIGITAL-TO-ANALOG CONVERTER MISMATCH CALIBRATION IN A SUCCESSIVE APPROXIMATION REGISTER ANALOG-TO-DIGITAL CONVERTER AND A SUCCESSIVE APPROXIMATION REGISTER ANALOG-TO-DIGITAL CONVERTER
    Publication number: 20180167078
    Abstract: A method of DAC mismatch calibration in a SAR ADC is disclosed. In one aspect, the method comprises determining a number of bits of an analog input signal (VIN), detecting if a binary code determined from the analog input signal (VIN) matches at least one trigger code, using at least one setting code to determine a calibration residue signal (V*RES) and a calibration bit (B*LSB), analyzing a least significant bit of the digital signal (COUT) and the calibration bit (B*LSB), determining an indication of a presence of DAC mismatch, and calibrating the DAC mismatch. As the determination of the calibration bit (B*LSB) requires only one additional comparison, when compared to the normal operation, the normal operation does not need to be interrupted. Therefore, the calibration can be done in the background and, as such, can be performed frequently thereby taking into account time-varying changes due to environmental effects.
    Type: Application
    Filed: December 6, 2017
    Publication date: June 14, 2018
    Inventors: Ming Ding, Pieter Harpe, Hanyue Li
  • Image-based drive-thru management system
    Patent number: 11900702
    Abstract: The subject matter of this specification can be implemented in, among other things, methods, systems, computer-readable storage medium. A method can include receiving, by a processing device, image data including one or more image frames indicative of a current state of a drive-thru area. The processing device determines a vehicle disposed within the drive-thru area based on the image data. The processing device receives order data with a pending meal order. The processing device determines a first association between the vehicle and the pending meal order based on the image data. The processing devices determine a meal delivery procedure associated with the based on the association between the vehicle and the pending meal order. The processing device performs may perform the meal delivery procedure. The processing device may provide the meal delivery procedure for display on a graphical user interface (GUI).
    Type: Grant
    Filed: February 17, 2023
    Date of Patent: February 13, 2024
    Assignee: Agot Co.
    Inventors: Evan DeSantola, Alex Litzenberger, Rassoul Mesbah, Prashasti Sar
  • NOVEL INTERFERON LAMBDA VARIANT AND METHOD OF PRODUCING THE SAME
    Publication number: 20230070752
    Abstract: Disclosed are a novel interferon lambda variant produced through structure-based glycoengineering and a method of producing the same. The novel interferon lambda variant and the method of producing the same exhibit remarkably improved production and yield in mammalian cell lines using structural information-based glycoengineering even through conventional purification protocols, and exhibit significantly improved therapeutic properties such as stability, half-life, and fraction of functional proteins during treatment, compared to wild-type interferon lambda. In addition, the novel interferon lambda variant and the method of producing the same according to the present invention have higher antiviral activity and interferon-stimulated gene (ISG)-inducing activity than wild-type interferon lambda, and thus are useful for the prevention and treatment of immune-related diseases such as cancer and autoimmune diseases as well as various viral infections such as infection with SARS-CoV-2 (COVID-19).
    Type: Application
    Filed: August 19, 2020
    Publication date: March 9, 2023
    Inventors: Ho Min KIM, Jae-Hee CHUNG, Eui-Cheol SHIN, Seon-Hui HONG
  • Radio system with multiple antenna arrays and adaptive waveforms
    Publication number: 20230061894
    Abstract: The radio system (10) comprises a waveform generator (1) alternately generating an FMCW wave representing a linearly frequency-modulated continuous wave for radar imaging and a CW wave representing a wave kept at a given frequency for measuring a velocity vector, an amplification chain (2), a set (4) of transmit antennas (41, 42, 43), a set (5) of receive antennas (51, 52, 531, 532), a set (7) of receivers (71-2, 731, 732), and a signal processor (9) implementing processing operations on FMCW signals received from the one or more lateral antennas (51, 52) of the set (5) of receive antennas (51, 52, 531, 532) and spectrally analysing CW signals received from the one or more lateral antennas (51, 52) and from the one or more ventral antennas (531, 532) of the set (5) of receive antennas (51, 52, 531, 532) so as to supply SAR images and components of the velocity vector of said airborne vehicle (20).
