Search Patents
  • CHLAMYDIA-FREE CELL LINES AND ANIMALS
    Publication number: 20020009802
    Abstract: Methods for clearing Chlamydia from biological materials, e.g., cells and animals, infected therewith are described. Methods for maintaining Chlamydia-free cells and animals are also described.
    Type: Application
    Filed: February 18, 1998
    Publication date: January 24, 2002
    Inventors: WILLIAM M. MITCHELL, CHARLES W. STRATTON
  • Phosphodiester alpha-GlcNAcase of the lysosomal targeting pathway
    Publication number: 20030148460
    Abstract: The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme phosphodiester &agr;-GlcNAcase, methods of producing and methods of purifying this enzyme.
    Type: Application
    Filed: November 29, 2002
    Publication date: August 7, 2003
    Applicant: NOVAZYME PHARMACEUTICALS, INC.
    Inventor: William M. Canfield
  • DELIVERY METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED GENOME ENGINEERING
    Publication number: 20140335063
    Abstract: Disclosed herein are methods and compositions for delivery of engineered nucleases and donor molecules into the genome of a cell.
    Type: Application
    Filed: May 6, 2014
    Publication date: November 13, 2014
    Inventors: Paula M. Cannon, Colin Michael Exline, Michael C. Holmes
  • COMPOSITIONS AND METHODS FOR MODULATING CELL DIFFERENTIATION
    Publication number: 20090221072
    Abstract: Compositions and methods are described for using the Ea4-peptide of pro-IGF-I or human Eb-peptide of pro-IGF-I to inhibit hematopoiesis and to induce differentiation of neuroblastoma cells and neuronal stem cells.
    Type: Application
    Filed: May 13, 2009
    Publication date: September 3, 2009
    Inventors: Thomas T. Chen, Maria J.M. Chen
  • Full-length infectious cDNA clones of tick borne flavivirus
    Publication number: 20040033594
    Abstract: Embodiments described herein include full-length infectious cDNA clones of Langat tick-borne flavivirus.
    Type: Application
    Filed: July 26, 2002
    Publication date: February 19, 2004
    Inventors: Alexander Pletnev, Robert M. Chanock
  • DNA molecules encoding mammalian cerberus-like proteins
    Patent number: 5935852
    Abstract: DNA molecules are disclosed which encode mammalian Cerberus-Like Proteins.
    Type: Grant
    Filed: July 3, 1997
    Date of Patent: August 10, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Maximillian Follettie, Edward M. DeRobertis
  • Siglec-12 polypeptides, polynucleotides, and methods of use thereof
    Publication number: 20030040604
    Abstract: Provided herein are polypeptide and polynucleotide sequences for a molecule having homology to the siglec family of polypeptides. Also provided are methods of making and using a siglec-like polypeptide and polynucleotide.
    Type: Application
    Filed: May 29, 2002
    Publication date: February 27, 2003
    Inventors: Dirk M. Anderson, John S. Marken
  • Mycobacterium Antigens
    Publication number: 20100317036
    Abstract: There is provided a diagnostic reagent for use in the detection of M. bovis or M. tuberculosis infection in an animal, comprising a peptide which has an epitope from Mycobacterium bovis hypothetic protein Mb3645c (SEQ ID NO: 1) or an epitope from a polypeptide having at least 76% identity with SEQ ID NO: 1.
    Type: Application
    Filed: November 6, 2008
    Publication date: December 16, 2010
    Applicant: The Secretary of State for Environment Food and Rural Affairs
    Inventors: Hanns Vordermeier, Benjamin Sidders, Neil Graham Stoker, Katie Ewer
  • Masp-3, a complement-fixing enzyme, and uses for it
    Publication number: 20030186419
    Abstract: The invention relates to the discovery and characterization of mannan binding lectin-associated serine protease 3 (MASP-3), a new serine protease that acts in the MBLectin complement fixation pathway.
