Abstract: A cell model for in vitro evaluation of compound-induced skin sensitization and a constructing method therefor. The method for constructing the cell model comprises the steps of: designing and constructing an sgRNA expression vector based on CRISPR/Cas9 vector system; designing and constructing a homologous recombinant vector capable of knocking a reporter gene linked to a self-cleaving peptide sequence into a specific site of the expression frame of the HMOX1 gene; co-transfecting the homologous recombinant vector, an hCas9 plasmid and the sgRNA expression vector into a cell, and carrying out monoclonal expansion to obtain the cell model. The present invention obtains a HaCaT cell model in which a luciferase gene is knocked in before the stop codon of the HMOX1 gene by combination of CRISPR/CAS9 and a monoclonal cell technique. The cell model realizes synchronous expression of the luciferase gene and the HMOX1 gene, thereby effectively distinguishing sensitizing compounds from non-sensitizing compounds.

Abstract: Novel combination therapies involving nitroxoline, its analogue or pharmaceutically acceptable salt thereof with at least one additional anti-cancer chemotherapy or immunotherapy agent are described. Related kits, pharmaceutical compositions and methods of production are also described.

Abstract: Provided is a display panel. The display panel includes a pixel driving circuit which including a drive transistor, a data write module, a light emission control module, a threshold compensation module and a bias adjustment module. The control terminal of the drive transistor is connected to the first node. The first terminal of the drive transistor is connected to a third node. The second terminal of the drive transistor is connected to a second node. The light emission control module is connected in series with the drive transistor and connected in series with a light-emitting element. The threshold compensation module is connected in series between the control terminal of the drive transistor and the second terminal of the drive transistor. The first terminal of the bias adjustment module is connected to a bias signal terminal and the second terminal is connected to the second terminal of the drive transistor.

Abstract: An optical calibration tool includes a first body, a light emitter, a light receiver, a second body, and a light reflecting member. The first body has a first engaging port and a second engaging port. The light emitter and the light receiver are disposed in the first body. The second body has a third engaging port and a channel communicated with each other. The third engaging port is configured to selectively engage one of the first engaging port and the second engaging port. When the third engaging port is engaged with the first engaging port, the light emitter is optically coupled to the light reflecting member. When the third engaging port is engaged with the second engaging port, the light receiver is optically coupled to the light reflecting member.

Abstract: A stator winding structure (100) for a motor. The motor is a three-phase alternating current motor having eight poles. Each phase comprises four shunt wound branches. The stator winding consists of multiple U-shaped flat copper wires (10). A connection portion of each U-shaped flat copper wire (10) disposed in the motor is located on the same side with respect to the motor. The technical solution also provides a motor comprising the stator winding structure (100) and a vehicle comprising the motor.

Abstract: In certain embodiments, the present invention provides a method of measuring the level of hydrophobicity of a chromatographic resin. In certain embodiments, the present invention provides a method of selecting a chromatographic resin condition for purifying a protein of interest from a mixture, wherein the protein of interest has low or no aggregation formation during chromatography. In certain embodiments, the present invention provides a method of selecting a chromatographic resin from a plurality of chromatographic resins for purifying a protein of interest from a mixture, wherein the protein of interest has low or no aggregation formation during chromatography.

Abstract: Disclosed is a method for convolution calculation in a neural network, comprising: reading an input feature map, depthwise convolution kernels and pointwise convolution kernels from a dynamic random access memory (DRAM); performing depthwise convolution calculations and pointwise convolution calculations by depthwise convolution calculation units and pointwise convolution calculation units, according to the input feature map, the depthwise convolution kernels and the pointwise convolution kernels to obtain output feature values of a first predetermined number p of points on all pointwise convolution output channels; storing the output feature values of a first predetermined number p of points on all pointwise convolution output channels into an on-chip memory; and repeating above operation to obtain output feature values of all points on all point wise convolution output channels. Therefore, the storage space for storing intermediate results may be reduced.

Abstract: A device for diverting and defoaming with a bent pipe applied to a high head water supply structure includes an inner well, an outer well, a baffle, and a plurality of overflow pipes. The baffle is respectively connected with an outer wall of the inner well and an inner wall of the outer well to form an overflow groove, the top end of the inner well is higher than the baffle to form an overflow weir, one end of the overflow pipe is provided with a first pipe orifice in the overflow groove, the other end of the overflow pipe is communicated with the inner well to form a second pipe orifice, the first pipe orifice is higher than the second pipe orifice, the overflow pipe is bent in the overflow groove to form a first bending part, and the first bending part is higher than the first pipe orifice.

Abstract: A downhole electromagnetic logging tool comprises a transmitting system, a magnetic field sensor array and a control module. The transmitting system and the magnetic field sensor array are both connected to the control module. The transmitting system comprises an upper emission coil and a lower emission coil, which are respectively arranged above and below the magnetic field sensor array, for generating magnetic fields of opposite polarities, allowing the magnetic fields to be concentrated at the magnetic field sensor array. A casing generates a secondary magnetic field, which is received by the magnetic field sensor array to complete detection of the casing.

Abstract: Various embodiments of the present disclosure are directed towards an integrated chip including a capacitor over a substrate. The capacitor includes a plurality of conductive layers and a plurality of dielectric layers. The plurality of conductive layers and dielectric layers define a base structure and a first protrusion structure extending downward from the base structure towards a bottom surface of the substrate. The first protrusion structure comprises one or more surfaces defining a first cavity. A top of the first cavity is disposed below the base structure.