    Type: Application
    Filed: December 30, 2020
    Publication date: March 2, 2023
    Inventors: Pierre BALDENSPERGER, Francois MAGNE
  • Methods for in vivo reduction of free radical levels and compostions useful therefor
    Publication number: 20030203887
    Abstract: In accordance with the present invention, there are provided methods for the in vivo reduction of free radical levels in mammalian subjects in need thereof. In contrast to the inhibitory approach described in the prior art (i.e., wherein the function of the species responsible for free radical production is inhibited), the present invention employs a scavenging approach whereby overproduced free radical is bound in vivo to a suitable free radical scavenger. An exemplary free radical scavenger contemplated for use in the practice of the present invention is a dithiocarbamate-ferrous iron complex. This complex binds to free radicals, forming a stable, water-soluble free radical-containing complex. When administered to a subject afflicted with a disorder associated with free radical overproduction (e.g.
    Type: Application
    Filed: May 7, 2003
    Publication date: October 30, 2003
    Applicant: MCW Research Foundation, Inc.,
    Inventor: Ching-San Lai
  • POLYPEPTIDE FRAGMENTS, IMMUNOGENIC COMPOSITION AGAINST SARS-CoV-2, AND IMPLEMENTATIONS THEREOF
    Publication number: 20240262869
    Abstract: The present disclosure discloses the polypeptide fragment having an amino acid sequence with at least 95% identity to the amino acid sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 4, and SEQ ID NO: 6. The present disclosure also discloses nucleic acid fragment encoding the polypeptide fragment as described herein. Moreover, the present disclosure also discloses recombinant construct, recombinant vector and recombinant host cells. Also disclosed herein is an immunogenic composition comprising the polypeptide fragment as described herein, and a method for preparing the said immunogenic composition. The immunogenic composition is in form of vaccine. The polypeptide fragment and/or immunogenic composition is capable of eliciting protection against severe acute respiratory syndrome coronavirus 2. A kit comprising the polypeptide, or the immunogenic composition as described herein is also disclosed.
    Type: Application
    Filed: June 29, 2021
    Publication date: August 8, 2024
    Applicants: Indian Institute of Science, MYNVAX PRIVATE LIMITED
    Inventors: Raghavan VARADARAJAN, Sameer Kumar MALLADI, Shahbaz AHMED, Suman PANDEY, Randhir SINGH
  • Image registration using rotation tolerant correlation method
    Patent number: 8155452
    Abstract: A method for correlating or finding similarity between two data sets. The method can be used for correlating two images with common scene content in order to find correspondence points between the data sets. These correspondence points then can be used to find the transformation parameters which when applied to image 2 brings it into alignment with image 1. The correlation metric has been found to be invariant under image rotation and when applied to corresponding areas of a reference and target image, creates a correlation surface superior to phase and norm cross correlation with respect to the correlation peak to correlation surface ratio. The correlation metric was also found to be superior when correlating data from different sensor types such as from SAR and EO sensors. This correlation method can also be applied to data sets other than image data including signal data.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: April 10, 2012
    Assignee: Harris Corporation
    Inventor: Kathleen Minear
  • STARS—a muscle-specific actin-binding protein
    Patent number: 7070957
    Abstract: The present invention relates to a new polypeptide and the gene coding therefore, gene being an evolutionarily conserved actin-binding protein, called STARS (striated muscle activator of Rho signalin), that is expressed specifically in cardiac and skeletal muscle cells and is upregulated in response to calcineurin signaling during cardiac hypertrophy. STARS is localized to the thin filament of the sar comere and to actin stress fibers where it promotes actin bundling. STARS stimulates the transcriptional activity of serum response factor (SRF) through a mechanism that requires actin bundling and Rho kinase activation. STARS provides a mechanism for selectively enhancing the transcriptional activity of SRF in muscle cells and for linking changes in actin dynamics to gene transcription. Also disclosed are methods of using the gene and protein in drug screening and therapy, including, for example, use of the gene in gene therapy to treat cardiovascular disease.