    Type: Application
    Filed: February 14, 2003
    Publication date: October 2, 2003
    Inventor: Jens Christian Jensenius
  • Targeted genomic alteration
    Publication number: 20110189775
    Abstract: Disclosed herein are methods and compositions for targeted integration and/or targeted excision of one or more sequences into a cell, for example, for expression of one or more polypeptides of interest.
    Type: Application
    Filed: January 24, 2011
    Publication date: August 4, 2011
    Inventors: William M. Ainley, Michael G. Murray, Fyodor Urnov, Bryan Zeitler
  • Labeled Macrophages and Methods of Use Thereof
    Publication number: 20090016956
    Abstract: Methods of making and using labeled macrophages are described.
    Type: Application
    Filed: April 28, 2008
    Publication date: January 15, 2009
    Inventors: Robert Bender, Allan M. Green, Perry Kim, Robert Kisilevsky, Douglas S. McNair, Shui-pang Tam
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20020146769
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: January 7, 2002
    Publication date: October 10, 2002
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Cheryl Evans, Vikki Spaulding
  • TRANSCRIPTOMIC BIOMARKER OF MYOCARDITIS
    Publication number: 20100190650
    Abstract: Molecular signatures that function as very sensitive diagnostic biomarker for myocarditis, heart disease and disorders thereof, are identified.
    Type: Application
    Filed: October 30, 2009
    Publication date: July 29, 2010
    Applicant: Univrsity of Miami
    Inventors: Joshua M. Hare, Bettina Heidecker
  • Antibodies to IL-17A
    Patent number: 7846443
    Abstract: Engineered antibodies to human IL-17A are provided, as well as uses thereof.
    Type: Grant
    Filed: August 9, 2007
    Date of Patent: December 7, 2010
    Assignee: Schering Corporation
    Inventors: Leonard G. Presta, Edward P. Bowman
  • HUMAN CHORDIN-RELATED PROTEINS AND POLYNUCLEOTIDES ENCODING THEM
    Publication number: 20020197666
    Abstract: Novel human chordin-related proteins and polynucleotides encoding them are disclosed.
    Type: Application
    Filed: August 13, 1999
    Publication date: December 26, 2002
    Inventors: KENNETH JACOBS, JOHN M. MCCOY, EDWARD R. LAVALLIE, LISA A. COLLINS-RACIE, DAVID MERBERG, MAURICE TREACY, ELIZABETH DIBLASIO-SMITH, ANGELA WIDOM
  • TARGETED CELL DEATH
    Publication number: 20090019554
    Abstract: The present invention provides compositions and methods for studying neuropathy. The compositions and methods provided herein are particularly useful for screening agents of therapeutic and/or diagnostic potential.
    Type: Application
    Filed: June 12, 2008
    Publication date: January 15, 2009
    Inventors: Stephen M. Selkirk, Robert H. Miller
  • Production of glycoproteins using manganese
    Patent number: 8617878
    Abstract: Culture media comprising manganese and methods of culturing cells to improve sialylation and glycosylation of glycoproteins are provided.
    Type: Grant
    Filed: May 20, 2011
    Date of Patent: December 31, 2013
    Assignee: Amgen Inc.
    Inventors: Christopher K. Crowell, Gustavo E. Grampp
  • Compositions and methods for gender sorting
    Patent number: 7083941
    Abstract: A yeast based transactivation assay for gender sorting is disclosed.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: August 1, 2006
    Assignee: Lifesensors, Inc.
    Inventors: Tauseef Butt, Hiep Tuan Tran
  • TRANSAMINASE BIOCATALYSTS
    Publication number: 20100285541
    Abstract: The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
    Type: Application
    Filed: February 26, 2010
    Publication date: November 11, 2010
    Applicant: CODEXIS, INC.
    Inventors: Christopher Saville, Emily Mundorff, Jeffrey C. Moore, Paul N. Devine, Jacob M. Janey
  • Recombinant cells regulated by tetracycline
    Patent number: 6242254
    Abstract: The present invention provides a recombinant, cell whose proliferation is controlled by tetracycline or a derivative thereof.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: June 5, 2001
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventor: Shimon Efrat