Abstract: A MRAM circuit structure is provided in the present invention, with the unit cell composed of three transistors in series and four MTJs, wherein the junction between first transistor and third transistor is first node, the junction between second transistor and third transistor is second node, and the other ends of first transistor and third transistor are connected to a common source line. First MTJ is connected to second MTJ in series to form a first MTJ pair that connecting to the first node, and third MTJ is connected to fourth MTJ in series to form a second MTJ pair that connecting to the second node.

Abstract: A conduit system for transporting gas from a gas containing chamber for processing a substrate from which semiconductor devices are formed includes a liner with a spiral vent. The conduit system utilizes a curtain of gas to prevent or reduce deposition of material onto an inner surface of the conduit transporting the gas from the gas containing chamber.

Abstract: An extremely high throughput (EHT) station (STA) configured for trigger based (TB) transmission may decode an trigger frame (TF) received from an access point (AP). The TF may include an assignment of resources comprising one or more 20 MHz channels. The EHT STA may determine which of the one or more assigned channels are available for transmission and which of the allocated channels are unavailable when the EHT STA is assigned more than one 20 MHz channel. The EHT STA may encode a EHT TB PPDU in response to the trigger frame. The EHT TB PPDU may be encoded to include an EHT preamble followed by a data field. The EHT preamble may be encoded to indicate channel availability. The EHT STA may generate signalling to cause the EHT STA to transmit the encoded EHT TB PPDU only on the assigned channels that have been determined to be available.

Abstract: The disclosure relates to an imaging system, including a first lens, a second lens, a third lens, a diaphragm, a fourth lens, a fifth lens, a sixth lens and a seventh lens arranged in sequence from an object side to an image side along an optical axis, wherein the first lens, the second lens, the third lens and the sixth lens all have refractive powers, the fourth lens has a negative refractive power, the fifth lens has a positive refractive power, and the seventh lens has a negative refractive power. The imaging system of the disclosure has excellent characteristics such as ultra-wide angle, thereby being able to satisfy more photography demands.

Abstract: Methods, systems, and devices for wireless communications are described for enabling a network equipment to reduce interference for downlink (DL) transmissions to a first device by determining a transmit precoding matrix indicator (TPMI) for uplink (UL) transmissions transmitted by a second device based on feedback from the first device. The first device may determine a subset of possible TPMIs that the second device may use for UL transmissions for full-duplex communications. The first device may indicate the subset to the network equipment. Based on the subset indicated by the first device, the network equipment may determine a pairing of the first device and the second device for full-duplex communications. Additionally, the network equipment may determine a TPMI for the second device to use in UL transmissions and indicate the TPMI to the second device.

Abstract: A memory device includes an alternating stack of dielectric layers and word line layers, pairs of bit lines and source lines spaced apart from one another, a data storage layer covering a sidewall of the alternating stack, and channel layers interposed between the data storage layer and the pairs of bit lines and source lines. The alternating stack includes a staircase structure in a staircase-shaped region, and the staircase structure steps downward from a first direction and includes at least one turn. The pairs of bit lines and source lines extend in a second direction that is substantially perpendicular to the first direction and are in lateral contact with the data storage layer through the channel layers. A semiconductor structure and a method are also provided.

Abstract: Disclosed are an atomizer, an atomization system and an operation method of the atomization system. The atomizer includes an atomization pipe, a reservoir and a flexible block piece. The atomization pipe includes an opening. The opening penetrates through an outer surface of the atomization pipe. The reservoir is disposed in the atomization pipe. The opening is communicated with the reservoir. The flexible block piece is disposed in the opening. The flexible block piece allows an injection needle to pass through the flexible block piece and enter the reservoir. The atomization system includes a base and the atomizer, and the atomizer is detachably connected to the base. The flexible block piece is filled in the opening to play a sealing role, and when specific liquid is consumed, the specific liquid can be injected into the reservoir by penetrating the injector into the flexible block piece, thus achieving reuse of the atomizer.

Abstract: A rotary table includes a housing having a first groove, a second groove and a drainage channel connecting the first groove and the second groove, a motor, a shaft located in the housing and provided with a guide portion, and a leak detection belt set in an accommodation chamber in the housing and embedded in the second groove. In this way, if liquid enters the housing, the guide portion of the shaft guides the liquid into the first groove, so that the liquid reaches the second groove along the drainage channel. At this time, the leak detection belt can be used for leakage detection to protect key components.

Abstract: The present disclosure provides an information searching method and information searching apparatus, a computer device, and a storage medium. The method includes: obtaining and presenting a plurality of question and answer topics in response to a searching operation for historical question and answer information, wherein the question and answer topics are determined based on aggregation results obtained by aggregating a plurality of rounds of historical question and answer information; obtaining, in response to any one of the plurality of question and answer topics represented being triggered, at least one sub-dimension tag under the question and answer topic; and presenting each sub-dimension tag, and presenting a sub-aggregation result under a selected sub-dimension tag according to timing information of historical question and answer information, wherein the sub-aggregation result is obtained by aggregating the aggregation result according to a target dimension indicated by the selected sub-dimension tag.