    Type: Grant
    Filed: August 20, 2003
    Date of Patent: July 4, 2006
    Assignee: Board of Regents, The University of Texas System
    Inventors: Eric Olson, Akiko Arai
  • Techniques for magnetic particle imaging
    Patent number: 10048224
    Abstract: A magnetic particle imaging apparatus includes magnets [106,107] that produce a gradient magnetic field having a field free region (FFR), excitation field electromagnets [102,114] that produce a radiofrequency magnetic field within the field free region, high-Q receiving coils [112] that detect a response of magnetic particles in the field free region to the excitation field. Field translation electromagnets create a homogeneous magnetic field displacing the field-free region through the field of view (FOV) allowing the imaging region to be scaled to optimize scan time, scanning power, amplifier heating, SAR, dB/dt, and/or slew rate. Efficient multi-resolution scanning techniques are also provided. Intermodulated low and radio-frequency excitation signals are processed to produce an image of a distribution of the magnetic nanoparticles within the imaging region. A single composite image is computed using deconvolution of multiple signals at different harmonics.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: August 14, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Patrick W. Goodwill, Steven M. Conolly
  • SYSTEMS AND METHODS FOR DYNAMIC TRANSMISSION POWER LIMIT BACK-OFF FOR SPECIFIC ABSORPTION RATE COMPLIANCE
    Publication number: 20120270592
    Abstract: This disclosure provides systems, methods and apparatus for providing transmission power limit back-off for Specific Absorption Rate (SAR) compliance. In one aspect, a method implemented in a wireless communication apparatus is provided. The method includes receiving an indication of at least one operating mode indicative of a proximity and an orientation of at least one transmitting antenna of the wireless communication apparatus. The method further includes selecting from a plurality of transformations associated with the at least one operating mode. The method further includes applying a selected transformation to adjust a relationship between a power transmission level of a first transmitter and a power transmission level of a second transmitter. The method further includes determining a target power transmission level of the first transmitter based on the adjusted relationship and a current power transmission level of the second transmitter.
    Type: Application
    Filed: March 2, 2012
    Publication date: October 25, 2012
    Applicant: QUALCOMM Incorporated
    Inventors: Francis Ming-Meng Ngai, John A. Forrester, Anshul Pandey, Supratik Bhattacharjee, Rema Vaidyanathan, Brian Michael George, Zhu Ji
  • Chemokine Receptor Antagonist and Medical Use Thereof
    Publication number: 20070254886
    Abstract: The present invention relates to a compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof, and medical use thereof (the symbols in the formula are as described in the specification). The compound represented by formula (I) has chemokine receptor (especially in CCR4 and/or CCR5) antagonistic activity. Therefore it is useful for prevention and/or treatment of a chemokine receptor-mediated disease such as inflammatory and/or allergic diseases [systemic inflammatory response syndrome (SIRS), anaphylaxis, anaphylactoid reaction, allergic angiitis, transplant rejection reaction, hepatitis, nephritis, nephropathy, pancreatitis, rhinitis, arthritis, inflammatory ocular disease, inflammatory bowel disease, disease in cerebro and/or circulatory system, respiratory disease, dermatosis, autoimmune disease, and the like], infection [viral disease (human immunodeficiency virus infection, acquired immunodeficiency syndrome, SARS, etc.
    Type: Application
    Filed: September 3, 2004
    Publication date: November 1, 2007
    Inventors: Hiromu Habashita, Hiroshi Ochiai, Natsuko Tokuda, Shiro Shibayama, Noriki Watanabe, Takaki Komiya, Kazuhiko Takeda
  • Storage of network data
    Patent number: 8510457
    Abstract: A generic method is described for storing data in the HSS (2) by the S-CSCF (1) of an IMS. When a SIP message containing new information relating to an IMPI/IMPU pair is received by the S-CSCF (1), a data package is created for storage at the HSS (2), containing the new information. An SAR command is sent to the HSS (2) containing an AVP including an instruction to the HSS (2) and the new data package. In one aspect a unique data package is controlled by the S-CSCF (1). When new information relating to the IMPI/IMPU is received in a SIP message, this is added to any previously sent data package to create a new data package. In another aspect the HSS (2) controls a unique data package, returning the data package to the S-CSCF (1) to be amended if necessary. In another aspect separate data packages are used.
    Type: Grant
    Filed: November 30, 2007
    Date of Patent: August 13, 2013
    Assignee: Telefonaktiebolaget L M Ericsson (Publ)
    Inventors: Maria-Carmen Belinchón Vergara, Hubert Przybysz, Juan Manuel Fernandez Galmes
  • Adaptive maximum power limiting using capacitive sensing in a wireless device
    Patent number: 9621211
    Abstract: An apparatus for satisfying Specific Absorption Rate (SAR) compliance criteria including a first capacitance sensor, a second capacitance sensor, a memory, and a processor. The memory is configured to store pre-established proximity regions that include a free space region of proximity based on baseline capacitance measurements obtained from the sensors when no human body is proximate a wireless device and a first region of proximity based on initial capacitance measurements obtained from the sensors when the human body is spaced apart from the wireless device by a first predetermined separation distance. The processor is configured to instruct a radio frequency (RF) transmitter to operate at a first output power when subsequent capacitance measurements received from the sensors are within the free space region of proximity and at a second output power, less than the first output power when the subsequent capacitance measurements are within the first region of proximity.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: April 11, 2017
    Assignee: Futurewei Technologies, Inc.
    Inventors: Ping Shi, Jinchun Ge
  • Merging multiple network data flows
    Patent number: 7843939
    Abstract: The disclosure presents techniques for merging multiple data flows in a network such as a Passive Optical Network (PON). The PON comprises an interface module and network nodes connected to the interface module via an optical fiber link. Each network node further serves client devices. The client devices request multiple data flows, requiring the interface module to serve multiple data flows to a network node for delivery to the devices. The interface module merges received data flows to permit multiple flows to be processed by a single segmentation and reassembly (SAR) engine, reducing hardware cost and complexity within the node. However, subunits associated with different data flows within a merged data flow are not interleaved with one another. Instead, the subunits associated with an original unit of information are transmitted contiguously within the merged data flow, facilitating identification and reassembly of the subunits for a particular microflow.
    Type: Grant
    Filed: October 27, 2008
    Date of Patent: November 30, 2010
    Assignee: Calix, Inc.
    Inventors: Duane M. Butler, Mike Conner, Christopher T. Bernard, Christopher D. Koch
  • Compositions and methods for modulating plant disease resistance and immunity
    Patent number: 9074005
    Abstract: Provided are methods for enhancing plant cell disease resistance, comprising (1) generating a homozygous gene modification of AtSR1 (or AtSR1 ortholog or homolog) in a plant or plant cell characterized by sialic acid-mediated systemic acquired resistance (SA-mediated SAR), wherein said gene modification reduces or eliminates the calmodulin-binding activity of the respective AtSR1 or AtSR1 ortholog or homolog; or (2) expression of a recombinant or mutant AtSR1 sequence (or AtSR1 gene ortholog or homolog sequence) encoding a modified AtSR1, or AtSR1 ortholog or homolog protein, in a plant or plant cell, wherein said protein modification reduces or eliminates the calmodulin-binding activity of the respective AtSR1 or AtSR1 ortholog or homolog protein. Plants and/or plant cells comprising said modified AtSR1, or AtSR1 ortholog or homolog proteins, and/or said expression means (e.g.
    Type: Grant
    Filed: January 4, 2010
    Date of Patent: July 7, 2015
    Assignee: Washington State University
    Inventors: Bachettira W. Poovaiah, Liqun Du
  • METHOD FOR IMPROVING SFDR AND SNDR OF CAPACITOR-RESISTOR COMBINED SAR ADC BY CAPACITOR RE-CONFIGURATION
    Publication number: 20180198457
    Abstract: A method for improving a spurious free dynamic range and a signal-to-noise-and-distortion ratio of a capacitor-resistor combined successive approximation register analog-to-digital converter by capacitor re-configuration, the method including: 1) arranging 128 unit capacitors in a positive array and a negative array, respectively, dividing unit capacitors of symmetrical positions of the positive array and the negative array into groups to yield a total of 128 groups of capacitors; 2) acquiring 128 digital codes corresponding to 128 groups of capacitors; 3) sorting the 128 groups of capacitors from maximum to minimum according to the 128 digital codes obtained in 2), and recording the 128 groups of capacitors after sorting as C1-C128; and 4) selecting 64 groups of capacitors from C33 to C96, and reconfiguring the 64 groups of capacitors in capacitor arrays of the capacitor-resistor analog-to-digital converter.
    Type: Application
    Filed: March 15, 2017
    Publication date: July 12, 2018
    Inventors: Hua FAN, Hadi HEIDARI, Franco MALOBERTI, Dagang LI, Daqian HU, Yuanjun CEN
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